JP2005161062A - 骨移植組成物 - Google Patents
骨移植組成物 Download PDFInfo
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- JP2005161062A JP2005161062A JP2004355406A JP2004355406A JP2005161062A JP 2005161062 A JP2005161062 A JP 2005161062A JP 2004355406 A JP2004355406 A JP 2004355406A JP 2004355406 A JP2004355406 A JP 2004355406A JP 2005161062 A JP2005161062 A JP 2005161062A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3629—Intestinal tissue, e.g. small intestinal submucosa
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
- A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physiology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
【解決手段】損傷した骨又は罹患した骨を修復誘導ために、粉末状の生分解性骨移植構成物の有効量を損傷又は罹患した領域に移植する工程を有し、前記骨移植構成物は脊椎動物の腸部の管腔部から剥離した粘膜下組織又はその消化物からなり、移植前に所定三次元形状に圧縮した粉末状とし、損傷した骨又は罹患した骨に移植する。
【選択図】なし
Description
脊椎動物の腸管の粘膜下組織及び基底部からなる小腸組織を組織切りばさみ、片刃かみそりの刃或いは他の適当な切断器具で任意の小片に切り刻む。得られた組織標本を丸底ステンレス鋼容器にいれ、液体窒素を容器に導入して組織標本を微粉砕用に凍結する。
微粉砕した腸の粘膜下組織からなる骨移植組成物は、酵素で消化することにより可溶化されほぼ均一な溶液を形成する。好ましい一態様においては、粉末状の微粉砕腸管粘膜下組織(実施例1と同様に生成した)は金網で容器にふるい入れ、再度浮遊させる。次にこの粉末を、塩酸でpHを2.5に調節した1mg/mlのペプシン(ミズーリ州、セントルイスのシグマ社)の0.1M酢酸溶液に入れ、48時間にわたり室温で消化した。反応溶媒は水酸化ナトリウムで中和し、ぺプシンの活動を不活性化した。可溶化した粘膜下組織は、次に溶液の塩析により濃縮し、分離してさらに精製及び/又は凍結乾燥し、粉末状のプロテアーゼ可溶化腸管粘膜下組織を生成した。
腸管粘膜下組織からなる2種類の骨移植組成物について、それらの骨組織の内因性成長の誘導を検討した。一方は自然の水和状態の粘膜下組織からなるもので、もう一方は乾燥凍結した粉末状の腸管粘膜下組織である。
Claims (4)
- 温血脊椎動物の骨の修復誘導方法であって、該方法は、前記脊椎動物の修復の必要な部位に生分解性骨移植構成物を有効量移植する工程からなり、前記骨移植構成物は基本的には、移植前に所定三次元形状に圧縮した粉末状の温血脊椎動物の腸管粘膜下組織又はその消化物からなり、前記の圧縮した粉末状の骨移植構成物は移植後その移植構成物が内因性組織に代わるまでその大体の形を維持することを特徴とする方法。
- 温血脊椎動物の骨の修復誘導方法であって、該方法は、前記脊椎動物の修復の必要な部位に生分解性骨移植構成物を有効量移植する工程からなり、前記骨移植構成物は基本的には、粉末状の温血脊椎動物の腸管粘膜下組織又はその消化物と生理学的適合性鉱物、成長因子、抗生物質、化学治療剤、抗原、抗体、酵素及びホルモンからなる群から選ばれる生物活性剤とからなり、前記粘膜下組織及び生物活性剤は移植前に所定三次元形状に圧縮し、前記の圧縮した粉末状の骨移植構成物は移植後その移植構成物が内因性組織に代わるまでその大体の形を維持することを特徴とする方法。
- 温血脊椎動物の骨の修復誘導に有用な生分解性骨移植構成物の生成における温血脊椎動物の腸粘膜下組織の使用であって、前記骨移植構成物は基本的には粉末状の温血脊椎動物の腸管粘膜下組織又はその消化物からなり、移植前に所定三次元形状に圧縮したもので、前記の圧縮した粉末状の骨移植構成物は移植後その移植構成物が内因性組織に代わるまでその大体の形を維持することを特徴とする使用。
- 温血脊椎動物の骨の修復誘導に有用な生分解性骨移植構成物の生成における温血脊椎動物の腸粘膜下組織の使用であり、前記骨移植構成物は基本的には粉末状の温血脊椎動物の腸管粘膜下組織又はその消化物と生理学的適合性鉱物、成長因子、抗生物質、化学治療剤、抗原、抗体、酵素及びホルモンからなる群から選ばれる生物活性剤とからなり、前記粘膜下組織及び生物活性剤は移植前に所定三次元形状に圧縮され、前記の圧縮された粉末状骨移植構成物は移植後その移植構成物が内因性組織に代わるまでその大体の形を維持することを特徴とする使用。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/386,432 US5641518A (en) | 1992-11-13 | 1995-02-10 | Method of repairing bone tissue |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52447296A Division JP4020962B2 (ja) | 1995-02-10 | 1996-02-09 | 骨移植組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2005161062A true JP2005161062A (ja) | 2005-06-23 |
Family
ID=23525546
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52447296A Expired - Lifetime JP4020962B2 (ja) | 1995-02-10 | 1996-02-09 | 骨移植組成物 |
JP2004355406A Pending JP2005161062A (ja) | 1995-02-10 | 2004-12-08 | 骨移植組成物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52447296A Expired - Lifetime JP4020962B2 (ja) | 1995-02-10 | 1996-02-09 | 骨移植組成物 |
Country Status (8)
Country | Link |
---|---|
US (1) | US5641518A (ja) |
EP (1) | EP0808167B1 (ja) |
JP (2) | JP4020962B2 (ja) |
AR (1) | AR000920A1 (ja) |
