JP2010523632A5 - - Google Patents
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- Publication number
- JP2010523632A5 JP2010523632A5 JP2010502559A JP2010502559A JP2010523632A5 JP 2010523632 A5 JP2010523632 A5 JP 2010523632A5 JP 2010502559 A JP2010502559 A JP 2010502559A JP 2010502559 A JP2010502559 A JP 2010502559A JP 2010523632 A5 JP2010523632 A5 JP 2010523632A5
- Authority
- JP
- Japan
- Prior art keywords
- terminus
- compound according
- medicament
- manufacture
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 9
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 5
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000007026 protein scission Effects 0.000 claims 4
- 239000004066 vascular targeting agent Substances 0.000 claims 4
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000004243 Tubulin Human genes 0.000 claims 1
- 108090000704 Tubulin Proteins 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960001338 colchicine Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0707034.5 | 2007-04-12 | ||
| GBGB0707034.5A GB0707034D0 (en) | 2007-04-12 | 2007-04-12 | Compounds |
| PCT/GB2008/001043 WO2008125800A2 (en) | 2007-04-12 | 2008-03-27 | Mmp activated vascular disrupting agents |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014090990A Division JP5911908B2 (ja) | 2007-04-12 | 2014-04-25 | 化合物 |
| JP2014090991A Division JP5931952B2 (ja) | 2007-04-12 | 2014-04-25 | 化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523632A JP2010523632A (ja) | 2010-07-15 |
| JP2010523632A5 true JP2010523632A5 (enExample) | 2011-05-12 |
| JP5537413B2 JP5537413B2 (ja) | 2014-07-02 |
Family
ID=38116587
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010502559A Expired - Fee Related JP5537413B2 (ja) | 2007-04-12 | 2008-03-27 | 化合物 |
| JP2014090990A Expired - Fee Related JP5911908B2 (ja) | 2007-04-12 | 2014-04-25 | 化合物 |
| JP2014090991A Expired - Fee Related JP5931952B2 (ja) | 2007-04-12 | 2014-04-25 | 化合物 |
| JP2016088836A Expired - Fee Related JP6170590B2 (ja) | 2007-04-12 | 2016-04-27 | 化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014090990A Expired - Fee Related JP5911908B2 (ja) | 2007-04-12 | 2014-04-25 | 化合物 |
| JP2014090991A Expired - Fee Related JP5931952B2 (ja) | 2007-04-12 | 2014-04-25 | 化合物 |
| JP2016088836A Expired - Fee Related JP6170590B2 (ja) | 2007-04-12 | 2016-04-27 | 化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US8691751B2 (enExample) |
| EP (4) | EP2481429B1 (enExample) |
| JP (4) | JP5537413B2 (enExample) |
| CY (1) | CY1120368T1 (enExample) |
| DK (3) | DK2481428T3 (enExample) |
| ES (3) | ES2683168T3 (enExample) |
| GB (1) | GB0707034D0 (enExample) |
| HK (1) | HK1258466A1 (enExample) |
| HR (1) | HRP20181043T1 (enExample) |
| HU (3) | HUE029080T2 (enExample) |
| LT (1) | LT2481429T (enExample) |
| PL (3) | PL2481429T3 (enExample) |
| PT (1) | PT2481429T (enExample) |
| SI (1) | SI2481429T1 (enExample) |
| TR (1) | TR201807811T4 (enExample) |
| WO (1) | WO2008125800A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0707034D0 (en) | 2007-04-12 | 2007-05-23 | St Andrews The | Compounds |
| GB0819287D0 (en) * | 2008-10-22 | 2008-11-26 | Univ Bradford | Compounds |
| GB2516882A (en) * | 2013-08-02 | 2015-02-11 | Univ Bradford | Tumour-targeted theranostic |
| US9169337B2 (en) | 2014-03-12 | 2015-10-27 | Chevron Phillips Chemical Company Lp | Polymers with improved ESCR for blow molding applications |
| ES2870449T3 (es) * | 2014-10-29 | 2021-10-27 | Bicyclerd Ltd | Ligandos peptídicos bicíclicos específicos de MT1-MMP |
| GB2545169B (en) * | 2015-12-01 | 2019-10-09 | Ellipses Pharma Ltd | Taxane Prodrug Comprising A Membrane Type Matrix Metalloproteinase Cleavage Site |
