WO2012177238A1 - System and method of repairing of neural networks - Google Patents

System and method of repairing of neural networks Download PDF

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Publication number
WO2012177238A1
WO2012177238A1 PCT/US2011/041193 US2011041193W WO2012177238A1 WO 2012177238 A1 WO2012177238 A1 WO 2012177238A1 US 2011041193 W US2011041193 W US 2011041193W WO 2012177238 A1 WO2012177238 A1 WO 2012177238A1
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Prior art keywords
severed
axon
damaged
neuron
treating
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PCT/US2011/041193
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French (fr)
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WO2012177238A8 (en
Inventor
Tamara Tennison
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Tamara Tennison
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Priority to PCT/US2011/041193 priority Critical patent/WO2012177238A1/en
Publication of WO2012177238A1 publication Critical patent/WO2012177238A1/en
Publication of WO2012177238A8 publication Critical patent/WO2012177238A8/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/0622Optical stimulation for exciting neural tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36042Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of grafted tissue, e.g. skeletal muscle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/004Magnetotherapy specially adapted for a specific therapy
    • A61N2/006Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B17/1128Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis of nerves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00434Neural system

Definitions

  • the present invention relates to a system for treating damaged or severed neural networks within the body, and, more particularly to provide system with a neurostimulator that optimizes the environment for maximum re-growth potential of nerve cells.
  • nerve cells may repair or heal themselves to re-establish neural networks.
  • the neural networks discussed herein relate the peripheral nerve cells. It should be recognized that the use of the techniques and technologies discussed herein, may be used to treat other nerve cells in the Central Nervous System (CNS) and brain. However, the primary objective of the invention is directed towards repairing the neural pathways of the Peripheral Nervous System (PNS).
  • PNS Peripheral Nervous System
  • neural networks in the PNS throughout the body carry nerve impulses that control various body functions and movements.
  • sensory feedback is also provided to the brain through these neural networks.
  • a neural network fails to relay a nerve impulse from or to the brain. This break in a neural network results in the loss of a body function, movement, or sensory ability.
  • An aim of the present invention is to re-establish a damaged peripheral nerve pathway such that nerve impulses can be relayed between a distal end of a neural network and the brain.
  • An aim of the invention is to repair a neuron that includes a severed axon. If the body of the neuron is destroyed, it will not regenerate itself. In the case where a neuron is destroyed, the destroyed neuron may be bypassed by causing axons from a healthy proximal or distal neuron to grow around the destroyed neuron and to reconnect to the dendrites of the first h ealthy neuron distal from the destroyed neuron. After injury occurs to a neuron and if the neuron body has not been destroyed, the proximal end of a severed axon begins to sprout new Schwan cells through restored connections.
  • proximal axons are able to re-grow as long as the cell body is left intact and only the axons have been severed. If these new growth axons reach neurolemmocytes in the endoneurial channel, the severed neural pathway may be reestablished such that nerve impulses can be relayed through the newly established region of the neural network. It is to this end that the present invention is practiced.
  • This standing wave energy is created between severed ends of a peripheral nerve.
  • the wave energy may be light or sound energy.
  • proximal end and distal end of the severed nerve are defined with respect to the Central Nervous System.
  • the device includes an alignment device that aligns the severed ends of the axon in proximity to one another.
  • a treatment device imparts at least positive stimuli onto a growth cone on the proximal end of the severed axon to cause the growth cone to grow towards a remaining endoneurial channel to reestablish a neural network.
  • the damaged region of the axon is treated with one or more of wave energy, electrical stimulation, magnetic stimulation and/or light and/or sound energy from a treatment device that may comprise a probe.
  • the present invention addresses these needs by providing a method for treating a damaged neuron that comprises a severed axon having a proximal end and a distal end.
  • the method is creating an image of a damaged region of a neural network that comprises the damaged neuron; aligning severed ends of the axon substantially near one another; and imparting energy into an end of a growth cone extending from the severed proximal end of the axon to cause the end of the growth cone to grow towards an endoneural channel remaining from a degenerated portion of the distal end.
  • the image is preferably created using an electronic imaging device and is preferably a 3 -dimensional image. In a particularly preferred
  • the 3-dimensional image is created using a microprocessor.
  • the damaged area Prior to creating the image of the damaged region of a neural network, the damaged area may be treated with a stain.
  • the method includes aligning the severed ends of the axon substantially near one another by imparting wave energy into and through tissue surrounding the damaged area of the neural network such that a new growth axon is aligned with an endoneurial channel.
  • the severed ends of the axon substantially near one another are aligned by using a plurality of oscillators that vary a frequency input to guide the severed ends of the neural pathway close to one another or by cutting material surrounding the severed ends and moving the se vered ends together through use of pressure w aves to guide the severed ends of the neural pathway close to one another.
  • Energy is preferably imparted into the end of the growth cone by means of at least one probe for stimulating the proximal end of the severed axon to cause it to grow towards the degenerated distal end such that a remaining tube of endoneurium material is penetrated by a re-grown end of the axon such that the neural pathway is re-established.
  • the probe may include a thin needle-like end which penetrates the skin and emits energy and preferably, the probe includes a cluster of instruments such as electric field generators, magnetic field generators, light sources, oscillators, receivers and sound sources. Alternatively, energy may be imparted into the end of the growth cone by means of a plurality of oscillators. The energy emitted from the probe includes both destructive and nondestructive energy levels.
  • a machine that treats a severed axon of a neuron includes a microprocessor for controlling a frequency of light and vibratory energy applied to the se vered axon of the neuron, with th e microprocessor including a member that stores instructions for operating the machine.
  • the machine further includes a power switch for energizing the machine, a light source, a vibratory energy source; a frequency controller and at least one probe.
  • Tire probe has a handle and including a heat dissipating material in contact therewith, a first light that indicates a treatment session is occurring, a second light that indicates when a treatment session has ended, a crystal quartz tip surrounded by a reflective metal sheath.
