JP2004527534A5 - - Google Patents
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- Publication number
- JP2004527534A5 JP2004527534A5 JP2002581397A JP2002581397A JP2004527534A5 JP 2004527534 A5 JP2004527534 A5 JP 2004527534A5 JP 2002581397 A JP2002581397 A JP 2002581397A JP 2002581397 A JP2002581397 A JP 2002581397A JP 2004527534 A5 JP2004527534 A5 JP 2004527534A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- group
- compound
- arylalkyl
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 28
- 125000003710 aryl alkyl group Chemical group 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 10
- 239000012453 solvate Substances 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 125000006239 protecting group Chemical group 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
- -1 3-methyl-2,5-dioxopyrrolidin-1-yl Chemical group 0.000 claims 2
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims 2
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000032050 esterification Effects 0.000 claims 2
- 238000005886 esterification reaction Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- AEKVHUMPLIWKBJ-UHFFFAOYSA-N (3-methyl-3-azabicyclo[2.2.1]heptan-7-yl)methyl benzoate Chemical compound CN1CC2CCC1C2COC(=O)C1=CC=CC=C1 AEKVHUMPLIWKBJ-UHFFFAOYSA-N 0.000 claims 1
- CUKXRHLWPSBCTI-UHFFFAOYSA-M 2-amino-5-bromobenzoate Chemical compound NC1=CC=C(Br)C=C1C([O-])=O CUKXRHLWPSBCTI-UHFFFAOYSA-M 0.000 claims 1
- USDCBCYUSFOCTQ-UHFFFAOYSA-N 3-azabicyclo[2.2.1]heptan-7-ylmethyl benzoate Chemical compound N1CC2CCC1C2COC(=O)C1=CC=CC=C1 USDCBCYUSFOCTQ-UHFFFAOYSA-N 0.000 claims 1
- PSIKHEPGARMYIK-UHFFFAOYSA-N 3-benzyl-7-(methoxymethyl)-3-azabicyclo[2.2.1]heptane Chemical compound COCC1C(C2)CCC1N2CC1=CC=CC=C1 PSIKHEPGARMYIK-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- WREXEJRKJWHFED-UHFFFAOYSA-N O=C1N(C(C2=CC=CC=C12)=O)C1=C(C(=O)O)C=C(C(=C1)OC)OC Chemical compound O=C1N(C(C2=CC=CC=C12)=O)C1=C(C(=O)O)C=C(C(=C1)OC)OC WREXEJRKJWHFED-UHFFFAOYSA-N 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- LKXYAAITLZWOKQ-UHFFFAOYSA-N n-[(3-benzyl-3-azabicyclo[2.2.1]heptan-7-yl)methyl]-1-phenylmethanesulfonamide Chemical compound C=1C=CC=CC=1CN1CC2CCC1C2CNS(=O)(=O)CC1=CC=CC=C1 LKXYAAITLZWOKQ-UHFFFAOYSA-N 0.000 claims 1
- ZAPBWKXYBVLFLX-UHFFFAOYSA-N n-[(3-benzyl-3-azabicyclo[2.2.1]heptan-7-yl)methyl]acetamide Chemical compound CC(=O)NCC1C(C2)CCC1N2CC1=CC=CC=C1 ZAPBWKXYBVLFLX-UHFFFAOYSA-N 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- VNYSCXBTXLQNLS-UHFFFAOYSA-N o-[(3-benzyl-3-azabicyclo[2.2.1]heptan-7-yl)methyl] n-benzylcarbamothioate Chemical compound C=1C=CC=CC=1CN1CC2CCC1C2COC(=S)NCC1=CC=CC=C1 VNYSCXBTXLQNLS-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 231100000167 toxic agent Toxicity 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10118551A DE10118551A1 (de) | 2001-04-14 | 2001-04-14 | Nikotinische Acetylcholinrezeptor Liganden |
| PCT/EP2002/002729 WO2002083640A1 (de) | 2001-04-14 | 2002-03-13 | Nikotinische acetylcholinrezeptor liganden |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004527534A JP2004527534A (ja) | 2004-09-09 |
| JP2004527534A5 true JP2004527534A5 (enExample) | 2005-12-22 |
Family
ID=7681551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002581397A Withdrawn JP2004527534A (ja) | 2001-04-14 | 2002-03-13 | ニコチン性アセチルコリン受容体リガンド |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20040110788A1 (enExample) |
| EP (1) | EP1379502A1 (enExample) |
| JP (1) | JP2004527534A (enExample) |
| AR (1) | AR033156A1 (enExample) |
| CA (1) | CA2443577A1 (enExample) |
| CZ (1) | CZ20032999A3 (enExample) |
| DE (1) | DE10118551A1 (enExample) |
| HU (1) | HUP0303980A3 (enExample) |
| SK (1) | SK13722003A3 (enExample) |
| WO (1) | WO2002083640A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0400970D0 (sv) * | 2004-04-14 | 2004-04-14 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| WO2007110782A1 (en) * | 2005-12-30 | 2007-10-04 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9020051D0 (en) * | 1990-09-13 | 1990-10-24 | Pfizer Ltd | Muscarinic receptor antagonists |
| WO1998048801A1 (en) * | 1997-04-26 | 1998-11-05 | Sumitomo Pharmaceuticals Co., Ltd. | 2-azabicyclo compounds |
| GB9822945D0 (en) * | 1998-10-20 | 1998-12-16 | Isis Innovations Ltd | Epibatidine analogues |
| DE10044905A1 (de) * | 2000-09-12 | 2002-03-21 | Merck Patent Gmbh | (2-Azabicyclo[2.2.1]hept-7-yl)methanol-Derivate als nikontinische Acetylcholinrezeptor Agonisten |
-
2001
- 2001-04-14 DE DE10118551A patent/DE10118551A1/de not_active Withdrawn
-
2002
- 2002-03-13 SK SK1372-2003A patent/SK13722003A3/sk unknown
- 2002-03-13 JP JP2002581397A patent/JP2004527534A/ja not_active Withdrawn
- 2002-03-13 US US10/474,801 patent/US20040110788A1/en not_active Abandoned
- 2002-03-13 EP EP02732477A patent/EP1379502A1/de not_active Withdrawn
- 2002-03-13 CA CA002443577A patent/CA2443577A1/en not_active Abandoned
- 2002-03-13 WO PCT/EP2002/002729 patent/WO2002083640A1/de not_active Ceased
- 2002-03-13 CZ CZ20032999A patent/CZ20032999A3/cs unknown
- 2002-03-13 HU HU0303980A patent/HUP0303980A3/hu unknown
- 2002-04-12 AR ARP020101346A patent/AR033156A1/es not_active Application Discontinuation
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