JP2005500357A5 - - Google Patents
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- Publication number
- JP2005500357A5 JP2005500357A5 JP2003517072A JP2003517072A JP2005500357A5 JP 2005500357 A5 JP2005500357 A5 JP 2005500357A5 JP 2003517072 A JP2003517072 A JP 2003517072A JP 2003517072 A JP2003517072 A JP 2003517072A JP 2005500357 A5 JP2005500357 A5 JP 2005500357A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- compound
- acceptable salt
- glucosyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 8
- 239000011780 sodium chloride Substances 0.000 claims 8
- MJAROVOYFMVSGP-DQSNCFNGSA-N (3R,4S,5S,6R)-2-[[(4R,4aR,7S,7aR,12bS)-7-hydroxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-9-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol Chemical group O([C@@H]1[C@]23CCN([C@H](C4)[C@@H]3CC[C@@H]1O)C)C1=C2C4=CC=C1OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O MJAROVOYFMVSGP-DQSNCFNGSA-N 0.000 claims 1
- FGEXYJIHXVZJMD-OHEXMFCKSA-N (3R,4S,5S,6R)-2-[[(4R,4aR,7S,7aR,12bS)-9-hydroxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol Chemical group O([C@H]1CC[C@H]2[C@H]3CC=4C5=C(C(=CC=4)O)O[C@@H]1[C@]52CCN3C)C1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O FGEXYJIHXVZJMD-OHEXMFCKSA-N 0.000 claims 1
- LAZTZBKWNKFJLP-AUTNIQMOSA-N (4R,4aR,7aR,12bS)-3-methyl-9-[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one Chemical compound O([C@@H]1[C@]23CCN([C@H](C4)[C@@H]3CCC1=O)C)C1=C2C4=CC=C1OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O LAZTZBKWNKFJLP-AUTNIQMOSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
Claims (13)
- ３−Ｏ−グルコシルヒドロモルホン又は薬学的に許容し得るこれらの塩である化合物。
- ３−Ｏ−グルコシルジヒドロイソモルフィン又は薬学的に許容し得るこれらの塩である化合物。
- ６−Ｏ−グルコシルジヒドロイソモルフィン又は薬学的に許容し得るこれらの塩である化合物。
- ３−Ｏ−グルコシルジヒドロモルフィン又は薬学的に許容し得るこれらの塩である化合物。
- ６−Ｏ−グルコシルジヒドロモルフィン又は薬学的に許容し得るこれらの塩である化合物。
- ノルジヒドロモルフィン−３−グルクロニド又は薬学的に許容し得るこれらの塩である化合物。
- ノルジヒドロイソモルフィン−３−グルクロニド又は薬学的に許容し得るこれらの塩である化合物。
- ノルヒドロモルホン−３−グルクロニド又は薬学的に許容し得るこれらの塩である化合物。
- 単離され、精製された形態のものである、請求項１〜８のいずれか１項に記載の化合物。
- β−グリコシドである、請求項１〜９のいずれか１項に記載の化合物。
- 有効量の請求項１〜１０のいずれか１項に記載の化合物と薬学的に許容し得るキャリア又はビヒクルとを含む組成物。
- 患者の痛みの治療のための請求項１〜１１のいずれか１項に記載の化合物の使用。
- 患者の痛みを治療するための薬剤の製造のための請求項１〜１１のいずれか１項に記載の化合物の使用。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30784501P | 2001-07-27 | 2001-07-27 | |
| PCT/US2002/023553 WO2003011881A2 (en) | 2001-07-27 | 2002-07-24 | Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005500357A JP2005500357A (ja) | 2005-01-06 |
| JP2005500357A5 true JP2005500357A5 (ja) | 2006-01-05 |
| JP4679055B2 JP4679055B2 (ja) | 2011-04-27 |
Family
ID=23191416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003517072A Expired - Fee Related JP4679055B2 (ja) | 2001-07-27 | 2002-07-24 | ヒドロモルホン、ジヒドロモルフィンおよびジヒドロイソモルフィンの糖誘導体、これらの組成物および痛みを治療あるいは予防するための使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6740641B2 (ja) |
| EP (1) | EP1412368B1 (ja) |
| JP (1) | JP4679055B2 (ja) |
| AT (1) | ATE371665T1 (ja) |
| AU (1) | AU2002329634B2 (ja) |
| CA (1) | CA2455774C (ja) |
| CY (1) | CY1107813T1 (ja) |
| DE (1) | DE60222137T2 (ja) |
| DK (1) | DK1412368T3 (ja) |
| ES (1) | ES2292806T3 (ja) |
| IL (2) | IL160085A0 (ja) |
| MX (1) | MXPA04000825A (ja) |
| PT (1) | PT1412368E (ja) |
