MXPA03010055A - Analogos de 17-metileno-androstan-3a-ol como inhibidores de hlc. - Google Patents
Analogos de 17-metileno-androstan-3a-ol como inhibidores de hlc.Info
- Publication number
- MXPA03010055A MXPA03010055A MXPA03010055A MXPA03010055A MXPA03010055A MX PA03010055 A MXPA03010055 A MX PA03010055A MX PA03010055 A MXPA03010055 A MX PA03010055A MX PA03010055 A MXPA03010055 A MX PA03010055A MX PA03010055 A MXPA03010055 A MX PA03010055A
- Authority
- MX
- Mexico
- Prior art keywords
- 3alpha
- androstan
- analogs
- methylene
- crh
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los analogos de 17-metileno-androstan-3a-ol son utiles como inhibidores de hormona liberadora de corticotropina (HLC), y especialmente como antidepresivos, cuando se administran al organo vomeronasal. Se describe una sintesis de 17-metiIenoandrost-4-en-3a -ol.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/848,247 US20030045514A1 (en) | 2001-05-03 | 2001-05-03 | 17-Methyleneandrostan-3alpha-ol analogs as CRH inhibitors |
PCT/US2002/013255 WO2002089814A1 (en) | 2001-05-03 | 2002-04-26 | 17-METHYLENE-ANDROSTAN-3α-OL ANALOGS AS CRH INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03010055A true MXPA03010055A (es) | 2004-04-02 |
Family
ID=25302777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03010055A MXPA03010055A (es) | 2001-05-03 | 2002-04-26 | Analogos de 17-metileno-androstan-3a-ol como inhibidores de hlc. |
Country Status (8)
Country | Link |
---|---|
US (2) | US20030045514A1 (es) |
EP (1) | EP1392320B1 (es) |
JP (1) | JP2004528364A (es) |
CA (1) | CA2484596A1 (es) |
DE (1) | DE60217480T2 (es) |
ES (1) | ES2278962T3 (es) |
MX (1) | MXPA03010055A (es) |
WO (1) | WO2002089814A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1789056A1 (en) * | 2004-06-29 | 2007-05-30 | Jado Technologies GmbH | Use of steroid-derived pharmaceutical compositions for treating disorders relating to pathological processes in lipid rafts |
MX2010011063A (es) * | 2008-04-09 | 2010-11-22 | Pherin Pharm Inc | Tratamiento esteroidal para sofocos. |
PE20091929A1 (es) * | 2008-05-21 | 2010-01-09 | Gruenenthal Chemie | Procedimientos para la sintesis selectiva del acetato de 3alfa-hidroxicloromadinona |
CN103347525A (zh) * | 2010-12-15 | 2013-10-09 | 哈博生物科学公司 | 制备3α-氧取代的甾族化合物的方法及化合物 |
HUE051938T2 (hu) | 2011-05-20 | 2021-03-29 | Inst Nat Sante Rech Med | CB1 receptor antagonisták |
AU2013351190B2 (en) | 2012-11-28 | 2018-03-29 | Alienor Farma | 3-(4'-substituted)-benzyl-ether derivatives of pregnenolone |
AU2013371025B2 (en) | 2012-12-28 | 2018-01-18 | Pherin Pharmaceuticals, Inc. | Use of pregn-4-en-20-yn-3-one for the treatment of depressive disorders |
US10729693B2 (en) * | 2018-03-02 | 2020-08-04 | Ponce Medical School Foundation, Inc. | Compositions and methods for the treatment of endometriosis |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5969168A (en) * | 1991-01-07 | 1999-10-19 | Pherin Corporation | Androstanes for inducing hypothalamic effects |
US5563131A (en) * | 1994-08-04 | 1996-10-08 | Pherin Corporation | Pregnane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods |
US5994333A (en) * | 1994-08-04 | 1999-11-30 | Pherin Corporation | Pregnane and cholane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods |
US6057439A (en) * | 1994-08-04 | 2000-05-02 | Pherin Corporation | Steroids as neurochemical stimulators of the VNO to alleviate symptoms of PMS and anxiety |
