JP2005501095A5 - - Google Patents
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- Publication number
- JP2005501095A5 JP2005501095A5 JP2003520451A JP2003520451A JP2005501095A5 JP 2005501095 A5 JP2005501095 A5 JP 2005501095A5 JP 2003520451 A JP2003520451 A JP 2003520451A JP 2003520451 A JP2003520451 A JP 2003520451A JP 2005501095 A5 JP2005501095 A5 JP 2005501095A5
- Authority
- JP
- Japan
- Prior art keywords
- medicament
- melatonin
- release formulation
- sustained release
- sustained
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 21
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 claims 6
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims 6
- 229960003987 melatonin Drugs 0.000 claims 6
- 238000009472 formulation Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 238000013268 sustained release Methods 0.000 claims 4
- 239000012730 sustained-release form Substances 0.000 claims 4
- 239000002249 anxiolytic agent Substances 0.000 claims 3
- 239000004925 Acrylic resin Substances 0.000 claims 2
- 229920000178 Acrylic resin Polymers 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 230000001430 anti-depressive effect Effects 0.000 claims 2
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 2
- 239000000935 antidepressant agent Substances 0.000 claims 2
- 229940005513 antidepressants Drugs 0.000 claims 2
- 230000000949 anxiolytic effect Effects 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003405 delayed action preparation Substances 0.000 claims 2
- 229940052760 dopamine agonists Drugs 0.000 claims 2
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- -1 hypnotic Substances 0.000 claims 2
- 230000000147 hypnotic effect Effects 0.000 claims 2
- 230000002685 pulmonary effect Effects 0.000 claims 2
- 239000000932 sedative agent Substances 0.000 claims 2
- 230000001624 sedative effect Effects 0.000 claims 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 229940125709 anorectic agent Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 230000003276 anti-hypertensive effect Effects 0.000 claims 1
- 230000000561 anti-psychotic effect Effects 0.000 claims 1
- 229940030600 antihypertensive agent Drugs 0.000 claims 1
- 239000002220 antihypertensive agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000000164 antipsychotic agent Substances 0.000 claims 1
- 229940005529 antipsychotics Drugs 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- 239000002830 appetite depressant Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000003204 tranquilizing agent Substances 0.000 claims 1
- 230000002936 tranquilizing effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL144900A IL144900A (en) | 2001-08-14 | 2001-08-14 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
| PCT/IL2002/000662 WO2003015690A2 (en) | 2001-08-14 | 2002-08-12 | Method for treating primary insomnia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005501095A JP2005501095A (ja) | 2005-01-13 |
| JP2005501095A5 true JP2005501095A5 (OSRAM) | 2006-01-05 |
Family
ID=11075696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003520451A Pending JP2005501095A (ja) | 2001-08-14 | 2002-08-12 | 原発性不眠症の治療方法 |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US8962024B2 (OSRAM) |
| EP (2) | EP3103443B1 (OSRAM) |
| JP (1) | JP2005501095A (OSRAM) |
| KR (1) | KR20040032917A (OSRAM) |
| CN (1) | CN100453078C (OSRAM) |
