JP2004530687A5 - - Google Patents
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- Publication number
- JP2004530687A5 JP2004530687A5 JP2002589016A JP2002589016A JP2004530687A5 JP 2004530687 A5 JP2004530687 A5 JP 2004530687A5 JP 2002589016 A JP2002589016 A JP 2002589016A JP 2002589016 A JP2002589016 A JP 2002589016A JP 2004530687 A5 JP2004530687 A5 JP 2004530687A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- oxocyclopentyl
- hept
- enyl
- enoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LPQWCDLULJJTGY-QBBBNRPDSA-N (z)-7-[(1r,2r,3r)-2-[(e,3s)-5-(3-chloro-1-benzothiophen-2-yl)-3-hydroxypent-1-enyl]-3-hydroxy-5-oxocyclopentyl]hept-5-enoic acid Chemical compound C(/[C@H](CCC1=C(C2=CC=CC=C2S1)Cl)O)=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O LPQWCDLULJJTGY-QBBBNRPDSA-N 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- -1 n-propenyl Chemical group 0.000 claims 6
- DIVLHKGWGUMUFX-MDPYPTNGSA-N (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3s)-3-hydroxy-5-naphthalen-2-ylpent-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid Chemical compound C(/[C@H](CCC=1C=C2C=CC=CC2=CC=1)O)=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O DIVLHKGWGUMUFX-MDPYPTNGSA-N 0.000 claims 4
- KPSZWAJWFMFMFF-UHFFFAOYSA-N delta-Hexylen-alpha-carbonsaeure Natural products CC=CCCCC(O)=O KPSZWAJWFMFMFF-UHFFFAOYSA-N 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 206010030043 Ocular hypertension Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 229940054534 ophthalmic solution Drugs 0.000 claims 2
- 239000002997 ophthalmic solution Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/859,770 US6531504B2 (en) | 2001-05-17 | 2001-05-17 | Prostanoic acid derivatives as agents for lowering intraocular pressure |
| PCT/US2002/014580 WO2002092099A1 (en) | 2001-05-17 | 2002-05-07 | Prostanoic acid derivatives as agents for lowering intraocular pressure |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004530687A JP2004530687A (ja) | 2004-10-07 |
| JP2004530687A5 true JP2004530687A5 (enExample) | 2005-12-22 |
| JP4606698B2 JP4606698B2 (ja) | 2011-01-05 |
Family
ID=25331661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002589016A Expired - Fee Related JP4606698B2 (ja) | 2001-05-17 | 2002-05-07 | 眼内圧降下剤としてのプロスタン酸誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6531504B2 (enExample) |
| EP (1) | EP1390036B1 (enExample) |
| JP (1) | JP4606698B2 (enExample) |
| AT (1) | ATE548042T1 (enExample) |
| AU (1) | AU2002316081B2 (enExample) |
| CA (1) | CA2446994C (enExample) |
| DK (1) | DK1390036T3 (enExample) |
| ES (1) | ES2381340T3 (enExample) |
| WO (1) | WO2002092099A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004211936B2 (en) * | 2003-02-11 | 2008-09-11 | Allergan, Inc. | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| US6875787B2 (en) * | 2003-02-11 | 2005-04-05 | Allergan, Inc. | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| US7855226B2 (en) * | 2003-02-11 | 2010-12-21 | Allergan, Inc. | Treatment of inflammatory bowel disease |
| US7179820B2 (en) * | 2003-06-06 | 2007-02-20 | Allergan, Inc. | Piperidinyl prostaglandin E analogs |
| US7186744B2 (en) * | 2003-11-13 | 2007-03-06 | Allergan, Inc. | Prostamides for the treatment of glaucoma and related diseases |
| US7169807B2 (en) * | 2004-04-09 | 2007-01-30 | Allergan, Inc. | 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists |
| WO2006041875A1 (en) | 2004-10-06 | 2006-04-20 | Allergan, Inc. | Novel prostamides for the treatment of glaucoma and related diseases |
| US7101906B2 (en) | 2004-11-16 | 2006-09-05 | Allergan, Inc. | 2,3,4-substituted cyclopentanones as therapeutic agents |
| US7893107B2 (en) * | 2005-11-30 | 2011-02-22 | Allergan, Inc. | Therapeutic methods using prostaglandin EP4 agonist components |
| US20070232660A1 (en) * | 2006-04-04 | 2007-10-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
| EP2220057A4 (en) * | 2007-11-14 | 2011-10-12 | Cayman Chem Co | PROSTAGLANDIN E1 AND E2 ANALOGUES FOR THE TREATMENT OF VARIOUS MEDICAL CONDITIONS |
| US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
| US20110020453A1 (en) * | 2009-02-06 | 2011-01-27 | Steven Blum | Topical Formulations Comprising Ion Channel Modulators |
| KR101045935B1 (ko) * | 2009-03-11 | 2011-07-01 | 연성정밀화학(주) | 프로스타글란딘 유도체의 제조방법 |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE37602B1 (en) * | 1971-05-11 | 1977-08-31 | Ici Ltd | Cyclopentane derivatives |
| AR204816A1 (es) * | 1972-11-08 | 1976-03-05 | Pfizer | Procedimiento para preparar una prostaglandina |
| US4994274A (en) | 1989-07-27 | 1991-02-19 | Allergan, Inc. | Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using |
| US5034413A (en) | 1989-07-27 | 1991-07-23 | Allergan, Inc. | Intraocular pressure reducing 9,11-diacyl prostaglandins |
| CA2021316C (en) | 1989-07-27 | 2000-10-24 | Ming Fai Chan | Intraocular pressure reducing 11-acyl prostaglandins |
| US5028624A (en) | 1989-07-27 | 1991-07-02 | Allergan, Inc. | Intraocular pressure reducing 9,15-diacyl prostaglandins |
| US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5972991A (en) * | 1992-09-21 | 1999-10-26 | Allergan | Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
| ES2105333T3 (es) * | 1992-10-13 | 1997-10-16 | Alcon Lab Inc | Combinaciones de prostaglandinas y derivados de clonidina para el tratamiento del glaucoma. |
| US5741810A (en) * | 1996-02-29 | 1998-04-21 | Allergan | Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents |
| SE9702706D0 (sv) * | 1997-07-11 | 1997-07-11 | Pharmacia & Upjohn Ab | Prostaglandin derivatives devoid of side-effects for the treatment of glaucoma |
| KR20010023837A (ko) * | 1997-09-09 | 2001-03-26 | 데이비드 엠 모이어 | Ｆｐ 작동약으로 유용한 방향족 ｃ16-ｃ20-치환된테트라히드로 프로스타글란딘 |
| CZ20013174A3 (cs) * | 1999-03-05 | 2002-02-13 | The Procter & Gamble Company | C16 nenasycené FP-selektivní prostaglandinové analogy |
-
2001
- 2001-05-17 US US09/859,770 patent/US6531504B2/en not_active Expired - Lifetime
-
2002
- 2002-05-07 ES ES02746356T patent/ES2381340T3/es not_active Expired - Lifetime
- 2002-05-07 AU AU2002316081A patent/AU2002316081B2/en not_active Ceased
- 2002-05-07 JP JP2002589016A patent/JP4606698B2/ja not_active Expired - Fee Related
- 2002-05-07 WO PCT/US2002/014580 patent/WO2002092099A1/en not_active Ceased
- 2002-05-07 AT AT02746356T patent/ATE548042T1/de active
- 2002-05-07 CA CA2446994A patent/CA2446994C/en not_active Expired - Fee Related
- 2002-05-07 DK DK02746356.1T patent/DK1390036T3/da active
- 2002-05-07 EP EP02746356A patent/EP1390036B1/en not_active Expired - Lifetime
- 2002-11-13 US US10/294,521 patent/US6670485B2/en not_active Expired - Fee Related
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