JP2004528809A5 - - Google Patents
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- Publication number
- JP2004528809A5 JP2004528809A5 JP2002532629A JP2002532629A JP2004528809A5 JP 2004528809 A5 JP2004528809 A5 JP 2004528809A5 JP 2002532629 A JP2002532629 A JP 2002532629A JP 2002532629 A JP2002532629 A JP 2002532629A JP 2004528809 A5 JP2004528809 A5 JP 2004528809A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- sequence seq
- consensus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 description 10
- 102100001715 RTN4RL1 Human genes 0.000 description 6
- 101710044032 RTN4RL1 Proteins 0.000 description 6
- 108010041253 Nogo Receptor 2 Proteins 0.000 description 4
- 102100001716 RTN4RL2 Human genes 0.000 description 4
- 229920002676 Complementary DNA Polymers 0.000 description 2
- 102000000343 Nogo Receptor 1 Human genes 0.000 description 2
- 108010041199 Nogo Receptor 1 Proteins 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 230000036881 Clu Effects 0.000 description 1
- 229920000453 Consensus sequence Polymers 0.000 description 1
- 229920001850 Nucleic acid sequence Polymers 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 230000000295 complement Effects 0.000 description 1
Description
【0398】
配列表のための手がかり:
配列番号1 ゲノム配列AC013606由来のヒトNgR2 cDNA配列
配列番号2 ヒトNgR2アミノ酸配列
配列番号3 AC021768由来のマウスNgR3 cDNA配列
配列番号4 マウスNgR3アミノ酸配列
配列番号5 ヒトNgR1アミノ酸配列
配列番号6 NgRのコンセンサスアミノ酸配列
配列番号7 hNogoA(Nogo−66)の番号1055〜1120アミノ酸残基
配列番号8 成熟ヒトNgR2アミノ酸配列
配列番号9 成熟マウスNgR3アミノ酸配列
配列番号10 コンセンサスNgR LLRNTアミノ酸配列
配列番号11 コンセンサスNgR LRRCTドメインアミノ酸配列
配列番号12 コンセンサスNgR LRRドメインアミノ酸配列
配列番号13 部分ヒトNgR3ヌクレオチド配列
配列番号14 部分ヒトNgR3アミノ酸配列
配列番号15 ヒトNgR2配列をコードするゲノム配列
配列番号16 マウスNgR3をコードするゲノム配列(相補鎖)
配列番号17 マウスNgR1アミノ酸配列
配列番号18 NgRのNTLRRCTドメインについてのコンセンサス配列
配列番号19 コンセンサスNgR LRRCTドメインアミノ酸配列。
【配列表】
配列表のための手がかり:
配列番号1 ゲノム配列AC013606由来のヒトNgR2 cDNA配列
配列番号2 ヒトNgR2アミノ酸配列
配列番号3 AC021768由来のマウスNgR3 cDNA配列
配列番号4 マウスNgR3アミノ酸配列
配列番号5 ヒトNgR1アミノ酸配列
配列番号6 NgRのコンセンサスアミノ酸配列
配列番号7 hNogoA(Nogo−66)の番号1055〜1120アミノ酸残基
配列番号8 成熟ヒトNgR2アミノ酸配列
配列番号9 成熟マウスNgR3アミノ酸配列
配列番号10 コンセンサスNgR LLRNTアミノ酸配列
配列番号11 コンセンサスNgR LRRCTドメインアミノ酸配列
配列番号12 コンセンサスNgR LRRドメインアミノ酸配列
配列番号13 部分ヒトNgR3ヌクレオチド配列
配列番号14 部分ヒトNgR3アミノ酸配列
配列番号15 ヒトNgR2配列をコードするゲノム配列
配列番号16 マウスNgR3をコードするゲノム配列(相補鎖)
配列番号17 マウスNgR1アミノ酸配列
配列番号18 NgRのNTLRRCTドメインについてのコンセンサス配列
配列番号19 コンセンサスNgR LRRCTドメインアミノ酸配列。
【配列表】
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23836100P | 2000-10-06 | 2000-10-06 | |
PCT/US2001/031488 WO2002029059A2 (en) | 2000-10-06 | 2001-10-06 | Nogo receptor homologs |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009022063A Division JP2009100767A (ja) | 2000-10-06 | 2009-02-02 | Nogoレセプターホモログ |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2004528809A JP2004528809A (ja) | 2004-09-24 |
JP2004528809A5 true JP2004528809A5 (ja) | 2005-03-03 |
JP4465148B2 JP4465148B2 (ja) | 2010-05-19 |
Family
ID=22897532
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002532629A Expired - Fee Related JP4465148B2 (ja) | 2000-10-06 | 2001-10-06 | Nogoレセプターホモログ |
JP2009022063A Withdrawn JP2009100767A (ja) | 2000-10-06 | 2009-02-02 | Nogoレセプターホモログ |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009022063A Withdrawn JP2009100767A (ja) | 2000-10-06 | 2009-02-02 | Nogoレセプターホモログ |
