JP2005503116A5 - - Google Patents
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- JP2005503116A5 JP2005503116A5 JP2002564541A JP2002564541A JP2005503116A5 JP 2005503116 A5 JP2005503116 A5 JP 2005503116A5 JP 2002564541 A JP2002564541 A JP 2002564541A JP 2002564541 A JP2002564541 A JP 2002564541A JP 2005503116 A5 JP2005503116 A5 JP 2005503116A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- pta
- ccr5
- domain
- chemokine receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 102000009410 Chemokine receptor Human genes 0.000 claims 63
- 108050000299 Chemokine receptor Proteins 0.000 claims 63
- 108091006027 G proteins Proteins 0.000 claims 31
- 102000030782 GTP binding Human genes 0.000 claims 31
- 108091000058 GTP-Binding Proteins 0.000 claims 31
- 125000003275 alpha amino acid group Chemical group 0.000 claims 28
- 210000004027 cell Anatomy 0.000 claims 22
- 210000004408 hybridoma Anatomy 0.000 claims 17
- 230000005764 inhibitory process Effects 0.000 claims 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 230000035605 chemotaxis Effects 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 208000035475 disorder Diseases 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 5
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 3
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 3
- 229940127089 cytotoxic agent Drugs 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 2
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 2
- 102100032367 C-C motif chemokine 5 Human genes 0.000 claims 2
- 102100032366 C-C motif chemokine 7 Human genes 0.000 claims 2
- 101710155834 C-C motif chemokine 7 Proteins 0.000 claims 2
- 102100034871 C-C motif chemokine 8 Human genes 0.000 claims 2
- 101710155833 C-C motif chemokine 8 Proteins 0.000 claims 2
- 108700012434 CCL3 Proteins 0.000 claims 2
- 102000000013 Chemokine CCL3 Human genes 0.000 claims 2
- 102000001326 Chemokine CCL4 Human genes 0.000 claims 2
- 108010055165 Chemokine CCL4 Proteins 0.000 claims 2
- 108010055166 Chemokine CCL5 Proteins 0.000 claims 2
- 102100023688 Eotaxin Human genes 0.000 claims 2
- 101710139422 Eotaxin Proteins 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 2
- 208000037357 HIV infectious disease Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 230000008614 cellular interaction Effects 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- AEUKDPKXTPNBNY-XEYRWQBLSA-N mcp 2 Chemical compound C([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)C1=CC=CC=C1 AEUKDPKXTPNBNY-XEYRWQBLSA-N 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102000004274 CCR5 Receptors Human genes 0.000 claims 1
- 108010017088 CCR5 Receptors Proteins 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 206010011831 Cytomegalovirus infection Diseases 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102100029567 Immunoglobulin kappa light chain Human genes 0.000 claims 1
- 101710189008 Immunoglobulin kappa light chain Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241000233870 Pneumocystis Species 0.000 claims 1
- 208000005585 Poxviridae Infections Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 229940045799 anthracyclines and related substance Drugs 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000000340 anti-metabolite Effects 0.000 claims 1
- 229940100197 antimetabolite Drugs 0.000 claims 1
- 239000002256 antimetabolite Substances 0.000 claims 1
- 239000003080 antimitotic agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940124522 antiretrovirals Drugs 0.000 claims 1
- 239000003903 antiretrovirus agent Substances 0.000 claims 1
- 230000001640 apoptogenic effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000973 chemotherapeutic effect Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 125000002228 disulfide group Chemical group 0.000 claims 1
