TR202021285A1 - Yara skarinin önlenmesi̇ ve tedavi̇si̇nde kullanilmak üzere erbium borat i̇çeren formülasyon - Google Patents
Yara skarinin önlenmesi̇ ve tedavi̇si̇nde kullanilmak üzere erbium borat i̇çeren formülasyonInfo
- Publication number
- TR202021285A1 TR202021285A1 TR2020/21285A TR202021285A TR202021285A1 TR 202021285 A1 TR202021285 A1 TR 202021285A1 TR 2020/21285 A TR2020/21285 A TR 2020/21285A TR 202021285 A TR202021285 A TR 202021285A TR 202021285 A1 TR202021285 A1 TR 202021285A1
- Authority
- TR
- Turkey
- Prior art keywords
- borate
- prevention
- treatment
- erbium
- formulation
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 14
- 238000009472 formulation Methods 0.000 title claims abstract description 11
- 230000002265 prevention Effects 0.000 title claims abstract description 7
- RNUUCZBUZFGLDV-UHFFFAOYSA-N B([O-])([O-])[O-].[Er+3] Chemical compound B([O-])([O-])[O-].[Er+3] RNUUCZBUZFGLDV-UHFFFAOYSA-N 0.000 title abstract description 9
- 231100000241 scar Toxicity 0.000 title description 7
- 206010052428 Wound Diseases 0.000 claims abstract description 12
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 12
- 239000003349 gelling agent Substances 0.000 claims abstract description 6
- 230000037390 scarring Effects 0.000 claims abstract description 6
- 239000004094 surface-active agent Substances 0.000 claims abstract description 6
- 239000002105 nanoparticle Substances 0.000 claims abstract description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 229920001992 poloxamer 407 Polymers 0.000 claims description 2
- HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 claims 1
- 229920001993 poloxamer 188 Polymers 0.000 claims 1
- 230000036573 scar formation Effects 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 150000000917 Erbium Chemical class 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 102000005741 Metalloproteases Human genes 0.000 description 1
- 108010006035 Metalloproteases Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- -1 erbium salts Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- ATINCSYRHURBSP-UHFFFAOYSA-K neodymium(iii) chloride Chemical compound Cl[Nd](Cl)Cl ATINCSYRHURBSP-UHFFFAOYSA-K 0.000 description 1
- VPOLVWCUBVJURT-UHFFFAOYSA-N pentadecasodium;pentaborate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-] VPOLVWCUBVJURT-UHFFFAOYSA-N 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Bu buluş, yara skarının önlenmesi ve tedavisinde kullanılmak üzere, Erbium borat nanopartikülleri, en az bir yüzey aktif madde ve taşıyıcı jel özellikli en az bir jelleştirici madde içeren jel formunda bir formülasyon ile ilgilidir.
Description
TARIFNAME YARA SKARININ ÖNLENMESI VE TEDAVISINDE KULLANILMAK ÜZERE ERBIUM BORAT IÇEREN FORMÜLASYON Teknik Alan Bu bulus, yara skarinin önlenmesi ve tedavisinde kullanilmak üzere, erbiuin borat içeren, jel formunda farmasötik bir formülasyon ile ilgilidir. Önceki Teknik Cerrahi müdahale, travma, yanik ve Cilt enfeksiyonu gibi durumlar ile olusan yaralar, siklikla geride bir yara izi kalmasina sebep olmaktadir. Söz konusu yara izi teknik alanda skar olarak isimlendirilmekte olup, yara iyilesme sürecinin dogal bir sonucudur. Ancak, skar olusumu, yeni travmalara karsi dayaniksiz olmasinin yani sira agri ve kanama gibi istenmeyen durumlari da beraberinde getirmektedir. Skar olusumu ile ilgili en önemli görülen sorun ise kozmetik olarak kötü bir görünüme yol açmasidir. Yaralarda skar olusuinunu önlemek ve/veya olusmus skarlari tedavi etmek üzere, krem, merhem, pomat formunda birçok farmasötik ya da kozmetik ainaçli ürün gelistirilmistir. Söz konusu ürünlere ek olarak, çesitli cerrahi dikis teknikleri denenmis ancak ürünlerden ve söz konusu dikis tekniklerinden istenilen seviyede bir sonuç alinamamistir. Teknigin bilinen durumunda yer alan EP0770392 B1 sayili Avrupa patent basvurusu dokümaninda, aralarinda erbium tuzlarinin da bulundugu çesitli bilesenlerin tuzlarin, skar olusumuna karsi etkili farmasötik, kozmetik veya der'matolojik bir bilesim elde etmek üzere kullanimi açiklanmaktadir. Söz konusu bulusun tercih edilen bir uygulamasinda, bulusa konu olan bilesim; erbium tuzlarinin yani sira neodim klorür, glikolik asit, hidroksipropilselüloz, sodyum hidroksit, etanol ve koruyucu gibi ek bilesenler de içermektedir. Dokümanda, ayrica, bulus konusu ürünün jel formuna sahip olabilecegi belirtilmistir. 