AU (1) | AU692063B2 (ja) |
CA (1) | CA2212647A1 (ja) |
DE (1) | DE69621595T2 (ja) |
WO (1) | WO1996024365A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101229435B1 (ko) | 2010-08-16 | 2013-02-05 | 한스바이오메드 주식회사 | 바이러스 불활화된 골이식용 골분의 제조방법 |
Families Citing this family (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
US6485723B1 (en) * | 1995-02-10 | 2002-11-26 | Purdue Research Foundation | Enhanced submucosal tissue graft constructs |
US5788625A (en) | 1996-04-05 | 1998-08-04 | Depuy Orthopaedics, Inc. | Method of making reconstructive SIS structure for cartilaginous elements in situ |
US20010048949A1 (en) * | 1996-08-16 | 2001-12-06 | Children's Medical Center Corporation | Isolated bladder submucosa for tissue reconstruction |
AU742457B2 (en) * | 1996-08-23 | 2002-01-03 | Cook Biotech, Incorporated | Graft prosthesis, materials and methods |
US8716227B2 (en) * | 1996-08-23 | 2014-05-06 | Cook Biotech Incorporated | Graft prosthesis, materials and methods |
US6666892B2 (en) * | 1996-08-23 | 2003-12-23 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
US6096347A (en) * | 1996-11-05 | 2000-08-01 | Purdue Research Foundation | Myocardial graft constructs |
AU8103198A (en) * | 1997-07-04 | 1999-01-25 | Torsana Osteoporosis Diagnostics A/S | A method for estimating the bone quality or skeletal status of a vertebrate |
CA2300260C (en) * | 1997-09-11 | 2011-05-10 | Purdue Research Foundation | Galactosidase modified submucosal tissue |
AU743808B2 (en) * | 1998-02-27 | 2002-02-07 | Purdue Research Foundation | Submucosa gel compositions |
US6972041B1 (en) * | 1998-03-16 | 2005-12-06 | Crosscart, Inc. | Bone xenografts |
US6458109B1 (en) | 1998-08-07 | 2002-10-01 | Hill-Rom Services, Inc. | Wound treatment apparatus |
US6918396B1 (en) | 1998-12-01 | 2005-07-19 | Purdue Research Foundation | Method for vocal cord reconstruction |
US8882850B2 (en) * | 1998-12-01 | 2014-11-11 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
US20030228288A1 (en) | 1999-10-15 | 2003-12-11 | Scarborough Nelson L. | Volume maintaining osteoinductive/osteoconductive compositions |
US6824533B2 (en) | 2000-11-29 | 2004-11-30 | Hill-Rom Services, Inc. | Wound treatment apparatus |
US6764462B2 (en) | 2000-11-29 | 2004-07-20 | Hill-Rom Services Inc. | Wound treatment apparatus |
US6576265B1 (en) * | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
WO2001045765A1 (en) | 1999-12-22 | 2001-06-28 | Acell, Inc. | Tissue regenerative composition |
US20040043006A1 (en) * | 2002-08-27 | 2004-03-04 | Badylak Stephen F. | Tissue regenerative composition |
US6579538B1 (en) | 1999-12-22 | 2003-06-17 | Acell, Inc. | Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof |
AU2001261595A1 (en) | 2000-05-22 | 2001-12-03 | Arthur C. Coffey | Combination sis and vacuum bandage and method |
US6332779B1 (en) | 2000-07-03 | 2001-12-25 | Osteotech, Inc. | Method of hard tissue repair |
US6863694B1 (en) | 2000-07-03 | 2005-03-08 | Osteotech, Inc. | Osteogenic implants derived from bone |
DE60101967T2 (de) * | 2000-07-03 | 2004-07-22 | Osteotech, Inc. | Knochenbildendes implantat aus knochen |