| WO (1) | WO2003011881A2 (ja) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7060708B2 (en) * | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| US20070066537A1 (en) * | 2002-02-22 | 2007-03-22 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US7338939B2 (en) * | 2003-09-30 | 2008-03-04 | New River Pharmaceuticals Inc. | Abuse-resistant hydrocodone compounds |
| US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| US7375082B2 (en) * | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
| US7105486B2 (en) * | 2002-02-22 | 2006-09-12 | New River Pharmaceuticals Inc. | Abuse-resistant amphetamine compounds |
| CA2477038A1 (en) * | 2002-02-22 | 2003-09-04 | New River Pharmaceuticals | Use of peptide-drug conjugation to reduce inter-subject variability of drug serum levels |
| US7700561B2 (en) * | 2002-02-22 | 2010-04-20 | Shire Llc | Abuse-resistant amphetamine prodrugs |
| AU2003219863C1 (en) * | 2002-02-22 | 2009-03-05 | Shire Llc | Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances |
| US7659253B2 (en) * | 2002-02-22 | 2010-02-09 | Shire Llc | Abuse-resistant amphetamine prodrugs |
| GB0218811D0 (en) * | 2002-08-14 | 2002-09-18 | Cenes Ltd | Salts of morphine-6-glucuronide |
| US8133881B2 (en) | 2003-01-13 | 2012-03-13 | Shire Llc | Carbohydrate conjugates to prevent abuse of controlled substances |
| BRPI0410792B8 (pt) * | 2003-05-29 | 2021-05-25 | New River Pharmaceuticals Inc | compostos de anfetamina resistentes à dependencia |
| JP4691500B2 (ja) * | 2003-09-30 | 2011-06-01 | シャイア エルエルシー | 過剰摂取又は乱用を防止するための薬学組成物 |
| WO2007121916A2 (en) * | 2006-04-21 | 2007-11-01 | Dsm Ip Assets B.V. | Use of opioid receptor antagonists |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| FR2939436B1 (fr) * | 2008-12-10 | 2010-12-17 | Sanofi Aventis | Synthese de morphine-6-glucuronide ou de l'un de ses derives |
| US8716350B2 (en) * | 2010-03-30 | 2014-05-06 | Algynomics Inc. | Compositions and methods for the treatment of somatosensory disorders |
| US8716349B2 (en) | 2010-03-30 | 2014-05-06 | Algynomics Inc. | Compositions and methods for the treatment of somatosensory disorders |
| SG188300A1 (en) | 2010-09-21 | 2013-04-30 | Purdue Pharma Lp | Buprenorphine analogs |
| KR101589846B1 (ko) | 2011-10-26 | 2016-01-28 | 켐팜 인코포레이티드 | 히드로모르폰의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 컨쥬게이트, 전구약물, 이의 제조 방법 및 용도 |
| US10138207B2 (en) | 2012-11-09 | 2018-11-27 | Purdue Pharma, L.P. | Benzomorphan analogs and the use thereof |
| US9175000B2 (en) | 2012-12-07 | 2015-11-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| EP2931724B1 (en) | 2012-12-14 | 2017-01-25 | Purdue Pharma LP | Pyridonemorphinan analogs and biological activity on opioid receptors |
| ES2621305T3 (es) | 2012-12-14 | 2017-07-03 | Purdue Pharma Lp | Morfinanos espirocíclicos y su uso |
| EP2951160B1 (en) | 2013-01-31 | 2019-04-24 | Purdue Pharma LP | Benzomorphan analogs and the use thereof |
| US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| HU231191B1 (hu) | 2013-04-15 | 2021-08-30 | Szegedi Tudományegyetem | Izotóp tartalmú morfin molekulák |
| EP3087073B1 (en) | 2013-12-26 | 2018-07-04 | Purdue Pharma LP | 10-substituted morphinan hydantoins |
| WO2015097548A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 7-beta-alkyl analogs of orvinols |
| WO2015097545A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
| US9340542B2 (en) | 2013-12-26 | 2016-05-17 | Purdue Pharma L.P. | Propellane-based compounds and the use thereof |