| CA3069042A1 (en) | 2017-07-07 | 2019-01-10 | Katholieke Universiteit Leuven | Treatment of avascular or hypovascular micro-tumors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6844318B2 (en) * | 2000-03-15 | 2005-01-18 | Bristol Myers Squibb Pharma Company | Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use |
| GB0018240D0 (en) * | 2000-07-25 | 2000-09-13 | Pharmacia & Upjohn Spa | Polymeric conjugates of antitumor agents |
| GB0105929D0 (en) * | 2001-03-09 | 2001-04-25 | Btg Int Ltd | Physiologically activated prodrugs |
| CA2802205C (en) | 2002-07-31 | 2016-01-19 | Seattle Genetics, Inc. | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
| US20050106100A1 (en) * | 2003-09-03 | 2005-05-19 | Harris Thomas D. | Compounds containing matrix metalloproteinase substrates and methods of their use |
| US8420603B2 (en) | 2004-05-14 | 2013-04-16 | Abraxis Bioscience, Llc | SPARC and methods of use thereof |
| CA2591914C (en) | 2005-01-24 | 2017-04-25 | Board Of Regents, The University Of Texas System | Fc-fusion constructs binding to phosphatidylserine and their therapeutic use |
| WO2006090813A1 (ja) * | 2005-02-25 | 2006-08-31 | National University Corporation Hokkaido University | 腫瘍組織で選択的に分解性を示す血中滞留性素子 |
| US7714016B2 (en) * | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
| GB0707034D0 (en) * | 2007-04-12 | 2007-05-23 | St Andrews The | Compounds |
| GB0819287D0 (en) | 2008-10-22 | 2008-11-26 | Univ Bradford | Compounds |
| GB2516882A (en) | 2013-08-02 | 2015-02-11 | Univ Bradford | Tumour-targeted theranostic |
-
2007
- 2007-04-12 GB GBGB0707034.5A patent/GB0707034D0/en not_active Ceased
-
2008
- 2008-03-27 TR TR2018/07811T patent/TR201807811T4/tr unknown
- 2008-03-27 DK DK12160556.2T patent/DK2481428T3/en active
- 2008-03-27 PL PL12160565T patent/PL2481429T3/pl unknown
- 2008-03-27 EP EP12160565.3A patent/EP2481429B1/en not_active Not-in-force
- 2008-03-27 PL PL08718877.7T patent/PL2134372T3/pl unknown
- 2008-03-27 PT PT121605653T patent/PT2481429T/pt unknown
- 2008-03-27 LT LTEP12160565.3T patent/LT2481429T/lt unknown
- 2008-03-27 EP EP08718877.7A patent/EP2134372B1/en not_active Not-in-force
- 2008-03-27 JP JP2010502559A patent/JP5537413B2/ja not_active Expired - Fee Related
- 2008-03-27 DK DK12160565.3T patent/DK2481429T3/en active
- 2008-03-27 ES ES12160565.3T patent/ES2683168T3/es active Active
- 2008-03-27 DK DK08718877.7T patent/DK2134372T3/en active
- 2008-03-27 WO PCT/GB2008/001043 patent/WO2008125800A2/en not_active Ceased
- 2008-03-27 ES ES08718877.7T patent/ES2573228T3/es active Active
- 2008-03-27 EP EP12160556.2A patent/EP2481428B1/en not_active Not-in-force
- 2008-03-27 PL PL12160556.2T patent/PL2481428T3/pl unknown
- 2008-03-27 HU HUE12160556A patent/HUE029080T2/en unknown
- 2008-03-27 US US12/595,482 patent/US8691751B2/en active Active
- 2008-03-27 HU HUE12160565A patent/HUE038633T2/hu unknown
- 2008-03-27 EP EP18156526.8A patent/EP3348282A1/en not_active Withdrawn
- 2008-03-27 ES ES12160556.2T patent/ES2573682T3/es active Active
- 2008-03-27 HU HUE08718877A patent/HUE027528T2/en unknown
- 2008-03-27 SI SI200831959T patent/SI2481429T1/en unknown
-
2013
- 2013-12-17 US US14/109,333 patent/US9358303B2/en not_active Expired - Fee Related
-
2014
- 2014-04-25 JP JP2014090990A patent/JP5911908B2/ja not_active Expired - Fee Related
- 2014-04-25 JP JP2014090991A patent/JP5931952B2/ja not_active Expired - Fee Related
-
2016
- 2016-04-27 JP JP2016088836A patent/JP6170590B2/ja not_active Expired - Fee Related
- 2016-05-06 US US15/148,368 patent/US9956296B2/en active Active
-
2018
- 2018-03-16 US US15/923,564 patent/US10556014B2/en not_active Expired - Fee Related
- 2018-06-27 CY CY20181100663T patent/CY1120368T1/el unknown
- 2018-07-05 HR HRP20181043TT patent/HRP20181043T1/hr unknown
-
2019
- 2019-01-16 HK HK19100772.3A patent/HK1258466A1/en unknown
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