US9387094B2 (en) * | 2000-07-19 | 2016-07-12 | Warsaw Orthopedic, Inc. | Osteoimplant and method of making same |
US8366787B2 (en) | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
US6638312B2 (en) | 2000-08-04 | 2003-10-28 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa (SIS) |
US6855135B2 (en) | 2000-11-29 | 2005-02-15 | Hill-Rom Services, Inc. | Vacuum therapy and cleansing dressing for wounds |
US6685681B2 (en) | 2000-11-29 | 2004-02-03 | Hill-Rom Services, Inc. | Vacuum therapy and cleansing dressing for wounds |
US7323193B2 (en) * | 2001-12-14 | 2008-01-29 | Osteotech, Inc. | Method of making demineralized bone particles |
EP1383549A1 (en) * | 2001-02-14 | 2004-01-28 | Osteotech, Inc. | Implant derived from bone |
US6682695B2 (en) | 2001-03-23 | 2004-01-27 | Clearant, Inc. | Methods for sterilizing biological materials by multiple rates |
US6696060B2 (en) | 2001-06-14 | 2004-02-24 | Clearant, Inc. | Methods for sterilizing preparations of monoclonal immunoglobulins |
WO2003002165A1 (en) * | 2001-06-28 | 2003-01-09 | Cook Biotech Incorporated | Graft prosthesis devices containing renal capsule collagen |
WO2003007786A2 (en) * | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Porous delivery scaffold and method |
US7819918B2 (en) | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
AU2002316694B2 (en) * | 2001-07-16 | 2007-09-06 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
WO2003007789A2 (en) * | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
JP4197158B2 (ja) * | 2001-07-16 | 2008-12-17 | デピュイ・プロダクツ・インコーポレイテッド | 天然に発生する生物学的に誘導されている材料による装置 |
US8025896B2 (en) | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
US8012205B2 (en) * | 2001-07-16 | 2011-09-06 | Depuy Products, Inc. | Cartilage repair and regeneration device |
JP4294474B2 (ja) * | 2001-07-16 | 2009-07-15 | デピュイ・プロダクツ・インコーポレイテッド | 半月板再生装置 |
DE60239342D1 (de) | 2001-07-16 | 2011-04-14 | Depuy Products Inc | Gerät zur reparatur von knorpelmaterial |
US7163563B2 (en) | 2001-07-16 | 2007-01-16 | Depuy Products, Inc. | Unitary surgical device and method |
US6946098B2 (en) | 2001-08-10 | 2005-09-20 | Clearant, Inc. | Methods for sterilizing biological materials |
US6749851B2 (en) | 2001-08-31 | 2004-06-15 | Clearant, Inc. | Methods for sterilizing preparations of digestive enzymes |
US7252799B2 (en) | 2001-08-31 | 2007-08-07 | Clearant, Inc. | Methods for sterilizing preparations containing albumin |
US20030095890A1 (en) | 2001-09-24 | 2003-05-22 | Shirley Miekka | Methods for sterilizing biological materials containing non-aqueous solvents |
US6783968B2 (en) | 2001-09-24 | 2004-08-31 | Clearant, Inc. | Methods for sterilizing preparations of glycosidases |
EP1450878A1 (en) | 2001-10-11 | 2004-09-01 | Hill-Rom Services, Inc. | Waste container for negative pressure therapy |
US7163691B2 (en) * | 2001-10-12 | 2007-01-16 | Osteotech, Inc. | Bone graft |
WO2003032735A1 (en) * | 2001-10-18 | 2003-04-24 | Lifecell Corporation | Remodeling of tissues and organs |
ATE390151T1 (de) * | 2001-10-26 | 2008-04-15 | Cook Biotech Inc | Medizinisches implantat mit netzartiger struktur |
CA2468307A1 (en) * | 2001-12-26 | 2003-07-17 | Hill-Rom Services, Inc. | Vacuum bandage packing |
