JP2005501838A5 - - Google Patents
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- Publication number
- JP2005501838A5 JP2005501838A5 JP2003518521A JP2003518521A JP2005501838A5 JP 2005501838 A5 JP2005501838 A5 JP 2005501838A5 JP 2003518521 A JP2003518521 A JP 2003518521A JP 2003518521 A JP2003518521 A JP 2003518521A JP 2005501838 A5 JP2005501838 A5 JP 2005501838A5
- Authority
- JP
- Japan
- Prior art keywords
- intensity
- indol
- methylethyl
- fluorophenyl
- dihydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 3- (4-fluorophenyl) -1- (1-methylethyl) -1H-indol-2-yl Chemical group 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 claims 2
- FJLGEFLZQAZZCD-UHFFFAOYSA-N 7-[3-(4-fluorophenyl)-1-propan-2-yl-2-indolyl]-3,5-dihydroxy-6-heptenoic acid Chemical compound C12=CC=CC=C2N(C(C)C)C(C=CC(O)CC(O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-UHFFFAOYSA-N 0.000 claims 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- XAADEOMJJKSZKX-UHFFFAOYSA-M sodium hept-2-enoate Chemical compound [Na+].CCCCC=CC([O-])=O XAADEOMJJKSZKX-UHFFFAOYSA-M 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960000868 fluvastatin sodium Drugs 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- OSRPNTNABHQMOT-UHFFFAOYSA-M sodium;3,5-dihydroxyhept-6-enoate Chemical compound [Na+].[O-]C(=O)CC(O)CC(O)C=C OSRPNTNABHQMOT-UHFFFAOYSA-M 0.000 claims 1
- ZGGHKIMDNBDHJB-UHFFFAOYSA-M sodium;7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(C=CC(O)CC(O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-UHFFFAOYSA-M 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01810756 | 2001-08-03 | ||
| PCT/EP2002/008276 WO2003013512A2 (en) | 2001-08-03 | 2002-07-25 | Crystalline forms of fluvastatin sodium |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010165635A Division JP2010265308A (ja) | 2001-08-03 | 2010-07-23 | 結晶形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005501838A JP2005501838A (ja) | 2005-01-20 |
| JP2005501838A5 true JP2005501838A5 (enExample) | 2006-01-05 |
| JP4681808B2 JP4681808B2 (ja) | 2011-05-11 |
Family
ID=8184071
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003518521A Expired - Fee Related JP4681808B2 (ja) | 2001-08-03 | 2002-07-25 | 結晶形 |
| JP2010165635A Pending JP2010265308A (ja) | 2001-08-03 | 2010-07-23 | 結晶形 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010165635A Pending JP2010265308A (ja) | 2001-08-03 | 2010-07-23 | 結晶形 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6696479B2 (enExample) |
| EP (1) | EP1429757B8 (enExample) |
| JP (2) | JP4681808B2 (enExample) |
| KR (1) | KR100975782B1 (enExample) |
| CN (2) | CN102516150A (enExample) |
| AR (1) | AR036205A1 (enExample) |
| AT (1) | ATE391502T1 (enExample) |
| AU (1) | AU2002333271B2 (enExample) |
| CA (1) | CA2454072A1 (enExample) |
| DE (1) | DE60226044T2 (enExample) |
| ES (1) | ES2304140T3 (enExample) |
| HU (1) | HUP0401141A3 (enExample) |
| IL (2) | IL159861A0 (enExample) |
| PL (1) | PL366905A1 (enExample) |
| RU (1) | RU2334738C2 (enExample) |
| WO (1) | WO2003013512A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7087631B2 (en) * | 2002-07-18 | 2006-08-08 | Inotek Pharmaceuticals Corporation | Aryltetrazole compounds, and compositions thereof |
| EP1525189A1 (en) * | 2002-07-26 | 2005-04-27 | Ciba Specialty Chemicals Holding Inc. | Crystalline polymorphic and amorphous forms of benazepril hydrochloride |
| WO2004096765A2 (en) * | 2003-05-01 | 2004-11-11 | Morepen Laboratories Ltd. | A novel crystalline polymorph of fluvastatin sodium and a process for preparing it |
| US7368468B2 (en) * | 2003-06-18 | 2008-05-06 | Teva Pharmaceutical Industries Ltd. | Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them |
| US7368581B2 (en) | 2003-06-18 | 2008-05-06 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of fluvastatin sodium crystal from XIV |
| KR20070092994A (ko) * | 2003-06-18 | 2007-09-14 | 테바 파마슈티컬 인더스트리즈 리미티드 | 플루바스타틴 나트륨 결정형 ｘｉｖ, ｌｘｘｉｉｉ,ｌｘｘｉｘ, ｌｘｘｘ 및 ｌｘｘｘｖｉｉ, 이의 제조 방법,이를 포함하는 조성물 및 이를 사용하는 방법 |
| EP1667791A1 (en) * | 2003-10-06 | 2006-06-14 | Solvias AG | Process for the parallel detection of crystalline forms of molecular solids |
| US7432380B2 (en) | 2003-10-16 | 2008-10-07 | Ciba Specialty Chemicals Corp. | Crystalline form of Fluvastatin sodium |
| US7851624B2 (en) * | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
| US20070179166A1 (en) * | 2003-12-24 | 2007-08-02 | Valerie Niddam-Hildesheim | Process for preparation of statins with high syn to anti ratio |
