CN1503782A - 海绵内酯酸的某些盐、含有它们的药物组合物及其在治疗肿瘤中的用途 - Google Patents

海绵内酯酸的某些盐、含有它们的药物组合物及其在治疗肿瘤中的用途 Download PDF

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Publication number
CN1503782A
CN1503782A CNA028083865A CN02808386A CN1503782A CN 1503782 A CN1503782 A CN 1503782A CN A028083865 A CNA028083865 A CN A028083865A CN 02808386 A CN02808386 A CN 02808386A CN 1503782 A CN1503782 A CN 1503782A
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CN
China
Prior art keywords
compound
formula
alkyl
treatment
cells
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Pending
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CNA028083865A
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English (en)
Chinese (zh)
Inventor
F��R������
F·R·小欣德
P·K·卡帕
E·M·勒泽尔
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Novartis AG
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Novartis AG
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Publication of CN1503782A publication Critical patent/CN1503782A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNA028083865A 2001-04-17 2002-04-16 海绵内酯酸的某些盐、含有它们的药物组合物及其在治疗肿瘤中的用途 Pending CN1503782A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28441201P 2001-04-17 2001-04-17
US60/284,412 2001-04-17

Publications (1)

Publication Number Publication Date
CN1503782A true CN1503782A (zh) 2004-06-09

Family

ID=23090120

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028083865A Pending CN1503782A (zh) 2001-04-17 2002-04-16 海绵内酯酸的某些盐、含有它们的药物组合物及其在治疗肿瘤中的用途

Country Status (7)

Country Link
US (1) US6734177B2 (enExample)
EP (1) EP1381591A2 (enExample)
JP (1) JP2004527583A (enExample)
CN (1) CN1503782A (enExample)
BR (1) BR0208884A (enExample)
CA (1) CA2443850A1 (enExample)
WO (1) WO2002098843A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101445499B (zh) * 2008-12-25 2011-12-21 中国人民解放军第二军医大学 一种二萜类抗肿瘤化合物及其制备方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7418429B1 (en) * 2000-10-20 2008-08-26 Accenture Pte. Ltd. Method and system for facilitating a trusted on-line transaction between insurance businesses and networked consumers
US7393862B2 (en) * 2002-05-17 2008-07-01 Celgene Corporation Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
NL1026695C2 (nl) * 2004-07-21 2006-01-24 Telesystems Holding Gmbh Verificatie van een communicatieverbinding.
US7214708B2 (en) * 2004-11-18 2007-05-08 Kosan Biosciences Incorporated Synthetic discodermolide analogs
WO2009006184A1 (en) * 2007-06-28 2009-01-08 The Trustees Of The University Of Pennsylvania Discodermolide analogues and methods of their use
KR101126084B1 (ko) * 2008-11-04 2012-03-29 한미홀딩스 주식회사 (3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4939168A (en) * 1989-08-11 1990-07-03 Harbor Branch Oceanographics Institution, Inc. Discodermolide compounds, compositions containing same and methods of preparation and use
GB9315802D0 (en) 1993-07-30 1993-09-15 Roussel Lab Ltd Chemical compounds
US6242616B1 (en) * 1996-12-03 2001-06-05 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US5789605A (en) 1996-12-03 1998-08-04 Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US6096904A (en) 1996-12-03 2000-08-01 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101445499B (zh) * 2008-12-25 2011-12-21 中国人民解放军第二军医大学 一种二萜类抗肿瘤化合物及其制备方法

Also Published As

Publication number Publication date
US20030032641A1 (en) 2003-02-13
JP2004527583A (ja) 2004-09-09
CA2443850A1 (en) 2002-12-12
EP1381591A2 (en) 2004-01-21
US6734177B2 (en) 2004-05-11
WO2002098843A2 (en) 2002-12-12
BR0208884A (pt) 2004-06-29
WO2002098843A3 (en) 2003-05-01

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