JP2005289996A5 - - Google Patents
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- Publication number
- JP2005289996A5 JP2005289996A5 JP2005099344A JP2005099344A JP2005289996A5 JP 2005289996 A5 JP2005289996 A5 JP 2005289996A5 JP 2005099344 A JP2005099344 A JP 2005099344A JP 2005099344 A JP2005099344 A JP 2005099344A JP 2005289996 A5 JP2005289996 A5 JP 2005289996A5
- Authority
- JP
- Japan
- Prior art keywords
- liquid formulation
- rapamycin
- liquid
- pharmaceutically acceptable
- formulations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012669 liquid formulation Substances 0.000 claims 10
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 8
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 8
- 229960002930 sirolimus Drugs 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000008137 solubility enhancer Substances 0.000 claims 4
- 239000003381 stabilizer Substances 0.000 claims 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000019553 vascular disease Diseases 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 1
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229960000235 temsirolimus Drugs 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US813965 | 2004-03-31 | ||
| US10/813,965 US7846940B2 (en) | 2004-03-31 | 2004-03-31 | Solution formulations of sirolimus and its analogs for CAD treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005289996A JP2005289996A (ja) | 2005-10-20 |
| JP2005289996A5 true JP2005289996A5 (cg-RX-API-DMAC7.html) | 2011-03-24 |
| JP4987241B2 JP4987241B2 (ja) | 2012-07-25 |
Family
ID=34940672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005099344A Expired - Fee Related JP4987241B2 (ja) | 2004-03-31 | 2005-03-30 | Cad治療のためのシロリムスおよびその類似体の溶液配合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7846940B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1591108B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4987241B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN1754536B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2502146C (cg-RX-API-DMAC7.html) |
Families Citing this family (50)
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| US8652502B2 (en) | 2003-12-19 | 2014-02-18 | Cordis Corporation | Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury |
| US7846940B2 (en) * | 2004-03-31 | 2010-12-07 | Cordis Corporation | Solution formulations of sirolimus and its analogs for CAD treatment |
| US8003122B2 (en) * | 2004-03-31 | 2011-08-23 | Cordis Corporation | Device for local and/or regional delivery employing liquid formulations of therapeutic agents |
| CN104147005B (zh) | 2005-02-09 | 2018-07-03 | 参天制药株式会社 | 用于治疗疾病或病症的液体制剂 |
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| JP5506378B2 (ja) | 2006-03-23 | 2014-05-28 | 参天製薬株式会社 | 血管透過性に関連する疾患または病気のための製剤および方法 |
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| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
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| US9220837B2 (en) | 2007-03-19 | 2015-12-29 | Insuline Medical Ltd. | Method and device for drug delivery |
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| EP2231229A1 (en) | 2007-12-18 | 2010-09-29 | Insuline Medical Ltd. | Drug delivery device with sensor for closed-loop operation |
| US8420110B2 (en) * | 2008-03-31 | 2013-04-16 | Cordis Corporation | Drug coated expandable devices |
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| EP2331187A4 (en) * | 2008-09-02 | 2011-09-28 | By Pass Inc | MICROPOROUS BALLOON CATHETER |
| BRPI0916125A2 (pt) | 2008-11-07 | 2015-11-03 | Insuline Medical Ltd | "dispositivo de tratamento" |
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| CN102448407B (zh) | 2009-09-16 | 2015-05-20 | 泰尔茂株式会社 | 生物体内留置用支架及支架输送系统 |
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| US10183143B2 (en) | 2013-03-15 | 2019-01-22 | Bitol Designs, Llc | Occlusion resistant catheter and method of use |
| CN104262614B (zh) * | 2014-08-22 | 2017-03-08 | 华中科技大学 | 一种具有抗癌活性的化合物及抗癌组合物 |
| CN113384390B (zh) | 2015-09-15 | 2023-08-22 | 萨维奇医疗股份有限公司 | 用于在组织腔中锚定护套的装置和方法 |
| CN106236339B (zh) * | 2016-07-22 | 2018-06-01 | 江苏大学 | 一种适用于分叉血管主支的锥形血管支架 |
| US11013731B2 (en) | 2017-01-06 | 2021-05-25 | Santen Pharmaceutical Co., Ltd. | Intratumoral administration of sirolimus for treatment of prostate cancer |
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-
2004
- 2004-03-31 US US10/813,965 patent/US7846940B2/en not_active Expired - Lifetime
-
2005
- 2005-03-22 CA CA2502146A patent/CA2502146C/en not_active Expired - Lifetime
- 2005-03-30 JP JP2005099344A patent/JP4987241B2/ja not_active Expired - Fee Related
- 2005-03-31 EP EP05252016.0A patent/EP1591108B1/en not_active Expired - Lifetime
- 2005-03-31 CN CN2005100717890A patent/CN1754536B/zh not_active Expired - Fee Related
- 2005-03-31 CN CN201210034073.3A patent/CN102641239B/zh not_active Expired - Fee Related
-
2010
- 2010-10-21 US US12/908,949 patent/US7932265B2/en not_active Expired - Fee Related
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