JP2005305167A - 脈管の病気の予防および治療のための薬物/薬物配給システム - Google Patents
脈管の病気の予防および治療のための薬物/薬物配給システム Download PDFInfo
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Abstract
【解決手段】 局所的配給システムがラパマイシンまたはその他の適当な薬物、物質または化合物により被覆されていて、経皮的で経内腔的な冠動脈血管形成術の後の新脈管内膜過形成の治療および予防のために内腔の中を通して配給される。この薬物または物質の局所的配給はこれらの作用効果を高めると共に全身系的な毒性を低下する。
【選択図】 図1
Description
本特許出願は2000年5月12日に出願されている米国仮特許出願第60/204,417号の恩典を主張していて2001年1月18日に出願されている米国仮特許出願第60/262,614号、2001年1月18日に出願されている米国仮特許出願第60/262,461号、2001年1月24日に出願されている米国仮特許出願第60/263,806号および2001年1月25日に出願されている米国仮特許出願第60/263,979号の恩典を主張している2000年5月19日に出願されている米国特許出願第09/575,480号の一部継続出願である2001年5月7日に出願されている米国特許出願第09/850,293号の一部継続出願である。
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(1)狭窄性脈管の再造形を予防するための方法において、ステントの15ミリメートル乃至18ミリメートル当たりに約35マイクログラムからステントの15ミリメートル乃至18ミリメートル当たりに約430マイクログラムの範囲内の治療の用量において抗増殖性および抗炎症性を有する一定の化合物の、一定のステントからの放出による、一定の制御された配給を含み、前記化合物がステントの基端側および先端側の両方における患部内の内腔の損失を実質的に減少し、この化合物が第1および第2の層を含む一定の高分子基質の中に組み込まれており、この場合に、この化合物がその第1の層の中に実質的に存在していて、第2の層がその化合物の制御された放出のための一定の拡散バリアとして作用し、前記高分子基質が約1ミクロンから約20ミクロンの範囲内の一定の厚さを有しており、前記第1の層が約8ミクロンから約12ミクロンの範囲内の一定の厚さを有しており、前記第2の層が約1ミクロン乃至約2ミクロンの範囲内の一定の厚さを有している方法。
(2)さらに、傷害に応答する一定の脈管壁部内の線維芽細胞の増殖を遮断することにより脈管の瘢痕組織の形成を減少するために前記化合物を利用する処理を含む実施態様1に記載の狭窄性の再造形を予防するための方法。
(3)前記化合物がラパマイシンを含む実施態様2に記載の狭窄性の再造形を予防するための方法。
(4)前記化合物が高親和性のサイトゾルのタンパク質であるFKBP12に結合してラパマイシンと同等の薬理学的特性を有する類似体および同類体を含む実施態様2に記載の狭窄性の再造形を予防するための方法。
(5)さらに、一定のコラーゲンの形成または代謝に関与する特定のタンパク質の翻訳に影響を及ぼすために前記化合物を利用する処理を含む実施態様1に記載の狭窄性の再造形を予防するための方法。
(7)前記化合物が高親和性のサイトゾルのタンパク質であるFKBP12に結合してラパマイシンと同等の薬理学的特性を有する類似体および同類体を含む実施態様5に記載の狭窄性の再造形を予防するための方法。
(8)再狭窄性の脈管の再造形を治療するための薬物配給装置において、
一定のステント、および
ステントの15ミリメートル乃至18ミリメートル当たりに約35マイクログラムからステントの15ミリメートル乃至18ミリメートル当たりに約430マイクログラムの範囲内の一定の治療の用量の抗増殖性および抗炎症性を有していて前記再狭窄性の脈管の再造形の治療のためのステントに放出可能に固定されている一定の薬剤を備えており、この薬剤が内腔内医療装置の基端側および先端側の両方における患部内の内腔の損失を実質的に減少し、さらに、この薬剤が第1および第2の層を含む一定の高分子基質の中に組み込まれており、この場合に、前記薬剤がその第1の層の中に実質的に存在していて、第2の層がその薬剤の制御された放出のための一定の拡散バリアとして作用し、前記高分子基質が約1ミクロンから約20ミクロンの範囲内の一定の厚さを有している薬物配給装置。
(9)さらに、前記薬剤が傷害に応答する一定の脈管壁部内の線維芽細胞の増殖を遮断することにより脈管の瘢痕組織の形成を減少する実施態様8に記載の薬物配給装置。
(10)前記薬剤がラパマイシンを含む実施態様9に記載の薬物配給装置。
(12)さらに、前記薬剤が一定のコラーゲンの形成または代謝に関与する特定のタンパク質の翻訳に影響を及ぼす実施態様8に記載の薬物配給装置。
(13)前記薬物がラパマイシンを含む実施態様12に記載の薬物配給装置。
(14)前記薬剤が高親和性のサイトゾルのタンパク質であるFKBP12に結合してラパマイシンと同等の薬理学的特性を有する類似体および同類体を含む実施態様12に記載の薬物配給装置。
102 帯域部分
104 連結部分
106 貯蔵領域
Claims (14)
