JP2005500375A5 - - Google Patents
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- Publication number
- JP2005500375A5 JP2005500375A5 JP2003520377A JP2003520377A JP2005500375A5 JP 2005500375 A5 JP2005500375 A5 JP 2005500375A5 JP 2003520377 A JP2003520377 A JP 2003520377A JP 2003520377 A JP2003520377 A JP 2003520377A JP 2005500375 A5 JP2005500375 A5 JP 2005500375A5
- Authority
- JP
- Japan
- Prior art keywords
- nerve
- graft
- chondroitin sulfate
- degrading enzyme
- neural tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000005036 nerve Anatomy 0.000 claims 86
- 238000000034 method Methods 0.000 claims 67
- 230000001537 neural effect Effects 0.000 claims 36
- 210000001519 tissue Anatomy 0.000 claims 32
- 102000004190 Enzymes Human genes 0.000 claims 27
- 108090000790 Enzymes Proteins 0.000 claims 27
- 230000000593 degrading effect Effects 0.000 claims 27
- 229940088598 enzyme Drugs 0.000 claims 27
- 102000005598 Chondroitin Sulfate Proteoglycans Human genes 0.000 claims 26
- 108010059480 Chondroitin Sulfate Proteoglycans Proteins 0.000 claims 26
- 238000000338 in vitro Methods 0.000 claims 11
- 238000012258 culturing Methods 0.000 claims 10
- 208000028389 Nerve injury Diseases 0.000 claims 5
- 230000008764 nerve damage Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000001737 promoting effect Effects 0.000 claims 5
- 239000003106 tissue adhesive Substances 0.000 claims 5
- 102000011413 Chondroitinases and Chondroitin Lyases Human genes 0.000 claims 4
- 108010023736 Chondroitinases and Chondroitin Lyases Proteins 0.000 claims 4
- 210000003169 central nervous system Anatomy 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 210000001428 peripheral nervous system Anatomy 0.000 claims 4
- 230000003376 axonal effect Effects 0.000 claims 3
- 230000008014 freezing Effects 0.000 claims 3
- 238000007710 freezing Methods 0.000 claims 3
- 208000014674 injury Diseases 0.000 claims 3
- 230000009545 invasion Effects 0.000 claims 3
- 108010003272 Hyaluronate lyase Proteins 0.000 claims 2
- 102000009066 Hyaluronoglucosaminidase Human genes 0.000 claims 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 230000000735 allogeneic effect Effects 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 229960002773 hyaluronidase Drugs 0.000 claims 2
- 210000000944 nerve tissue Anatomy 0.000 claims 2
- 210000002241 neurite Anatomy 0.000 claims 2
- 238000003522 neurite outgrowth assay Methods 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 2
- 238000009877 rendering Methods 0.000 claims 2
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- 108090000819 Chondroitin-sulfate-ABC endolyases Proteins 0.000 claims 1
- 102000037716 Chondroitin-sulfate-ABC endolyases Human genes 0.000 claims 1
- 101710106625 Chondroitinase-AC Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102000000424 Matrix Metalloproteinase 2 Human genes 0.000 claims 1
- 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 claims 1
- 102000001776 Matrix metalloproteinase-9 Human genes 0.000 claims 1
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 1
- 102100024588 Podocalyxin-like protein 2 Human genes 0.000 claims 1
- 108091010857 Podocalyxin-like protein 2 Proteins 0.000 claims 1
- 102000016611 Proteoglycans Human genes 0.000 claims 1
- 108010067787 Proteoglycans Proteins 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 210000000578 peripheral nerve Anatomy 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000011550 stock solution Substances 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31187001P | 2001-08-13 | 2001-08-13 | |
| US60/311,870 | 2001-08-13 | ||