EP1461113A4 (en) * | 2001-12-26 | 2009-05-06 | Hill Rom Services Inc | ASSOCIATION SET FOR WOUND VACUUM THERAPY |
AU2002359828A1 (en) | 2001-12-26 | 2003-07-24 | Hill-Rom Services Inc. | Vented vacuum bandage and method |
CA2481016C (en) | 2002-04-10 | 2012-04-03 | Hill-Rom Services, Inc. | Access openings in vacuum bandage |
CA2483908C (en) * | 2002-05-02 | 2012-02-21 | Purdue Research Foundation | Vascularization enhanced graft constructs |
EP1503625B1 (en) * | 2002-05-02 | 2010-07-07 | Purdue Research Foundation | Vascularization enhanced graft constructs |
CN1665527A (zh) * | 2002-05-02 | 2005-09-07 | 普渡研究基金会 | 血管化增强的移植构造物 |
US20040166169A1 (en) * | 2002-07-15 | 2004-08-26 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
US6908591B2 (en) | 2002-07-18 | 2005-06-21 | Clearant, Inc. | Methods for sterilizing biological materials by irradiation over a temperature gradient |
JP2005536275A (ja) | 2002-08-21 | 2005-12-02 | ヒル−ロム サービシズ,インコーポレイテッド | 創傷閉鎖を防止するための創傷用パッキング |
US7682392B2 (en) | 2002-10-30 | 2010-03-23 | Depuy Spine, Inc. | Regenerative implants for stabilizing the spine and devices for attachment of said implants |
US20040175366A1 (en) * | 2003-03-07 | 2004-09-09 | Acell, Inc. | Scaffold for cell growth and differentiation |
US20040176855A1 (en) * | 2003-03-07 | 2004-09-09 | Acell, Inc. | Decellularized liver for repair of tissue and treatment of organ deficiency |
NZ544050A (en) | 2003-06-11 | 2009-03-31 | Osteotech Inc | Osteoimplants and methods for their manufacture |
AU2004253508A1 (en) | 2003-06-25 | 2005-01-13 | Acell, Inc. | Conditioned matrix compositions for tissue restoration |
WO2005023321A2 (en) * | 2003-09-04 | 2005-03-17 | Cook Biotech Incorporated | Extracellular matrix composite materials, and manufacture and use thereof |
AU2005212334B2 (en) * | 2004-02-09 | 2011-06-16 | Cook Medical Technologies Llc | Stent graft devices having collagen coating |
US7569233B2 (en) * | 2004-05-04 | 2009-08-04 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
WO2006015287A2 (en) * | 2004-07-30 | 2006-02-09 | Cook Biotech Incorporated | Graft with increased resistance to enzymatic degradation |
US7513866B2 (en) * | 2004-10-29 | 2009-04-07 | Depuy Products, Inc. | Intestine processing device and associated method |
US8329202B2 (en) * | 2004-11-12 | 2012-12-11 | Depuy Products, Inc. | System and method for attaching soft tissue to an implant |
US7354627B2 (en) | 2004-12-22 | 2008-04-08 | Depuy Products, Inc. | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
US20060206139A1 (en) * | 2005-01-19 | 2006-09-14 | Tekulve Kurt J | Vascular occlusion device |
DE202005009755U1 (de) * | 2005-06-21 | 2005-09-08 | Cervitech, Inc. | Halter für Zwischenwirbelprothesen |
US20060292227A1 (en) * | 2005-06-23 | 2006-12-28 | Mcpherson Timothy B | Extracellular matrix material particles and methods of preparation |
US7595062B2 (en) | 2005-07-28 | 2009-09-29 | Depuy Products, Inc. | Joint resurfacing orthopaedic implant and associated method |
WO2007056671A1 (en) * | 2005-11-02 | 2007-05-18 | Osteotech, Inc. | Hemostatic bone graft |