Country Status (12)
Country | Link |
---|---|
US (5) | US20030124704A1 (ja) |
EP (1) | EP1325130B1 (ja) |
JP (2) | JP4465148B2 (ja) |
AT (1) | ATE458815T1 (ja) |
AU (2) | AU1153902A (ja) |
CA (1) | CA2424834A1 (ja) |
DE (1) | DE60141409D1 (ja) |
DK (1) | DK1325130T3 (ja) |
ES (1) | ES2341608T3 (ja) |
NZ (1) | NZ525422A (ja) |
PT (1) | PT1325130E (ja) |
WO (1) | WO2002029059A2 (ja) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7119165B2 (en) | 2000-01-12 | 2006-10-10 | Yale University | Nogo receptor-mediated blockade of axonal growth |
DK1325130T3 (da) * | 2000-10-06 | 2010-05-25 | Univ Yale | Nogo-Receptorhomologer |
EP1423427A2 (en) * | 2001-08-27 | 2004-06-02 | Novartis AG | Nogo receptor homologues and their use |
JP2005519584A (ja) * | 2001-10-22 | 2005-07-07 | ノバルティス アクチエンゲゼルシャフト | Nogoレセプターホモログおよびそれらの使用 |
US7309485B2 (en) * | 2001-12-03 | 2007-12-18 | Children's Medical Center Corporation | Reducing myelin-mediated inhibition of axon regeneration |
AU2003246254A1 (en) * | 2002-07-05 | 2004-01-23 | Shionogi And Co., Ltd. | NOVEL Nogo RECEPTOR-LIKE POLYPEPTIDE AND DNA THEREOF |
BR0313331A (pt) | 2002-08-10 | 2007-07-24 | Univ Yale | antagonistas de receptor de nogo |
PL378582A1 (pl) | 2003-03-19 | 2006-05-02 | Biogen Idec Ma Inc. | Białko wiążące receptor Nogo |
US7541335B2 (en) | 2003-04-04 | 2009-06-02 | University Of Rochester | Nogo-receptors and methods of use |
US20070065429A1 (en) * | 2003-04-16 | 2007-03-22 | Biogen Idec Ma Inc. | Nogo-receptor antagonists for the treatment of conditions involving amyloid plaques |
US20080274112A1 (en) * | 2003-08-07 | 2008-11-06 | Lee Daniel H S | Nogo Receptor Antagonists |
US8912144B2 (en) * | 2003-12-16 | 2014-12-16 | Children's Medical Center Corporation | Method for treating stroke via administration of NEP1-40 and inosine |
US20080274077A1 (en) * | 2003-12-16 | 2008-11-06 | Children's Medical Center Corporation | Method for Treating Neurological Disorders |
JP2007519737A (ja) * | 2004-01-30 | 2007-07-19 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Nogoレセプターアンタゴニストを使用するドーパミンニューロン変性に関する状態の処置 |
AU2005258335B2 (en) | 2004-06-24 | 2011-03-17 | Biogen Ma Inc. | Treatment of conditions involving demyelination |
WO2006047049A2 (en) * | 2004-10-01 | 2006-05-04 | Yale University | Nogo-a polypeptide fragments, variant nogo receptor-1 polypeptides, and uses thereof |
EP1904091A4 (en) * | 2005-07-07 | 2009-12-23 | Univ Yale | COMPOSITIONS AND METHODS FOR SUPPRESSING THE INHIBITION OF AXON GROWTH |
MX2008000253A (es) | 2005-07-08 | 2008-04-02 | Biogen Idec Inc | Anticuerpos de sp35 y usos de los mismos. |
CA2619406A1 (en) * | 2005-08-25 | 2007-03-01 | Biogen Idec Ma Inc. | Nogo receptor polypeptides and polypeptide fragments and uses thereof |
ES2550099T3 (es) | 2006-01-27 | 2015-11-04 | Biogen Ma Inc. | Antagonistas del receptor Nogo |
JP2009538282A (ja) * | 2006-05-15 | 2009-11-05 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 乏突起膠細胞の生存を促進させるためのNogo受容体−1(NgR1)アンタゴニストの使用 |
US20080025959A1 (en) * | 2006-05-24 | 2008-01-31 | Richard Daneman | Permeability of blood-brain barrier |