| JP6353543B2 (ja) | 2013-12-26 | 2018-07-04 | パーデュー、ファーマ、リミテッド、パートナーシップ | 環縮小モルフィナン及びその使用 |
| WO2015099863A1 (en) | 2013-12-27 | 2015-07-02 | Purdue Pharma L.P. | 6-substituted and 7-substituted morphinan analogs and the use thereof |
| WO2015183780A1 (en) | 2014-05-27 | 2015-12-03 | Purdue Pharma L.P. | Spirocyclic morphinans and use thereof |
| JP6360915B2 (ja) | 2014-06-13 | 2018-07-18 | パーデュー、ファーマ、リミテッド、パートナーシップ | アザモルフィナン誘導体及びその使用 |
| KR20170094251A (ko) | 2014-12-02 | 2017-08-17 | 켐팜 인코포레이티드 | 옥시모르폰의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트, 이의 전구 약물, 제조 방법 및 용도 |
| MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
| ITUB20154996A1 (it) | 2015-10-27 | 2017-04-27 | Nobili S P A | Attrezzatura per l?erogazione di un liquido di trattamento ad una rispettiva coltura o piantagione agricola. |
| CN109640991A (zh) | 2016-07-29 | 2019-04-16 | 詹森药业有限公司 | 治疗前列腺癌的方法 |
| US10745402B2 (en) | 2017-01-02 | 2020-08-18 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| WO2020012248A1 (en) | 2018-07-13 | 2020-01-16 | Alkermes Pharma Ireland Limited | Novel naphthylenyl compounds for long-acting injectable compositions and related methods |
| WO2020012245A1 (en) | 2018-07-13 | 2020-01-16 | Alkermes Pharma Ireland Limited | Thienothiophene-naltrexone prodrugs for long-acting injectable compositions |
| WO2020094634A1 (en) | 2018-11-05 | 2020-05-14 | Alkermes Pharma Ireland Limited | Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods |
| WO2024042226A2 (en) * | 2022-08-25 | 2024-02-29 | Biosynth Gmbh | Procedure for production of opioid-antagonist-releasing compounds and their use as a medicine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE92497T1 (de) | 1988-01-12 | 1993-08-15 | Baker Norton Pharma | Glucuronsaeure-derivate von opioid-antagonisten. |
| FR2680786B1 (fr) * | 1991-09-04 | 1995-03-10 | Irepa | Procede de synthese de glucuronides d'epoxy-4,5 morphinanes. |
| CA2211596A1 (en) * | 1995-11-29 | 1997-06-19 | Gregori Valencia Parera | Glycoconjugates of opiated substances |
| GB9711118D0 (en) | 1997-05-29 | 1997-07-23 | Rolabo Sl | Compound |
-
2002
- 2002-07-22 US US10/199,526 patent/US6740641B2/en not_active Expired - Lifetime
- 2002-07-24 EP EP02765874A patent/EP1412368B1/en not_active Expired - Lifetime
- 2002-07-24 MX MXPA04000825A patent/MXPA04000825A/es active IP Right Grant
- 2002-07-24 DK DK02765874T patent/DK1412368T3/da active
- 2002-07-24 DE DE60222137T patent/DE60222137T2/de not_active Expired - Lifetime
- 2002-07-24 CA CA2455774A patent/CA2455774C/en not_active Expired - Fee Related
- 2002-07-24 AT AT02765874T patent/ATE371665T1/de active
- 2002-07-24 IL IL16008502A patent/IL160085A0/xx unknown
- 2002-07-24 WO PCT/US2002/023553 patent/WO2003011881A2/en active IP Right Grant
- 2002-07-24 PT PT02765874T patent/PT1412368E/pt unknown
- 2002-07-24 ES ES02765874T patent/ES2292806T3/es not_active Expired - Lifetime
- 2002-07-24 JP JP2003517072A patent/JP4679055B2/ja not_active Expired - Fee Related
- 2002-07-24 AU AU2002329634A patent/AU2002329634B2/en not_active Ceased
-
2004
- 2004-01-27 IL IL160085A patent/IL160085A/en not_active IP Right Cessation
-
2007
- 2007-11-26 CY CY20071101510T patent/CY1107813T1/el unknown
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