JP2004527583A5 - - Google Patents
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- Publication number
- JP2004527583A5 JP2004527583A5 JP2003501833A JP2003501833A JP2004527583A5 JP 2004527583 A5 JP2004527583 A5 JP 2004527583A5 JP 2003501833 A JP2003501833 A JP 2003501833A JP 2003501833 A JP2003501833 A JP 2003501833A JP 2004527583 A5 JP2004527583 A5 JP 2004527583A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- alkyl
- benzyl
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000011734 sodium Substances 0.000 claims 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 125000001033 ether group Chemical group 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 239000003495 polar organic solvent Substances 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28441201P | 2001-04-17 | 2001-04-17 | |
| PCT/EP2002/004218 WO2002098843A2 (en) | 2001-04-17 | 2002-04-16 | Certain salts of discodermolide acid, pharmaceutical compositions containing them and their use in treating tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004527583A JP2004527583A (ja) | 2004-09-09 |
| JP2004527583A5 true JP2004527583A5 (enExample) | 2005-12-22 |
Family
ID=23090120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003501833A Pending JP2004527583A (ja) | 2001-04-17 | 2002-04-16 | ディスコデルモライド酸のある種の塩、それらを含有する医薬組成物および腫瘍の処置におけるそれらの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6734177B2 (enExample) |
| EP (1) | EP1381591A2 (enExample) |
| JP (1) | JP2004527583A (enExample) |
| CN (1) | CN1503782A (enExample) |
| BR (1) | BR0208884A (enExample) |
| CA (1) | CA2443850A1 (enExample) |
| WO (1) | WO2002098843A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7418429B1 (en) * | 2000-10-20 | 2008-08-26 | Accenture Pte. Ltd. | Method and system for facilitating a trusted on-line transaction between insurance businesses and networked consumers |
| US7393862B2 (en) | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
| NL1026695C2 (nl) * | 2004-07-21 | 2006-01-24 | Telesystems Holding Gmbh | Verificatie van een communicatieverbinding. |
| US7214708B2 (en) * | 2004-11-18 | 2007-05-08 | Kosan Biosciences Incorporated | Synthetic discodermolide analogs |
| WO2009006184A1 (en) * | 2007-06-28 | 2009-01-08 | The Trustees Of The University Of Pennsylvania | Discodermolide analogues and methods of their use |
| KR101126084B1 (ko) * | 2008-11-04 | 2012-03-29 | 한미홀딩스 주식회사 | (3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체 |
| CN101445499B (zh) * | 2008-12-25 | 2011-12-21 | 中国人民解放军第二军医大学 | 一种二萜类抗肿瘤化合物及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4939168A (en) * | 1989-08-11 | 1990-07-03 | Harbor Branch Oceanographics Institution, Inc. | Discodermolide compounds, compositions containing same and methods of preparation and use |
| GB9315802D0 (en) | 1993-07-30 | 1993-09-15 | Roussel Lab Ltd | Chemical compounds |
| US5789605A (en) | 1996-12-03 | 1998-08-04 | Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof |
| US6242616B1 (en) * | 1996-12-03 | 2001-06-05 | The Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives |
| US6096904A (en) | 1996-12-03 | 2000-08-01 | The Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives |
-
2002
- 2002-04-15 US US10/122,812 patent/US6734177B2/en not_active Expired - Fee Related
- 2002-04-16 JP JP2003501833A patent/JP2004527583A/ja active Pending
- 2002-04-16 CN CNA028083865A patent/CN1503782A/zh active Pending
- 2002-04-16 EP EP02742902A patent/EP1381591A2/en not_active Withdrawn
- 2002-04-16 WO PCT/EP2002/004218 patent/WO2002098843A2/en not_active Ceased
- 2002-04-16 BR BR0208884-3A patent/BR0208884A/pt not_active IP Right Cessation
- 2002-04-16 CA CA002443850A patent/CA2443850A1/en not_active Abandoned
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