MXPA05012655A - Isomeros puros d-(17a)-13 -etil-17-hidroxi -18, 19-dinorpregn- 4-eno-20-ino -3-ona-3e -y ??3z- oxima, asi como el proceso para la sintesis de la mezcla de isomeros y los isomeros puros. - Google Patents
Isomeros puros d-(17a)-13 -etil-17-hidroxi -18, 19-dinorpregn- 4-eno-20-ino -3-ona-3e -y ??3z- oxima, asi como el proceso para la sintesis de la mezcla de isomeros y los isomeros puros.Info
- Publication number
- MXPA05012655A MXPA05012655A MXPA05012655A MXPA05012655A MXPA05012655A MX PA05012655 A MXPA05012655 A MX PA05012655A MX PA05012655 A MXPA05012655 A MX PA05012655A MX PA05012655 A MXPA05012655 A MX PA05012655A MX PA05012655 A MXPA05012655 A MX PA05012655A
- Authority
- MX
- Mexico
- Prior art keywords
- isomers
- pure
- dinorpregn
- yne
- ene
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000583 progesterone congener Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Indole Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente invencion se refiere al isomero d-(17?)-13-etil -17-hidroxi-18, 19-dinorpregn-4 -eno-20-ino -3-ona- 3E-oxima puro de la formula (IA), el isomero de d-(17?)-13-etil- 17-hidroxi-18, 19-dinorpregn-4- eno-20-ino- 3-ona-3E-oxima puro de la formula (IB), los cuales tienen actividad de gestagen, asi como al proceso para la sintesis de la mezcla de los isomeros anteriores y los isomeros puros. La presente invencion tambien se refiere a las composiciones farmaceuticas - y al proceso para su sintesis - las cuales contienen ya sea el isomero puro de la formula (IA) o el isomero puro de la formula (IB) como el ingrediente activo, o en combinacion con otros ingredientes activos (por ejemplo un agente de oestrogenos) junto con materiales auxiliares farmaceuticos que comunmente se utilizan en la practica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0301981A HUP0301981A2 (hu) | 2003-06-30 | 2003-06-30 | Tiszta d-(17alfa)-13-etil-17-hidroxi-18,19-dinor-pregn-4-én-20-in-3-on-3E- és 3Z-oxim izomerek, valamint eljárás az izomer keverékek és a tiszta izomerek előállítására |
| PCT/HU2004/000030 WO2005000867A1 (en) | 2003-06-30 | 2004-04-29 | PURE D-(17α)-13-ETHYL-17-HYDROXY-18,19-DINORPREGN-4-ENE-20-YNE-3-ONE-3E- AND -3Z-OXIME ISOMERS, AS WELL AS PROCESS FOR THE SYNTHESIS OF THE MIXTURE OF ISOMERS AND THE PURE ISOMERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05012655A true MXPA05012655A (es) | 2006-02-22 |
Family
ID=90001693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05012655A MXPA05012655A (es) | 2003-06-30 | 2004-04-29 | Isomeros puros d-(17a)-13 -etil-17-hidroxi -18, 19-dinorpregn- 4-eno-20-ino -3-ona-3e -y ??3z- oxima, asi como el proceso para la sintesis de la mezcla de isomeros y los isomeros puros. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1641812B1 (es) |
| JP (1) | JP2007534617A (es) |
| CN (1) | CN100497368C (es) |
| AT (1) | ATE470669T1 (es) |
| AU (1) | AU2004251117A1 (es) |
| BR (1) | BRPI0411734A (es) |
| CA (1) | CA2526305A1 (es) |
| DE (1) | DE602004027629D1 (es) |
| EA (1) | EA008174B1 (es) |
| HR (1) | HRP20060040A2 (es) |
| HU (1) | HUP0301981A2 (es) |
| MX (1) | MXPA05012655A (es) |
| NO (1) | NO20060456L (es) |
| NZ (1) | NZ544481A (es) |
| RS (1) | RS20050816A (es) |
| UA (1) | UA85190C2 (es) |
| WO (1) | WO2005000867A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6734277B2 (en) | 2002-05-09 | 2004-05-11 | General Electric Company | Method of enhancing pit replication in optical disks |
| US7576226B2 (en) | 2003-06-30 | 2009-08-18 | Richter Gedeon Vegyeszeti Gyar Rt. | Process of making isomers of norelgestromin and methods using the same |
| CA2575138A1 (en) * | 2004-08-12 | 2006-02-23 | Sicor, Inc. | Process for the preparation of 3-oximino steroids |
| US9056061B2 (en) * | 2005-09-23 | 2015-06-16 | Alza Corporation | Transdermal nicotine salt delivery system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1123104A (en) * | 1965-10-22 | 1968-08-14 | Ortho Pharma Corp | 3-oxime-steroids and method of preparation |
| AT343292B (de) * | 1973-03-01 | 1978-05-26 | Ortho Pharma Corp | Verfahren zur herstellung von neuen steroid-3-oxim-derivaten |
| US4027019A (en) * | 1975-07-24 | 1977-05-31 | Ortho Pharmaceutical Corporation | 3-Oximes of D-17α-ethynyl-19-nortestosterone esters and method |
| JPS624400A (ja) * | 1985-06-29 | 1987-01-10 | 内藤 喜之 | マイクロ波用アンテナ |
| NO301689B1 (no) * | 1987-09-24 | 1997-12-01 | Jencap Research Ltd | Kontraseptivt preparat i form av en forpakning |
| HU228434B1 (en) * | 1995-06-07 | 2013-03-28 | Ortho Mcneil Pharm Inc | Transdermal medicament for administering 17-deacetyl norgestimate alone or in combination with an estrogen |
-
2003
- 2003-06-30 HU HU0301981A patent/HUP0301981A2/hu unknown
-
2004
- 2004-04-29 CN CNB2004800152174A patent/CN100497368C/zh not_active Expired - Fee Related
- 2004-04-29 MX MXPA05012655A patent/MXPA05012655A/es unknown
- 2004-04-29 AT AT04730317T patent/ATE470669T1/de not_active IP Right Cessation
- 2004-04-29 UA UAA200600814A patent/UA85190C2/ru unknown
- 2004-04-29 JP JP2006518377A patent/JP2007534617A/ja active Pending
- 2004-04-29 EA EA200600120A patent/EA008174B1/ru not_active IP Right Cessation
- 2004-04-29 WO PCT/HU2004/000030 patent/WO2005000867A1/en active Application Filing
- 2004-04-29 BR BRPI0411734-4A patent/BRPI0411734A/pt not_active IP Right Cessation
- 2004-04-29 DE DE602004027629T patent/DE602004027629D1/de not_active Expired - Lifetime
- 2004-04-29 NZ NZ544481A patent/NZ544481A/xx unknown
- 2004-04-29 RS YUP-2005/0816A patent/RS20050816A/sr unknown
- 2004-04-29 AU AU2004251117A patent/AU2004251117A1/en not_active Abandoned
- 2004-04-29 CA CA002526305A patent/CA2526305A1/en not_active Abandoned
- 2004-04-29 EP EP04730317A patent/EP1641812B1/en not_active Expired - Lifetime
-
2006
- 2006-01-27 HR HR20060040A patent/HRP20060040A2/xx not_active Application Discontinuation
- 2006-01-27 NO NO20060456A patent/NO20060456L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0301981D0 (en) | 2003-09-29 |
| AU2004251117A1 (en) | 2005-01-06 |
| NO20060456L (no) | 2006-03-30 |
| RS20050816A (en) | 2007-08-03 |
| NZ544481A (en) | 2009-05-31 |
| CN1798758A (zh) | 2006-07-05 |
| CA2526305A1 (en) | 2005-01-06 |
| WO2005000867A1 (en) | 2005-01-06 |
| ATE470669T1 (de) | 2010-06-15 |
| HUP0301981A2 (hu) | 2005-04-28 |
| EP1641812A1 (en) | 2006-04-05 |
| UA85190C2 (en) | 2009-01-12 |
| BRPI0411734A (pt) | 2006-08-08 |
| CN100497368C (zh) | 2009-06-10 |
| EA008174B1 (ru) | 2007-04-27 |
| DE602004027629D1 (de) | 2010-07-22 |
| EP1641812B1 (en) | 2010-06-09 |
| EA200600120A1 (ru) | 2006-06-30 |
| HRP20060040A2 (en) | 2007-08-31 |
| JP2007534617A (ja) | 2007-11-29 |
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