| PCT/US2002/025922 WO2003015612A2 (en) | 2001-08-13 | 2002-08-13 | Materials and methods to promote repair of nerve tissue |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005500375A JP2005500375A (ja) | 2005-01-06 |
| JP2005500375A5 true JP2005500375A5 (OSRAM) | 2005-12-22 |
| JP4749667B2 JP4749667B2 (ja) | 2011-08-17 |
Family
ID=23208862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003520377A Expired - Lifetime JP4749667B2 (ja) | 2001-08-13 | 2002-08-13 | 神経組織の修復を促進するための材料および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (8) | US6972168B2 (OSRAM) |
| EP (1) | EP1425390B1 (OSRAM) |
| JP (1) | JP4749667B2 (OSRAM) |
| KR (1) | KR20040021697A (OSRAM) |
| CN (1) | CN1553952A (OSRAM) |
| AT (1) | ATE543509T1 (OSRAM) |
| BR (1) | BR0211888A (OSRAM) |
| CA (1) | CA2455827C (OSRAM) |
| ES (1) | ES2378227T3 (OSRAM) |
| HU (1) | HUP0500634A3 (OSRAM) |
| IL (1) | IL160188A0 (OSRAM) |
| MX (1) | MXPA04001334A (OSRAM) |
| WO (1) | WO2003015612A2 (OSRAM) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670179B1 (en) * | 2001-08-01 | 2003-12-30 | University Of Kentucky Research Foundation | Molecular functionalization of carbon nanotubes and use as substrates for neuronal growth |
| JP4749667B2 (ja) | 2001-08-13 | 2011-08-17 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | 神経組織の修復を促進するための材料および方法 |
| GB0205022D0 (en) * | 2002-03-04 | 2002-04-17 | Univ Cambridge Tech | Materials and methods for the treatment of cns damage |
| EP1575548B1 (en) * | 2002-05-04 | 2011-03-09 | Acorda Therapeutics, Inc. | Compositions and methods for promoting neuronal outgrowth |
| US7163545B2 (en) * | 2002-07-29 | 2007-01-16 | Mayo Foundation For Medical Education And Research | Spinal cord surgical implant |
| EP1530643B1 (en) * | 2002-08-15 | 2011-05-04 | Acorda Therapeutics, Inc. | Chimeric protein |
| US7135027B2 (en) * | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
| US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
| MXPA05012305A (es) * | 2003-05-16 | 2006-04-18 | Acorda Therapeutics Inc | Composiciones y metodos para el tratamiento de lesiones del snc. |
| AU2004247025B8 (en) * | 2003-05-16 | 2011-06-30 | Acorda Therapeutics, Inc. | Fusion proteins for the treatment of CNS |
| US7429375B2 (en) | 2003-05-16 | 2008-09-30 | Acorda Therapeutics, Inc. | Proteoglycan degrading mutants for the treatment of CNS |
| WO2005074655A2 (en) * | 2004-01-30 | 2005-08-18 | Emory University | Materials and method for promotion of nerve regeneration |
| ES2411504T3 (es) * | 2004-05-18 | 2013-07-05 | Acorda Therapeutics, Inc. | Métodos de purificación de condroitinasa y formulaciones estables de la misma |
| WO2005122734A2 (en) * | 2004-06-14 | 2005-12-29 | The Research Foundation Of State University Of New York | Nanosphere/microsphere delivery system for the treatment of spinal cord injury |
| US20060041318A1 (en) * | 2004-08-19 | 2006-02-23 | Shannon Donald T | Laminar skin-bone fixation transcutaneous implant and method for use thereof |
| WO2007038548A2 (en) * | 2005-09-26 | 2007-04-05 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase abci mutants |
| US7599774B2 (en) * | 2006-03-10 | 2009-10-06 | Gm Global Technology Operations, Inc. | Method and system for adaptively compensating closed-loop front-wheel steering control |
| KR101368742B1 (ko) * | 2006-05-19 | 2014-02-28 | 세이가가쿠 고교 가부시키가이샤 | 뇌손상 개선제 |
| EP2450442B1 (en) | 2006-10-10 | 2017-07-19 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase abci mutants |
| WO2008149428A1 (ja) * | 2007-06-05 | 2008-12-11 | Glycoscience Laboratories, Inc. | 自己免疫疾患、炎症及び神経疾患の治療剤及び予防剤 |
| US9820747B2 (en) * | 2008-04-04 | 2017-11-21 | The Cleveland Clinic Foundation | Use of epineural sheath grafts for neural regeneration and protection |
