JP2004537974A5 - - Google Patents
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- Publication number
- JP2004537974A5 JP2004537974A5 JP2002571810A JP2002571810A JP2004537974A5 JP 2004537974 A5 JP2004537974 A5 JP 2004537974A5 JP 2002571810 A JP2002571810 A JP 2002571810A JP 2002571810 A JP2002571810 A JP 2002571810A JP 2004537974 A5 JP2004537974 A5 JP 2004537974A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- gag
- hiv env
- pol
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims 17
- 108700004029 pol Genes Proteins 0.000 claims 16
- 108700004026 gag Genes Proteins 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 101150088264 pol gene Proteins 0.000 claims 12
- 101150098622 gag gene Proteins 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 claims 8
- 241000288906 Primates Species 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 6
- 230000028993 immune response Effects 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000013612 plasmid Substances 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 5
- 102100034353 Integrase Human genes 0.000 claims 4
- 101800001690 Transmembrane protein gp41 Proteins 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 108010078428 env Gene Products Proteins 0.000 claims 2
- 108700004025 env Genes Proteins 0.000 claims 2
- 101150030339 env gene Proteins 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 108010061833 Integrases Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000037452 priming Effects 0.000 claims 1
- 230000005026 transcription initiation Effects 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27443401P | 2001-03-08 | 2001-03-08 | |
| PCT/US2002/006713 WO2002072754A2 (en) | 2001-03-08 | 2002-03-01 | Mva expressing modified hiv envelope, gag, and pol genes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010019755A Division JP2010115208A (ja) | 2001-03-08 | 2010-01-29 | 改変ＨＩＶエンベロープ、ｇａｇ、およびｐｏｌ遺伝子を発現するＭＶＡ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004537974A JP2004537974A (ja) | 2004-12-24 |
| JP2004537974A5 true JP2004537974A5 (cg-RX-API-DMAC7.html) | 2006-01-05 |
| JP4554887B2 JP4554887B2 (ja) | 2010-09-29 |
Family
ID=23048178
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002571810A Expired - Lifetime JP4554887B2 (ja) | 2001-03-08 | 2002-03-01 | 改変ＨＩＶエンベロープ、ｇａｇ、およびｐｏｌ遺伝子を発現するＭＶＡ |
| JP2010019755A Ceased JP2010115208A (ja) | 2001-03-08 | 2010-01-29 | 改変ＨＩＶエンベロープ、ｇａｇ、およびｐｏｌ遺伝子を発現するＭＶＡ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010019755A Ceased JP2010115208A (ja) | 2001-03-08 | 2010-01-29 | 改変ＨＩＶエンベロープ、ｇａｇ、およびｐｏｌ遺伝子を発現するＭＶＡ |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20040146528A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1372710B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP4554887B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN100446812C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE445411T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2002252199B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2454959C (cg-RX-API-DMAC7.html) |
| CY (1) | CY1109659T1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60234018D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1372710T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2334335T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1372710E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002072754A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2388015A1 (en) | 2000-03-02 | 2011-11-23 | Emory University | DNA expression vectors and methods of use |
| US8623379B2 (en) * | 2000-03-02 | 2014-01-07 | Emory University | Compositions and methods for generating an immune response |
| DE60234018D1 (de) | 2001-03-08 | 2009-11-26 | Univ Emory | Mva-exprimierende modifizierte hiv-envelope-, gag-, und pol-gene |