US20080063627A1 (en) * | 2006-09-12 | 2008-03-13 | Surmodics, Inc. | Tissue graft materials containing biocompatible agent and methods of making and using same |
CA2667214C (en) * | 2006-10-23 | 2015-12-01 | Cook Biotech Incorporated | Processed ecm materials with enhanced component profiles |
US7871440B2 (en) | 2006-12-11 | 2011-01-18 | Depuy Products, Inc. | Unitary surgical device and method |
US8343536B2 (en) | 2007-01-25 | 2013-01-01 | Cook Biotech Incorporated | Biofilm-inhibiting medical products |
US20080279833A1 (en) * | 2007-05-10 | 2008-11-13 | Matheny Robert G | Laminate sheet articles for tissue regeneration |
US20090082816A1 (en) | 2007-09-20 | 2009-03-26 | Graham Matthew R | Remodelable orthopaedic spacer and method of using the same |
US8679176B2 (en) | 2007-12-18 | 2014-03-25 | Cormatrix Cardiovascular, Inc | Prosthetic tissue valve |
US8257434B2 (en) * | 2007-12-18 | 2012-09-04 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valve |
EP2254608B1 (en) * | 2008-02-07 | 2016-05-04 | Shahar Cohen | Compartmental extract compositions for tissue engineering |
EP3184552B1 (en) | 2008-09-02 | 2020-08-12 | Tautona Group LP | Threads of hyaluronic acid, methods of making thereof and uses thereof |
CA2742047A1 (en) * | 2008-10-24 | 2010-04-29 | Warsaw Orthopedic, Inc. | Compositions and methods for promoting bone formation |
US8469779B1 (en) | 2009-01-02 | 2013-06-25 | Lifecell Corporation | Method for debristling animal skin |
ES2553762T3 (es) * | 2009-02-18 | 2015-12-11 | Cormatrix Cardiovascular, Inc. | Composiciones y métodos para prevenir la arritmia cardiaca |
BRPI1015119B8 (pt) | 2009-05-06 | 2021-06-22 | Hansa Medical Products Inc | dispositivo auto-ajustável para vedar uma fístula |
US8298586B2 (en) | 2009-07-22 | 2012-10-30 | Acell Inc | Variable density tissue graft composition |
US8652500B2 (en) * | 2009-07-22 | 2014-02-18 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
US9375513B2 (en) | 2011-04-14 | 2016-06-28 | Lifecell Corporation | Regenerative materials |
WO2012166538A1 (en) | 2011-05-27 | 2012-12-06 | Cormatrix Cardiovascular, Inc. | Sterilized, acellular extracellular matrix compositions and methods of making thereof |
US9089523B2 (en) | 2011-07-28 | 2015-07-28 | Lifecell Corporation | Natural tissue scaffolds as tissue fillers |
AU2012355463C1 (en) | 2011-12-20 | 2016-09-22 | Lifecell Corporation | Sheet tissue products |
DK3501558T3 (da) | 2011-12-20 | 2021-03-01 | Lifecell Corp | Flydbare vævsprodukter |
EP3797801A1 (en) | 2012-01-24 | 2021-03-31 | LifeCell Corporation | Elongated tissue matrices |
CA2871665A1 (en) | 2012-04-24 | 2013-10-31 | Lifecell Corporation | Flowable tissue matrices |
WO2014011402A1 (en) | 2012-07-13 | 2014-01-16 | Lifecell Corporation | Methods for improved treatment of adipose tissue |
EP2900288B1 (en) | 2012-09-26 | 2018-01-31 | Lifecell Corporation | Processed adipose tissue |
EP3659633A1 (en) | 2013-02-06 | 2020-06-03 | LifeCell Corporation | Methods for localized modification of tissue products |
US9878071B2 (en) | 2013-10-16 | 2018-01-30 | Purdue Research Foundation | Collagen compositions and methods of use |