GB9626746D0 (en) * | 1996-12-23 | 1997-02-12 | Knoll Ag | Process |
-
2001
- 2001-05-03 US US09/848,247 patent/US20030045514A1/en not_active Abandoned
-
2002
- 2002-04-26 CA CA002484596A patent/CA2484596A1/en not_active Abandoned
- 2002-04-26 ES ES02769291T patent/ES2278962T3/es not_active Expired - Lifetime
- 2002-04-26 JP JP2002586949A patent/JP2004528364A/ja active Pending
- 2002-04-26 EP EP02769291A patent/EP1392320B1/en not_active Expired - Lifetime
- 2002-04-26 MX MXPA03010055A patent/MXPA03010055A/es active IP Right Grant
- 2002-04-26 WO PCT/US2002/013255 patent/WO2002089814A1/en active IP Right Grant
- 2002-04-26 DE DE60217480T patent/DE60217480T2/de not_active Expired - Lifetime
-
2003
- 2003-06-13 US US10/461,788 patent/US20030220309A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2278962T3 (es) | 2007-08-16 |
WO2002089814A1 (en) | 2002-11-14 |
DE60217480T2 (de) | 2007-10-25 |
US20030045514A1 (en) | 2003-03-06 |
JP2004528364A (ja) | 2004-09-16 |
US20030220309A1 (en) | 2003-11-27 |
EP1392320A1 (en) | 2004-03-03 |
CA2484596A1 (en) | 2002-11-14 |
DE60217480D1 (de) | 2007-02-22 |
EP1392320B1 (en) | 2007-01-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GEP20074078B (en) | Fluoro substituted cyclo-alkanoindoles, compositions comprising them and their use | |
MXPA05001061A (es) | Composiciones farmaceuticas, acuosas de 2,6-diisopropilfenol. | |
BRPI0417684A (pt) | composto, composição farmacêutica, e, uso de um composto | |
WO2003103603A3 (en) | NEW FORMIATE-TYPE SALT OF O-DESMETHYLVENLAFAXINE | |
TNSN07235A1 (en) | Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride | |
UY27465A1 (es) | Métodos y composiciones para tratar flavivirus y pestivirus con 4' modificaciones nucleosides | |
IL161154A0 (en) | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | |
AU7743001A (en) | Cyclopentanoindoles, compositions containing such compounds and methods of treatment | |
MXPA05002942A (es) | Forma de dosificacion oral de liberacion modificada. | |
AU8645401A (en) | Substituted pyrazoles | |
ATE423562T1 (de) | Alpha-ketoamidhaltige multikatalytische protease inhibitoren | |
TW200605863A (en) | Bazedoxifene acetate formulations | |
EG23185A (en) | Active compound combinations having insecticidal and acaricidal properties. | |
EP1755388A4 (en) | MIXED CO-CRYSTALS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | |
MXPA03010055A (es) | Analogos de 17-metileno-androstan-3a-ol como inhibidores de hlc. | |
AP2002002427A0 (en) | Ppar compounds. | |
RS44204A (en) | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | |
DK1414467T3 (da) | Topisk behandling af mastalgi | |
RS44304A (en) | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | |
DK1401279T3 (da) | Acaricidpulver | |
TW200706173A (en) | Oral composition comprising carbamylating agent | |
WO2003073988A3 (en) | Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof | |
MXPA05012655A (es) | Isomeros puros d-(17a)-13 -etil-17-hidroxi -18, 19-dinorpregn- 4-eno-20-ino -3-ona-3e -y ??3z- oxima, asi como el proceso para la sintesis de la mezcla de isomeros y los isomeros puros. | |
ATE364619T1 (de) | Tibolonformulierungen | |
WO2003070177A3 (en) | Use of melatonin analogues for induction of general anesthesia |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |