JP2004531516A - 新規ベンジリデンアミノグアニジンおよびそれらのメラノコルチンレセプターリガンドとしての使用方法 - Google Patents
新規ベンジリデンアミノグアニジンおよびそれらのメラノコルチンレセプターリガンドとしての使用方法 Download PDFInfo
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- JP2004531516A JP2004531516A JP2002579418A JP2002579418A JP2004531516A JP 2004531516 A JP2004531516 A JP 2004531516A JP 2002579418 A JP2002579418 A JP 2002579418A JP 2002579418 A JP2002579418 A JP 2002579418A JP 2004531516 A JP2004531516 A JP 2004531516A
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- guanidine
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0108631.3A GB0108631D0 (en) | 2001-04-05 | 2001-04-05 | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| PCT/GB2002/001593 WO2002081430A2 (en) | 2001-04-05 | 2002-04-05 | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
Publications (2)
| Publication Number | Publication Date |
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| JP2004531516A true JP2004531516A (ja) | 2004-10-14 |
| JP2004531516A5 JP2004531516A5 (enExample) | 2005-09-02 |
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| JP2002579418A Withdrawn JP2004531516A (ja) | 2001-04-05 | 2002-04-05 | 新規ベンジリデンアミノグアニジンおよびそれらのメラノコルチンレセプターリガンドとしての使用方法 |
| JP2002578935A Withdrawn JP2004531510A (ja) | 2001-04-05 | 2002-04-05 | ベンジリデンアミノグアニジンの、メラノコルチンレセプターリガンドとしての使用方法 |
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| JP2002578935A Withdrawn JP2004531510A (ja) | 2001-04-05 | 2002-04-05 | ベンジリデンアミノグアニジンの、メラノコルチンレセプターリガンドとしての使用方法 |
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| US (2) | US20040106683A1 (enExample) |
| EP (2) | EP1372625A1 (enExample) |
| JP (2) | JP2004531516A (enExample) |
| KR (2) | KR20030092045A (enExample) |
| BR (2) | BR0208658A (enExample) |
| CA (2) | CA2443057A1 (enExample) |
| GB (1) | GB0108631D0 (enExample) |
| IL (2) | IL158248A0 (enExample) |
| MX (2) | MXPA03008972A (enExample) |
| WO (2) | WO2002081430A2 (enExample) |
| ZA (1) | ZA200307453B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010513258A (ja) * | 2006-12-14 | 2010-04-30 | アキュア ファーマ エービー | メラノコルチン受容体リガンドとしての新規アミノグアニジン |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0019357D0 (en) | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| GB0108631D0 (en) * | 2001-04-05 | 2001-05-30 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| GB0119172D0 (en) * | 2001-08-06 | 2001-09-26 | Melacure Therapeutics Ab | Phenyl pyrrole derivatives |
| EP1447416B1 (en) | 2003-01-23 | 2010-03-03 | Kuraray Co., Ltd. | Polyvinyl acetal and its use |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
| WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2045250A1 (en) * | 2007-09-26 | 2009-04-08 | Action Pharma A/S | Ring-substituted phenyl pyrrole aminoguanidine derivatives |
| ES2627848T3 (es) | 2008-06-04 | 2017-07-31 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| US8410284B2 (en) | 2008-10-22 | 2013-04-02 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| WO2010051206A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| JP5514831B2 (ja) | 2008-11-17 | 2014-06-04 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病の治療のための置換二環式アミン |
| WO2011011506A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| CA2768577A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| US8785634B2 (en) | 2010-04-26 | 2014-07-22 | Merck Sharp & Dohme Corp | Spiropiperidine prolylcarboxypeptidase inhibitors |
| WO2011143057A1 (en) | 2010-05-11 | 2011-11-17 | Merck Sharp & Dohme Corp. | Novel prolylcarboxypeptidase inhibitors |
| EP2579873A4 (en) | 2010-06-11 | 2013-11-27 | Merck Sharp & Dohme | NOVEL PROLYLCARBOXYPEPTIDASE HEMMER |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CA2826649C (en) | 2011-02-25 | 2016-07-26 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| US20140045746A1 (en) | 2012-08-02 | 2014-02-13 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| JP2016516004A (ja) | 2013-02-22 | 2016-06-02 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 抗糖尿病二環式化合物 |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| PL3004138T3 (pl) | 2013-06-05 | 2024-07-29 | Bausch Health Ireland Limited | Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| JP6994939B2 (ja) * | 2014-07-02 | 2022-02-04 | インフレクティス・バイオサイエンス | プロテオパチーの処置のためのベンジリデングアニジン誘導体の新規な治療的使用 |
| WO2018106518A1 (en) | 2016-12-06 | 2018-06-14 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