AU2015231110B2 (en) | 2014-03-21 | 2019-03-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix |
EP3193953B1 (en) * | 2014-09-19 | 2020-03-11 | Osiris Therapeutics, Inc. | Bone repair product and methods of use thereof |
RU2564800C1 (ru) * | 2014-11-06 | 2015-10-10 | Федеральное государственное бюджетное учреждение "Приволжский федеральный медицинский исследовательский центр" Министерства здравоохранения Российской Федерации | Способ оперативного лечения ложных суставов проксимального отдела локтевой кости |
US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
US11919941B2 (en) | 2015-04-21 | 2024-03-05 | Purdue Research Foundation | Cell-collagen-silica composites and methods of making and using the same |
AU2017274190A1 (en) | 2016-06-03 | 2018-12-13 | Lifecell Corporation | Methods for localized modification of tissue products |
EP3558405A1 (en) | 2016-12-22 | 2019-10-30 | LifeCell Corporation | Devices and methods for tissue cryomilling |
JP7282380B2 (ja) | 2017-03-02 | 2023-05-29 | ユニバーシティ オブ ピッツバーグ - オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | がんを処置するための細胞外マトリクス(ecm)ヒドロゲルおよびその可溶性画分 |
US11213545B2 (en) | 2017-03-02 | 2022-01-04 | University of Pittsburgh—of the Commonwealth System of Higher Education | ECM hydrogel for treating esophageal inflammation |
EP3615568A4 (en) | 2017-04-25 | 2021-01-20 | Purdue Research Foundation | TISSUE RESTORATION THREE-DIMENSIONAL (3D) ARTIFICIAL MUSCLE |
CA3075099A1 (en) | 2017-10-18 | 2019-04-25 | Lifecell Corporation | Adipose tissue products and methods of production |
US11123375B2 (en) | 2017-10-18 | 2021-09-21 | Lifecell Corporation | Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products |
ES2960617T3 (es) | 2017-10-19 | 2024-03-05 | Lifecell Corp | Productos de matriz de tejido acelular fluida y métodos de producción |
US11246994B2 (en) | 2017-10-19 | 2022-02-15 | Lifecell Corporation | Methods for introduction of flowable acellular tissue matrix products into a hand |
AU2020283895A1 (en) | 2019-05-30 | 2022-01-06 | Lifecell Corporation | Biologic breast implant |
US11826490B1 (en) | 2020-12-29 | 2023-11-28 | Acell, Inc. | Extracellular matrix sheet devices with improved mechanical properties and method of making |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5553214A (en) * | 1978-10-09 | 1980-04-18 | Merck Patent Gmbh | Molded mixture based on reabsorbent collagen in body*its manufacture and its medical use |
JPH0268067A (ja) * | 1988-09-02 | 1990-03-07 | Junko Shibuya | 動物の骨の圧縮成型物及びその成型方法 |
JPH04279520A (ja) * | 1990-05-31 | 1992-10-05 | Eisai Co Ltd | 骨内部埋め込み用製剤 |
WO1994011008A1 (en) * | 1992-11-13 | 1994-05-26 | Purdue Research Foundation | Fluidized intestinal submucosa and its use as an injectable tissue graft |
WO1994021556A1 (en) * | 1993-03-24 | 1994-09-29 | Children's Medical Center Corporation | Isolation of the calcium-phosphate crystals of bone |
US5352463A (en) * | 1992-11-13 | 1994-10-04 | Badylak Steven F | Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2987062A (en) * | 1956-07-23 | 1961-06-06 | Arthur E Ellison | Bone splint with absorbable section |
