JP2004536109A5 - - Google Patents
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- Publication number
- JP2004536109A5 JP2004536109A5 JP2003510071A JP2003510071A JP2004536109A5 JP 2004536109 A5 JP2004536109 A5 JP 2004536109A5 JP 2003510071 A JP2003510071 A JP 2003510071A JP 2003510071 A JP2003510071 A JP 2003510071A JP 2004536109 A5 JP2004536109 A5 JP 2004536109A5
- Authority
- JP
- Japan
- Prior art keywords
- moiety
- pharmaceutical formulation
- pharmaceutical
- skeleton
- organic cyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 125000004122 cyclic group Chemical group 0.000 claims 14
- 239000000825 pharmaceutical preparation Substances 0.000 claims 11
- 229940024606 amino acid Drugs 0.000 claims 8
- 235000001014 amino acid Nutrition 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 7
- 230000021164 cell adhesion Effects 0.000 claims 7
- 239000003446 ligand Substances 0.000 claims 7
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- -1 acylamines Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000006841 cyclic skeleton Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000009007 Diagnostic Kit Methods 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 claims 2
- ORQXBVXKBGUSBA-UHFFFAOYSA-N cyclohexyl D-alanine Natural products OC(=O)C(N)CC1CCCCC1 ORQXBVXKBGUSBA-UHFFFAOYSA-N 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- UGWULZWUXSCWPX-UHFFFAOYSA-N 2-sulfanylideneimidazolidin-4-one Chemical compound O=C1CNC(=S)N1 UGWULZWUXSCWPX-UHFFFAOYSA-N 0.000 claims 1
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- LRQKBLKVPFOOQJ-RXMQYKEDSA-N D-norleucine Chemical compound CCCC[C@@H](N)C(O)=O LRQKBLKVPFOOQJ-RXMQYKEDSA-N 0.000 claims 1
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 claims 1
- 229930195709 D-tyrosine Natural products 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- 229930064664 L-arginine Natural products 0.000 claims 1
- 235000014852 L-arginine Nutrition 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 235000009697 arginine Nutrition 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 150000001765 catechin Chemical class 0.000 claims 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims 1
- 235000005487 catechin Nutrition 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 150000002357 guanidines Chemical class 0.000 claims 1
- 150000001469 hydantoins Chemical class 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000012907 medicinal substance Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 150000003585 thioureas Chemical class 0.000 claims 1
- 125000001680 trimethoxyphenyl group Chemical group 0.000 claims 1
- 229960004441 tyrosine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30282201P | 2001-07-02 | 2001-07-02 | |
| US30286801P | 2001-07-03 | 2001-07-03 | |
| PCT/US2002/020948 WO2003004062A1 (en) | 2001-07-02 | 2002-07-02 | Pharmaceutical formulations and ligands for use therein; mimetics for uea-1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004536109A JP2004536109A (ja) | 2004-12-02 |
| JP2004536109A5 true JP2004536109A5 (enExample) | 2006-01-05 |
Family
ID=26973111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003510071A Pending JP2004536109A (ja) | 2001-07-02 | 2002-07-02 | Ｕｅａ１ミメティック医薬製剤および医薬製剤用リガンド |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7166296B2 (enExample) |
| EP (1) | EP1404372B1 (enExample) |
| JP (1) | JP2004536109A (enExample) |
| AT (1) | ATE459376T1 (enExample) |
| CA (1) | CA2452257A1 (enExample) |
| DE (1) | DE60235549D1 (enExample) |
| WO (1) | WO2003004062A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| WO2007052641A1 (ja) * | 2005-11-01 | 2007-05-10 | Kumamoto University | 腸管免疫賦活剤 |
| KR101138312B1 (ko) | 2009-04-13 | 2012-04-27 | 주식회사 바이오에프디엔씨 | 펩타이드 유도체 및 그를 포함하는 화장료 조성물 |
| WO2012156376A1 (en) | 2011-05-13 | 2012-11-22 | Merrion Pharmaceuticals Ireland Ltd. | Use of plant lectins to target leukocytes |
-
2002
- 2002-07-02 CA CA002452257A patent/CA2452257A1/en not_active Abandoned
- 2002-07-02 JP JP2003510071A patent/JP2004536109A/ja active Pending
- 2002-07-02 US US10/187,550 patent/US7166296B2/en not_active Expired - Fee Related
- 2002-07-02 DE DE60235549T patent/DE60235549D1/de not_active Expired - Fee Related
- 2002-07-02 AT AT02761028T patent/ATE459376T1/de not_active IP Right Cessation
- 2002-07-02 EP EP02761028A patent/EP1404372B1/en not_active Expired - Lifetime
- 2002-07-02 WO PCT/US2002/020948 patent/WO2003004062A1/en not_active Ceased
-
2006
- 2006-06-20 US US11/425,237 patent/US20060276628A1/en not_active Abandoned
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