| US20180230105A1 (en) | 2017-01-13 | 2018-08-16 | Regents Of The University Of Minnesota | Therapeutic compounds |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2584784A (en) * | 1949-05-21 | 1952-02-05 | Du Pont | Salts of 1-salicylalaminoguanidine |
| DE1165013B (de) * | 1960-08-09 | 1964-03-12 | Vismara Francesco Spa | Verfahren zur Herstellung von Guanylhydrazonen |
| GB1223492A (en) * | 1967-10-13 | 1971-02-24 | American Home Prod | Guanidines |
| US3592935A (en) * | 1969-12-11 | 1971-07-13 | Sandoz Ag | Substituted benzylidene hydrazines as anti-inflammatory agents |
| US3982020A (en) * | 1970-03-17 | 1976-09-21 | Sandoz, Inc. | Substituted benzylidene hydrazines for treating hyperglycemia, obesity and inflammation |
| US4060640A (en) * | 1970-04-29 | 1977-11-29 | Shell Oil Company | Therapeutic agents |
| US3816531A (en) * | 1970-07-01 | 1974-06-11 | American Home Prod | (2,6-disubstituted benzylidene)amino guanidines and related compounds |
| US3896232A (en) * | 1973-01-11 | 1975-07-22 | Sandoz Ag | Substituted benzylidene hydrazines as anti-migraine syndrome agents |
| US3941825A (en) * | 1973-07-27 | 1976-03-02 | American Cyanamid Company | Substituted aminobenzylideneamino guanidine compounds |
| US4006250A (en) * | 1975-08-25 | 1977-02-01 | American Home Products Corporation | Systemic treatment of psoriasis |
| EP0600973A1 (en) * | 1991-08-27 | 1994-06-15 | The Upjohn Company | A method for treatment of metabolic disorders and metabolism |
| US5599984A (en) * | 1994-01-21 | 1997-02-04 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| SE9604348D0 (sv) * | 1996-11-26 | 1996-11-26 | Wapharm Ab | Användning av hydroxyguanidiner |
| US6503950B1 (en) * | 1999-08-23 | 2003-01-07 | David M. Ockert | Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms |
| AU7802700A (en) * | 1999-10-06 | 2001-05-10 | Melacure Therapeutics Ab | Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase |
| GB0019357D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| GB0019359D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel guanidines |
| GB0108631D0 (en) * | 2001-04-05 | 2001-05-30 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
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2001
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2002
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- 2002-04-05 US US10/472,768 patent/US20040106683A1/en not_active Abandoned
- 2002-04-05 EP EP02707025A patent/EP1372625A1/en not_active Withdrawn
- 2002-04-05 BR BR0208658-1A patent/BR0208658A/pt not_active Application Discontinuation
- 2002-04-05 WO PCT/GB2002/001593 patent/WO2002081430A2/en not_active Ceased
- 2002-04-05 BR BR0208657-3A patent/BR0208657A/pt not_active Application Discontinuation
- 2002-04-05 MX MXPA03008972A patent/MXPA03008972A/es unknown
- 2002-04-05 CA CA002443057A patent/CA2443057A1/en not_active Abandoned
- 2002-04-05 US US10/472,767 patent/US20040106682A1/en not_active Abandoned
- 2002-04-05 KR KR10-2003-7012904A patent/KR20030092045A/ko not_active Withdrawn
- 2002-04-05 EP EP02707026A patent/EP1383740A2/en not_active Withdrawn
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- 2002-04-05 KR KR10-2003-7012903A patent/KR20030088056A/ko not_active Withdrawn
- 2002-04-05 IL IL15824802A patent/IL158248A0/xx unknown
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- 2002-04-05 MX MXPA03008973A patent/MXPA03008973A/es unknown
- 2002-04-05 JP JP2002578935A patent/JP2004531510A/ja not_active Withdrawn
- 2002-04-05 IL IL15824702A patent/IL158247A0/xx unknown
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2003
- 2003-09-25 ZA ZA200307453A patent/ZA200307453B/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010513258A (ja) * | 2006-12-14 | 2010-04-30 | アキュア ファーマ エービー | メラノコルチン受容体リガンドとしての新規アミノグアニジン |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002080896A1 (en) | 2002-10-17 |
| KR20030088056A (ko) | 2003-11-15 |
| KR20030092045A (ko) | 2003-12-03 |
| US20040106683A1 (en) | 2004-06-03 |
| EP1383740A2 (en) | 2004-01-28 |
| CA2443099A1 (en) | 2002-10-17 |
| ZA200307453B (en) | 2004-09-27 |
| US20040106682A1 (en) | 2004-06-03 |
| EP1372625A1 (en) | 2004-01-02 |
| BR0208658A (pt) | 2004-03-02 |
| IL158248A0 (en) | 2004-05-12 |
| MXPA03008973A (es) | 2004-02-12 |
| CA2443057A1 (en) | 2002-10-17 |
| GB0108631D0 (en) | 2001-05-30 |
| JP2004531510A (ja) | 2004-10-14 |
| WO2002081430A3 (en) | 2003-08-14 |
| BR0208657A (pt) | 2004-03-02 |
| IL158247A0 (en) | 2004-05-12 |
| WO2002081430A2 (en) | 2002-10-17 |
| MXPA03008972A (es) | 2004-02-12 |
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