JP2004531523A5 - - Google Patents
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- Publication number
- JP2004531523A5 JP2004531523A5 JP2002580954A JP2002580954A JP2004531523A5 JP 2004531523 A5 JP2004531523 A5 JP 2004531523A5 JP 2002580954 A JP2002580954 A JP 2002580954A JP 2002580954 A JP2002580954 A JP 2002580954A JP 2004531523 A5 JP2004531523 A5 JP 2004531523A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- amino
- a3rag
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/832,818 US20040204481A1 (en) | 2001-04-12 | 2001-04-12 | Activation of natural killer cells by adenosine A3 receptor agonists |
| PCT/IL2002/000298 WO2002083152A1 (en) | 2001-04-12 | 2002-04-11 | Activation of natural killer cells by adenosine a3 receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004531523A JP2004531523A (ja) | 2004-10-14 |
| JP2004531523A5 true JP2004531523A5 (https=) | 2005-06-30 |
Family
ID=25262686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002580954A Withdrawn JP2004531523A (ja) | 2001-04-12 | 2002-04-11 | アデノシンａ３レセプターアゴニストによるナチュラルキラー細胞の活性化 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20040204481A1 (https=) |
| EP (1) | EP1383515B1 (https=) |
| JP (1) | JP2004531523A (https=) |
| AT (1) | ATE284698T1 (https=) |
| DE (1) | DE60202278T2 (https=) |
| IL (1) | IL157841A0 (https=) |
| WO (1) | WO2002083152A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7414036B2 (en) | 2002-01-25 | 2008-08-19 | Muscagen Limited | Compounds useful as A3 adenosine receptor agonists |
| AR049384A1 (es) * | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
| CN103087133B (zh) | 2004-05-26 | 2016-09-14 | 伊诺泰克制药公司 | 嘌呤衍生物作为腺苷a1受体激动剂及其用法 |
| US7825102B2 (en) | 2004-07-28 | 2010-11-02 | Can-Fite Biopharma Ltd. | Treatment of dry eye conditions |
| EP1778239B1 (en) * | 2004-07-28 | 2013-08-21 | Can-Fite Biopharma Ltd. | Adenosine a3 receptor agonists for the treatment of dry eye disorders including sjogren's syndrome |
| CN101437526A (zh) | 2004-09-20 | 2009-05-20 | 伊诺泰克制药公司 | 嘌呤衍生物及其用法 |
| AU2005306325A1 (en) * | 2004-11-22 | 2006-05-26 | King Pharmaceuticals Research & Development Inc. | Enhancing treatment of HIF-1 mediated disorders with adenosine A3 receptor agonists |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| EA015683B1 (ru) | 2005-11-30 | 2011-10-31 | Инотек Фармасьютикалз Корпорейшн | Производные пурина и способы их применения |
| GB0625100D0 (en) * | 2006-12-15 | 2007-01-24 | Univ Murcia | Epigallocatechin-3-gallate compositions for cancer therapy and chemoprotection |
| US20090088403A1 (en) * | 2007-05-07 | 2009-04-02 | Randy Blakely | A3 adenosine receptors as targets for the modulation of central serotonergic signaling |
| WO2010065959A1 (en) * | 2008-12-05 | 2010-06-10 | Northeastern University | Method of preparing adenosine-resistant anti-tumor t lymphocytes for adoptive immunotherapy |
| LT2523669T (lt) | 2010-01-11 | 2017-04-25 | Inotek Pharmaceuticals Corporation | Akispūdžio mažinimo būdas, derinys ir rinkinys |
| PH12012501906A1 (en) | 2010-03-26 | 2013-01-14 | Inotek Pharmaceuticals Corp | Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof |
| UA117095C2 (uk) | 2011-12-22 | 2018-06-25 | Аліос Біофарма, Інк. | Нуклеозидна сполука або її фармацевтично прийнятна сіль |
| PT2807178T (pt) | 2012-01-26 | 2017-08-08 | Inotek Pharmaceuticals Corp | Polimorfos anidros de nitrato de (2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-dihidroxitetrahidrofuran-2-il)}metilo e seus processos de preparação |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| NZ630759A (en) | 2013-03-15 | 2017-07-28 | Inotek Pharmaceuticals Corp | Ophthalmic formulations comprising an a1 agonist |
| CA3109361A1 (en) * | 2018-08-30 | 2020-03-05 | HCW Biologics, Inc. | Single-chain and multi-chain chimeric polypeptides and uses thereof |
| US11518792B2 (en) | 2018-08-30 | 2022-12-06 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| US11401324B2 (en) | 2018-08-30 | 2022-08-02 | HCW Biologics, Inc. | Single-chain chimeric polypeptides and uses thereof |
| CN120924491A (zh) | 2019-06-21 | 2025-11-11 | 免疫生物公司 | 多链嵌合多肽和其用途 |
| WO2021163299A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Chromatography resin and uses thereof |
| CA3169243A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of activating regulatory t cells |
| AU2021220870A1 (en) | 2020-02-11 | 2022-08-04 | Immunitybio, Inc. | Methods of treating age-related and inflammatory diseases |
| CN115836087A (zh) | 2020-04-29 | 2023-03-21 | Hcw生物科技公司 | 抗cd26蛋白及其用途 |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| WO2023201311A1 (en) | 2022-04-13 | 2023-10-19 | HCW Biologics, Inc. | Multi-chain chimeric polypeptide for use in the treatment of treating neuroinflammatory disorder |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121272A (en) * | 1997-07-10 | 2000-06-01 | Can Fite Technologies Ltd | Pharmaceutical compositions comprising adenosine and their use for treating or preventing leukopenia |
| IL133680A0 (en) * | 1999-09-10 | 2001-04-30 | Can Fite Technologies Ltd | Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist |
-
2001
- 2001-04-12 US US09/832,818 patent/US20040204481A1/en not_active Abandoned
-
2002
- 2002-04-11 AT AT02726402T patent/ATE284698T1/de not_active IP Right Cessation
- 2002-04-11 JP JP2002580954A patent/JP2004531523A/ja not_active Withdrawn
- 2002-04-11 IL IL15784102A patent/IL157841A0/xx unknown
- 2002-04-11 WO PCT/IL2002/000298 patent/WO2002083152A1/en not_active Ceased
- 2002-04-11 DE DE60202278T patent/DE60202278T2/de not_active Expired - Fee Related
- 2002-04-11 EP EP02726402A patent/EP1383515B1/en not_active Expired - Lifetime
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