JP2004532892A5 - - Google Patents
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- Publication number
- JP2004532892A5 JP2004532892A5 JP2003503264A JP2003503264A JP2004532892A5 JP 2004532892 A5 JP2004532892 A5 JP 2004532892A5 JP 2003503264 A JP2003503264 A JP 2003503264A JP 2003503264 A JP2003503264 A JP 2003503264A JP 2004532892 A5 JP2004532892 A5 JP 2004532892A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- apc
- protein
- delivery system
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003795 chemical substances by application Substances 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 12
- 101800004937 Protein C Proteins 0.000 claims 10
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 claims 10
- 101800001700 Saposin-D Proteins 0.000 claims 10
- 229960000856 protein c Drugs 0.000 claims 10
- 206010052428 Wound Diseases 0.000 claims 8
- 208000027418 Wounds and injury Diseases 0.000 claims 8
- 239000012190 activator Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 5
- 101000924577 Homo sapiens Adenomatous polyposis coli protein Proteins 0.000 claims 4
- 101500025568 Homo sapiens Saposin-D Proteins 0.000 claims 4
- 108060005987 Kallikrein Proteins 0.000 claims 4
- 102000001399 Kallikrein Human genes 0.000 claims 4
- 206010040943 Skin Ulcer Diseases 0.000 claims 4
- 108090000190 Thrombin Proteins 0.000 claims 4
- 102000012607 Thrombomodulin Human genes 0.000 claims 4
- 108010079274 Thrombomodulin Proteins 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 102000055691 human APC Human genes 0.000 claims 4
- 229940100689 human protein c Drugs 0.000 claims 4
- 231100000019 skin ulcer Toxicity 0.000 claims 4
- 229960004072 thrombin Drugs 0.000 claims 4
- 230000029663 wound healing Effects 0.000 claims 4
- 230000001737 promoting effect Effects 0.000 claims 3
- 206010007710 Cartilage injury Diseases 0.000 claims 2
- 101710111620 Protein C activator Proteins 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 206010040893 Skin necrosis Diseases 0.000 claims 2
- 206010072170 Skin wound Diseases 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 claims 2
- 229960005080 warfarin Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR5637A AUPR563701A0 (en) | 2001-06-13 | 2001-06-13 | Treatment and composition for wound healing |
| AUPR5637 | 2001-06-13 | ||
| AUPS1433 | 2002-04-02 | ||
| AUPS1433A AUPS143302A0 (en) | 2002-04-02 | 2002-04-02 | Treatment and composition for wound healing |
| PCT/AU2002/000751 WO2002100445A1 (en) | 2001-06-13 | 2002-06-11 | Treatment and composition for wound healing |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2004532892A JP2004532892A (ja) | 2004-10-28 |
| JP2004532892A5 true JP2004532892A5 (https=) | 2006-01-05 |
| JP4351041B2 JP4351041B2 (ja) | 2009-10-28 |
| JP2004532892A6 JP2004532892A6 (ja) | 2009-12-24 |
Family
ID=25646727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003503264A Expired - Lifetime JP4351041B2 (ja) | 2001-06-13 | 2002-06-11 | 傷治癒のための処置および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20040176288A1 (https=) |
| EP (1) | EP1404412B1 (https=) |
| JP (1) | JP4351041B2 (https=) |
| AT (1) | ATE550073T1 (https=) |
| AU (1) | AU2002302192B2 (https=) |
| CA (1) | CA2450240A1 (https=) |
| ES (1) | ES2384099T3 (https=) |
| WO (1) | WO2002100445A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60335997D1 (de) | 2002-09-16 | 2011-03-24 | Agennix Inc | Lactoferrin-zusammensetzungen und verfahren zur behandlung von diabetischen ulcus |
| WO2006047744A2 (en) | 2004-10-26 | 2006-05-04 | Agennix Incorporated | Compositions of lactoferrin related peptides and uses thereof |
| EP1841442A4 (en) * | 2005-01-07 | 2009-12-09 | Northern Sydney And Central Co | TREATMENT OF AUTOIMMUNE DISEASES AND INFLAMMATORY DISEASES |
| DK1853631T3 (en) * | 2005-01-24 | 2016-03-29 | Univ Texas | Fc-FUSION CONSTRUCTIONS BINDING TO PHOSPHATIDYLSERINE AND THERAPEUTIC APPLICATION THEREOF |
| JP4832515B2 (ja) * | 2005-06-09 | 2011-12-07 | ブルー ブラッド バイオテック コーポレーション | 創傷治癒用の組成物及びその使用 |
| CA2634045C (en) * | 2005-12-20 | 2019-05-07 | Swiss-American Products, Inc. | Protease compositions for the treatment of damaged tissue |