| AR (1) | AR034975A1 (OSRAM) |
| AU (1) | AU2002326114C1 (OSRAM) |
| BR (1) | BR0211855A (OSRAM) |
| CA (1) | CA2454699C (OSRAM) |
| CL (1) | CL2002001701A1 (OSRAM) |
| CR (1) | CR7271A (OSRAM) |
| CY (2) | CY1118924T1 (OSRAM) |
| DK (2) | DK1441702T3 (OSRAM) |
| EA (1) | EA200400302A1 (OSRAM) |
| ES (2) | ES2626591T3 (OSRAM) |
| GT (1) | GT200200164A (OSRAM) |
| HU (1) | HU230786B1 (OSRAM) |
| IL (1) | IL144900A (OSRAM) |
| IS (1) | IS3004B (OSRAM) |
| JO (1) | JO3446B1 (OSRAM) |
| LT (1) | LT1441702T (OSRAM) |
| MX (1) | MXPA04001372A (OSRAM) |
| NO (1) | NO334788B2 (OSRAM) |
| NZ (1) | NZ531318A (OSRAM) |
| PA (1) | PA8552301A1 (OSRAM) |
| PE (1) | PE20030331A1 (OSRAM) |
| PL (1) | PL367872A1 (OSRAM) |
| PT (2) | PT3103443T (OSRAM) |
| PY (1) | PY0218122A (OSRAM) |
| RU (1) | RU2560840C2 (OSRAM) |
| SI (1) | SI1441702T1 (OSRAM) |
| UA (1) | UA87262C2 (OSRAM) |
| UY (1) | UY27401A1 (OSRAM) |
| WO (1) | WO2003015690A2 (OSRAM) |
| ZA (1) | ZA200402005B (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL144900A (en) | 2001-08-14 | 2013-12-31 | Neurim Pharma 1991 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
| IL149377A (en) * | 2002-04-28 | 2012-10-31 | Neurim Pharma 1991 | Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds |
| AR056076A1 (es) * | 2005-09-20 | 2007-09-19 | Takeda Pharmaceutical | Agente profilactico o terapeutico para el desorden de sueno |
| US20070088079A1 (en) * | 2005-09-20 | 2007-04-19 | Takeda Pharmaceutical Company Limited | Prophylactic or therapeutic agent for sleep disorder |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| US8940326B2 (en) | 2007-03-19 | 2015-01-27 | Vita Sciences Llc | Transdermal patch and method for delivery of vitamin B12 |
| WO2008122102A1 (en) * | 2007-04-05 | 2008-10-16 | Iomedix Development International Srl | Melatonin-based composition for improved sleep |
| US20080248106A1 (en) | 2007-04-05 | 2008-10-09 | Marvin Heuer | Melatonin-based composition for improved sleep |
| US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
| WO2012103411A2 (en) * | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
| MX386987B (es) | 2016-10-31 | 2025-03-19 | Neurim Pharma 1991 | Mini-tabletas de melatonina y métodos de fabricación de las mismas. |
| US10849856B2 (en) | 2016-10-31 | 2020-12-01 | Neurim Pharmaceuticals Ltd. | Melatonin mini-tablets and method of manufacturing the same |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3126375A (en) | 1964-03-24 | Chioacyl | ||
| US2789118A (en) | 1956-03-30 | 1957-04-16 | American Cyanamid Co | 16-alpha oxy-belta1, 4-pregnadienes |
| US2990401A (en) | 1958-06-18 | 1961-06-27 | American Cyanamid Co | 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids |
| US3048581A (en) | 1960-04-25 | 1962-08-07 | Olin Mathieson | Acetals and ketals of 16, 17-dihydroxy steroids |
| US3749712A (en) | 1970-09-25 | 1973-07-31 | Sigma Tau Ind Farmaceuti | Triamcinolone acetonide esters and process for their preparation |
| SE378110B (OSRAM) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| US3996359A (en) | 1972-05-19 | 1976-12-07 | Ab Bofors | Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith |
| SE378109B (OSRAM) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| JPS6045513A (ja) * | 1983-05-18 | 1985-03-12 | モナシユ ユニバ−シテイ | 身体行動および機能の日周期の不調を軽減する薬剤 |
| DE3466215D1 (en) * | 1983-05-18 | 1987-10-22 | Univ Monash | The use of melatonin for the manufacture of a medicament |