  • a system for treating a damaged region of a neural network includes an image creating device that creates a three-dimensional image of a damaged region of the neural network that i s to be treated, an alignment device that aligns ends of a severed axon with one another; and a treatment device that imparts energy into a growth cone extending from a proximal end of a severed axon.
  • FIGs. 1 A-1C show a portion of a neural network that is injured and treated in accord with the present invention
  • FIGs. 2 A-2E show a severed end of an axon having a plurality of growth cones one of which is subjected to a treatment that causes it to grow towards an endoneurial channel that remains from a severed end of the axon;
  • FIG. 3 is a perspective view of a treatment machine for use in repairing a damaged nerve cell
  • FIGs. 4A-4C show a severed axon having a proximal and distal end that are aligned in substantial proximity with one another prior to treating the proximal end;
  • Fig. 5 is a flowchart showing the process steps in practicing the invention; and
  • Fig. 6 shows a combination imaging and treatment machine.
  • the present invention relates to a system that includes several devices and process steps that are implemented for treating damaged or se vered neural networks within the body. It is well known that neurons are electrically excitable and damage to these networks can cause numerous diseases such as Parkinson's, Huntington's or Alzheimer's. Injury, such as spinal cord damage or blows to the brain, can cause damage to neurons as well, see "The Life and Death of a Neuron” (http://www.ninds.nih.gov/disorders/brain basics ninds neuron. htm) or “Neuron” (http:en.wikipedia.org/wiki/Neuron), both incorporated herein by reference in their entireties.
  • the damaged or severed neural network is identified.
  • An image which is representative of a severed or damaged neural network, is produced to provide an accurate locale of the damaged portions of the neural network that are to be treated. If necessary, an accurate location of each severed ends of an axon(s) is located using an electronic imaging de vice.
  • a microprocessor creates a three dimensional analysis of the damaged neurons. Severed ends of axon(s) are aligned by imparting wave energy into and through the tissue surrounding the damaged area of the neural network such that a new growth axon is aligned with an endoneurial channel.
  • the ends of severed nerve cells are aligned in proximity to one another such that axons grown from the proximal end of a severed nerve are directed to grow towards the neurolemmocytes in the endoneurial channel to re-establish a severed neural network.
  • Energy imparted into the area surrounding the damaged nerve cell acts to push the severed ends of the axon into alignment with one another and to cause them to re- grow towards one another to establish a neural pathway.
  • the invention aims to provide a neurostimulator that optimizes the environment for maximum re-growth potential of nerve cells. An end of a growth con is steered to grow towards the remaining endoneurial channel from a severed end of an axon.
  • [24] ' ⁇ electromagnetic waves are the focus of this invention.
  • the method includes working in the meridians of the body that are 1 ⁇ 2 inch apart with a fiber optic needle encased in stainless steel, preferably with articulating prisms at the tip of th needle .
  • This procedure known as stylo stixis, reopens the ion channels to restore growth that would normally occur in an electronic chemical process but in this method is produced through electromagnetic wavelengths.
  • the present invention is a system and method of re-establishing neural networks in the body.
  • the system includes an imaging device or means that creates a 3-dimensional image of a broken region of a neural network including severed ends of an axon extending from a neuron.
  • a patient may be given a pharmacological mixture of a liquid which may contain protein of glucose based radio pharmaceutical.
  • the liquid may be taken orally or intravenously to illuminate electrical synapses in nerve cells for recording the frequency of the neurons surrounding the damaged or disconnected area(s) of the neural network.
  • a microprocessor programmed with software measures mass energy, signal velocity, particle velocity, particle displacement and momentum to determine the appropriate frequency, accurate image and correct placement of the treatment probe or probes.
  • the microprocessor may also calibrate the probe(s) to align signal patterns to create new growth and or repair of the damaged nerve cells. This process may involve the use of harmonic resonance frequencies and light waves to detect and/or repair the damaged cells.
  • An alignment device or means is provided for aligning the severed ends of the axon such that a proximal end is aligned near a distal end.
  • a treatment device or means includes at least one probe for stimulating the proximal end of the severed axon to cause it to grow towards the degenerated distal end such that a remaining tube of endoneurium material is penetrated by a re-grown end of the axon such that the neural pathway is re-est ablished.
  • An imaging device includes a means that produces an accurate image
  • the image includes at least a three-dimensional rendering of the location of the damaged or severed area of the neural network.
  • the damaged area is treated with a stain prior to creating an image of it.
  • Magnetic Resonance Imaging Machines may be utilized in creating the image of the damaged region of the neural pathway.
  • any electronic device that can segregate between different types of human tissue may be utilized in creating an image of the damaged region.
  • an alignment device includes oscillators that vary a frequency input to guide the severed ends of the neural pathway close to one another.
  • the oscillators may also be used elicit a growth response from a damaged nerve cell.
  • the present invention first causes the ends severed ends of the severed nerve to be brought together in close proximity and thereafter a unique frequency is directed towards the proximal end of the nerve to cause it to grow towards the distal end of the severed nerve.
  • a treatment device which may comprise part of the imaging device, includes oscillators that create positive stimuli to encourage a direction of growth for a growth cone growing from a proximal end of the severed axon.
  • a resonance frequency, unique to the damaged nerve cell, is determined and thereafter used to as a neurostimulator to trigger a response in a re-growing end of an axon to cause it to grow in a particular direction.
  • the particular direction is an accurate pathway, preferably the shortest pathway, between an injured neuron that includes a severed axon and the closest neuron on the distal end of the injured or severed region and having dendrites that connect to the severed end of the axon.
  • CXher wav energy may be imparted to create a pathway through which the re-grown axon is directed into the endoneurial tube left by a degenerated end of a severed axon.
