JP2004528311A - Ｆａｓ媒介アポトーシスの刺激剤としての置換ジアリールウレア - Google Patents

Ｆａｓ媒介アポトーシスの刺激剤としての置換ジアリールウレア Download PDF

Info

Publication number
JP2004528311A
JP2004528311A JP2002576193A JP2002576193A JP2004528311A JP 2004528311 A JP2004528311 A JP 2004528311A JP 2002576193 A JP2002576193 A JP 2002576193A JP 2002576193 A JP2002576193 A JP 2002576193A JP 2004528311 A JP2004528311 A JP 2004528311A
Authority
JP
Japan
Prior art keywords
compound
fas
optionally substituted
pharmaceutically acceptable
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2002576193A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004528311A5 (https=
Inventor
ルイーズ・ロビンソン
ヒューゴ・オー・ビラー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/082,802 external-priority patent/US6525091B2/en
Application filed by Telik Inc filed Critical Telik Inc
Publication of JP2004528311A publication Critical patent/JP2004528311A/ja
Publication of JP2004528311A5 publication Critical patent/JP2004528311A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/42—Y being a hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2002576193A 2001-03-07 2002-03-01 Ｆａｓ媒介アポトーシスの刺激剤としての置換ジアリールウレア Withdrawn JP2004528311A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27398801P 2001-03-07 2001-03-07
US10/082,802 US6525091B2 (en) 2001-03-07 2002-02-22 Substituted diarylureas as stimulators for Fas-mediated apoptosis
PCT/US2002/006217 WO2002076930A2 (en) 2001-03-07 2002-03-01 Substituted diarylureas as stimulators for fas-mediated apoptosis

Publications (2)

Publication Number Publication Date
JP2004528311A true JP2004528311A (ja) 2004-09-16
JP2004528311A5 JP2004528311A5 (https=) 2006-01-05

Family

ID=26767870

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002576193A Withdrawn JP2004528311A (ja) 2001-03-07 2002-03-01 Ｆａｓ媒介アポトーシスの刺激剤としての置換ジアリールウレア

Country Status (8)

Country Link
EP (1) EP1366021B1 (https=)
JP (1) JP2004528311A (https=)
AT (1) ATE366720T1 (https=)
AU (1) AU2002306618B2 (https=)
CA (1) CA2434020A1 (https=)
DE (1) DE60221104T2 (https=)
ES (1) ES2286267T3 (https=)
WO (1) WO2002076930A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE538794T1 (de) 1999-01-13 2012-01-15 Bayer Healthcare Llc Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
MXPA04007832A (es) 2002-02-11 2005-09-08 Bayer Pharmaceuticals Corp Aril-ureas con actividad inhibitoria de angiogenesis.
US7645903B2 (en) 2002-10-31 2010-01-12 Ge Healthcare Bio-Sciences Ab Use of urea variants as affinity ligands
WO2004113274A2 (en) 2003-05-20 2004-12-29 Bayer Pharmaceuticals Corporation Diaryl ureas with kinase inhibiting activity
EA010485B1 (ru) 2003-07-23 2008-10-30 Байер Фамэсьютиклс Копэрейшн Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты)
US12098117B2 (en) * 2018-12-11 2024-09-24 Duke University Compositions and methods for the treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3214468A (en) * 1959-08-14 1965-10-26 Geigy Ag J R Bis-(trifluoromethyl)-carbanilides
US6093742A (en) * 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
BR9814375A (pt) * 1997-12-22 2002-05-21 Bayer Ag Inibição de raf cinase usando difenil uréias substituìdas simétricas e assimétricas
JP3887769B2 (ja) * 1997-12-22 2007-02-28 バイエル コーポレイション 対称および非対称ジフェニル尿素を用いるｐ３８キナーゼの阻害
EP1071658B1 (en) * 1998-04-17 2004-06-16 Parker Hughes Institute Btk inhibitors and methods for their identification and use

Also Published As

Publication number Publication date
ATE366720T1 (de) 2007-08-15
DE60221104T2 (de) 2008-03-13
EP1366021B1 (en) 2007-07-11
EP1366021A2 (en) 2003-12-03
CA2434020A1 (en) 2002-10-03
AU2002306618B2 (en) 2006-11-09
WO2002076930A3 (en) 2003-01-16
DE60221104D1 (de) 2007-08-23
ES2286267T3 (es) 2007-12-01
WO2002076930A2 (en) 2002-10-03

Similar Documents

Publication Publication Date Title
US6525091B2 (en) Substituted diarylureas as stimulators for Fas-mediated apoptosis
JP3476203B2 (ja) カルシトニン擬似体
US6265428B1 (en) Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
JP2575183B2 (ja) 抗高脂血性および抗アテローム性動脈硬化性の尿素およびカルバメート化合物
JP5837091B2 (ja) ピルビン酸キナーゼｍ２（ｐｋｍ２）調節剤としての新規ｎ−（４−（アゼチジン−１−カルボニル）フェニル）−（ヘテロ−）アリールスルホンアミド誘導体
JP2009527579A (ja) 神経細胞の中の新規の非選択性陽イオンチャンネル、および脳腫脹を処置するための方法
KR20230008763A (ko) Nek7 키나제의 저해제
JP2002533404A (ja) 新生物形成の治療における組合わせ療法としてインテグリン拮抗剤及び放射線治療を使用する方法
WO1998037077A9 (en) Calcitonin mimetics
JP2020019807A (ja) 化合物及びそれらの使用の方法
JP2021530554A (ja) 異常なａｃｖｒ１発現を伴う疾患を処置するための方法およびそこで使用するためのａｃｖｒ１阻害剤
JP2004528311A (ja) Ｆａｓ媒介アポトーシスの刺激剤としての置換ジアリールウレア
JP2003520236A (ja) 不安方法
CN104644639A (zh) 用于调控激酶级联的药物组合物及其使用方法
JP2002509152A (ja) 血小板ａｄｐ受容体阻害剤
AU2002306618A1 (en) Substituted diarylureas as stimulators for Fas-mediated apoptosis
JP2005075832A (ja) 神経保護、抗うつおよび抗虚血活性を有する新規アダマンタン誘導体、およびその製造法
EP1368318B1 (en) Calcilytic compounds
JP2022502378A (ja) ２’−ハロゲン化−４’−チオ−２’−デオキシ−５−アザシチジンアナログおよびその使用
JPH09323928A (ja) 神経分化誘導剤
JP2001513503A (ja) 心臓血管系の疾病の治療に用いられるマクロファージスカベンジャー受容体アンタゴニスト
JPH06500775A (ja) 新規な５ＨＴ１ａ受容体を介する悪性細胞増殖の調節
Chang et al. Correlation of delayed hypersensitivity responses with chemotherapeutic results in advanced Hodgkin's disease
WO2002072096A1 (en) Acridines as stimulators for fas-mediated apoptosis
JP2000500490A (ja) 糖尿病治療用の４−ヒドロキシクマリン−３−カルボキシアミド

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050105

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050224

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050224

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20080130