DK1390036T3 - Prostansyrederivater som midler til nedsættelse af intraokulært tryk - Google Patents
Prostansyrederivater som midler til nedsættelse af intraokulært trykInfo
- Publication number
- DK1390036T3 DK1390036T3 DK02746356.1T DK02746356T DK1390036T3 DK 1390036 T3 DK1390036 T3 DK 1390036T3 DK 02746356 T DK02746356 T DK 02746356T DK 1390036 T3 DK1390036 T3 DK 1390036T3
- Authority
- DK
- Denmark
- Prior art keywords
- agents
- acid derivatives
- co2r
- halogen
- intraocular pressure
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title 1
- 230000004410 intraocular pressure Effects 0.000 title 1
- WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 title 1
- 208000010412 Glaucoma Diseases 0.000 abstract 2
- 206010030043 Ocular hypertension Diseases 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 125000000520 N-substituted aminocarbonyl group Chemical group [*]NC(=O)* 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/859,770 US6531504B2 (en) | 2001-05-17 | 2001-05-17 | Prostanoic acid derivatives as agents for lowering intraocular pressure |
| PCT/US2002/014580 WO2002092099A1 (en) | 2001-05-17 | 2002-05-07 | Prostanoic acid derivatives as agents for lowering intraocular pressure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1390036T3 true DK1390036T3 (da) | 2012-04-10 |
Family
ID=25331661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02746356.1T DK1390036T3 (da) | 2001-05-17 | 2002-05-07 | Prostansyrederivater som midler til nedsættelse af intraokulært tryk |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6531504B2 (enExample) |
| EP (1) | EP1390036B1 (enExample) |
| JP (1) | JP4606698B2 (enExample) |
| AT (1) | ATE548042T1 (enExample) |
| AU (1) | AU2002316081B2 (enExample) |
| CA (1) | CA2446994C (enExample) |
| DK (1) | DK1390036T3 (enExample) |
| ES (1) | ES2381340T3 (enExample) |
| WO (1) | WO2002092099A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004211936B2 (en) * | 2003-02-11 | 2008-09-11 | Allergan, Inc. | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| US6875787B2 (en) * | 2003-02-11 | 2005-04-05 | Allergan, Inc. | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| US7855226B2 (en) * | 2003-02-11 | 2010-12-21 | Allergan, Inc. | Treatment of inflammatory bowel disease |
| US7179820B2 (en) * | 2003-06-06 | 2007-02-20 | Allergan, Inc. | Piperidinyl prostaglandin E analogs |
| US7186744B2 (en) * | 2003-11-13 | 2007-03-06 | Allergan, Inc. | Prostamides for the treatment of glaucoma and related diseases |
| US7169807B2 (en) * | 2004-04-09 | 2007-01-30 | Allergan, Inc. | 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists |
| WO2006041875A1 (en) | 2004-10-06 | 2006-04-20 | Allergan, Inc. | Novel prostamides for the treatment of glaucoma and related diseases |
| US7101906B2 (en) | 2004-11-16 | 2006-09-05 | Allergan, Inc. | 2,3,4-substituted cyclopentanones as therapeutic agents |
| US7893107B2 (en) * | 2005-11-30 | 2011-02-22 | Allergan, Inc. | Therapeutic methods using prostaglandin EP4 agonist components |
| US20070232660A1 (en) * | 2006-04-04 | 2007-10-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
| EP2220057A4 (en) * | 2007-11-14 | 2011-10-12 | Cayman Chem Co | PROSTAGLANDIN E1 AND E2 ANALOGUES FOR THE TREATMENT OF VARIOUS MEDICAL CONDITIONS |
| US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
| US20110020453A1 (en) * | 2009-02-06 | 2011-01-27 | Steven Blum | Topical Formulations Comprising Ion Channel Modulators |
| KR101045935B1 (ko) * | 2009-03-11 | 2011-07-01 | 연성정밀화학(주) | 프로스타글란딘 유도체의 제조방법 |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE37602B1 (en) * | 1971-05-11 | 1977-08-31 | Ici Ltd | Cyclopentane derivatives |
| AR204816A1 (es) * | 1972-11-08 | 1976-03-05 | Pfizer | Procedimiento para preparar una prostaglandina |
| US4994274A (en) | 1989-07-27 | 1991-02-19 | Allergan, Inc. | Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using |
| US5034413A (en) | 1989-07-27 | 1991-07-23 | Allergan, Inc. | Intraocular pressure reducing 9,11-diacyl prostaglandins |
| CA2021316C (en) | 1989-07-27 | 2000-10-24 | Ming Fai Chan | Intraocular pressure reducing 11-acyl prostaglandins |
| US5028624A (en) | 1989-07-27 | 1991-07-02 | Allergan, Inc. | Intraocular pressure reducing 9,15-diacyl prostaglandins |
| US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5972991A (en) * | 1992-09-21 | 1999-10-26 | Allergan | Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