  • the treatment device comprises a probe that includes a thin needle-like end which penetrates the skin and emits energy into a damaged region of the body to stimulate axon growth to recreate a neural pathway enabling nerve impulses to be transmitted from the CNS to a distal end of the neural pathway.
  • the probe may include a cluster of instruments, including, but not limited to, electric field generators, magnetic field generators, light sources, oscillators, receivers and sound sources. Energy emitted from the probe may include both destructive and nondestructive energy levels.
  • the probe may comprise a crystal oscillator that sets up a particular electric or magnetic field within the damaged region of the nerve cell to cause polarization of particular cell materials. That is, positive and negative domains within the cellular material may be aligned in a particular direction or periodically flipped from one direction to the other such that a particular portion of the cell may be either positively or negatively charged. The charge may be changed to an opposite charge by reorienting the electric or magnetic field emitted by the probe.
  • the probe may include a light source, preferably a light emitting diode that emits a particular pulsed light that stimulates a damaged region of a nerve cell. Other light sources, such as sunlight or lamps of various light wave frequencies may be utilized in repairing the nerve cells.
  • the probe may also comprise an energy imparting device such as an oscillator that imparts wave energy into the tissue surroundin the severed axon to create a moving or standing wave of energy.
  • an energy imparting device such as an oscillator that imparts wave energy into the tissue surroundin the severed axon to create a moving or standing wave of energy.
  • Other electrical stimulators may be used to stimulate growth of a growth cone from the proximal severed end of the axon. Oscillators may be calibrated according to each damaged neuron.
  • oscillators may be used to treat the damaged region of the neural network.
  • a light and or sound source may be used to stimulate growth of the severed end of the neuron.
  • the light and/or sound source m ay emit a continuous or pulsed source of light and/or sound.
  • the method taught by the present invention includes a method of promoting nerve repair, comprising the steps of providing an imaging device that creates a computer model of a damage nerve region.
  • the step of imaging the damaged region may include having the patient drink solution of potassium, sodium and chlorine.
  • a proximal severed end of a neuron is stimulated to cause a growth cone to grow towards an endoneurial channel remaining from a degenerated distal end of the severed axon.
  • a standing wave is created by an oscillator that imparts energy into the region between severed ends of the nerve cell.
  • This standing wave gui des a newly formed growth cone from the proximal end of the severed axon into the endoneurial channel which will cause them to make contact with the neurolemmocytes to reestablish a neural pathway. Ill is process enables a quicker recovery of the damaged neuron.
  • the oscillator may include a sound and/or light generating mechanism.
  • the steps include immobilizing the affected area and scanning the area to determine a location of the damaged or severed nerve ends. If ends of an axon are severed then the ends are aligned by cutting material surrounding them and moving the ends together through use of pressure waves. Destructive energy may be imparted int o areas where material is to be destroyed or cut. An image created by an imaging device is referenced to determine the extent of damage to the neural network. Energy is imparted by the system to treat the damaged neural region. Acupuncture needles comprising silicon fibers may also be placed in the energy meridians of the nervous system and body to administer treatment.
  • Fig. 1A shows a healthy part of a neural network.
  • a neural network includes neuron 100 A that relay muscle control and sensory information from and to the CNS. This information is relayed from one neuron 100 to another by way of an axon 105 having ends which terminate in a synaptic gap 115 to relay information to dendrites 110 of an adjoining neuron 10013.
  • the axon 105 includes a healthy myelin sheath 106 A.
  • Fig. IB shows that axon 105 is severed into two pieces 105 A, 105B.
  • the proximal end 105 A of the severed axon will begin sprouting growth cones 107 as shown in Fig. lC.
  • the distal end 105B of the severed axon, including myelin sheath 106B begins to degenerate until only an endoneurial tube 120 remains .
  • the present invention aims to realign the ends of the severed axon 105 in substantial proximity to one another and thereafter stimulate an end of a growth cone causing it to grow towards the remaining endonurial tube 120 to reestablish the neural network.
  • FIGs. 2A-2E show an enlarged view of the severed end of the axon having a plurality of growth cones one of which is subjected to a treatment that causes it to grow towards an endoneurial channel that remains from a severed end of the axon.
  • a proximal severed end 105A of an axon has a plurality of growth cones 107.
  • a location of each of the axon's se vered ends is determined by subjecting the damaged area to an imaging means.
  • the imaging means may include an MRI machine or other such device that creates an accurate image of injured area. Images created by the imaging device are used in determining where wave energy is applied and the frequency of said wave energy that is applied.
  • a pluralit of images are taken of the are from different locations about the injured area to create a three-dimensional representation of the severed ends of the axon 105 A, 105B to determine where the remaining endoneurial tube 120 is located.
  • the operator or computer assisted programming views the growth cones and selects an appropriate one to be directed into endoneurial channel that remains from the severed end of the axon.
  • Wave energy may be utilized as a neurostimulator to cause a particular part of the growth con to grow in a particular direction.
  • Destructive wave energy may also be introduced into th injured region surrounding the damaged neural pathway to destroy objects that may be between a growth cone and the endoneiirial tube 120.
  • Fig. 2B represents the application of wave energy from three sources, each of which may be housed in a probe or treatment machine as discussed hereinafter.
  • wave energy is directed into a particular face or region of the growth cone.
  • This wave energy comprises either positive or negative stimuli that encourages the growth cone to grow in a particular direction.
  • this stimuli is moved towards the endoneiirial tube 120 to cause the selected growth cone to grow into an open end thereof.
  • the growth cone makes contact with the endoneiirial tube 120, it will quickly grow into the tube and reestablish the neural pathway, as shown in Fig. 2D.
  • the myelin sheath will regenerate over the axon as shown in Fig. 2E.
  • Fig. 3 is a perspective view of a treatment machine for use in repairing a damaged nerve cell.
