PL378421A1 - Pochodne kwasu 10,10-dialkiloprostanowego jako środki do obniżania ciśnienia śródgałkowego - Google Patents
Pochodne kwasu 10,10-dialkiloprostanowego jako środki do obniżania ciśnienia śródgałkowegoInfo
- Publication number
- PL378421A1 PL378421A1 PL378421A PL37842104A PL378421A1 PL 378421 A1 PL378421 A1 PL 378421A1 PL 378421 A PL378421 A PL 378421A PL 37842104 A PL37842104 A PL 37842104A PL 378421 A1 PL378421 A1 PL 378421A1
- Authority
- PL
- Poland
- Prior art keywords
- agents
- acid derivatives
- intraocular pressure
- glaucoma
- prostanoic acid
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title 1
- 230000004410 intraocular pressure Effects 0.000 title 1
- WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000000520 N-substituted aminocarbonyl group Chemical group [*]NC(=O)* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 or CO2R Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Wynalazek dotyczy sposobu leczenia nadciśnienia śródgałkowego lub jaskry, polegającego na podawaniu pacjentowi cierpiącemu na nadciśnienie śródgałkowe lub jaskrę skutecznej ilości związku o ogólnym wzorze (I), w którym linia kreskowana oznacza ewentualnie obecne wiązanie, kreskowany klin oznacza konfigurację wiązania skierowanego w dół (α), pełny trójkąt oznacza konfigurację wiązania skierowanego w górę (β); n oznacza 0-6; X oznacza CH2, S lub O; Y oznacza ugrupowanie farmaceutycznie dopuszczalnej soli CO2H, lub CO2R, CONR2, CONHCH2CH2OH, CON (CH2CH2OH)2, CH2OR, P(O)(OR)2, CONRSO2R, i SONR2, albo 1-R-podstawiony tetrazolil-5; R oznacza H, C1-6-alkil lub C2-6-alkenyl; R2 i R3 oznaczają liniowe C1-6-alkile, takie same lub różne, które mogą być związane ze sobą z utworzeniem pierścienia zawierającego atom węgla, do którego są przyłączone.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/365,369 US6875787B2 (en) | 2003-02-11 | 2003-02-11 | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
US10/772,720 US20040235958A1 (en) | 2003-02-11 | 2004-02-04 | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
Publications (2)
Publication Number | Publication Date |
---|---|
PL378421A1 true PL378421A1 (pl) | 2006-04-03 |
PL209130B1 PL209130B1 (pl) | 2011-07-29 |
Family
ID=32871611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL378421A PL209130B1 (pl) | 2003-02-11 | 2004-02-06 | Pochodne kwasu 10,10-dialkiloprostanowego, roztwór do stosowania w okulistyce, sposób wytwarzania związków pośrednich i zastosowanie pochodnych kwasu 10,10-dialkiloprostanowego |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1608309B1 (pl) |
JP (1) | JP5319065B2 (pl) |
KR (1) | KR101077461B1 (pl) |
AU (1) | AU2004211936B2 (pl) |
BR (1) | BRPI0407400A (pl) |
CA (1) | CA2515631C (pl) |
MX (1) | MXPA05008431A (pl) |
NO (1) | NO334659B1 (pl) |
NZ (1) | NZ541352A (pl) |
PL (1) | PL209130B1 (pl) |
RU (1) | RU2336081C2 (pl) |
WO (1) | WO2004071428A2 (pl) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7855226B2 (en) | 2003-02-11 | 2010-12-21 | Allergan, Inc. | Treatment of inflammatory bowel disease |
CA2585367A1 (en) * | 2004-10-26 | 2006-05-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
AU2012200514B2 (en) * | 2005-03-17 | 2014-03-06 | Allergan, Inc. | Treatment of inflammatory bowel disease |
PL2084124T3 (pl) * | 2006-10-02 | 2014-08-29 | Techfields Biochem Co Ltd | Dodatnio naładowane rozpuszczalne w wodzie proleki prostaglandyn i związków pokrewnych o bardzo dużych szybkościach przenikania przez skórę |
CN105566192B (zh) * | 2006-10-02 | 2019-01-22 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性的前列腺素及相关化合物的前药 |
US8455547B2 (en) * | 2008-02-05 | 2013-06-04 | Allergan, Inc. | Substituted cyclopentanes having prostaglandin activity |
US7732443B2 (en) * | 2008-03-18 | 2010-06-08 | Yariv Donde | Therapeutic substituted cyclopentanes |
WO2009137345A1 (en) * | 2008-05-09 | 2009-11-12 | Allergan, Inc. | Therapeutic compounds |
EP2488168A1 (en) | 2009-10-14 | 2012-08-22 | Gemmus Pharma Inc. | Combination therapy treatment for viral infections |
CN103068382A (zh) * | 2010-07-30 | 2013-04-24 | 阿勒根公司 | 用于皮肤修复的化合物和方法 |
SG187861A1 (en) * | 2010-08-17 | 2013-03-28 | Allergan Inc | Ep2 or ep4 agonists for treating corneal haze |
AU2014305843B2 (en) | 2013-08-09 | 2019-08-29 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4117014A (en) | 1976-01-09 | 1978-09-26 | Abbott Laboratories | Prostaglandin derivatives |
JPS59101458A (ja) * | 1982-12-01 | 1984-06-12 | Nippon Iyakuhin Kogyo Kk | 新規なチアプロスタグランジン誘導体及びその製法 |