| US4600723A (en) * | 1983-05-18 | 1986-07-15 | Monash University | Method for minimizing disturbances in circadian rhythms of bodily performance and function |
| US5151446A (en) | 1989-09-25 | 1992-09-29 | Northwestern University | Substituted 2-amidotetralins as melatonin agonists and antagonists |
| FR2658818B1 (fr) | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5707652A (en) | 1990-12-04 | 1998-01-13 | State Of Oregon | Methods of treating circadian rhythm phase disorders |
| US5591768A (en) * | 1990-12-04 | 1997-01-07 | State Of Oregan, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Methods for treating circadian rhythm phase disturbances |
| EP0518468B1 (en) * | 1991-05-09 | 1999-06-30 | Neurim Pharmaceuticals (1991) Limited | Melatonin containing compositions |
| IT1251544B (it) * | 1991-05-13 | 1995-05-17 | Gabriele Biella | Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico |
| FR2680507B1 (fr) | 1991-08-23 | 1993-10-08 | Adir Cie | Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| ATE141051T1 (de) * | 1992-04-07 | 1996-08-15 | Neurim Pharma 1991 | Verwendung von melatonin zur herstellung eines arzneimittels zur behandlung der gutartigen prostatahyperplasie |
| US5449683A (en) * | 1992-10-01 | 1995-09-12 | Massachussetts Institute Of Technology | Methods of inducing sleep using melatonin |
| IL103411A (en) | 1992-10-11 | 1996-11-14 | Neurim Pharma 1991 | Melatonin Controlled Pharmacy Preparation for the Correction of Melatonin Deficiency or Distortion in Melatonin in Human Plasma |
| TW336932B (en) | 1992-12-17 | 1998-07-21 | Pfizer | Amino-substituted pyrazoles |
| CA2150703C (en) | 1992-12-17 | 2002-01-08 | Pfizer Limited | Substituted pyrazoles |
| TW444018B (en) | 1992-12-17 | 2001-07-01 | Pfizer | Pyrazolopyrimidines |
| ES2128544T3 (es) | 1992-12-17 | 1999-05-16 | Pfizer | Pirrolopirimidinas como antagonistas del crf. |
| US5712303A (en) | 1992-12-17 | 1998-01-27 | Pfizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
| AU7550994A (en) | 1993-07-26 | 1995-02-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Sustained release oral compositions containing melatonin |
| US5654325A (en) * | 1993-11-18 | 1997-08-05 | Eli Lilly And Company | Melatonin derivatives for use in treating sleep disorders |
| US5403851A (en) | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
| US6469044B1 (en) | 1995-02-01 | 2002-10-22 | Neurim Pharmaceuticals (1991) Ltd. | Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies |
| US5688520A (en) * | 1995-03-29 | 1997-11-18 | Minnesota Mining And Manufacturing Company | Transmucosal delivery of melatonin for prevention of migraine |
| EP0748627A3 (en) | 1995-06-14 | 1997-05-21 | Lilly Co Eli | Melatonin agonists for the treatment of benign forms of hyperplasia of the prostate |
| NO981489L (no) * | 1995-10-03 | 1998-05-22 | Interneuron Pharma | Blandinger av melatonin og analgetika samt anvendelser derav |
| US6274604B1 (en) * | 1996-07-17 | 2001-08-14 | Merck & Co., Inc. | Alteration of circadian rhythmicity with a tachykinin antagonist |
| US5776969A (en) | 1997-02-27 | 1998-07-07 | Eli Lilly And Company | Treatment of sleep disorders |
| US5826408A (en) * | 1997-05-08 | 1998-10-27 | Riverwood International Corporation | Rotary flap tucker for a cartoning machine |