  • the machine includes a power switch, a light source, a plurality of probe connectors, a frequency controller and a readout for indicating the frequency of the light or vibratory energy.
  • the probes include a handle arranged against a granite member that diffuses heat created by the transmission of both light and vibratory energy. Two liglits are provided on each probe. One light is green; the other is red. The green light indicates that the treatment session should be continued. The red light is a warning light to indicate when the treatment has been concluded. Typical treatment times are forty-five seconds to one hour. In a typical machine, three probes are included.
  • Each probe has a unique frequency and is provided in different widths and lengths.
  • Each probe tip comprises a silicon quartz crystal that is surrounded by a reflective metal sheath.
  • the probe may be used in conjunction with a table that comprises a magnetic field for treating a damaged neural network.
  • a calibration circuit may be provided in each probe along with a timer circuit.
  • Figs. 4A-4C show a severed axon having a proximal and distal end that are aligned in substantial proximity with one another prior to treating the proximal end.
  • the severed ends of the nerve cells m ay be ali gned using vibratory energy.
  • Fig. 5 is a flowchart showing the process steps in practicing the invention.
  • an imaging device such as a magnetic resonance imaging machine.
  • a pharmacological mixture may be introduced into the patient to aid in the imaging step.
  • the exact location of the severed nerve cells is determined. If necessary, the severed ends of the nerve cells are aligned in proximity to one another.
  • the location of growth cones may also be determined. Wave and light energy may be directed onto the growth cones to cause them to grow into the endoneurial channel to reestablish a connection in the nerve cell.
  • terahertz terahertz
  • the nonlinear properties of a crystal are used to generate a wave.
  • a short laser pulse hits the: crystal, generally zinc telluride (ZnTe) or lithium niobate (LiNb0 3 ).
  • the laser pulse induces a second-order nonlinear polarization, proportional to the intensity envelope of the laser pulse.
  • the generated polarization peaks around a few terahertz.
  • the terah ertz field measured is th e radiated field of the polarization.
  • Periodically-poled LiNbOS generates 1 ⁇ 2 of a wave in each domain of the crystal. Stacking together many alternating domains produces a THz waveform consisting of many oscillations. Further basis for this method is shown at "Fiber Optic Sensors with Mechanical Resonators, in which the Output Signal is Amplitude of Vibration" (see http://physics-animations.com/Englisli/analog.htm) , incorporated herein by reference in its entirety.

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Abstract

A method and system for re-establishing a pathway in a damaged or severed neural network includes an imaging device, an alignment device and a treatment device. An accurate image of the damaged neural network is created. An alignment device imparts wave energy into a damaged region of the neural network to direct re-growth axons into a remaining endoneurial tube to direct axon growth back to the correct targets to re-establish the severed neural network.

Description

S YSTEM AND METHOD OF REPAIRING OF NEURAL NETWORKS
CROSS REFERENCE TO RELATED APPLICATION
[01] The present application claims priority from U.S. Provisional Application Ser. No. 61 263,544, filed November 23, 2009.
BACKGROUND OF THE INVENTION
1. Field of the Invention
[02] The present invention relates to a system for treating damaged or severed neural networks within the body, and, more particularly to provide system with a neurostimulator that optimizes the environment for maximum re-growth potential of nerve cells.
2. Description of Related Art
[03] It is known that damaged nerve cells, "neurons" may repair or heal themselves to re-establish neural networks. For purposes of this disclosure, the neural networks discussed herein relate the peripheral nerve cells. It should be recognized that the use of the techniques and technologies discussed herein, may be used to treat other nerve cells in the Central Nervous System (CNS) and brain. However, the primary objective of the invention is directed towards repairing the neural pathways of the Peripheral Nervous System (PNS).
[04] There are many neural networks in the PNS throughout the body. These pathways carry nerve impulses that control various body functions and movements. Likewise, sensory feedback is also provided to the brain through these neural networks. When damaged or severed, a neural network fails to relay a nerve impulse from or to the brain. This break in a neural network results in the loss of a body function, movement, or sensory ability. An aim of the present invention is to re-establish a damaged peripheral nerve pathway such that nerve impulses can be relayed between a distal end of a neural network and the brain.
[05] An aim of the invention is to repair a neuron that includes a severed axon. If the body of the neuron is destroyed, it will not regenerate itself. In the case where a neuron is destroyed, the destroyed neuron may be bypassed by causing axons from a healthy proximal or distal neuron to grow around the destroyed neuron and to reconnect to the dendrites of the first h ealthy neuron distal from the destroyed neuron. After injury occurs to a neuron and if the neuron body has not been destroyed, the proximal end of a severed axon begins to sprout new Schwan cells through restored connections. The proximal axons are able to re-grow as long as the cell body is left intact and only the axons have been severed. If these new growth axons reach neurolemmocytes in the endoneurial channel, the severed neural pathway may be reestablished such that nerve impulses can be relayed through the newly established region of the neural network. It is to this end that the present invention is practiced.
[06] When severed, the distal end of any severed axons experience Wallerian degeneration w ithin hours of the injury. During this process, the severed axons and myelin degenerate, but the endoneurium remains. Endoneurium is a delicate connective tissue that holds the nerve fibers together and supports them within the peripheral nerves. A tube of endoneurium material remains after the distal end of the severed axon degenerates. If an end of a regenerated axon reaches a remaining endoneurium of the sev ered or distal nerve end, the regenerating axon will grow through the remaining endoneurial tube to direct axon growth back to the correct targets to re-establish the severed neural network. It is this process that the invention aims to exploit in reestablishing a neural pathway.
[07] It is a primary aim of the present in vention to teach a system and method for promoting or regenerating axons through a use of creating a standing wave of energy that oscillates at a particular frequency unique to a damaged nerve cell. This standing wave energy is created between severed ends of a peripheral nerve. The wave energy may be light or sound energy. The terms "proximal end" and "distal end" of the severed nerve are defined with respect to the Central Nervous System.
