MXPA05008431A - Derivados de acido 10,10-dialquil prostanoico como agentes para reducir la presion intraocular. - Google Patents
Derivados de acido 10,10-dialquil prostanoico como agentes para reducir la presion intraocular.Info
- Publication number
- MXPA05008431A MXPA05008431A MXPA05008431A MXPA05008431A MXPA05008431A MX PA05008431 A MXPA05008431 A MX PA05008431A MX PA05008431 A MXPA05008431 A MX PA05008431A MX PA05008431 A MXPA05008431 A MX PA05008431A MX PA05008431 A MXPA05008431 A MX PA05008431A
- Authority
- MX
- Mexico
- Prior art keywords
- agents
- acid derivatives
- intraocular pressure
- indicates
- configuration
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title 1
- 230000004410 intraocular pressure Effects 0.000 title 1
- WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 title 1
- 208000010412 Glaucoma Diseases 0.000 abstract 2
- 206010030043 Ocular hypertension Diseases 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000520 N-substituted aminocarbonyl group Chemical group [*]NC(=O)* 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion proporciona un metodo para tratar la hipertension ocular o glaucoma, que comprende administrar a un animal que tiene hipertension ocular o glaucoma una cantidad terapeuticamente efectiva de un compuesto representado por la formula general (I); en donde la linea punteada indica la presencia o ausencia de un enlace, la linea sombreada indica la configuracion ((bajo), y los triangulos solidos indican la configuracion ((alto); B es un enlace covalente sencillo, doble, o triple; n es 0-6; x es CH2, S u O; Y es cualquier sal farmaceuticamente aceptable de CO2H, o CO2R, CONR2, CONHCH2CH2OH, CON(CH2CH2OH)2, CH2OR, P(O) (OR)2, CONRSO2R, SONR2, o la formula (Ia), R es H, alquilo C1-6 o alquenilo C2-6; R2 y R3 son alquilo lineal C1-6 el cual puede ser el mismo o diferente, y puede esta enlazado a cada uno de los otros de tal manera que formen un anillo que incorpora el carbono al cual esta enlazado comunmente.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/365,369 US6875787B2 (en) | 2003-02-11 | 2003-02-11 | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| US10/772,720 US20040235958A1 (en) | 2003-02-11 | 2004-02-04 | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| PCT/US2004/003433 WO2004071428A2 (en) | 2003-02-11 | 2004-02-06 | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05008431A true MXPA05008431A (es) | 2005-10-19 |
Family
ID=32871611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05008431A MXPA05008431A (es) | 2003-02-11 | 2004-02-06 | Derivados de acido 10,10-dialquil prostanoico como agentes para reducir la presion intraocular. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1608309B1 (es) |
| JP (1) | JP5319065B2 (es) |
| KR (1) | KR101077461B1 (es) |
| AU (1) | AU2004211936B2 (es) |
| BR (1) | BRPI0407400A (es) |
| CA (1) | CA2515631C (es) |
| MX (1) | MXPA05008431A (es) |
| NO (1) | NO334659B1 (es) |
| NZ (1) | NZ541352A (es) |
| PL (1) | PL209130B1 (es) |
| RU (1) | RU2336081C2 (es) |
| WO (1) | WO2004071428A2 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7855226B2 (en) | 2003-02-11 | 2010-12-21 | Allergan, Inc. | Treatment of inflammatory bowel disease |
| JP2008518013A (ja) * | 2004-10-26 | 2008-05-29 | アラーガン、インコーポレイテッド | プロスタグランジンｅｐ４アゴニストによる処置方法およびデリバリー方法 |
| AU2012200514B2 (en) * | 2005-03-17 | 2014-03-06 | Allergan, Inc. | Treatment of inflammatory bowel disease |
| CA2665081C (en) | 2006-10-02 | 2015-12-01 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates |
| CN105566192B (zh) * | 2006-10-02 | 2019-01-22 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性的前列腺素及相关化合物的前药 |
| US8455547B2 (en) * | 2008-02-05 | 2013-06-04 | Allergan, Inc. | Substituted cyclopentanes having prostaglandin activity |
| US7732443B2 (en) * | 2008-03-18 | 2010-06-08 | Yariv Donde | Therapeutic substituted cyclopentanes |
| RU2500674C2 (ru) * | 2008-05-09 | 2013-12-10 | Аллерган, Инк. | Терапевтические соединения |
| WO2011047048A1 (en) | 2009-10-14 | 2011-04-21 | Gemmus Pharma, Inc. | Combination therapy treatment for viral infections |
| MX2013001227A (es) * | 2010-07-30 | 2013-04-24 | Allergan Inc | Compuestos y metodos para reparacion de piel. |
| SG187861A1 (en) * | 2010-08-17 | 2013-03-28 | Allergan Inc | Ep2 or ep4 agonists for treating corneal haze |
| JP6694385B2 (ja) | 2013-08-09 | 2020-05-13 | アーデリクス，インコーポレーテッド | リン酸塩輸送阻害のための化合物及び方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117014A (en) * | 1976-01-09 | 1978-09-26 | Abbott Laboratories | Prostaglandin derivatives |
| JPS59101458A (ja) * | 1982-12-01 | 1984-06-12 | Nippon Iyakuhin Kogyo Kk | 新規なチアプロスタグランジン誘導体及びその製法 |
| JPS632972A (ja) * | 1986-06-20 | 1988-01-07 | Nippon Iyakuhin Kogyo Kk | 新規プロスタグランジンｅ↓１誘導体及びその製法 |
| US5462968A (en) * | 1994-01-19 | 1995-10-31 | Allergan, Inc. | EP2 -receptor agonists as agents for lowering intraocular pressure |
| US5877211A (en) * | 1997-11-21 | 1999-03-02 | Allergan | EP2 receptor agonists as neuroprotective agents for the eye |
| US6410591B1 (en) * | 2001-05-08 | 2002-06-25 | Allergan Sales, Inc. | 3,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
| US6531504B2 (en) * | 2001-05-17 | 2003-03-11 | Allergan, Inc. | Prostanoic acid derivatives as agents for lowering intraocular pressure |
| WO2002102389A1 (en) * | 2001-06-14 | 2002-12-27 | Allergan, Inc. | 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
-
2004
- 2004-02-06 RU RU2005129072/04A patent/RU2336081C2/ru active
- 2004-02-06 WO PCT/US2004/003433 patent/WO2004071428A2/en active Application Filing
- 2004-02-06 PL PL378421A patent/PL209130B1/pl unknown
- 2004-02-06 MX MXPA05008431A patent/MXPA05008431A/es active IP Right Grant
- 2004-02-06 BR BRPI0407400-9A patent/BRPI0407400A/pt not_active Application Discontinuation
- 2004-02-06 NZ NZ541352A patent/NZ541352A/en not_active IP Right Cessation
- 2004-02-06 CA CA2515631A patent/CA2515631C/en not_active Expired - Fee Related
- 2004-02-06 AU AU2004211936A patent/AU2004211936B2/en not_active Ceased
- 2004-02-06 JP JP2006503371A patent/JP5319065B2/ja not_active Expired - Lifetime
- 2004-02-06 KR KR1020057014697A patent/KR101077461B1/ko active IP Right Grant
- 2004-02-06 EP EP04709028A patent/EP1608309B1/en not_active Expired - Lifetime
-
2005
- 2005-08-01 NO NO20053715A patent/NO334659B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2515631A1 (en) | 2004-08-26 |
| WO2004071428A3 (en) | 2005-11-10 |
| WO2004071428A2 (en) | 2004-08-26 |
| KR20050101202A (ko) | 2005-10-20 |
| NO334659B1 (no) | 2014-05-12 |
| AU2004211936A1 (en) | 2004-08-26 |
| RU2005129072A (ru) | 2006-02-27 |
| RU2336081C2 (ru) | 2008-10-20 |
| NO20053715D0 (no) | 2005-08-01 |
| CA2515631C (en) | 2013-08-20 |
| PL209130B1 (pl) | 2011-07-29 |
| BRPI0407400A (pt) | 2006-02-21 |
| EP1608309B1 (en) | 2012-07-11 |
| AU2004211936B2 (en) | 2008-09-11 |
| NO20053715L (no) | 2005-10-27 |
| NZ541352A (en) | 2007-12-21 |
| JP2006517587A (ja) | 2006-07-27 |
| EP1608309A2 (en) | 2005-12-28 |
| JP5319065B2 (ja) | 2013-10-16 |
| PL378421A1 (pl) | 2006-04-03 |
| KR101077461B1 (ko) | 2011-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |