JP2004529928A5 - - Google Patents
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- Publication number
- JP2004529928A5 JP2004529928A5 JP2002582932A JP2002582932A JP2004529928A5 JP 2004529928 A5 JP2004529928 A5 JP 2004529928A5 JP 2002582932 A JP2002582932 A JP 2002582932A JP 2002582932 A JP2002582932 A JP 2002582932A JP 2004529928 A5 JP2004529928 A5 JP 2004529928A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen atom
- hydroxy
- alkyl
- agent according
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 24
- 239000003795 chemical substances by application Substances 0.000 claims 19
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 208000027866 inflammatory disease Diseases 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 230000002757 inflammatory effect Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical group CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 108010036949 Cyclosporine Proteins 0.000 claims 2
- 208000003435 Optic Neuritis Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229960001265 ciclosporin Drugs 0.000 claims 2
- 229930182912 cyclosporin Natural products 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 2
- 206010010736 Conjunctival ulcer Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022873 Ocular disease Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 206010039705 Scleritis Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 206010064996 Ulcerative keratitis Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 208000010217 blepharitis Diseases 0.000 claims 1
- 201000007717 corneal ulcer Diseases 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 239000003885 eye ointment Substances 0.000 claims 1
- 230000001976 improved effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000007803 itching Effects 0.000 claims 1
- 206010023332 keratitis Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28316901P | 2001-04-12 | 2001-04-12 | |
| PCT/JP2002/003664 WO2002085359A1 (en) | 2001-04-12 | 2002-04-12 | Agent for topical ophthalmic treatment of ocular inflammatory diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004529928A JP2004529928A (ja) | 2004-09-30 |
| JP2004529928A5 true JP2004529928A5 (OSRAM) | 2005-12-22 |
Family
ID=23084835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002582932A Abandoned JP2004529928A (ja) | 2001-04-12 | 2002-04-12 | 眼炎症疾患用眼局所処置剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20020187998A1 (OSRAM) |
| EP (1) | EP1379247A1 (OSRAM) |
| JP (1) | JP2004529928A (OSRAM) |
| KR (1) | KR20040007494A (OSRAM) |
| CN (1) | CN1503671A (OSRAM) |
| AR (1) | AR033151A1 (OSRAM) |
| BR (1) | BR0208939A (OSRAM) |
| CA (1) | CA2445508A1 (OSRAM) |
| MX (1) | MXPA03009273A (OSRAM) |
| NO (1) | NO20034560L (OSRAM) |
| NZ (1) | NZ529255A (OSRAM) |
| WO (1) | WO2002085359A1 (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003004098A1 (en) * | 2001-07-06 | 2003-01-16 | Sucampo Ag | Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent |
| RU2004118424A (ru) * | 2001-11-19 | 2005-05-10 | Новартис АГ (CH) | Применение аскомицина для лечения блефарита |
| US20050239813A1 (en) * | 2002-08-09 | 2005-10-27 | Sucampo Pharmaceuticals Inc. | Pharmaceutical compositions comprising fk506 derivatives and their use for the treatment of allergic diseases |
| US7354574B2 (en) | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| US20040198763A1 (en) * | 2003-01-16 | 2004-10-07 | Sucampo Ag | Method of treating dry eye with a macrolide compound |
| US7220422B2 (en) * | 2003-05-20 | 2007-05-22 | Allergan, Inc. | Methods and compositions for treating eye disorders |
| US7083802B2 (en) | 2003-07-31 | 2006-08-01 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| WO2005027906A1 (en) | 2003-09-18 | 2005-03-31 | Macusight, Inc. | Transscleral delivery |
| US7087237B2 (en) | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| US7083803B2 (en) | 2003-09-19 | 2006-08-01 | Advanced Ocular Systems Limited | Ocular solutions |
| US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
| GB2438544A (en) | 2005-02-09 | 2007-11-28 | Cooper Internat Corp | Liquid formulations for treatment of diseases or conditions |
| CA2635797C (en) | 2006-02-09 | 2015-03-31 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
| CN101443004B (zh) | 2006-03-23 | 2013-03-06 | 参天制药株式会社 | 用于与血管通透性有关的疾病或病症的制剂 |
| US8536190B2 (en) * | 2007-01-30 | 2013-09-17 | Allergan, Inc. | Treating unwanted ocular conditions using an ascomycin macrolactam |
| WO2015188126A1 (en) * | 2014-06-06 | 2015-12-10 | The Schepens Eye Research Institute, Inc. | Compositions and methods for treating tumors and immune based inflammatory diseases |
| PT3721868T (pt) * | 2015-01-26 | 2022-08-12 | Bausch & Lomb | Composição para suspensão oftálmica |
| KR101710412B1 (ko) | 2015-09-15 | 2017-02-27 | 인제대학교 산학협력단 | Ycg063을 유효성분으로 함유하는 염증성 안구질환 예방 또는 치료용 약학조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| EP0406791B1 (en) * | 1989-07-05 | 1995-02-01 | Fujisawa Pharmaceutical Co., Ltd. | Aqueous liquid composition for external use |
| DE69021833T2 (de) * | 1989-11-09 | 1996-03-21 | Sandoz Ag | Heteroatome enthaltende tricyclische Verbindungen. |
| IE65341B1 (en) * | 1990-11-08 | 1995-10-18 | Fujisawa Pharmaceutical Co | Suspensions containing tricyclic compounds |
| ATE198708T1 (de) * | 1991-04-26 | 2001-02-15 | Fujisawa Pharmaceutical Co | Verwendung von makrolid-verbindungen gegen augenerkrankungen |
| AR004480A1 (es) * | 1995-04-06 | 1998-12-16 | Amico Derin C D | Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen |
-
2002
- 2002-04-11 AR ARP020101334A patent/AR033151A1/es not_active Application Discontinuation
- 2002-04-12 WO PCT/JP2002/003664 patent/WO2002085359A1/en not_active Ceased
- 2002-04-12 EP EP02717124A patent/EP1379247A1/en not_active Withdrawn
- 2002-04-12 CA CA002445508A patent/CA2445508A1/en not_active Abandoned
- 2002-04-12 KR KR10-2003-7013323A patent/KR20040007494A/ko not_active Withdrawn
- 2002-04-12 US US10/120,515 patent/US20020187998A1/en not_active Abandoned
- 2002-04-12 BR BR0208939-4A patent/BR0208939A/pt not_active IP Right Cessation
- 2002-04-12 NZ NZ529255A patent/NZ529255A/en unknown
- 2002-04-12 CN CNA028082001A patent/CN1503671A/zh active Pending
- 2002-04-12 JP JP2002582932A patent/JP2004529928A/ja not_active Abandoned
- 2002-04-12 MX MXPA03009273A patent/MXPA03009273A/es unknown
-
2003
- 2003-10-10 NO NO20034560A patent/NO20034560L/no not_active Application Discontinuation
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