JP2005281197A - 不全角化抑制剤、毛穴縮小剤及び皮膚外用剤 - Google Patents
不全角化抑制剤、毛穴縮小剤及び皮膚外用剤 Download PDFInfo
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- JP2005281197A JP2005281197A JP2004097799A JP2004097799A JP2005281197A JP 2005281197 A JP2005281197 A JP 2005281197A JP 2004097799 A JP2004097799 A JP 2004097799A JP 2004097799 A JP2004097799 A JP 2004097799A JP 2005281197 A JP2005281197 A JP 2005281197A
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- alanyl
- histidine
- poe
- acid
- pore
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- 229960002675 xylitol Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Abstract
【解決手段】β−アラニル−L−ヒスチジン及び/又はその塩からなる不全角化抑制剤、毛穴縮小剤。また、β−アラニル−L−ヒスチジン及び/又はその塩を有効成分とする不全角化抑制剤、毛穴縮小剤。さらに、前記不全角化抑制剤、毛穴縮小剤を含有する不全角化抑制用皮膚外用剤、毛穴縮小用皮膚外用剤。
【選択図】なし
Description
β−アラニル−L−ヒスチジンの3質量%水溶液(30質量%エタノールを含む)を調製した。なお、pHは1Nの塩酸を用いて7.5に調整した。
健常人5人の男性頬部を用い、1ヶ月間1日2回試料を塗布する実験を行った。3質量%β−アラニル−L−ヒスチジン水溶液(15質量%エタノールを含む)を塗布試料として調製した。なおpHは7.5になるように、1N塩酸で調整した。対照は15質量%エタノール水溶液を用い、3質量%β−アラニル−L−ヒスチジン水溶液と対照試料を半面ずつ塗布した。
成分 配合量(質量%)
(1)1,3−ブチレングリコール 6.0
(2)グリセリン 4.0
(3)オレイルアルコール 0.1
(4)POE(20)ソルビタンモノラウリン酸エステル 0.5
(5)POE(15)ラウリルアルコールエステル 0.5
(6)エタノール 10.0
(7)β−アラニル−L−ヒスチジン 3.0
(8)精製水 残余
成分 配合量(質量%)
(アルコール相)
(1)エタノール 10.0
(2)オレイルアルコール 0.1
(3)POE(20)ソルビタンモノラウリン酸エステル 0.5
(4)POE(15)ラウリルエーテル 0.5
(5)防腐剤 適量
(6)香料 適量
(水相)
(7)1,3−ブチレングリコール 6.0
(8)β−アラニル−L−ヒスチジン 3.0
(9)グリセリン 4.0
(10)イオン交換水 残余
水相、アルコール相をそれぞれ調製後、混合した。
成分 配合量(質量%)
(1)ステアリルアルコール 6.0
(2)ステアリン酸 2.0
(3)水添ラノリン 4.0
(4)スクワラン 9.0
(5)オクチルドデカノール 10.0
(6)1,3−ブチレングリコール 6.0
(7)ポリエチレングリコール1500 4.0
(8)POE(25)セチルアルコールエステル 3.0
(9)モノステアリン酸グリセリン 2.0
(10)β−アラニル−L−ヒスチジン 0.2
(11)トコフェロール 0.1
(12)精製水 残余
成分 配合量(質量%)
(1)ステアリン酸 5.0
(2)ステアリルアルコール 4.0
(3)イソプロピルミリステート 18.0
(4)グリセリンモノステアリン酸エステル 3.0
(5)プロピレングリコール 10.0
(6)β−アラニル−L−ヒスチジン 3.0
(7)水酸化カリウム 0.2
(8)亜硫酸水素ナトリウム 0.01