[08] It is an object of the invention to teach a system that comprises an imaging device that creates an accurate image of the location of severed ends of an axon. The device includes an alignment device that aligns the severed ends of the axon in proximity to one another. A treatment device imparts at least positive stimuli onto a growth cone on the proximal end of the severed axon to cause the growth cone to grow towards a remaining endoneurial channel to reestablish a neural network.
[09] It is a further object of the invention to teach a process whereby images of a severed axon are created and displayed in an electronic format. The images are used to locate the proximal and distal ends of the severed axon. Thereafter, the proximal end of the severed axon is aligned in substantial alignment with the distal end of the severed axon, if necessary. The damaged region of the axon is treated with one or more of wave energy, electrical stimulation, magnetic stimulation and/or light and/or sound energy from a treatment device that may comprise a probe.
[10] Finally, it is an object of the present invention to accomplish the foregoing objectives in. a simple and cost effective manner.
[1 1 ] The above and further objects, detai ls and advantages of the invention wi ll become apparent from the following detailed description, whe read in conjunction with the accompanying drawings.
SUMMARY OF THE INVENTION
[12] The present invention addresses these needs by providing a method for treating a damaged neuron that comprises a severed axon having a proximal end and a distal end. The method is creating an image of a damaged region of a neural network that comprises the damaged neuron; aligning severed ends of the axon substantially near one another; and imparting energy into an end of a growth cone extending from the severed proximal end of the axon to cause the end of the growth cone to grow towards an endoneural channel remaining from a degenerated portion of the distal end. The image is preferably created using an electronic imaging device and is preferably a 3 -dimensional image. In a particularly preferred
embodiment, the 3-dimensional image is created using a microprocessor. Prior to creating the image of the damaged region of a neural network, the damaged area may be treated with a stain. Preferably the method includes aligning the severed ends of the axon substantially near one another by imparting wave energy into and through tissue surrounding the damaged area of the neural network such that a new growth axon is aligned with an endoneurial channel. Alternatively, the severed ends of the axon substantially near one another are aligned by using a plurality of oscillators that vary a frequency input to guide the severed ends of the neural pathway close to one another or by cutting material surrounding the severed ends and moving the se vered ends together through use of pressure w aves to guide the severed ends of the neural pathway close to one another. Energy is preferably imparted into the end of the growth cone by means of at least one probe for stimulating the proximal end of the severed axon to cause it to grow towards the degenerated distal end such that a remaining tube of endoneurium material is penetrated by a re-grown end of the axon such that the neural pathway is re-established. The probe may include a thin needle-like end which penetrates the skin and emits energy and preferably, the probe includes a cluster of instruments such as electric field generators, magnetic field generators, light sources, oscillators, receivers and sound sources. Alternatively, energy may be imparted into the end of the growth cone by means of a plurality of oscillators. The energy emitted from the probe includes both destructive and nondestructive energy levels.
[13] A machine that treats a severed axon of a neuron is provided. The machine includes a microprocessor for controlling a frequency of light and vibratory energy applied to the se vered axon of the neuron, with th e microprocessor including a member that stores instructions for operating the machine. The machine further includes a power switch for energizing the machine, a light source, a vibratory energy source; a frequency controller and at least one probe. Tire probe has a handle and including a heat dissipating material in contact therewith, a first light that indicates a treatment session is occurring, a second light that indicates when a treatment session has ended, a crystal quartz tip surrounded by a reflective metal sheath.
[14] A system for treating a damaged region of a neural network is disclosed. The system includes an image creating device that creates a three-dimensional image of a damaged region of the neural network that i s to be treated, an alignment device that aligns ends of a severed axon with one another; and a treatment device that imparts energy into a growth cone extending from a proximal end of a severed axon.
BRIEF DESCRIPTION OF THE DRAWINGS
[15] A more comp lete de scription of the subj ect matter of the present invention and the advantages thereof, can be achieved by reference to the following detailed description by which reference is made to the accompanying drawings in which:
[16] Figs. 1 A-1C show a portion of a neural network that is injured and treated in accord with the present invention;
[17] Figs. 2 A-2E show a severed end of an axon having a plurality of growth cones one of which is subjected to a treatment that causes it to grow towards an endoneurial channel that remains from a severed end of the axon;
[18] Fig. 3 is a perspective view of a treatment machine for use in repairing a damaged nerve cell;
[19] Figs. 4A-4C show a severed axon having a proximal and distal end that are aligned in substantial proximity with one another prior to treating the proximal end; [20] Fig. 5 is a flowchart showing the process steps in practicing the invention; and [21] Fig. 6 shows a combination imaging and treatment machine.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
[22] Hie follo wing detai led descri ption i s of the best presently contemplated mode of carrying out the invention, litis description is not to be taken in a limiting sense, but is made merely for the purpose of illustrating general principles of embodiments of the invention. The embodiments of the invention and the various features and advantageous details thereof are more fully explained with reference to the non-limiting embodiments and examples that are described and/ or illustrated in the accompanying drawings and set forth in the following description. It should be noted that the features illustrated in the drawings are not necessarily drawn to scale, and the features of one embodiment may be employed with the other embodiments as the skilled artisan recognizes, even if not explicitly stated herein. Descriptions of well-known components and techniques may be omitted to avoid obscuring the invention. The examples used herein are intended merely to facilitate an understanding of ways in which the invention may be practiced and to further enable those skilled in the art to practice the invention. Accordingly, the examples and embodiments set forth herein should not be construed as limiting the scope of the invention, which is defined by the appended claims. Moreover, it is noted that like reference numerals represent similar parts throughout the several views of the drawings.
