JP2005247711A - N−アシルスルホンアミド結合を有する新規ホスミドシン類縁体 - Google Patents
N−アシルスルホンアミド結合を有する新規ホスミドシン類縁体 Download PDFInfo
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- JP2005247711A JP2005247711A JP2004056989A JP2004056989A JP2005247711A JP 2005247711 A JP2005247711 A JP 2005247711A JP 2004056989 A JP2004056989 A JP 2004056989A JP 2004056989 A JP2004056989 A JP 2004056989A JP 2005247711 A JP2005247711 A JP 2005247711A
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- oxoadenosine
- group
- derivative according
- sulfamoyl
- amino acid
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
2’、3’−O−イソプロピリデン−5’−O−スルファモイル−8−オキソアデノシン
5’−O−スルファモイル−8−オキソアデノシン
2’、3’−O−イソプロピリデン−5’−O−[N−(N−BOC−L−プロリル)−スルファモイル]−8−オキソアデノシン
5’−O−[N−(L−プロリル)−スルファモイル]−8−オキソアデノシン
Claims (11)
- アミノ酸に由来するアシル基がL−プロリル、L−アラニル、又はL−イソロイシルである、請求項1記載の8−オキソアデノシン誘導体。
- アミノ基の保護基が、t−ブトキシカルボニル、ベンジルオキシカルボニル、又は9−フルオレニルメトキシカルボニルである、請求項1又は2記載の8−オキソアデノシン誘導体。
- 窒素原子を一つ含む複素環化合物における置換基Rが炭素数1〜5を有する、請求項4記載の8−オキソアデノシン誘導体。
- 窒素原子を一つ含む複素環化合物に由来する基がピロリジン−2−イル、ピペリジン−2−イル、アゼチジン−2−イル、1−メチルピロリジン−2−イル、1−メチルピペリジン−2−イル、1−メチルアゼチジン−2−イル、又はキヌリジン−2−イルである、請求項4記載の8−オキソアデノシン誘導体。
- 2’、3’−O−イソプロピリデン−5’−O−スルファモイル−8−オキソアデノシンである請求項1記載の8−オキソアデノシン誘導体。
- 5’−O−スルファモイル−8−オキソアデノシンである請求項1記載の8−オキソアデノシン誘導体。
- 2’、3’−O−イソプロピリデン−5’−O−[N−(N−BOC−L−プロリル)−スルファモイル]−8−オキソアデノシンである請求項1記載の8−オキソアデノシン誘導体。
- 5’−O−[N−(L−プロリル)−スルファモイル]−8−オキソアデノシンである請求項1記載の8−オキソアデノシン誘導体。
- 8−オキソアデノシン誘導体の5’位をアミノスルファモイル化し、その後、一般式(I)のA1を縮合させることを含む、請求項1〜10のいずれか一項に記載の8−オキソアデノシン誘導体の合成方法。
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JP2004056989A JP4643156B2 (ja) | 2004-03-02 | 2004-03-02 | N−アシルスルホンアミド結合を有する新規ホスミドシン類縁体 |
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JP2004056989A JP4643156B2 (ja) | 2004-03-02 | 2004-03-02 | N−アシルスルホンアミド結合を有する新規ホスミドシン類縁体 |
Publications (2)
Publication Number | Publication Date |
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JP2005247711A true JP2005247711A (ja) | 2005-09-15 |
JP4643156B2 JP4643156B2 (ja) | 2011-03-02 |
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JP2004056989A Expired - Fee Related JP4643156B2 (ja) | 2004-03-02 | 2004-03-02 | N−アシルスルホンアミド結合を有する新規ホスミドシン類縁体 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010500353A (ja) * | 2006-08-08 | 2010-01-07 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | E1活性化酵素のインヒビターとして有用なヘテロアリール化合物 |
-
2004
- 2004-03-02 JP JP2004056989A patent/JP4643156B2/ja not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
JPN7010003524, 関根光雄 等, "ホソミドシンとその類縁体の合成および抗ガン活性", 日本化学会第81春季年会−講演予稿集 II, 2002, p.934, 2 F5−28 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010500353A (ja) * | 2006-08-08 | 2010-01-07 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | E1活性化酵素のインヒビターとして有用なヘテロアリール化合物 |
JP2015013904A (ja) * | 2006-08-08 | 2015-01-22 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | E1活性化酵素のインヒビターとして有用なヘテロアリール化合物 |
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JP4643156B2 (ja) | 2011-03-02 |
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