(9)防腐剤 適量
(10)香料 適量
(11)イオン交換水 残余
イオン交換水にプロピレングリコール、β−アラニル−L−ヒスチジン及び水酸化カリウムを加えて溶解し、加熱して70℃に保った(水相)。他の成分を混合し、加熱融解して70℃に保った(油相)。水相に油相を徐々に加えて予備乳化し、ホモミキサーで均一に乳化後、よくかきまぜながら30℃まで冷却した。
成分 配合量(質量%)
ステアリン酸 6.0
ソルビタンモノステアリン酸エステル 2.0
POE(20)ソルビタンモノステアリン酸エステル 1.5
プロピレングリコール 10.0
グリセリントリオクタノエート 10.0
スクワレン 5.0
β−アラニル−L−ヒスチジン 0.01
亜硫酸水素ナトリウム 0.01
エチルパラベン 0.3
香料 適量
イオン交換水 残余
イオン交換水にプロピレングリコールを加えて溶解し、加熱して70℃に保った(水相)。他の成分を混合し、加熱融解して70℃に保った(油相)。水相に油相を徐々に加え、予備乳化を行い、ホモミキサーで均一に乳化した後、よくかきまぜながら30℃まで冷却した。
成分 配合量(質量%)
(A相)
(1)エチルアルコール(95%) 10.0
(2)POE(20)オクチルドデカノール 1.0
(3)パントテニルエチルエーテル 0.1
(4)ASDA・4Na 1.5
(5)メチルパラベン 0.15
(6)エタノール 10.0
(B相)
(7)水酸化カリウム 0.1
(C相)
(8)グリセリン 5.0
(9)ジプロピレングリコール 10.0
(10)β−アラニル−L−ヒスチジン 1.0
(11)カルボキシビニルポリマー 0.2
(12)精製水 残余
成分 配合量(質量%)
(A相)
95%エタノール 10.0
POE(20)オクチルドデカノール 1.0
メチルパラベン 0.15
パントテニルエチルエーテル 0.1
(B相)
水酸化カリウム 0.1
(C相)
グリセリン 5.0
ジプロピレングリコール 10.0
亜硫酸水素ナトリウム 0.03
カルボキシビニルポリマー 0.2
β−アラニル−L−ヒスチジン塩酸塩 2.0
イオン交換水 残余
A相、C相をそれぞれ均一に溶解し、C相にA相を加えて可溶化した。次いでB相を加えて混合した。
成分 配合量(質量%)
(1)ステアリン酸 2.5
(2)セチルアルコール 1.5
(3)ワセリン 5.0
(4)流動パラフィン 10.0
(5)POE(10)モノオレイン酸エステル 2.0
(6)PEG1500 3.0
(7)トリエタノールアミン 1.0
(8)β−アラニル−L−ヒスチジン 1.0
(9)亜硫酸水素ナトリウム 0.01
(10)エチルパラベン 0.3
(11)カルボキシビニルポリマー 0.05
(12)香料 適量
(13)イオン交換水 残余
少量のイオン交換水にカルボキシビニルポリマーを溶解した(A相)。イオン交換水の残部にPEG1500、β−アラニル−L−ヒスチジン及びトリエタノールアミンを加え、加熱溶解して70℃に保った(水相)。他の成分を混合し、加熱融解して70℃に保った(油相)。水相に油相を加えて予備乳化を行い、A相を加えてホモミキサーで均一に乳化した後、よくかきまぜながら30℃まで冷却した。
成分 配合量(質量%)
(1)95%エタノール 10.0
(2)ジプロピレングリコール 15.0
(3)POE(15モル)オレイルアルコールエーテル 2.0
(4)サルコシン 0.5
(5)亜硫酸水素ナトリウム 0.03
(6)β−アラニル−L−ヒスチジン 0.5
(7)カルボキシビニルポリマー 1.0
(8)苛性カリ 0.15
(9)L−アルギニン 0.1
(10)香料 適量
(11)防腐剤 適量
(12)精製水 残余
(12)精製水に(4)および(7)を均一に溶解した(水相)。一方、(1)に(2)、(3)、および(5)、(6)、(10)を溶解し、これを水相に添加した。次いで(8)、(9)で中和させ増粘して、ゼリーを得た。
成分 配合量(質量%)
(1)95%エタノール 10.0
(2)ジプロピレングリコール 15.0
(3)POE(50)オレイルエーテル 2.0
(4)カルボキシビニルポリマー 1.0
