JP2005120063A - 咽頭における炎症の治療のためのアンブロキソール - Google Patents
咽頭における炎症の治療のためのアンブロキソール Download PDFInfo
- Publication number
- JP2005120063A JP2005120063A JP2003387250A JP2003387250A JP2005120063A JP 2005120063 A JP2005120063 A JP 2005120063A JP 2003387250 A JP2003387250 A JP 2003387250A JP 2003387250 A JP2003387250 A JP 2003387250A JP 2005120063 A JP2005120063 A JP 2005120063A
- Authority
- JP
- Japan
- Prior art keywords
- ambroxol
- pharmaceutical composition
- preparation
- inflammation
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- JBDGDEWWOUBZPM-XYPYZODXSA-N ambroxol Chemical compound NC1=C(Br)C=C(Br)C=C1CN[C@@H]1CC[C@@H](O)CC1 JBDGDEWWOUBZPM-XYPYZODXSA-N 0.000 title claims abstract description 32
- 229960005174 ambroxol Drugs 0.000 title claims abstract description 30
- 210000003800 pharynx Anatomy 0.000 title claims description 15
- 206010061218 Inflammation Diseases 0.000 title claims description 7
- 230000004054 inflammatory process Effects 0.000 title claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 20
- 239000011159 matrix material Substances 0.000 claims abstract description 5
- 150000003839 salts Chemical class 0.000 claims abstract description 5
- 206010065716 Pharyngeal inflammation Diseases 0.000 claims abstract description 4
- 239000007921 spray Substances 0.000 claims abstract description 4
- 150000005846 sugar alcohols Chemical class 0.000 claims abstract description 4
- 239000012669 liquid formulation Substances 0.000 claims abstract description 3
- QNVKOSLOVOTXKF-UHFFFAOYSA-N 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydron;chloride Chemical compound Cl.NC1=C(Br)C=C(Br)C=C1CNC1CCC(O)CC1 QNVKOSLOVOTXKF-UHFFFAOYSA-N 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 11
- 229960000985 ambroxol hydrochloride Drugs 0.000 claims description 9
- 201000007100 Pharyngitis Diseases 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 230000000699 topical effect Effects 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000013355 food flavoring agent Nutrition 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
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- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 239000003765 sweetening agent Substances 0.000 claims description 4
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- 235000003599 food sweetener Nutrition 0.000 claims description 3
- 206010068319 Oropharyngeal pain Diseases 0.000 claims description 2
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- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims 1
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- 238000000338 in vitro Methods 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- 230000002757 inflammatory effect Effects 0.000 description 4
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- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
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- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
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- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
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- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
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- NNQSGBRGJHSRFN-UHFFFAOYSA-N isoflavan Chemical class C1OC2=CC=CC=C2CC1C1=CC=CC=C1 NNQSGBRGJHSRFN-UHFFFAOYSA-N 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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Images
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003387250A JP2005120063A (ja) | 2003-10-14 | 2003-10-14 | 咽頭における炎症の治療のためのアンブロキソール |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003387250A JP2005120063A (ja) | 2003-10-14 | 2003-10-14 | 咽頭における炎症の治療のためのアンブロキソール |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005120063A true JP2005120063A (ja) | 2005-05-12 |
| JP2005120063A5 JP2005120063A5 (enExample) | 2006-11-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003387250A Pending JP2005120063A (ja) | 2003-10-14 | 2003-10-14 | 咽頭における炎症の治療のためのアンブロキソール |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2005120063A (enExample) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001151677A (ja) * | 1999-11-26 | 2001-06-05 | Taisho Pharmaceut Co Ltd | 咽頭用組成物 |
| WO2003072094A1 (de) * | 2002-02-27 | 2003-09-04 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Ambroxol für die behandlung von schmerzhaften zuständen im mund und rachenraum |
-
2003
- 2003-10-14 JP JP2003387250A patent/JP2005120063A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001151677A (ja) * | 1999-11-26 | 2001-06-05 | Taisho Pharmaceut Co Ltd | 咽頭用組成物 |
| WO2003072094A1 (de) * | 2002-02-27 | 2003-09-04 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Ambroxol für die behandlung von schmerzhaften zuständen im mund und rachenraum |
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