| GR1005700B (el) * | 2006-09-01 | 2007-10-22 | (40%) ����� �������� | Τροπος αντιμετωπισης της 1ης φασης του εγκαυματοσσε μη σηπτικους ασθενεις με συνεχη ενδοφλεβια χορηγηση ενεργοποιημενης πρωτεινης-c για 48 ωρες με στοχο τη μειωση της τελικης εγκαυματικης βλαβης καιαυξηση της ταχυτητας επουλωσης κατα τα πρωτα επτα μετεγκαυματικα 24ωρα |
| AR067345A1 (es) * | 2007-07-10 | 2009-10-07 | Paion Deutschland Gmbh | Uso de trombomodulina para la preparacion de un medicamento trombolitico |
| EP2014296A1 (en) * | 2007-07-10 | 2009-01-14 | PAION Deutschland GmbH | Novel strategies for increasing the reperfusion in obstructed blood vessel |
| GB2457965B8 (en) * | 2008-07-01 | 2011-02-16 | Renovo Ltd | Methods and systems for determining efficacy of medicaments. |
| EP2852401A4 (en) * | 2012-04-02 | 2015-11-11 | Univ Saint Louis | METHOD AND COMPOSITIONS FOR REDUCING THE POSTSURFACE OF POST-SURGICAL TERMINATION |
| AU2013286812B2 (en) * | 2012-07-04 | 2017-04-20 | Zz Biotech Llc | Treatment of inflammatory skin disorders |
| PT3137102T (pt) * | 2014-04-16 | 2021-09-28 | Zz Biotech Llc | Apc para utilização no tratamento de cicatrização cutânea anormal |
| PL3131572T3 (pl) * | 2014-04-16 | 2022-02-07 | Zz Biotech Llc | Analog apc do zastosowania w zaleczaniu rany |
| TR202021285A1 (tr) * | 2020-12-22 | 2022-07-21 | Univ Yeditepe | Yara skarinin önlenmesi̇ ve tedavi̇si̇nde kullanilmak üzere erbium borat i̇çeren formülasyon |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5571786A (en) * | 1990-08-16 | 1996-11-05 | Immuno Aktiengesellschaft | Use of protein C or the activation peptide of protein C for preparing a pharmaceutical preparation |
| US6197325B1 (en) * | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US5648380A (en) * | 1991-03-01 | 1997-07-15 | Warner-Lambert Company | Anti-inflammatory wound healing compositions and methods for preparing and using same |
| AT397615B (de) | 1991-05-14 | 1994-05-25 | Immuno Ag | Arzneimittel enthaltend protein c |
| US5279956A (en) * | 1991-06-24 | 1994-01-18 | The Scripps Research Institute | Activated protein C polypeptides and anti-peptide antibodies, diagnostic methods and systems for inhibiting activated protein C |
| EP0651655A4 (en) * | 1992-07-24 | 1996-05-29 | Oklahoma Med Res Found | REDUCTION OF MICROVASCULAR BLEEDING DURING SURGERY BY BLOCKING PROTEIN C ACTIVATION |
| US5583102A (en) * | 1993-12-03 | 1996-12-10 | University Of Iowa Research Foundation | Human thrombomodulin in wound healing |
| WO1995030429A1 (en) * | 1994-05-04 | 1995-11-16 | Board Of Trustees Of The University Of Arkansas | Novel ophthalmologic uses of protein c |
| JP3802104B2 (ja) | 1995-05-31 | 2006-07-26 | 財団法人化学及血清療法研究所 | 脊髄損傷に伴う神経障害の予防・治療剤 |
| SE9600216D0 (sv) * | 1996-01-18 | 1996-01-18 | Hans Arne Hansson | Styrning av läkningsprocesser |
| HUP0001237A3 (en) * | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
| JP3578627B2 (ja) * | 1998-05-15 | 2004-10-20 | 株式会社ホギメディカル | 創傷患部の治癒を促進する組織シーラント |
| JP2002542148A (ja) | 1998-12-21 | 2002-12-10 | イーライ・リリー・アンド・カンパニー | 敗血症の処置のための組み合わせ療法 |
| WO2001056532A2 (en) | 2000-02-04 | 2001-08-09 | The Scripps Research Institute | Neuroprotective, antithrombotic and anti-inflammatory uses of activated protein c (apc) |
| ES2242740T3 (es) * | 2000-03-28 | 2005-11-16 | Eli Lilly And Company | Proteina c activada para el tratamiento de pancreatitis. |
| US7204981B2 (en) * | 2000-03-28 | 2007-04-17 | Eli Lilly And Company | Methods of treating diseases with activated protein C |
-
2002
- 2002-06-11 JP JP2003503264A patent/JP4351041B2/ja not_active Expired - Lifetime
- 2002-06-11 ES ES02729651T patent/ES2384099T3/es not_active Expired - Lifetime
- 2002-06-11 EP EP02729651A patent/EP1404412B1/en not_active Expired - Lifetime
- 2002-06-11 AT AT02729651T patent/ATE550073T1/de active
- 2002-06-11 WO PCT/AU2002/000751 patent/WO2002100445A1/en not_active Ceased
- 2002-06-11 AU AU2002302192A patent/AU2002302192B2/en not_active Expired
- 2002-06-11 CA CA002450240A patent/CA2450240A1/en not_active Abandoned
- 2002-06-13 US US10/480,586 patent/US20040176288A1/en not_active Abandoned
-
2009
- 2009-07-17 US US12/504,898 patent/US8728512B2/en not_active Expired - Fee Related
-
2014
- 2014-04-09 US US14/248,790 patent/US20140219991A1/en not_active Abandoned
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