| WO2005080332A1 (en) * | 2004-01-14 | 2005-09-01 | Cadila Healthcare Limited | Novel form of fluvastatin sodium |
| US20070173536A1 (en) * | 2004-02-06 | 2007-07-26 | Ciba Specialty Chemicals Holding Inc. | Crystalline forms of zolmitriptan |
| US7241800B2 (en) | 2004-03-17 | 2007-07-10 | Mai De Ltd. | Anhydrous amorphous form of fluvastatin sodium |
| WO2006021967A1 (en) * | 2004-08-26 | 2006-03-02 | Biocon Limited | Process for the preparation of fluvastatin sodium form a. |
| WO2006030304A2 (en) * | 2004-09-17 | 2006-03-23 | Ranbaxy Laboratories Limited | Novel forms of fluvastatin sodium, processes for preparation and pharmaceutical compositions thereof |
| WO2006085338A2 (en) * | 2005-02-11 | 2006-08-17 | Jubilant Organosys Limited | Novel polymorphic forms of fluvastatin sodium and process for preparing the same |
| WO2006109147A1 (en) * | 2005-04-12 | 2006-10-19 | Glenmark Pharmaceuticals Limited | Substantially pure amorphous fluvastatin, processes for its preparation and pharmaceutical compositions containing same |
| WO2007039784A2 (en) * | 2005-10-06 | 2007-04-12 | Wockhardt Limited | A novel crystalline polymorph of fluvastatin sodium and process for preparing it |
| WO2007054951A1 (en) * | 2005-11-14 | 2007-05-18 | Hetero Drugs Limited | Process for amorphous esomeprazole |
| CA2642180A1 (en) * | 2006-02-27 | 2007-09-07 | Teva Pharmaceutical Industries Ltd. | Fluvastatin sodium novel forms and preparation therof |
| US20110015247A1 (en) * | 2008-04-04 | 2011-01-20 | Shodhana Laboratories Limited | Novel crystalline form of carvedilol dihydrogen phosphate and related processes |
| CN101684121B (zh) * | 2008-09-22 | 2013-04-03 | 重庆医药工业研究院有限责任公司 | 培美曲塞二酸的新晶型及其制备方法 |
| JP6115288B2 (ja) * | 2012-04-27 | 2017-04-19 | 株式会社島津製作所 | 質量分析におけるピーク検出方法及びそのシステム |
| TW201806928A (zh) * | 2016-07-01 | 2018-03-01 | 第一三共股份有限公司 | 胺基羧酸之酸加成鹽的結晶及其製造方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1984002131A1 (fr) * | 1982-11-22 | 1984-06-07 | Sandoz Ag | Produits analogues de mevalolactone et leurs derives, leurs procedes de production, compositions pharmaceutiques les contenant ainsi que leur utilisation en tant que produits pharmaceutiques |
| PH23486A (en) * | 1982-11-22 | 1989-08-16 | Sanzoz Inc | Indole analogs of mevalonolactone,pharmaceutical compositions containing the same and method of use thereof |
| US4739073A (en) * | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
| HU217629B (hu) * | 1991-12-12 | 2000-03-28 | Novartis Ag. | Eljárás fluvasztatint tartalmazó stabilizált gyógyszerkészítmények előállítására |
| HRP960313B1 (en) * | 1995-07-17 | 2002-08-31 | Warner Lambert Co | Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1) |
| ATE234282T1 (de) * | 1996-06-24 | 2003-03-15 | Novartis Pharma Gmbh | Polymorphe verbindungen |
| US6858643B2 (en) * | 2000-10-31 | 2005-02-22 | Ciba Specialty Chemicals Corporation | Crystalline forms of Fluvastatin sodium |
-
2002
- 2002-07-25 KR KR1020047001615A patent/KR100975782B1/ko not_active Expired - Fee Related
- 2002-07-25 AT AT02794517T patent/ATE391502T1/de not_active IP Right Cessation
- 2002-07-25 EP EP02794517A patent/EP1429757B8/en not_active Expired - Lifetime
- 2002-07-25 WO PCT/EP2002/008276 patent/WO2003013512A2/en not_active Ceased
- 2002-07-25 CN CN2011103995817A patent/CN102516150A/zh active Pending
- 2002-07-25 JP JP2003518521A patent/JP4681808B2/ja not_active Expired - Fee Related
- 2002-07-25 CA CA002454072A patent/CA2454072A1/en not_active Abandoned
- 2002-07-25 CN CN028151321A patent/CN1536999B/zh not_active Expired - Fee Related
- 2002-07-25 HU HU0401141A patent/HUP0401141A3/hu unknown
- 2002-07-25 RU RU2004106528/04A patent/RU2334738C2/ru not_active IP Right Cessation
- 2002-07-25 DE DE60226044T patent/DE60226044T2/de not_active Expired - Lifetime
- 2002-07-25 ES ES02794517T patent/ES2304140T3/es not_active Expired - Lifetime
- 2002-07-25 PL PL02366905A patent/PL366905A1/xx not_active Application Discontinuation
- 2002-07-25 IL IL15986102A patent/IL159861A0/xx active IP Right Grant
- 2002-07-25 AU AU2002333271A patent/AU2002333271B2/en not_active Ceased
- 2002-07-30 US US10/208,687 patent/US6696479B2/en not_active Expired - Lifetime
- 2002-08-01 AR ARP020102927A patent/AR036205A1/es unknown
-
2004
- 2004-01-14 IL IL159861A patent/IL159861A/en not_active IP Right Cessation
-
2010
- 2010-07-23 JP JP2010165635A patent/JP2010265308A/ja active Pending
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