| EP2288376B1 (en) | 2008-04-18 | 2016-01-13 | Collplant Ltd. | Methods of generating and using procollagen |
| WO2010100247A1 (en) | 2009-03-06 | 2010-09-10 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Novel therapy for anxiety |
| US8758374B2 (en) | 2010-09-15 | 2014-06-24 | University Of Utah Research Foundation | Method for connecting nerves via a side-to-side epineurial window using artificial conduits |
| WO2012177238A1 (en) * | 2011-06-21 | 2012-12-27 | Tamara Tennison | System and method of repairing of neural networks |
| WO2013066619A1 (en) | 2011-10-17 | 2013-05-10 | University Of Utah Research Foundation | Methods and devices for connecting nerves |
| US10842494B2 (en) | 2011-10-17 | 2020-11-24 | University Of Utah Research Foundation | Methods and devices for connecting nerves |
| US20140341871A1 (en) | 2011-12-30 | 2014-11-20 | Paul R. Morris | Regenerative tissue matrix |
| CN102716470B (zh) * | 2012-06-28 | 2015-02-04 | 中国人民解放军第三军医大学第三附属医院 | 一种治疗周围神经损伤的药物组合物 |
| WO2016145452A1 (en) * | 2015-03-12 | 2016-09-15 | Myoscience, Inc. | Methods and systems for preventing neuroma formations |
| US11513039B2 (en) | 2015-05-28 | 2022-11-29 | Axogen Corporation | Nerve culture system |
| US9690975B2 (en) * | 2015-05-28 | 2017-06-27 | Axogen Corporation | Quantitative structural assay of a nerve graft |
| US11156595B2 (en) * | 2015-05-28 | 2021-10-26 | Axogen Corporation | Organotypic DRG-peripheral nerve culture system |
| CN105239137A (zh) * | 2015-10-29 | 2016-01-13 | 无锡桥阳机械制造有限公司 | 一种电镀工艺 |
| US10064938B2 (en) | 2016-03-11 | 2018-09-04 | University Of Wyoming | Localized immunosuppression of allografts for peripheral nerve repair |
| WO2018111900A1 (en) * | 2016-12-12 | 2018-06-21 | The Regents Of The University Of California | Biomimetic implants |
| WO2018127554A1 (en) * | 2017-01-06 | 2018-07-12 | Novahep Ab | Methods of preparing bioengineered or bioprinted organ or tissue, and uses thereof |
| WO2019054407A1 (ja) * | 2017-09-15 | 2019-03-21 | 東洋紡株式会社 | 神経保護材 |
| WO2019099394A1 (en) * | 2017-11-15 | 2019-05-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Systems and methods for reconstruction of nerve defects |
| CA3290756A1 (en) * | 2018-04-12 | 2025-11-29 | Axogen Corporation | Tissue grafts with pre-made attachment points |
| WO2020014889A1 (zh) * | 2018-07-18 | 2020-01-23 | 中山大学附属第一医院 | 四肢主干神经的仿生修复体模型的建立方法 |
| CN108992709B (zh) * | 2018-07-27 | 2021-05-14 | 山东省眼科研究所 | 一种脱细胞神经基质材料及其制备方法和应用 |
| US11376219B2 (en) | 2018-07-30 | 2022-07-05 | University Of Wyoming | Localized immunosuppression of allografts for peripheral nerve repair |
| US20200054467A1 (en) * | 2018-08-20 | 2020-02-20 | Zakary Llamo-Cohen | Method for establishing an electrically conductive artificial nerve |
| IL283079B2 (en) * | 2018-11-15 | 2024-01-01 | Axogen Corp | Materials and methods for nerve repair with animal-sourced nerve grafts |
| US11147558B2 (en) * | 2018-11-15 | 2021-10-19 | Axogen Corporation | Materials and methods for nerve repair with animal-sourced grafts |
| CN109893680B (zh) * | 2019-03-07 | 2021-10-08 | 宁波光远致信生物科技有限公司 | 一种修复纤维膜、修复套接管及其制备方法和用途 |
| EP4682246A3 (en) | 2019-12-30 | 2026-04-22 | Renerva, LLC | Extracellular matrix systems, devices, and methods of deployment |
| TW202233262A (zh) * | 2020-10-22 | 2022-09-01 | 美商阿克松根股份有限公司 | 成束神經移植物、製造成束神經移植物之方法以及使用成束神經移植物之治療方法 |
| WO2022256401A1 (en) * | 2021-06-01 | 2022-12-08 | Xenotherapeutics, Inc. | Xenogeneic nerve transplants and methods |
| WO2023056008A2 (en) * | 2021-09-30 | 2023-04-06 | Renerva, Llc | Nerve graft systems, devices, and methods |
| WO2023212531A1 (en) * | 2022-04-27 | 2023-11-02 | Board Of Regents, The University Of Texas System | Polyethylene glycol-fusion in nerve repair |