(5)水酸化ナトリウム 0.15
(6)β−アラニル−L−ヒスチジン塩酸塩 1.0
(7)メチルパラベン 0.2
(8)香料 適量
(9)イオン交換水 残余
イオン交換水にカルボキシビニルポリマーを均一に溶解した(A相)。95%エタノールにグリシルグリシン、β−アラニル−L−ヒスチジン塩酸塩及びPOE(50)オレイルエーテルを溶解し、A相に添加した。水酸化ナトリウム以外の成分を添加後、水酸化ナトリウムを添加して中和増粘させた。
成分 配合量(質量%)
(A相)
ジプロピレングリコール 5.0
POE(60)硬化ヒマシ油 5.0
(B相)
オリーブ油 5.0
酢酸トコフェロール 0.2
エチルパラベン 0.2
香料 0.2
(C相)
β−アラニル−L−ヒスチジン 1.0
亜硫酸水素ナトリウム 0.03
ポリビニルアルコール(ケン化度90,重合度2000) 13.0
エタノール 7.0
イオン交換水 残余
A相、B相、C相をそれぞれ均一に溶解し、A相にB相を加えて可溶化した。次いでこれをC相に加えて混合した。
成分 配合量(質量%)
(アルコール相)
95%エタノール 10.0
POE(15モル)オレイルアルコールエーテル 2.0
防腐剤 適量
香料 適量
(水相)
β−アラニル−L−ヒスチジン 0.5
グルタチオン 3.0
アルブチン 3.0
ポリビニルアルコール 12.0
ポリエチレングリコール1500 1.0
イオン交換水 残余
80℃にて水相を調製し、50℃に冷却した。次いで、室温で調製したアルコール相を添加後均一に混合し、放冷した。
成分 配合量(質量%)
(アルコール相)
95%エタノール 2.0
防腐剤 適量
香料 適量
色剤 適量
(水相)
β−アラニル−L−ヒスチジン 1.0
プロピレングリコール 7.0
亜鉛華 25.0
カオリン 20.0
イオン交換水 残余
室温にて水相を均一に調製した。次いで、室温にて調製したアルコール相を添加し均一に混合した。
成分 配合量(質量%)
(アルコール相)
95%エタノール 2.0
防腐剤 適量
香料 適量
色剤 適量
(水相)
β−アラニル−L−ヒスチジン塩酸塩 0.2
プロピレングリコール 7.0
亜鉛華 25.0
カオリン 20.0
イオン交換水 残余
室温にて水相を均一に調製した。次いで、室温にて調製したアルコール相を添加し均一に混合した。
成分 配合量(質量%)
(1)タルク 15.0
(2)セリサイト 10.0
(3)球状ナイロン粉末 10.0
(4)多孔性無水ケイ酸粉末 15.0
(5)窒化ホウ素 5.0
(6)二酸化チタン 5.0
(7)酸化鉄 3.0
(8)ステアリン酸亜鉛 5.0
(9)β−アラニル−L−ヒスチジン 1.0
(10)流動パラフィン 残余
(11)トリイソオクタン酸グリセリン 15.0
(12)セスキオレイン酸ソルビタン 1.5
(13)防腐剤 適量
(14)香料 適量
(1)〜(8)の各成分を混合粉砕したところへ、(9)〜(14)の各成分を混合したものを加えて攪拌混合し、容器に成型して固形ファンデ−ションを得た。
成分 配合量(質量%)
(1)球状ナイロン 10.0
(2)多孔性無水ケイ酸粉末 8.0
(3)雲母チタン 2.0
(4)シリコーン処理セリサイト 2.0
(5)シリコーン処理マイカ 12.0
(6)シリコーン処理二酸化チタン 5.0
(7)シリコーン処理酸化鉄 2.0
(8)イオン交換水 残余
(9)β−アラニル−L−ヒスチジン 2.0
(10)デカメチルシクロペンタンシロキサン 18.0
(11)ジメチルポリシロキサン 5.0
(12)スクワラン 1.0
(13)POE変性ジメチルポリシロキサン 2.0
(14)防腐剤 適量
(15)香料 適量
(9)〜(15)の各成分を均一に混合溶解したものに、混合粉砕した(1)〜(7)を加えて分散させた。この分散液に、(8)を加えて乳化し、容器に充填して油中水型乳化ファンデ−ションを得た。
Claims (6)
- β−アラニル−L−ヒスチジン及び/又はその塩からなる不全角化抑制剤。
- β−アラニル−L−ヒスチジン及び/又はその塩を有効成分とする不全角化抑制剤。
- 請求項1又は2に記載の不全角化抑制剤を含有する不全角化抑制用皮膚外用剤。