[23] Generally, the present invention relates to a system that includes several devices and process steps that are implemented for treating damaged or se vered neural networks within the body. It is well known that neurons are electrically excitable and damage to these networks can cause numerous diseases such as Parkinson's, Huntington's or Alzheimer's. Injury, such as spinal cord damage or blows to the brain, can cause damage to neurons as well, see "The Life and Death of a Neuron" (http://www.ninds.nih.gov/disorders/brain basics ninds neuron. htm) or "Neuron" (http:en.wikipedia.org/wiki/Neuron), both incorporated herein by reference in their entireties. In this invention, the damaged or severed neural network is identified. An image, which is representative of a severed or damaged neural network, is produced to provide an accurate locale of the damaged portions of the neural network that are to be treated. If necessary, an accurate location of each severed ends of an axon(s) is located using an electronic imaging de vice. In one instance, a microprocessor creates a three dimensional analysis of the damaged neurons. Severed ends of axon(s) are aligned by imparting wave energy into and through the tissue surrounding the damaged area of the neural network such that a new growth axon is aligned with an endoneurial channel. That is, the ends of severed nerve cells are aligned in proximity to one another such that axons grown from the proximal end of a severed nerve are directed to grow towards the neurolemmocytes in the endoneurial channel to re-establish a severed neural network. Energy imparted into the area surrounding the damaged nerve cell acts to push the severed ends of the axon into alignment with one another and to cause them to re- grow towards one another to establish a neural pathway. Thus, the invention aims to provide a neurostimulator that optimizes the environment for maximum re-growth potential of nerve cells. An end of a growth con is steered to grow towards the remaining endoneurial channel from a severed end of an axon. [24] 'ΠΙζ electromagnetic waves are the focus of this invention. The method includes working in the meridians of the body that are ½ inch apart with a fiber optic needle encased in stainless steel, preferably with articulating prisms at the tip of th needle . This procedure, known as stylo stixis, reopens the ion channels to restore growth that would normally occur in an electronic chemical process but in this method is produced through electromagnetic wavelengths.
[25] The present invention is a system and method of re-establishing neural networks in the body. The system includes an imaging device or means that creates a 3-dimensional image of a broken region of a neural network including severed ends of an axon extending from a neuron. A patient may be given a pharmacological mixture of a liquid which may contain protein of glucose based radio pharmaceutical. The liquid may be taken orally or intravenously to illuminate electrical synapses in nerve cells for recording the frequency of the neurons surrounding the damaged or disconnected area(s) of the neural network. Once the frequencies of the nerve cells is recorded and fed into an oscillator, a microprocessor programmed with software measures mass energy, signal velocity, particle velocity, particle displacement and momentum to determine the appropriate frequency, accurate image and correct placement of the treatment probe or probes. The microprocessor may also calibrate the probe(s) to align signal patterns to create new growth and or repair of the damaged nerve cells. This process may involve the use of harmonic resonance frequencies and light waves to detect and/or repair the damaged cells. An alignment device or means is provided for aligning the severed ends of the axon such that a proximal end is aligned near a distal end. A treatment device or means includes at least one probe for stimulating the proximal end of the severed axon to cause it to grow towards the degenerated distal end such that a remaining tube of endoneurium material is penetrated by a re-grown end of the axon such that the neural pathway is re-est ablished.
[26] An imaging device includes a means that produces an accurate image
representative of a damaged nerve cell. The image includes at least a three-dimensional rendering of the location of the damaged or severed area of the neural network. In one instance, the damaged area is treated with a stain prior to creating an image of it. Magnetic Resonance Imaging Machines may be utilized in creating the image of the damaged region of the neural pathway. Typically, any electronic device that can segregate between different types of human tissue may be utilized in creating an image of the damaged region.
[27] The severed ends of the neural network are brought into close proximity with one another through various surgical techniques which may include the use of oscillatory means that impart wave energy into the damaged region of the neural network. In one instance, an alignment device includes oscillators that vary a frequency input to guide the severed ends of the neural pathway close to one another. The oscillators may also be used elicit a growth response from a damaged nerve cell. The present invention first causes the ends severed ends of the severed nerve to be brought together in close proximity and thereafter a unique frequency is directed towards the proximal end of the nerve to cause it to grow towards the distal end of the severed nerve.
[28] In one instance a treatment device, which may comprise part of the imaging device, includes oscillators that create positive stimuli to encourage a direction of growth for a growth cone growing from a proximal end of the severed axon. A resonance frequency, unique to the damaged nerve cell, is determined and thereafter used to as a neurostimulator to trigger a response in a re-growing end of an axon to cause it to grow in a particular direction. The particular direction is an accurate pathway, preferably the shortest pathway, between an injured neuron that includes a severed axon and the closest neuron on the distal end of the injured or severed region and having dendrites that connect to the severed end of the axon. In this manner, the amount of recovery time for a nerve injury is advantageously shortened. CXher wav energy may be imparted to create a pathway through which the re-grown axon is directed into the endoneurial tube left by a degenerated end of a severed axon.
[29] In one instance, the treatment device comprises a probe that includes a thin needle-like end which penetrates the skin and emits energy into a damaged region of the body to stimulate axon growth to recreate a neural pathway enabling nerve impulses to be transmitted from the CNS to a distal end of the neural pathway. The probe may include a cluster of instruments, including, but not limited to, electric field generators, magnetic field generators, light sources, oscillators, receivers and sound sources. Energy emitted from the probe may include both destructive and nondestructive energy levels.
[30] The probe may comprise a crystal oscillator that sets up a particular electric or magnetic field within the damaged region of the nerve cell to cause polarization of particular cell materials. That is, positive and negative domains within the cellular material may be aligned in a particular direction or periodically flipped from one direction to the other such that a particular portion of the cell may be either positively or negatively charged. The charge may be changed to an opposite charge by reorienting the electric or magnetic field emitted by the probe. Otherwise the probe may include a light source, preferably a light emitting diode that emits a particular pulsed light that stimulates a damaged region of a nerve cell. Other light sources, such as sunlight or lamps of various light wave frequencies may be utilized in repairing the nerve cells.