| US6472421B1 (en) * | 1998-11-13 | 2002-10-29 | Nymox Corporation | Methods for treating, preventing, and reducing the risk of the onset of alzheimer's disease using an HMG CoA reductase inhibitor |
| HK1052655A1 (zh) * | 2000-01-05 | 2003-09-26 | 纽里姆药品(1991)有限公司 | 用於治療對抗高血壓藥的抗藥性和相關病症的方法和製劑 |
| IL144900A (en) | 2001-08-14 | 2013-12-31 | Neurim Pharma 1991 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
| US6703412B1 (en) * | 2002-09-27 | 2004-03-09 | Holly A. Rosenthal | Method of treating sleeplessness with melatonin on an acute basis |
| JP2014533981A (ja) | 2011-09-27 | 2014-12-18 | アイビス・メディカル・インコーポレーテッド | 胃内インプラントデバイス |
-
2001
- 2001-08-14 IL IL144900A patent/IL144900A/en active IP Right Grant
-
2002
- 2002-07-29 PY PY200200218122A patent/PY0218122A/es unknown
- 2002-07-29 UY UY27401A patent/UY27401A1/es not_active Application Discontinuation
- 2002-07-31 CL CL2002001701A patent/CL2002001701A1/es unknown
- 2002-08-05 AR ARP020102964A patent/AR034975A1/es not_active Application Discontinuation
- 2002-08-08 JO JOP/2002/0086A patent/JO3446B1/ar active
- 2002-08-09 PA PA20028552301A patent/PA8552301A1/es unknown
- 2002-08-12 CN CNB028158326A patent/CN100453078C/zh not_active Ceased
- 2002-08-12 ES ES02760523.7T patent/ES2626591T3/es not_active Expired - Lifetime
- 2002-08-12 PT PT161724158T patent/PT3103443T/pt unknown
- 2002-08-12 DK DK02760523.7T patent/DK1441702T3/en active
- 2002-08-12 PT PT2760523T patent/PT1441702T/pt unknown
- 2002-08-12 WO PCT/IL2002/000662 patent/WO2003015690A2/en not_active Ceased
- 2002-08-12 EA EA200400302A patent/EA200400302A1/ru unknown
- 2002-08-12 EP EP16172415.8A patent/EP3103443B1/en not_active Revoked
- 2002-08-12 LT LTEP02760523.7T patent/LT1441702T/lt unknown
- 2002-08-12 EP EP02760523.7A patent/EP1441702B1/en not_active Revoked
- 2002-08-12 DK DK16172415.8T patent/DK3103443T3/da active
- 2002-08-12 PL PL02367872A patent/PL367872A1/xx not_active Application Discontinuation
- 2002-08-12 NZ NZ531318A patent/NZ531318A/en not_active IP Right Cessation
- 2002-08-12 MX MXPA04001372A patent/MXPA04001372A/es unknown
- 2002-08-12 RU RU2011131532/15A patent/RU2560840C2/ru active
- 2002-08-12 KR KR10-2004-7002245A patent/KR20040032917A/ko not_active Ceased
- 2002-08-12 CA CA2454699A patent/CA2454699C/en not_active Expired - Lifetime
- 2002-08-12 AU AU2002326114A patent/AU2002326114C1/en not_active Expired
- 2002-08-12 JP JP2003520451A patent/JP2005501095A/ja active Pending
- 2002-08-12 US US10/486,688 patent/US8962024B2/en active Active
- 2002-08-12 HU HU0401042A patent/HU230786B1/hu unknown
- 2002-08-12 IS IS7136A patent/IS3004B/is unknown
- 2002-08-12 ES ES16172415T patent/ES2882584T3/es not_active Expired - Lifetime
- 2002-08-12 SI SI200231087T patent/SI1441702T1/sl unknown
- 2002-08-12 BR BR0211855-6A patent/BR0211855A/pt not_active Application Discontinuation
- 2002-08-13 GT GT200200164A patent/GT200200164A/es unknown
- 2002-08-13 PE PE2002000731A patent/PE20030331A1/es not_active Application Discontinuation
- 2002-12-08 UA UA2004031856A patent/UA87262C2/uk unknown
-
2004
- 2004-01-09 NO NO20040087A patent/NO334788B2/no not_active IP Right Cessation
- 2004-03-03 CR CR7271A patent/CR7271A/es unknown
- 2004-03-12 ZA ZA2004/02005A patent/ZA200402005B/en unknown
-
2017
- 2017-05-31 CY CY20171100561T patent/CY1118924T1/el unknown
-
2021
- 2021-08-31 CY CY20211100776T patent/CY1124763T1/el unknown
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