- 狭窄性脈管の再造形を予防するための方法において、ステントの15ミリメートル乃至18ミリメートル当たりに約35マイクログラムからステントの15ミリメートル乃至18ミリメートル当たりに約430マイクログラムの範囲内の治療の用量において抗増殖性および抗炎症性を有する一定の化合物の、一定のステントからの放出による、一定の制御された配給を含み、前記化合物がステントの基端側および先端側の両方における患部内の内腔の損失を実質的に減少し、この化合物が第1および第2の層を含む一定の高分子基質の中に組み込まれており、この場合に、この化合物がその第1の層の中に実質的に存在していて、第2の層がその化合物の制御された放出のための一定の拡散バリアとして作用し、前記高分子基質が約1ミクロンから約20ミクロンの範囲内の一定の厚さを有しており、前記第1の層が約8ミクロンから約12ミクロンの範囲内の一定の厚さを有しており、前記第2の層が約1ミクロン乃至約2ミクロンの範囲内の一定の厚さを有している方法。
- さらに、傷害に応答する一定の脈管壁部内の線維芽細胞の増殖を遮断することにより脈管の瘢痕組織の形成を減少するために前記化合物を利用する処理を含む請求項1に記載の狭窄性の再造形を予防するための方法。
- 前記化合物がラパマイシンを含む請求項2に記載の狭窄性の再造形を予防するための方法。
- 前記化合物が高親和性のサイトゾルのタンパク質であるFKBP12に結合してラパマイシンと同等の薬理学的特性を有する類似体および同類体を含む請求項2に記載の狭窄性の再造形を予防するための方法。
- さらに、一定のコラーゲンの形成または代謝に関与する特定のタンパク質の翻訳に影響を及ぼすために前記化合物を利用する処理を含む請求項1に記載の狭窄性の再造形を予防するための方法。
- 前記化合物がラパマイシンを含む請求項5に記載の狭窄性の再造形を予防するための方法。
- 前記化合物が高親和性のサイトゾルのタンパク質であるFKBP12に結合してラパマイシンと同等の薬理学的特性を有する類似体および同類体を含む請求項5に記載の狭窄性の再造形を予防するための方法。
- 再狭窄性の脈管の再造形を治療するための薬物配給装置において、
一定のステント、および
ステントの15ミリメートル乃至18ミリメートル当たりに約35マイクログラムからステントの15ミリメートル乃至18ミリメートル当たりに約430マイクログラムの範囲内の一定の治療の用量の抗増殖性および抗炎症性を有していて前記再狭窄性の脈管の再造形の治療のためのステントに放出可能に固定されている一定の薬剤を備えており、この薬剤が内腔内医療装置の基端側および先端側の両方における患部内の内腔の損失を実質的に減少し、さらに、この薬剤が第1および第2の層を含む一定の高分子基質の中に組み込まれており、この場合に、前記薬剤がその第1の層の中に実質的に存在していて、第2の層がその薬剤の制御された放出のための一定の拡散バリアとして作用し、前記高分子基質が約1ミクロンから約20ミクロンの範囲内の一定の厚さを有している薬物配給装置。 - さらに、前記薬剤が傷害に応答する一定の脈管壁部内の線維芽細胞の増殖を遮断することにより脈管の瘢痕組織の形成を減少する請求項8に記載の薬物配給装置。
- 前記薬剤がラパマイシンを含む請求項9に記載の薬物配給装置。
- 前記薬剤が高親和性のサイトゾルのタンパク質であるFKBP12に結合してラパマイシンと同等の薬理学的特性を有する類似体および同類体を含む請求項9に記載の薬物配給装置。
- さらに、前記薬剤が一定のコラーゲンの形成または代謝に関与する特定のタンパク質の翻訳に影響を及ぼす請求項8に記載の薬物配給装置。
- 前記薬物がラパマイシンを含む請求項12に記載の薬物配給装置。
- 前記薬剤が高親和性のサイトゾルのタンパク質であるFKBP12に結合してラパマイシンと同等の薬理学的特性を有する類似体および同類体を含む請求項12に記載の薬物配給装置。
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- 2005-04-20 EP EP05252466A patent/EP1588726A1/en not_active Withdrawn
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JPH08224297A (ja) * | 1994-12-13 | 1996-09-03 | Advanced Cardeovascular Syst Inc | ステント構造体に巻くための高分子フィルム |
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Also Published As
Publication number | Publication date |
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US7300662B2 (en) | 2007-11-27 |
CA2504401A1 (en) | 2005-10-21 |
US20040260268A1 (en) | 2004-12-23 |
CA2504401C (en) | 2013-12-17 |
EP1588726A1 (en) | 2005-10-26 |
US20070026036A1 (en) | 2007-02-01 |
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