| CN115944784B (zh) * | 2023-01-04 | 2024-12-03 | 南通大学 | 一种细胞化纤维支架及其制备方法和应用 |
| CN116570770B (zh) * | 2023-07-12 | 2023-11-07 | 天新福（北京）医疗器材股份有限公司 | 一种双层冻干管状物及其制备方法与应用 |
| AU2024363792A1 (en) * | 2023-10-17 | 2026-04-23 | Axogen Corporation | Methods for analyzing a processed nerve graft |
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| US40112A (en) * | 1863-09-29 | Improvement in metallic cartridges | ||
| US77258A (en) * | 1868-04-28 | Improvement in weeding-hoe | ||
| US4778467A (en) * | 1984-04-25 | 1988-10-18 | The University Of Utah | Prostheses and methods for promoting nerve regeneration and for inhibiting the formation of neuromas |
| US4696816A (en) * | 1985-11-07 | 1987-09-29 | Brown Mark D | Method for treating intervertebral disc displacement with enzymes |
| US4933185A (en) * | 1986-09-24 | 1990-06-12 | Massachusetts Institute Of Technology | System for controlled release of biologically active compounds |
| US4877029A (en) * | 1987-03-30 | 1989-10-31 | Brown University Research Foundation | Semipermeable nerve guidance channels |
| US4870966A (en) * | 1988-02-01 | 1989-10-03 | American Cyanamid Company | Bioabsorbable surgical device for treating nerve defects |
| AU6872691A (en) | 1989-10-27 | 1991-05-31 | Case Western Reserve University | Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans |
| AU6734190A (en) | 1989-10-31 | 1991-05-31 | La Jolla Cancer Research Foundation | Inhibitor of laminin neurite promoting activity |
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| US5173295A (en) * | 1990-10-05 | 1992-12-22 | Advance Biofactures Of Curacao, N.V. | Method of enhancing the regeneration of injured nerves and adhesive pharamaceutical formulation therefor |
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| WO2002009756A1 (en) | 2000-07-28 | 2002-02-07 | Sumitomo Pharmaceuticals Company, Limited | Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient |
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| WO2005118609A2 (en) | 2004-05-26 | 2005-12-15 | California Institute Of Technology | Small molecule stimulators of neuronal growth |
-
2002
- 2002-08-13 JP JP2003520377A patent/JP4749667B2/ja not_active Expired - Lifetime
- 2002-08-13 BR BR0211888-2A patent/BR0211888A/pt not_active IP Right Cessation
- 2002-08-13 CA CA2455827A patent/CA2455827C/en not_active Expired - Lifetime
- 2002-08-13 WO PCT/US2002/025922 patent/WO2003015612A2/en not_active Ceased
- 2002-08-13 EP EP02763451A patent/EP1425390B1/en not_active Expired - Lifetime
- 2002-08-13 KR KR10-2004-7002131A patent/KR20040021697A/ko not_active Withdrawn
- 2002-08-13 US US10/218,864 patent/US6972168B2/en not_active Expired - Lifetime
- 2002-08-13 AT AT02763451T patent/ATE543509T1/de active
- 2002-08-13 US US10/218,316 patent/US7851447B2/en not_active Expired - Lifetime
- 2002-08-13 IL IL16018802A patent/IL160188A0/xx unknown
- 2002-08-13 ES ES02763451T patent/ES2378227T3/es not_active Expired - Lifetime
- 2002-08-13 CN CNA028178866A patent/CN1553952A/zh active Pending
- 2002-08-13 US US10/218,315 patent/US20030077258A1/en not_active Abandoned
- 2002-08-13 HU HU0500634A patent/HUP0500634A3/hu unknown
- 2002-08-13 MX MXPA04001334A patent/MXPA04001334A/es active IP Right Grant
-
2004
- 2004-03-29 US US10/812,776 patent/US7732200B2/en not_active Expired - Lifetime
-
2008
- 2008-08-12 US US12/190,359 patent/US20080299536A1/en not_active Abandoned
-
2010
- 2010-12-13 US US12/966,540 patent/US8986733B2/en not_active Expired - Fee Related
-
2013
- 2013-02-25 US US13/776,606 patent/US9402868B2/en not_active Expired - Fee Related
-
2016
- 2016-08-02 US US15/226,409 patent/US10441681B2/en not_active Expired - Fee Related
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