DE2917446A1 (de) * | 1979-04-28 | 1980-11-06 | Merck Patent Gmbh | Chirurgisches material |
US4263185A (en) * | 1979-10-01 | 1981-04-21 | Belykh Sergei I | Biodestructive material for bone fixation elements |
US4902508A (en) * | 1988-07-11 | 1990-02-20 | Purdue Research Foundation | Tissue graft composition |
US4956178A (en) * | 1988-07-11 | 1990-09-11 | Purdue Research Foundation | Tissue graft composition |
US5129906A (en) * | 1989-09-08 | 1992-07-14 | Linvatec Corporation | Bioabsorbable tack for joining bodily tissue and in vivo method and apparatus for deploying same |
US5037950A (en) * | 1990-02-09 | 1991-08-06 | Ethicon, Inc. | Bioabsorbable copolymers of polyalkylene carbonate/RHO-dioxanone for sutures and coatings |
US5281422A (en) * | 1991-09-24 | 1994-01-25 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
EP0726844A1 (en) * | 1992-10-30 | 1996-08-21 | Ole Oestergaard | Method for manufacturing a film used for the production of bags and corresponding bag |
-
1995
- 1995-02-10 US US08/386,432 patent/US5641518A/en not_active Expired - Lifetime
-
1996
- 1996-02-09 EP EP96903815A patent/EP0808167B1/en not_active Expired - Lifetime
- 1996-02-09 DE DE69621595T patent/DE69621595T2/de not_active Expired - Lifetime
- 1996-02-09 AU AU47780/96A patent/AU692063B2/en not_active Expired
- 1996-02-09 WO PCT/US1996/001833 patent/WO1996024365A1/en active IP Right Grant
- 1996-02-09 JP JP52447296A patent/JP4020962B2/ja not_active Expired - Lifetime
- 1996-02-09 AR ARP960101334A patent/AR000920A1/es unknown
- 1996-02-09 CA CA002212647A patent/CA2212647A1/en not_active Abandoned
-
2004
- 2004-12-08 JP JP2004355406A patent/JP2005161062A/ja active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5553214A (en) * | 1978-10-09 | 1980-04-18 | Merck Patent Gmbh | Molded mixture based on reabsorbent collagen in body*its manufacture and its medical use |
JPH0268067A (ja) * | 1988-09-02 | 1990-03-07 | Junko Shibuya | 動物の骨の圧縮成型物及びその成型方法 |
JPH04279520A (ja) * | 1990-05-31 | 1992-10-05 | Eisai Co Ltd | 骨内部埋め込み用製剤 |
WO1994011008A1 (en) * | 1992-11-13 | 1994-05-26 | Purdue Research Foundation | Fluidized intestinal submucosa and its use as an injectable tissue graft |
US5352463A (en) * | 1992-11-13 | 1994-10-04 | Badylak Steven F | Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor |
WO1994021556A1 (en) * | 1993-03-24 | 1994-09-29 | Children's Medical Center Corporation | Isolation of the calcium-phosphate crystals of bone |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101229435B1 (ko) | 2010-08-16 | 2013-02-05 | 한스바이오메드 주식회사 | 바이러스 불활화된 골이식용 골분의 제조방법 |
Also Published As
Publication number | Publication date |
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JP4020962B2 (ja) | 2007-12-12 |
EP0808167B1 (en) | 2002-06-05 |
EP0808167A4 (en) | 1998-06-10 |
US5641518A (en) | 1997-06-24 |
CA2212647A1 (en) | 1996-08-15 |
JPH10513388A (ja) | 1998-12-22 |
DE69621595D1 (de) | 2002-07-11 |
AU4778096A (en) | 1996-08-27 |
EP0808167A1 (en) | 1997-11-26 |
DE69621595T2 (de) | 2003-01-16 |
AR000920A1 (es) | 1997-08-27 |
WO1996024365A1 (en) | 1996-08-15 |
AU692063B2 (en) | 1998-05-28 |
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