| AU2003220111B2 (en) * | 2002-03-08 | 2008-07-31 | Emory University | Compositions and methods for generating an immune response |
| CN1490056A (zh) * | 2002-10-18 | 2004-04-21 | ��¡���ɵ°��̲��о����� | 针对hiv-1的免疫方法和组合物 |
| EP2363143A3 (en) * | 2003-03-28 | 2012-02-15 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | MVA expressing modified hiv envelope, gag, and pol genes |
| AU2004279362B2 (en) * | 2003-09-15 | 2011-03-17 | Genvec, Inc. | HIV vaccines based on ENV of multiple clades of HIV |
| DE602004027767D1 (de) * | 2003-11-24 | 2010-07-29 | Bavarian Nordic As | Promotoren zur Expression in modifiziertem Vaccinia Virus Ankara |
| CN1304580C (zh) * | 2004-07-09 | 2007-03-14 | 楼伟 | 重组表达人获得性免疫缺陷病毒I型的表面糖蛋白gp160 |
| AU2005274948B2 (en) * | 2004-07-16 | 2011-09-22 | Genvec, Inc. | Vaccines against aids comprising CMV/R-nucleic acid constructs |
| DK1789438T3 (en) | 2004-08-27 | 2015-07-20 | Us Government | Recombinant MVA viruses expressing MODIFIED env, gag and pol genes of HIV CLADE A / G, CLADE CLADE B AND C |
| AU2012202786B8 (en) * | 2004-08-27 | 2015-05-21 | Emory University | Recombinant MVA viruses expressing Clade A/G, Clade B, and Clade C modified HIV ENV, GAG and POL genes |
| ES2281252B1 (es) * | 2005-07-27 | 2009-02-16 | Consejo Superior De Investigaciones Cientificas | Vectores recombinantes basados en el virus modificado de ankara (mva) como vacunas preventivas y terapeuticas contra el sida. |
| FR2893254B1 (fr) * | 2005-11-14 | 2007-12-21 | Biomerieux Sa | Composition comprenant un vecteur synthetique colloidal bioresorbable et un vecteur viral et son utilisation prophylactique, therapeutique et diagnostique. |
| CN101020052A (zh) * | 2006-02-16 | 2007-08-22 | 中国疾病预防控制中心性病艾滋病预防控制中心 | 基于复制型痘苗病毒载体的艾滋病疫苗 |
| CN101394868B (zh) * | 2006-03-07 | 2011-08-10 | 浙江海正药业股份有限公司 | 重组腺病毒5型/35型和痘病毒mva活病毒载体疫苗的联用诱导强大的免疫应答的方法 |
| WO2007136763A2 (en) * | 2006-05-19 | 2007-11-29 | Sanofi Pasteur, Inc. | Immunological composition |
| CA2682045A1 (en) * | 2007-03-26 | 2008-10-02 | International Aids Vaccine Initiative | Method of eliciting immune response with a modified mva viral hiv-1 vector |
| EP2042604A1 (en) * | 2007-09-26 | 2009-04-01 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | VV promoter driven overexpression of recombinant antigens |
| US20090263828A1 (en) * | 2008-04-16 | 2009-10-22 | Franco Lori | Novel assay for precursor T-cells having high proliferative capacity (PHPC-asay) |
| ES2641915T3 (es) * | 2008-09-10 | 2017-11-14 | Institut National De La Sante Et De La Recherche Medicale | Construcción de un gen sintético que codifica el gag del VIH1 y su utilización para la obtención de vacunas contra el VIH-1 |
| AP2012006258A0 (en) * | 2009-10-13 | 2012-06-30 | Geovax Inc | Eliciting immune responses using recombinant MVA viruses expressing HIV ENV, GAG and POL antigens. |
| TWI448338B (zh) | 2010-05-19 | 2014-08-11 | Nippon Steel & Sumitomo Metal Corp | 具有ｌ字狀形狀之零件的壓製成形方法 |
| CN105709221B (zh) | 2011-04-06 | 2020-11-17 | 拜欧瓦克西姆有限公司 | 用于预防和/或治疗人中的hiv疾病的药物组合物 |
| WO2014018850A2 (en) * | 2012-07-27 | 2014-01-30 | The Trustees Of The University Of Pennsylvania | Cytoplasmic tail modifications to boost surface expression and immunogenicity of envelope glycoproteins |
| WO2016068919A1 (en) | 2014-10-29 | 2016-05-06 | Geovax, Inc. | Combination therapy for treating viral reservoirs |
| WO2016115116A1 (en) | 2015-01-12 | 2016-07-21 | Geovax, Inc. | Compositions and methods for generating an immune response to a hemorrhagic fever virus |
| CA3011014A1 (en) | 2016-01-08 | 2017-07-13 | Harriet Robinson | Compositions and methods for generating an immune response to a tumor associated antigen |
| BR112018015696A2 (pt) | 2016-02-03 | 2018-12-26 | Geovax Inc | composições e métodos para gerar uma resposta imune para um flavivírus |