- 230000003828 downregulation Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 201000000317 pneumocystosis Diseases 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 230000003827 upregulation Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/779,880 US20020061834A1 (en) | 2000-02-09 | 2001-02-09 | Human G-protein Chemokine receptor (CCR5) HDGNR10 |
| PCT/US2001/004153 WO2001058916A2 (en) | 2000-02-09 | 2001-02-09 | Antibodies to ccr5 |
| US29725701P | 2001-06-12 | 2001-06-12 | |
| US31045801P | 2001-08-08 | 2001-08-08 | |
| US32844701P | 2001-10-12 | 2001-10-12 | |
| US34172501P | 2001-12-21 | 2001-12-21 | |
| PCT/US2002/003634 WO2002064612A2 (en) | 2001-02-09 | 2002-02-08 | Human g-protein chemokine receptor (ccr5) hdgnr10 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005032376A Division JP2005124588A (ja) | 2001-02-09 | 2005-02-08 | ヒトｇタンパク質ケモカインレセプター（ｃｃｒ５）ｈｄｇｎｒ１０ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005503116A JP2005503116A (ja) | 2005-02-03 |
| JP2005503116A5 true JP2005503116A5 (enExample) | 2005-12-22 |
Family
ID=27555666
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002564541A Withdrawn JP2005503116A (ja) | 2001-02-09 | 2002-02-08 | ヒトｇタンパク質ケモカインレセプター（ｃｃｒ５）ｈｄｇｎｒ１０ |
| JP2005032376A Pending JP2005124588A (ja) | 2001-02-09 | 2005-02-08 | ヒトｇタンパク質ケモカインレセプター（ｃｃｒ５）ｈｄｇｎｒ１０ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005032376A Pending JP2005124588A (ja) | 2001-02-09 | 2005-02-08 | ヒトｇタンパク質ケモカインレセプター（ｃｃｒ５）ｈｄｇｎｒ１０ |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1366058B1 (enExample) |
| JP (2) | JP2005503116A (enExample) |
| CN (1) | CN1564826A (enExample) |
| AU (1) | AU2002250032B2 (enExample) |
| CA (1) | CA2437811A1 (enExample) |
| WO (1) | WO2002064612A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
| US7118859B2 (en) | 1996-01-17 | 2006-10-10 | Progenics Pharmaceuticals, Inc. | Methods for inhibiting HIV-1 infection |
| US7858298B1 (en) | 1996-04-01 | 2010-12-28 | Progenics Pharmaceuticals Inc. | Methods of inhibiting human immunodeficiency virus type 1 (HIV-1) infection through the administration of CCR5 chemokine receptor antagonists |
| US7175988B2 (en) | 2001-02-09 | 2007-02-13 | Human Genome Sciences, Inc. | Human G-protein Chemokine Receptor (CCR5) HDGNR10 |
| US7393934B2 (en) | 2001-12-21 | 2008-07-01 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor (CCR5) HDGNR10 |
| US7122185B2 (en) | 2002-02-22 | 2006-10-17 | Progenics Pharmaceuticals, Inc. | Anti-CCR5 antibody |
| CN1994465B (zh) * | 2006-10-13 | 2010-06-09 | 中国人民解放军第四军医大学 | Ccr5自体多肽疫苗及其制备方法 |
| MX2013010330A (es) | 2011-03-09 | 2014-11-26 | Richard G Pestell | Líneas de célula cancerosa de próstata, signaturas de gen, y usos de las mismas. |
| US9354144B2 (en) * | 2011-09-20 | 2016-05-31 | Bio-Rad Laboratories, Inc. | Customized quality controls for analytical assays |
| HK1209673A1 (en) * | 2012-05-14 | 2016-04-08 | Prostagene Llc | Using modulators of ccr5 for treating cancer |
| WO2017156248A1 (en) * | 2016-03-11 | 2017-09-14 | Rush University Medical Center | Compositions and methods for treating parkinson's disease |
| WO2020151666A1 (zh) * | 2019-01-25 | 2020-07-30 | 四川大学华西医院 | 血管瘤治疗的生物标记物 |
| CN114075286A (zh) * | 2020-08-21 | 2022-02-22 | 张家港博泽利斯生物技术有限公司 | 一种抗人cxcr1蛋白单克隆抗体的制备方法 |
| CN117849340A (zh) * | 2023-10-16 | 2024-04-09 | 首都医科大学附属北京地坛医院 | 可溶性因子簇在早期神经梅毒检测中的应用 |
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2002
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- 2002-02-08 JP JP2002564541A patent/JP2005503116A/ja not_active Withdrawn
- 2002-02-08 CN CNA028047389A patent/CN1564826A/zh active Pending
- 2002-02-08 WO PCT/US2002/003634 patent/WO2002064612A2/en not_active Ceased
- 2002-02-08 EP EP02718923A patent/EP1366058B1/en not_active Expired - Lifetime
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2005
- 2005-02-08 JP JP2005032376A patent/JP2005124588A/ja active Pending
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