EP2503341A3 (en) * | 2006-11-14 | 2012-10-03 | Genentech, Inc. | Modulators of Neuronal Regeneration |
US20100047232A1 (en) * | 2006-11-14 | 2010-02-25 | Jasvinder Atwal | Modulators of neuronal regeneration |
WO2009009743A2 (en) * | 2007-07-12 | 2009-01-15 | Institute For Advance Study | Sequence optimization for expression of a foreign gene |
AU2008335245A1 (en) * | 2007-12-11 | 2009-06-18 | Genentech, Inc. | Modulators of neuronal regeneration |
WO2009114197A2 (en) | 2008-03-13 | 2009-09-17 | Yale University | Reactivation of axon growth and recovery in chronic spinal cord injury |
CL2009001155A1 (es) * | 2008-05-13 | 2010-06-04 | Genentech Inc | Anticuerpo anti-pirb/lilrb aislado; polinucleotido que lo codifica; vector; celula huesped; metodo de obtencion; composicion farmaceutica que lo comprende; kit; y su uso para tratar enfermedades neurodegenerativas. |
EP2315779A2 (en) | 2008-07-09 | 2011-05-04 | Biogen Idec MA Inc. | Compositions comprising antibodies to lingo or fragments thereof |
EP2392208B1 (en) * | 2010-06-07 | 2016-05-04 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins comprising a DNA-binding domain of a Tal effector protein and a non-specific cleavage domain of a restriction nuclease and their use |
US9120111B2 (en) | 2012-02-24 | 2015-09-01 | Rain Bird Corporation | Arc adjustable rotary sprinkler having full-circle operation and automatic matched precipitation |
CN104470541A (zh) | 2012-05-14 | 2015-03-25 | 比奥根艾迪克Ma公司 | 用于治疗涉及运动神经元的疾患的lingo-2拮抗剂 |
US9156043B2 (en) | 2012-07-13 | 2015-10-13 | Rain Bird Corporation | Arc adjustable rotary sprinkler with automatic matched precipitation |
JP2018504400A (ja) | 2015-01-08 | 2018-02-15 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Lingo‐1拮抗薬及び脱髄障害の治療のための使用 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5250414A (en) | 1988-11-04 | 1993-10-05 | Erziehungsdirektion Of The Canton Zurich | Diagnostic methods using neurite growth regulatory factors |
WO1990005191A1 (en) | 1988-11-04 | 1990-05-17 | Erziehungsdirektion Of The Canton Zurich | Neurite growth regulatory factors |
CA1341050C (en) | 1988-11-04 | 2000-07-11 | Martin E. Schwab | Neurite growth regulatory factors |
JPH07509002A (ja) | 1993-02-11 | 1995-10-05 | エルツィーヒュングスディレクション オブ ザ キャントン チューリッヒ | ニューロトロフィンとミエリン−関連の軸索成長阻害タンパク質に対する抗体との組み合わせが中枢神経系の再生を促進する |
WO2000073452A2 (en) | 1999-06-02 | 2000-12-07 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
WO2000053758A2 (en) | 1999-03-08 | 2000-09-14 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
US5858708A (en) | 1996-08-12 | 1999-01-12 | Bandman; Olga | Polynucleotides encoding two novel human neuroendocrine-specific proteins |
JP2003521216A (ja) * | 1997-08-05 | 2003-07-15 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 90個のヒト分泌タンパク質 |
NZ507435A (en) | 1998-03-10 | 2003-12-19 | Genentech Inc | Novel polypeptides and nucleic acids with homology to cornichon |
AU4682999A (en) * | 1998-06-16 | 2000-01-05 | Human Genome Sciences, Inc. | 94 human secreted proteins |
JP2002522016A (ja) | 1998-07-22 | 2002-07-23 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 神経内分泌特異的タンパク質に類似したタンパク質、およびそれをコードするcDNA |