| AU2017221379A1 (en) | 2016-02-16 | 2018-08-16 | Geovax Inc. | Multivalent HIV vaccine boost compositions and methods of use |
| WO2018195447A1 (en) * | 2017-04-20 | 2018-10-25 | Geovax Labs, Inc. | Recombinant mva-based hiv immunogens and uses thereof |
| US20200171141A1 (en) * | 2017-07-18 | 2020-06-04 | Geovax, Inc. | Compositions and Methods for Generating an Immune Response to LASV |
| US11311612B2 (en) | 2017-09-19 | 2022-04-26 | Geovax, Inc. | Compositions and methods for generating an immune response to treat or prevent malaria |
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| IL82104A0 (en) * | 1986-04-08 | 1987-10-30 | Usa | Recombinant vaccinia virus expressing human retrovirus genes and method for producing htlb-iii envelope proteins |
| US5169763A (en) * | 1986-04-08 | 1992-12-08 | Transgene S.A., Institut Pasteur | Viral vector coding glycoprotein of HIV-1 |
| US5256767A (en) * | 1987-06-10 | 1993-10-26 | The Immune Response Corporation | Retroviral antigens |
| CA1341245C (en) * | 1988-01-12 | 2001-06-05 | F. Hoffmann-La Roche Ag | Recombinant vaccinia virus mva |
| CA1340729C (en) | 1988-03-23 | 1999-09-07 | Mohan Bir Singh | Ryegrass pollen allergen |
| IL89567A0 (en) | 1988-03-28 | 1989-09-10 | Univ Leland Stanford Junior | Mutated hiv envelope protein |
| US5614404A (en) * | 1988-06-10 | 1997-03-25 | Theriod Biologics, Incorporated | Self-assembled, defective, non-self-propagating lentivirus particles |
| US5747324A (en) * | 1988-06-10 | 1998-05-05 | Therion Biologics Corporation | Self-assembled, defective, non-self-propagating lentivirus particles |
| WO1989012095A1 (en) * | 1988-06-10 | 1989-12-14 | Applied Biotechnology, Inc. | A method of evaluating recombinant vaccines against immunodeficiency virus |
| US6306625B1 (en) * | 1988-12-30 | 2001-10-23 | Smithkline Beecham Biologicals, Sa | Method for obtaining expression of mixed polypeptide particles in yeast |
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| GB8923123D0 (en) * | 1989-10-13 | 1989-11-29 | Connaught Lab | A vaccine for human immunodeficiency virus |
| JPH05503629A (ja) * | 1989-11-20 | 1993-06-17 | オンコーゲン リミテッド パートナーシップ | 抗ウィルス剤及び免疫原として使用される、非複製組換え製レトロウィルス粒子 |
| IE71643B1 (en) * | 1990-11-20 | 1997-02-26 | Virogenetics Corp | A recombinant poxviral vaccine for canine distemper |
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| JP3602530B2 (ja) * | 1991-03-07 | 2004-12-15 | ヴァイロジェネティクス コーポレイション | 遺伝子操作したワクチン菌株 |
| US5445953A (en) * | 1991-08-26 | 1995-08-29 | Immuno Aktiengesellschaft | Direct molecular cloning of a modified poxvirus genome |
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| DE69133333T2 (de) * | 1991-08-26 | 2004-07-29 | Baxter Healthcare S.A. | Ein intaktes FPV-tk-Gen enthaltender rekombinanter Virus der Vogelpocken |
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| US5658785A (en) * | 1994-06-06 | 1997-08-19 | Children's Hospital, Inc. | Adeno-associated virus materials and methods |
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| WO1996033219A1 (en) * | 1995-04-19 | 1996-10-24 | Polymun Scientific Immunbiologische Forschung Gmbh | Monoclonal antibodies against hiv-1 and vaccines made thereof |
| US5741492A (en) * | 1996-01-23 | 1998-04-21 | St. Jude Children's Research Hospital | Preparation and use of viral vectors for mixed envelope protein vaccines against human immunodeficiency viruses |
| FR2747046B1 (fr) * | 1996-04-05 | 1998-06-19 | Univ Paris Curie | Nouveaux vaccins issus de plasmovirus |
| US5846946A (en) * | 1996-06-14 | 1998-12-08 | Pasteur Merieux Serums Et Vaccins | Compositions and methods for administering Borrelia DNA |
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| US6201663B1 (en) * | 1996-09-05 | 2001-03-13 | Kabushiki Kaisha Ohara | Magnetic head having a slider made of a glass-ceramic |