[31] The probe may also comprise an energy imparting device such as an oscillator that imparts wave energy into the tissue surroundin the severed axon to create a moving or standing wave of energy. Other electrical stimulators may be used to stimulate growth of a growth cone from the proximal severed end of the axon. Oscillators may be calibrated according to each damaged neuron. Moreover, oscillators may be used to treat the damaged region of the neural network. In another embodiment, a light and or sound source may be used to stimulate growth of the severed end of the neuron. The light and/or sound source m ay emit a continuous or pulsed source of light and/or sound.
[32] The method taught by the present invention includes a method of promoting nerve repair, comprising the steps of providing an imaging device that creates a computer model of a damage nerve region. The step of imaging the damaged region may include having the patient drink solution of potassium, sodium and chlorine. A proximal severed end of a neuron is stimulated to cause a growth cone to grow towards an endoneurial channel remaining from a degenerated distal end of the severed axon. In one instance, a standing wave is created by an oscillator that imparts energy into the region between severed ends of the nerve cell. This standing wave gui des a newly formed growth cone from the proximal end of the severed axon into the endoneurial channel which will cause them to make contact with the neurolemmocytes to reestablish a neural pathway. Ill is process enables a quicker recovery of the damaged neuron. The oscillator may include a sound and/or light generating mechanism.
[33] In one instance, the steps include immobilizing the affected area and scanning the area to determine a location of the damaged or severed nerve ends. If ends of an axon are severed then the ends are aligned by cutting material surrounding them and moving the ends together through use of pressure waves. Destructive energy may be imparted int o areas where material is to be destroyed or cut. An image created by an imaging device is referenced to determine the extent of damage to the neural network. Energy is imparted by the system to treat the damaged neural region. Acupuncture needles comprising silicon fibers may also be placed in the energy meridians of the nervous system and body to administer treatment.
[34] Now referring to figures, Fig. 1A shows a healthy part of a neural network. In the PNS, a neural network includes neuron 100 A that relay muscle control and sensory information from and to the CNS. This information is relayed from one neuron 100 to another by way of an axon 105 having ends which terminate in a synaptic gap 115 to relay information to dendrites 110 of an adjoining neuron 10013. The axon 105 includes a healthy myelin sheath 106 A.
[35] When injury occurs to the neural network, the information may fail to be transmitted between neurons 100 A, l'OOB. For example, Fig. IB shows that axon 105 is severed into two pieces 105 A, 105B. In an effort to reestablish communications with the distal end of the neural network, the proximal end 105 A of the severed axon will begin sprouting growth cones 107 as shown in Fig. lC. The distal end 105B of the severed axon, including myelin sheath 106B begins to degenerate until only an endoneurial tube 120 remains . Should one of the growth cones 120 reach the remaining endoneurial tube 120, the neuron 100A will reestablish neural contact with the neuron lOOB, as shown in Fig. ID. The present invention aims to realign the ends of the severed axon 105 in substantial proximity to one another and thereafter stimulate an end of a growth cone causing it to grow towards the remaining endonurial tube 120 to reestablish the neural network.
[36] Figs. 2A-2E show an enlarged view of the severed end of the axon having a plurality of growth cones one of which is subjected to a treatment that causes it to grow towards an endoneurial channel that remains from a severed end of the axon. In Fig. 2A, a proximal severed end 105A of an axon has a plurality of growth cones 107. A location of each of the axon's se vered ends is determined by subjecting the damaged area to an imaging means. The imaging means may include an MRI machine or other such device that creates an accurate image of injured area. Images created by the imaging device are used in determining where wave energy is applied and the frequency of said wave energy that is applied.
[37] In a preferred embodiment, a pluralit of images are taken of the are from different locations about the injured area to create a three-dimensional representation of the severed ends of the axon 105 A, 105B to determine where the remaining endoneurial tube 120 is located. The operator or computer assisted programming views the growth cones and selects an appropriate one to be directed into endoneurial channel that remains from the severed end of the axon. Wave energy may be utilized as a neurostimulator to cause a particular part of the growth con to grow in a particular direction. Destructive wave energy may also be introduced into th injured region surrounding the damaged neural pathway to destroy objects that may be between a growth cone and the endoneiirial tube 120.
[38] Fig. 2B represents the application of wave energy from three sources, each of which may be housed in a probe or treatment machine as discussed hereinafter. After an appropriate growth cone is selected, wave energy is directed into a particular face or region of the growth cone. This wave energy comprises either positive or negative stimuli that encourages the growth cone to grow in a particular direction. As shown in Fig. 2C, this stimuli is moved towards the endoneiirial tube 120 to cause the selected growth cone to grow into an open end thereof. Once the growth cone makes contact with the endoneiirial tube 120, it will quickly grow into the tube and reestablish the neural pathway, as shown in Fig. 2D. The myelin sheath will regenerate over the axon as shown in Fig. 2E.
[39] Fig. 3 is a perspective view of a treatment machine for use in repairing a damaged nerve cell. In one instance, the machine includes a power switch, a light source, a plurality of probe connectors, a frequency controller and a readout for indicating the frequency of the light or vibratory energy. The probes include a handle arranged against a granite member that diffuses heat created by the transmission of both light and vibratory energy. Two liglits are provided on each probe. One light is green; the other is red. The green light indicates that the treatment session should be continued. The red light is a warning light to indicate when the treatment has been concluded. Typical treatment times are forty-five seconds to one hour. In a typical machine, three probes are included. Each probe has a unique frequency and is provided in different widths and lengths. Each probe tip comprises a silicon quartz crystal that is surrounded by a reflective metal sheath. The probe may be used in conjunction with a table that comprises a magnetic field for treating a damaged neural network. A calibration circuit may be provided in each probe along with a timer circuit.