CZ304224B6 (cs) * | 1998-11-06 | 2014-01-15 | Schwab | Monoklonální protilátka |
JP3695642B2 (ja) | 1998-12-01 | 2005-09-14 | ジェネンテック・インコーポレーテッド | 血管形成及び心臓血管新生の促進又は阻害 |
DE69940964D1 (de) | 1998-12-22 | 2009-07-16 | Genentech Inc | Verfahren und Zusammensetzungen zur Hemmung des neoplastischen Zellenwachstums |
EP1263948A2 (en) | 1999-03-08 | 2002-12-11 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
WO2000058473A2 (en) | 1999-03-31 | 2000-10-05 | Curagen Corporation | Nucleic acids including open reading frames encoding polypeptides; 'orfx' |
AU3632600A (en) | 1999-05-14 | 2000-12-05 | Genentech Inc. | Compositions and methods for the treatment of immune related diseases |
EP1268506A4 (en) | 1999-07-30 | 2004-07-28 | Millennium Pharm Inc | SECRET PROTEINS AND THEIR USE |
AU2575901A (en) | 1999-12-08 | 2001-06-18 | Millennium Pharmaceuticals, Inc. | Novel leucine rich repeat-containing molecules and uses therefor |
CZ20022438A3 (cs) * | 2000-01-12 | 2002-10-16 | Yale University | Nukleová kyselina kódující receptor Nogo, izolovaný polypeptid a farmaceutický přípravek pro stimulaci růstu axonů |
US7119165B2 (en) * | 2000-01-12 | 2006-10-10 | Yale University | Nogo receptor-mediated blockade of axonal growth |
US6436703B1 (en) * | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
CA2376873A1 (en) | 2000-04-18 | 2001-10-25 | Teijin Limited | Oxygen concentrating apparatus |
DK1325130T3 (da) * | 2000-10-06 | 2010-05-25 | Univ Yale | Nogo-Receptorhomologer |
EP1423427A2 (en) | 2001-08-27 | 2004-06-02 | Novartis AG | Nogo receptor homologues and their use |
JP2005519584A (ja) | 2001-10-22 | 2005-07-07 | ノバルティス アクチエンゲゼルシャフト | Nogoレセプターホモログおよびそれらの使用 |
BR0313331A (pt) | 2002-08-10 | 2007-07-24 | Univ Yale | antagonistas de receptor de nogo |
-
2001
- 2001-10-06 DK DK01979595.4T patent/DK1325130T3/da active
- 2001-10-06 DE DE60141409T patent/DE60141409D1/de not_active Expired - Lifetime
- 2001-10-06 AT AT01979595T patent/ATE458815T1/de active
- 2001-10-06 PT PT01979595T patent/PT1325130E/pt unknown
- 2001-10-06 JP JP2002532629A patent/JP4465148B2/ja not_active Expired - Fee Related
- 2001-10-06 CA CA002424834A patent/CA2424834A1/en not_active Abandoned
- 2001-10-06 AU AU1153902A patent/AU1153902A/xx active Pending
- 2001-10-06 EP EP01979595A patent/EP1325130B1/en not_active Expired - Lifetime
- 2001-10-06 WO PCT/US2001/031488 patent/WO2002029059A2/en active Application Filing
- 2001-10-06 ES ES01979595T patent/ES2341608T3/es not_active Expired - Lifetime
- 2001-10-06 NZ NZ525422A patent/NZ525422A/en unknown
- 2001-10-06 US US09/972,546 patent/US20030124704A1/en not_active Abandoned
- 2001-10-06 AU AU2002211539A patent/AU2002211539B2/en not_active Ceased
-
2003
- 2003-12-12 US US10/735,256 patent/US7173118B2/en not_active Expired - Lifetime
-
2006
- 2006-10-06 US US11/544,013 patent/US7456255B2/en not_active Expired - Lifetime
-
2008
- 2008-11-24 US US12/277,187 patent/US20090175850A1/en not_active Abandoned
-
2009
- 2009-02-02 JP JP2009022063A patent/JP2009100767A/ja not_active Withdrawn
-
2010
- 2010-11-23 US US12/952,747 patent/US20110129477A1/en not_active Abandoned
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