| US6204250B1 (en) * | 1996-11-22 | 2001-03-20 | The Mount Sinai Medical Center Of The City Of New York | Immunization of infants |
| US6077662A (en) * | 1996-11-27 | 2000-06-20 | Emory University | Virus-like particles, methods and immunogenic compositions |
| US6099847A (en) * | 1997-05-15 | 2000-08-08 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric Gag pseudovirions |
| GB9711957D0 (en) | 1997-06-09 | 1997-08-06 | Isis Innovation | Methods and reagents for vaccination |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| US6054312A (en) * | 1997-08-29 | 2000-04-25 | Selective Genetics, Inc. | Receptor-mediated gene delivery using bacteriophage vectors |
| US6121021A (en) * | 1997-12-16 | 2000-09-19 | Connaught Laboratories Limited | Constitutive expression of non-infectious HIV-like particles |
| US6156952A (en) * | 1998-04-09 | 2000-12-05 | Constituent Institution Of The University Of Maryland System | HIV transgenic animals and uses therefor |
| AUPP349698A0 (en) * | 1998-05-13 | 1998-06-04 | Altronic Distributors Pty Ltd | Mounting assembly |
| GB2337755B (en) * | 1998-05-29 | 2003-10-29 | Secr Defence | Virus vaccine |
| EP1087789A2 (en) | 1998-06-26 | 2001-04-04 | Aventis Pasteur | Use of poxviruses as enhancer of specific immunity |
| WO2000011140A1 (en) | 1998-08-20 | 2000-03-02 | The Wistar Institute Of Anatomy And Biology | Methods of augmenting mucosal immunity through systemic priming and mucosal boosting |
| JP2003530307A (ja) | 1999-07-06 | 2003-10-14 | メルク・アンド・カンパニー・インコーポレーテッド | ｇａｇ遺伝子保有アデノウイルスＨＩＶワクチン |
| US6256183B1 (en) * | 1999-09-09 | 2001-07-03 | Ferraz Shawmut Inc. | Time delay fuse with mechanical overload device and indicator actuator |
| JP4805511B2 (ja) * | 1999-12-23 | 2011-11-02 | メディカル リサーチ カウンシル | Ｈｉｖに対する免疫応答における改善、または免疫応答に関する改善 |
| AUPQ520800A0 (en) | 2000-01-21 | 2000-02-17 | Alfred Hospital | Prime-boost vaccination strategy |
| EP2388015A1 (en) * | 2000-03-02 | 2011-11-23 | Emory University | DNA expression vectors and methods of use |
| CA2416725A1 (en) | 2000-04-27 | 2001-11-08 | Aventis Pasteur Limited | Immunizing against hiv infection |
| DE60234018D1 (de) | 2001-03-08 | 2009-11-26 | Univ Emory | Mva-exprimierende modifizierte hiv-envelope-, gag-, und pol-gene |
| CA2452119C (en) | 2001-07-05 | 2013-10-15 | Chiron Corporation | Polynucleotides encoding antigenic hiv type b and/or type c polypeptides, polypeptides and uses thereof |
-
2002
- 2002-03-01 DE DE60234018T patent/DE60234018D1/de not_active Expired - Lifetime
- 2002-03-01 EP EP02721259A patent/EP1372710B1/en not_active Expired - Lifetime
- 2002-03-01 ES ES02721259T patent/ES2334335T3/es not_active Expired - Lifetime
- 2002-03-01 JP JP2002571810A patent/JP4554887B2/ja not_active Expired - Lifetime
- 2002-03-01 DK DK02721259.6T patent/DK1372710T3/da active
- 2002-03-01 CA CA2454959A patent/CA2454959C/en not_active Expired - Lifetime
- 2002-03-01 CN CNB028095383A patent/CN100446812C/zh not_active Expired - Fee Related
- 2002-03-01 WO PCT/US2002/006713 patent/WO2002072754A2/en not_active Ceased
- 2002-03-01 AT AT02721259T patent/ATE445411T1/de active
- 2002-03-01 PT PT02721259T patent/PT1372710E/pt unknown
- 2002-03-01 AU AU2002252199A patent/AU2002252199B2/en not_active Ceased
-
2003
- 2003-08-22 US US10/646,628 patent/US20040146528A1/en not_active Abandoned
-
2008
- 2008-01-22 US US12/018,150 patent/US7867982B2/en not_active Expired - Fee Related
-
2009
- 2009-12-23 CY CY20091101339T patent/CY1109659T1/el unknown
-
2010
- 2010-01-29 JP JP2010019755A patent/JP2010115208A/ja not_active Ceased
-
2011
- 2011-01-10 US US12/987,791 patent/US8916172B2/en not_active Expired - Fee Related
-
2014
- 2014-12-10 US US14/566,066 patent/US20150238593A1/en not_active Abandoned
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