25418.109 teknik alandaki çözüm yöntemleri olarak bilinmektedir. Bulus ile Çözülen Sorunlar Bu bulusun amaci, yara skarinin önlenmesi ve tedavisinde kullanilmak üzere erbium borat içeren, jel formunda bir formülasyon gerçeklestirmektir. Bulus konusu jel formunda formülasyon, yara olustuktan sonra ortaya çikmasi muhtemel olan skarin olusumunu önleyerek, etkin bir kozmetik sonuç ortaya koyabilmektedir. Bulusun Ayrintili Açiklamasi Bulus konusu erbiyum borat temelli farmasötik formülasyon, yara skarinin önlenmesi ve tedavisinde kullanilmakta olup; etken bilesen olarak erbiyum borat nanopartikülleri ve en az bir yüzey aktif madde ve tasiyici jel özellikli en az bir jellestirici madde içermektedir. Bulusun bir uygulamasinda yüzey aktif madde olarak Plurononic F6& Pluronic F127 ve bunlarin karisimlarindan olusan bir gruptan seçilen en az bir yüzey aktif madde kullanilmaktadir. Bulusun bir uygulamasinda, j ellestiriei madde olarak Carbopol kullanilmaktadir. Bulusun bir uygulamasinda, farmasötik formülasyon, kütlece % 0,5-10 Pluronic 0,1-10 Sodyum pentaborat içermektedir. 25418.109 Bulusun farkli bir uygulamasinda, farmasötik formülasyon, kütlece % 0,5-10 NP, % 0,1-10 NaOl-l, % 0,01-10 Chlorhexidine içermektedir. Bulus konusu farmsötik bilesim, yara olustuktan sonra ortaya çikmasi muhtemel olan skarin olusumunu önleyerek, etkin bir kozmetik sonuç ortaya koyabilmektedir. Bulusun gelistirilmesi süresinde gerçeklestirilen deneysel çalismalardan, in vitro çalisinalarda erbium borat temelli formülasyonun yara skari olusumunda temel eleman olan kollajen l türevi yerine yara izi birakmadan iyilesme ile karakterize olan kollagen 3 türevinin ve tibromodulin ifadeleri arttigi gözlemlenmektedir. Ek olarak yara skari formasyonunun ortadan kaldirilmasinda oldukça önemli olan matriks metalloproteaz protein 9 enziminin aktivitesinin arttigi belirlenmistir. Ayrica siçanlar üzerinde yapilan in vi'vo çalismada kontrol grubu ile karsilastirildiginda erbium borat temelli formülasyonun daha az yara skari TR TR TR
Claims (1)
1.ISTEMLER . Yara skarinin önlenmesi ve tedavisinde kullanilmak üzere, - Erbium borat nanoparrikülleri, - En az bir yüzey aktif madde ve - Tasiyici jel özellikli en az bir jellestirici madde içermesi ile karakterize edilen jel formunda bir formülasyon. . Yüzey aktif madde olarak Pluronic F68 ve/veya Pluronic F127 içermesi ile karakterize edilen Istem 1”deki gibi bir formülasyon. . J ellestirici madde olarak Carbopol içermesi ile karakterize edilen Istem 1 veya karakterize edilen lstem l”deki gibi bir formülasyon. içermesi ile karakterize edilen Istem 1”deki gibi bir formülasyon. TR TR TR
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2020/21285A TR202021285A1 (tr) | 2020-12-22 | 2020-12-22 | Yara skarinin önlenmesi̇ ve tedavi̇si̇nde kullanilmak üzere erbium borat i̇çeren formülasyon |
US18/268,997 US20240050468A1 (en) | 2020-12-22 | 2021-11-09 | Formulation comprising erbium borate for use in prevention and treatment of wound scars |
PCT/TR2021/051172 WO2022139731A1 (en) | 2020-12-22 | 2021-11-09 | Formulation comprising erbium borate for use in prevention and treatment of wound scars |
EP21911712.4A EP4267244A1 (en) | 2020-12-22 | 2021-11-09 | Formulation comprising erbium borate for use in prevention and treatment of wound scars |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2020/21285A TR202021285A1 (tr) | 2020-12-22 | 2020-12-22 | Yara skarinin önlenmesi̇ ve tedavi̇si̇nde kullanilmak üzere erbium borat i̇çeren formülasyon |
Publications (1)
Publication Number | Publication Date |
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TR202021285A1 true TR202021285A1 (tr) | 2022-07-21 |
Family
ID=82160041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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TR2020/21285A TR202021285A1 (tr) | 2020-12-22 | 2020-12-22 | Yara skarinin önlenmesi̇ ve tedavi̇si̇nde kullanilmak üzere erbium borat i̇çeren formülasyon |
Country Status (4)
Country | Link |
---|---|
US (1) | US20240050468A1 (tr) |
EP (1) | EP4267244A1 (tr) |
TR (1) | TR202021285A1 (tr) |
WO (1) | WO2022139731A1 (tr) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2010270723A1 (en) * | 2009-07-06 | 2012-02-09 | Molycorp Minerals Llc | Ceria for use as an antimicrobial barrier and disinfectant in a wound dressing |
WO2014168595A1 (en) * | 2013-04-08 | 2014-10-16 | Yeditepe Universitesi | Polymer based hydrogel |
WO2020091699A1 (en) * | 2018-10-31 | 2020-05-07 | Yeditepe Universitesi | Use of nano-sized lanthanide borate (dysprosium borate and erbium borate) compounds for wound healing purposes and production method thereof |
-
2020
- 2020-12-22 TR TR2020/21285A patent/TR202021285A1/tr unknown
-
2021
- 2021-11-09 US US18/268,997 patent/US20240050468A1/en active Pending
- 2021-11-09 EP EP21911712.4A patent/EP4267244A1/en active Pending
- 2021-11-09 WO PCT/TR2021/051172 patent/WO2022139731A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP4267244A1 (en) | 2023-11-01 |
US20240050468A1 (en) | 2024-02-15 |
WO2022139731A1 (en) | 2022-06-30 |
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