| ES2105333T3 (es) * | 1992-10-13 | 1997-10-16 | Alcon Lab Inc | Combinaciones de prostaglandinas y derivados de clonidina para el tratamiento del glaucoma. |
| US5741810A (en) * | 1996-02-29 | 1998-04-21 | Allergan | Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents |
| SE9702706D0 (sv) * | 1997-07-11 | 1997-07-11 | Pharmacia & Upjohn Ab | Prostaglandin derivatives devoid of side-effects for the treatment of glaucoma |
| KR20010023837A (ko) * | 1997-09-09 | 2001-03-26 | 데이비드 엠 모이어 | Ｆｐ 작동약으로 유용한 방향족 ｃ16-ｃ20-치환된테트라히드로 프로스타글란딘 |
| CZ20013174A3 (cs) * | 1999-03-05 | 2002-02-13 | The Procter & Gamble Company | C16 nenasycené FP-selektivní prostaglandinové analogy |
-
2001
- 2001-05-17 US US09/859,770 patent/US6531504B2/en not_active Expired - Lifetime
-
2002
- 2002-05-07 ES ES02746356T patent/ES2381340T3/es not_active Expired - Lifetime
- 2002-05-07 AU AU2002316081A patent/AU2002316081B2/en not_active Ceased
- 2002-05-07 JP JP2002589016A patent/JP4606698B2/ja not_active Expired - Fee Related
- 2002-05-07 WO PCT/US2002/014580 patent/WO2002092099A1/en not_active Ceased
- 2002-05-07 AT AT02746356T patent/ATE548042T1/de active
- 2002-05-07 CA CA2446994A patent/CA2446994C/en not_active Expired - Fee Related
- 2002-05-07 DK DK02746356.1T patent/DK1390036T3/da active
- 2002-05-07 EP EP02746356A patent/EP1390036B1/en not_active Expired - Lifetime
- 2002-11-13 US US10/294,521 patent/US6670485B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6670485B2 (en) | 2003-12-30 |
| EP1390036A1 (en) | 2004-02-25 |
| JP4606698B2 (ja) | 2011-01-05 |
| WO2002092099A1 (en) | 2002-11-21 |
| CA2446994A1 (en) | 2002-11-21 |
| US20020177620A1 (en) | 2002-11-28 |
| EP1390036B1 (en) | 2012-03-07 |
| AU2002316081B2 (en) | 2007-11-15 |
| US6531504B2 (en) | 2003-03-11 |
| CA2446994C (en) | 2011-02-01 |
| ES2381340T3 (es) | 2012-05-25 |
| US20030105155A1 (en) | 2003-06-05 |
| ATE548042T1 (de) | 2012-03-15 |
| JP2004530687A (ja) | 2004-10-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1390036T3 (da) | Prostansyrederivater som midler til nedsættelse af intraokulært tryk | |
| WO2002089813A3 (en) | 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure | |
| ATE305463T1 (de) | Omega-zykloalkyl 17-heteroaryl prostaglandin-e2- analoga als ep2-rezeptoragonisten | |
| LU91162I2 (fr) | Aloxi-Palonosétrone et ses dérivés pharmaceutiquement acceptables. | |
| EA200401431A1 (ru) | Производные триазола в качестве антагонистов рецептора тахикинина | |
| EA200300982A1 (ru) | Гетероциклические производные для лечения рака и других пролиферативных заболеваний | |
| HRP20090162T1 (en) | Quinolinone-carboxamide compounds as 5-ht4 receptor agonists | |
| DK1063228T3 (da) | Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf | |
| PA8573501A1 (es) | Derivados de benzoxazina y su empleo | |
| DK1395263T3 (da) | 3, 7 eller 3 og 7 thia- eller oxaprostansyrederivater som midler til at sænke intraokulært tryk | |
| ID24846A (id) | Turunan-turunan bifenilamidina | |
| EA200401519A1 (ru) | N- ациламинобензольные производные в качестве селективных ингибиторов моноаминооксидазы b | |
| DK1157998T3 (da) | Heterocykliske forbindelser, mellemprodukter derfor og elastaseinhibitorer | |
| DOP2025000069A (es) | Inhibidores de sik novedosos | |
| WO2002100388A3 (en) | Cyclopentane heptan (ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents for the treatment of ocular hypertension | |
| ES2191341T3 (es) | Derivados de la 2-fenoxianilina. | |
| ATE308540T1 (de) | Antithrombosemittel | |
| MXPA05008431A (es) | Derivados de acido 10,10-dialquil prostanoico como agentes para reducir la presion intraocular. | |
| DK0871626T3 (da) | Triazoloner som apolipoprotein-B syntheseinhibitorer | |
| PE20001596A1 (es) | Derivados de morfolina | |
| EA200300010A1 (ru) | Производные 2-аминотиазолина и их применение в качестве ингибиторов no-синтазы | |
| BR0013409B1 (pt) | compostos fungicidas possuindo uma porção flúorvinil ou fluorpropenil-oxifeniloxima e processo para preparação dos mesmos. | |
| EA200500032A1 (ru) | Производные ацилоксипирролидина и их применение в качестве лигандов v1b или v1b и v1a рецепторов | |
| CR20240203A (es) | Compuestos de heteroaril-urea novedosos como inhibidores de kv7.2 | |
| EA199900460A1 (ru) | Производные бензолсульфоамида и лекарственные средства, содержащие упомянутые производные |