JPS632972A (ja) * | 1986-06-20 | 1988-01-07 | Nippon Iyakuhin Kogyo Kk | 新規プロスタグランジンe↓1誘導体及びその製法 |
US5462968A (en) * | 1994-01-19 | 1995-10-31 | Allergan, Inc. | EP2 -receptor agonists as agents for lowering intraocular pressure |
US5877211A (en) * | 1997-11-21 | 1999-03-02 | Allergan | EP2 receptor agonists as neuroprotective agents for the eye |
US6410591B1 (en) * | 2001-05-08 | 2002-06-25 | Allergan Sales, Inc. | 3,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
US6531504B2 (en) * | 2001-05-17 | 2003-03-11 | Allergan, Inc. | Prostanoic acid derivatives as agents for lowering intraocular pressure |
AU2002259210B2 (en) * | 2001-06-14 | 2007-11-08 | Allergan, Inc. | 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
-
2004
- 2004-02-06 KR KR1020057014697A patent/KR101077461B1/ko active IP Right Grant
- 2004-02-06 JP JP2006503371A patent/JP5319065B2/ja not_active Expired - Lifetime
- 2004-02-06 PL PL378421A patent/PL209130B1/pl unknown
- 2004-02-06 AU AU2004211936A patent/AU2004211936B2/en not_active Ceased
- 2004-02-06 NZ NZ541352A patent/NZ541352A/en not_active IP Right Cessation
- 2004-02-06 EP EP04709028A patent/EP1608309B1/en not_active Expired - Lifetime
- 2004-02-06 CA CA2515631A patent/CA2515631C/en not_active Expired - Fee Related
- 2004-02-06 WO PCT/US2004/003433 patent/WO2004071428A2/en active Application Filing
- 2004-02-06 BR BRPI0407400-9A patent/BRPI0407400A/pt not_active Application Discontinuation
- 2004-02-06 MX MXPA05008431A patent/MXPA05008431A/es active IP Right Grant
- 2004-02-06 RU RU2005129072/04A patent/RU2336081C2/ru active
-
2005
- 2005-08-01 NO NO20053715A patent/NO334659B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO334659B1 (no) | 2014-05-12 |
AU2004211936A1 (en) | 2004-08-26 |
RU2005129072A (ru) | 2006-02-27 |
CA2515631A1 (en) | 2004-08-26 |
EP1608309B1 (en) | 2012-07-11 |
BRPI0407400A (pt) | 2006-02-21 |
JP5319065B2 (ja) | 2013-10-16 |
WO2004071428A3 (en) | 2005-11-10 |
PL209130B1 (pl) | 2011-07-29 |
JP2006517587A (ja) | 2006-07-27 |
RU2336081C2 (ru) | 2008-10-20 |
AU2004211936B2 (en) | 2008-09-11 |
NO20053715D0 (no) | 2005-08-01 |
EP1608309A2 (en) | 2005-12-28 |
NZ541352A (en) | 2007-12-21 |
KR20050101202A (ko) | 2005-10-20 |
CA2515631C (en) | 2013-08-20 |
WO2004071428A2 (en) | 2004-08-26 |
NO20053715L (no) | 2005-10-27 |
KR101077461B1 (ko) | 2011-10-26 |
MXPA05008431A (es) | 2005-10-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20053715L (no) | 10,10-dialkylprostanoinsyrederivater som midler for a senke intraokulaert trykk | |
TW200512184A (en) | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure | |
KR880007460A (ko) | 3-헤테로-치환된-n-벤질-인돌 | |
MY116542A (en) | New inhibitors of platelet aggregation. | |
NO20050470L (no) | Aminoalkoholderivater | |
HK1061645A1 (en) | 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure | |
WO2003094845A3 (en) | Pyridine-based thyroid receptor ligands | |
KR970701722A (ko) | 포스폰산 디에스테르 유도체(phosphonic diester derivative) | |
WO2002089813A3 (en) | 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure | |
EP0330461A3 (en) | Piperidine derivatives | |
WO2001058866A3 (en) | Ocular hypotensive lipids | |
DK1043310T3 (da) | Biphenylamidinderivater | |
CA2332513A1 (fr) | Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
DK1390036T3 (da) | Prostansyrederivater som midler til nedsættelse af intraokulært tryk | |
AU2002346671B2 (en) | Aminoalkyl-benzofuran-5-OL compounds for the treatment of glaucoma | |
ES2172376A1 (es) | Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
EP0307061B1 (en) | Anxiolytically active piperazine derivatives | |
JP2005513103A5 (pl) | ||
US4558037A (en) | Cardiovascular composition | |
US6127413A (en) | Ocular depressor | |
KR920006326A (ko) | 새로운 아미노산 유도체, 그것의 제조방법 및 그것을 함유하는 약학적 조성물 | |
EA200000373A2 (ru) | Новые соединения 1-аза-2-алкил-6-арилциклоалкана, способ их получения и содержащие их фармацевтические композиции | |
IL88573A (en) | 2-plasmin inhibitor depressant, urokinase secretion accelerator or thrombolytic composition comprising trihydroxypiperidine derivatives, nojirimycin or castanospermine | |
ES2354516T3 (es) | Derivados de pirrolid-2-ona 1,5-disustituida para su uso como agonista del receptor de ep4 en el tratamiento de enfermedades oculares tales como glaucoma. | |
CA2151443A1 (en) | Cycloheptimidazole derivatives, method of manufacturing the same and therapeutic agents containing these compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RECP | Rectifications of patent specification |