JP2004528364A5 - - Google Patents
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- Publication number
- JP2004528364A5 JP2004528364A5 JP2002586949A JP2002586949A JP2004528364A5 JP 2004528364 A5 JP2004528364 A5 JP 2004528364A5 JP 2002586949 A JP2002586949 A JP 2002586949A JP 2002586949 A JP2002586949 A JP 2002586949A JP 2004528364 A5 JP2004528364 A5 JP 2004528364A5
- Authority
- JP
- Japan
- Prior art keywords
- methyleneandrost
- pharmaceutical composition
- compound
- give
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 6
- JMCNUPJJRLUBQN-JZCOGDJRSA-N (3r,8s,9s,10r,13s,14s)-10,13-dimethyl-17-methylidene-1,2,3,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-ol Chemical compound O[C@@H]1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=C)[C@@H]4[C@@H]3CCC2=C1 JMCNUPJJRLUBQN-JZCOGDJRSA-N 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims 5
- 229940127557 pharmaceutical product Drugs 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- JMCNUPJJRLUBQN-SIRBJWHBSA-N (3s,8s,9s,10r,13s,14s)-10,13-dimethyl-17-methylidene-1,2,3,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-ol Chemical compound O[C@H]1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=C)[C@@H]4[C@@H]3CCC2=C1 JMCNUPJJRLUBQN-SIRBJWHBSA-N 0.000 claims 2
- QXEURENTQIAFIS-FSGKZVOOSA-N (8s,9s,10r,13s,14s)-10,13-dimethyl-17-methylidene-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=C)[C@@H]4[C@@H]3CCC2=C1 QXEURENTQIAFIS-FSGKZVOOSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- CDCQHKMEOJJEBD-SIRBJWHBSA-N (3s,8s,9s,10r,13s,14s)-10,13-dimethyl-17-methylidene-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-ol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=C)[C@@H]4[C@@H]3CC=C21 CDCQHKMEOJJEBD-SIRBJWHBSA-N 0.000 claims 1
- FMGSKLZLMKYGDP-UHFFFAOYSA-N Dehydroepiandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 FMGSKLZLMKYGDP-UHFFFAOYSA-N 0.000 claims 1
- 238000006751 Mitsunobu reaction Methods 0.000 claims 1
- 238000007239 Wittig reaction Methods 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- XQTIWNLDFPPCIU-UHFFFAOYSA-N cerium(3+) Chemical class [Ce+3] XQTIWNLDFPPCIU-UHFFFAOYSA-N 0.000 claims 1
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 229960002847 prasterone Drugs 0.000 claims 1
- 229910000033 sodium borohydride Inorganic materials 0.000 claims 1
- 239000012279 sodium borohydride Substances 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 210000001121 vomeronasal organ Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/848,247 US20030045514A1 (en) | 2001-05-03 | 2001-05-03 | 17-Methyleneandrostan-3alpha-ol analogs as CRH inhibitors |
| PCT/US2002/013255 WO2002089814A1 (en) | 2001-05-03 | 2002-04-26 | 17-METHYLENE-ANDROSTAN-3α-OL ANALOGS AS CRH INHIBITORS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004528364A JP2004528364A (ja) | 2004-09-16 |
| JP2004528364A5 true JP2004528364A5 (https=) | 2005-12-22 |
Family
ID=25302777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002586949A Pending JP2004528364A (ja) | 2001-05-03 | 2002-04-26 | ＣＲＨインヒビターとしての１７−メチレンアンドロスタン−３α−オールアナログ |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20030045514A1 (https=) |
| EP (1) | EP1392320B1 (https=) |
| JP (1) | JP2004528364A (https=) |
| CA (1) | CA2484596A1 (https=) |
| DE (1) | DE60217480T2 (https=) |
| ES (1) | ES2278962T3 (https=) |
| MX (1) | MXPA03010055A (https=) |
| WO (1) | WO2002089814A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008504329A (ja) * | 2004-06-29 | 2008-02-14 | ヤド テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 脂質ラフト内の病理プロセスに関係する障害を治療するためのステロイド由来の医薬組成物の使用 |
| DK2278880T3 (da) * | 2008-04-09 | 2012-11-12 | Pherin Pharm Inc | Steroidbehandling af hedeture |
| CL2009001233A1 (es) * | 2008-05-21 | 2009-08-07 | Gruenenthal Gmbh | Procedimiento para la obtencion del acetato de 3 alfa-hidrocicloromadinona por reduccion del acetato de cloromadinona con un hidruro,con posterior inversion de la configuracion de la posicion 3; y uno de los compuestos intermediarios considerados. |
| US20120214987A1 (en) * | 2010-12-15 | 2012-08-23 | Yu Ge | Methods and compounds for preparing 3alpha-oxygen substituted steroids |
| AU2012260955B2 (en) * | 2011-05-20 | 2017-08-17 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Antagonists of CB1 receptor. |
| AU2013351190B2 (en) | 2012-11-28 | 2018-03-29 | Alienor Farma | 3-(4'-substituted)-benzyl-ether derivatives of pregnenolone |
| AU2013371025B2 (en) | 2012-12-28 | 2018-01-18 | Pherin Pharmaceuticals, Inc. | Use of pregn-4-en-20-yn-3-one for the treatment of depressive disorders |
| US10729693B2 (en) * | 2018-03-02 | 2020-08-04 | Ponce Medical School Foundation, Inc. | Compositions and methods for the treatment of endometriosis |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5969168A (en) * | 1991-01-07 | 1999-10-19 | Pherin Corporation | Androstanes for inducing hypothalamic effects |
| US6057439A (en) * | 1994-08-04 | 2000-05-02 | Pherin Corporation | Steroids as neurochemical stimulators of the VNO to alleviate symptoms of PMS and anxiety |
| US5563131A (en) * | 1994-08-04 | 1996-10-08 | Pherin Corporation | Pregnane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods |
| US5994333A (en) * | 1994-08-04 | 1999-11-30 | Pherin Corporation | Pregnane and cholane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods |
| GB9626746D0 (en) * | 1996-12-23 | 1997-02-12 | Knoll Ag | Process |
-
2001
- 2001-05-03 US US09/848,247 patent/US20030045514A1/en not_active Abandoned
-
2002
- 2002-04-26 CA CA002484596A patent/CA2484596A1/en not_active Abandoned
- 2002-04-26 MX MXPA03010055A patent/MXPA03010055A/es active IP Right Grant
- 2002-04-26 WO PCT/US2002/013255 patent/WO2002089814A1/en not_active Ceased
- 2002-04-26 JP JP2002586949A patent/JP2004528364A/ja active Pending
- 2002-04-26 DE DE60217480T patent/DE60217480T2/de not_active Expired - Lifetime
- 2002-04-26 EP EP02769291A patent/EP1392320B1/en not_active Expired - Lifetime
- 2002-04-26 ES ES02769291T patent/ES2278962T3/es not_active Expired - Lifetime
-
2003
- 2003-06-13 US US10/461,788 patent/US20030220309A1/en not_active Abandoned
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