[40] Figs. 4A-4C show a severed axon having a proximal and distal end that are aligned in substantial proximity with one another prior to treating the proximal end. As can be understood from these drawings, the severed ends of the nerve cells m ay be ali gned using vibratory energy.
[41] Fig. 5 is a flowchart showing the process steps in practicing the invention. After an injury to a neural network has been sustained, an image is created with an imaging device such as a magnetic resonance imaging machine. As previously discussed, a pharmacological mixture may be introduced into the patient to aid in the imaging step. The exact location of the severed nerve cells is determined. If necessary, the severed ends of the nerve cells are aligned in proximity to one another. The location of growth cones may also be determined. Wave and light energy may be directed onto the growth cones to cause them to grow into the endoneurial channel to reestablish a connection in the nerve cell.
[42] In a preferred embodiment of the present invention, terahertz (THz)
electromagnetic waves are used. Research towards the development of electronic oscillators capable of reaching THz frequencies pushes out the limits of high-speed electronics and are used in the probes (see web site, "Michigan Engineering / Terahertz Electromagnetic Waves" at http://www.engm. umich.edu/researeh/euos/Resear^
netic_Waves.html), incorporated herein by reference in its entirety. The nonlinear properties of a crystal are used to generate a wave. A short laser pulse hits the: crystal, generally zinc telluride (ZnTe) or lithium niobate (LiNb03). The laser pulse induces a second-order nonlinear polarization, proportional to the intensity envelope of the laser pulse. For ultrafast pulses (on the order of 100 femtoseconds or shorter), the generated polarization peaks around a few terahertz. The terah ertz field measured is th e radiated field of the polarization. Periodically-poled LiNbOS (PPLN) generates ½ of a wave in each domain of the crystal. Stacking together many alternating domains produces a THz waveform consisting of many oscillations. Further basis for this method is shown at "Fiber Optic Sensors with Mechanical Resonators, in which the Output Signal is Amplitude of Vibration" (see http://physics-animations.com/Englisli/analog.htm) , incorporated herein by reference in its entirety.
[43] Obviously, many modifications may be made without departing from the basic spirit of the present invention. Accordingly, it will be appreciated by those skilled in the art that within the scope of the appended claims, the invention may be practiced other than has been specifically described herein. Many improvements, modifications, and additions will be apparent to the skilled artisan without departing from the spirit and scope of the present invention as described herein and defined in the following claims.

Claims

What is claimed is: 1. A method for treating a damaged neuron that comprises a severed axon having a proximal end and a distal end, said method comprising:
creating an image of a damaged region of a neural network that compri ses the damaged neuron;
aligning severed ends of the axon substantially near one another; and
imparting energy into an end of a growth cone extending from the severed proximal end of the axon to cause the end of the growth cone to grow towards an endoneurial channel remaining from a degenerated portion of the distal end.
2. The method for treating a damaged neuron of claim 1 wherein the image is created using an electronic imaging device.
3. The method for treating a damaged neuron of claim 1 wherein the image is a 3- dimensional image.
4. The method for treating a damaged neuron of claim 3 wherein the 3-dimensional image is created using a microprocessor.
5. The method for treating a damaged neuron of claim 1 wherein, prior to creating the image of the damaged region of a neural network, the damaged area is treated with a stain.
6. The method for treating a damaged neuron of claim 1 wherein the severed ends of the axon substantially near one another are aligned by imparting wave energy into and through tissue surrounding the damaged area of the neural network such that a new growth axon is aligned with an endoneurial channel,
7. The method for treating a damaged neuron of claim 1 wherein the severed ends of the axon substantially near one another are aligned by using a plurality of oscillators that vary a frequency input to guide the severed ends of the neural pathw ay close to one another.
8. The method for treating a damaged neuron of claim 1 wherein the severed ends of the axon substantially near one another are aligned by cutting material surrounding the severed ends and moving the severed ends together through use of pressure waves to guide the severed ends of the neural pathway close to one another.
9. The method for treating a damaged neuron of claim 1 wherein energy is imparted into the end of the growth cone by means of at least one probe for stimulating the proximal end of the severed axon to cause it to grow towards the degenerated distal end such that a remaining tube of endoneurium material is penetrated by a re-grown end of the axon such that the neural pathway is re-established.
10. The method for treating a damaged neuron of claim 9 wherein the probe includes a thin needle-like end which penetrates the skin and emits energy.
1 1. The method for treating a damaged neuron of claim 9 wherein the probe includes a cluster of instruments selected from the group consisting of electric field generators, magnetic field generators, light sources, oscillators, receivers and sound sources.
12. 'The method for treating a damaged neuron of claim 9 wherein energy is imparted into the end of the growth cone by means of a plurality of oscillators.
13. The method for treating a damaged neuron of claim 1 wherein the energy emitted from the probe includes both destructive and nondestructive energ levels.
14. A machine that treats a severed axon of a neuron, said machine comprising: a microprocessor for controlling a frequency of light and vibratory energy applied to the severed axon of the neuron, said microprocessor including a member that stores mstructions for operating the machine;
a power switch for energizing said machine;
a light source;
a vibratory energy source;
a frequency controller;
and at least one probe, said probe comprising a handle and including a heat dissipating material in contact therewith, a first light that indicates a treatment session is occurring, a second light that indicates when a treatment session has ended, a crystal quartz tip surrounded by a reflective metal sheath.
15. A system for treating a damaged region of a neural network, said system comprising:
an image creating device that creates a three-dimensional image of a damaged region of the neural network that is to be treated;
an alignment device that aligns ends of a severed axon with one another; and, a treatment device that imparts energy into a growth cone extending from a proximal end of a severed axon.
PCT/US2011/041193 2011-06-21 2011-06-21 System and method of repairing of neural networks WO2012177238A1 (en)

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