- β−アラニル−L−ヒスチジン及び/又はその塩からなる毛穴縮小剤。
- β−アラニル−L−ヒスチジン及び/又はその塩を有効成分とする毛穴縮小剤。
- 請求項4又は5に記載の毛穴縮小剤を含有する毛穴縮小用皮膚外用剤。
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006254875A (ja) * | 2005-03-18 | 2006-09-28 | Shiseido Co Ltd | 不全角化を抑制する物質のスクリーニング方法、同方法によりスクリーニングされた物質及び不全角化を抑制する方法 |
WO2006120941A1 (ja) * | 2005-05-09 | 2006-11-16 | Shiseido Company, Ltd. | 不全角化抑制剤、毛穴縮小剤及び皮膚外用組成物 |
WO2007125657A1 (ja) * | 2007-06-22 | 2007-11-08 | Shiseido Company, Ltd. | 皮膚化粧料 |
JP2015030675A (ja) * | 2013-07-31 | 2015-02-16 | 株式会社コーセー | 毛穴収縮剤 |
US11501457B2 (en) | 2020-05-08 | 2022-11-15 | The Procter & Gamble Company | Methods for identifying dendritic pores |
US11776161B2 (en) | 2018-08-21 | 2023-10-03 | The Procter & Gamble Company | Methods for identifying pore color |
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2004
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2006254875A (ja) * | 2005-03-18 | 2006-09-28 | Shiseido Co Ltd | 不全角化を抑制する物質のスクリーニング方法、同方法によりスクリーニングされた物質及び不全角化を抑制する方法 |
JP4585342B2 (ja) * | 2005-03-18 | 2010-11-24 | 株式会社資生堂 | 不全角化を抑制する物質のスクリーニング方法、同方法によりスクリーニングされた物質及び不全角化を抑制する方法 |
WO2006120941A1 (ja) * | 2005-05-09 | 2006-11-16 | Shiseido Company, Ltd. | 不全角化抑制剤、毛穴縮小剤及び皮膚外用組成物 |
WO2007125657A1 (ja) * | 2007-06-22 | 2007-11-08 | Shiseido Company, Ltd. | 皮膚化粧料 |
JPWO2007125657A1 (ja) * | 2007-06-22 | 2010-04-08 | 株式会社資生堂 | 皮膚化粧料 |
US20110098231A1 (en) * | 2007-06-22 | 2011-04-28 | Shiseido Company, Ltd. | Skin Cosmetic |
JP2015030675A (ja) * | 2013-07-31 | 2015-02-16 | 株式会社コーセー | 毛穴収縮剤 |
US11776161B2 (en) | 2018-08-21 | 2023-10-03 | The Procter & Gamble Company | Methods for identifying pore color |
US11501457B2 (en) | 2020-05-08 | 2022-11-15 | The Procter & Gamble Company | Methods for identifying dendritic pores |
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