CA2443577A1 - Nicotinic acetylcholine receptor ligands - Google Patents
Nicotinic acetylcholine receptor ligands Download PDFInfo
- Publication number
- CA2443577A1 CA2443577A1 CA002443577A CA2443577A CA2443577A1 CA 2443577 A1 CA2443577 A1 CA 2443577A1 CA 002443577 A CA002443577 A CA 002443577A CA 2443577 A CA2443577 A CA 2443577A CA 2443577 A1 CA2443577 A1 CA 2443577A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- compounds
- azabicyclo
- benzyl
- hept
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 title claims abstract description 13
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 title claims abstract description 13
- 239000003446 ligand Substances 0.000 title claims abstract description 7
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- -1 3-methyl-2,5-dioxopyrrolidin-1-yl Chemical group 0.000 claims description 168
- 150000003839 salts Chemical class 0.000 claims description 55
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 54
- 238000006243 chemical reaction Methods 0.000 claims description 29
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 125000004432 carbon atom Chemical group C* 0.000 claims description 21
- 239000012453 solvate Substances 0.000 claims description 21
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- ZAPBWKXYBVLFLX-UHFFFAOYSA-N n-[(3-benzyl-3-azabicyclo[2.2.1]heptan-7-yl)methyl]acetamide Chemical compound CC(=O)NCC1C(C2)CCC1N2CC1=CC=CC=C1 ZAPBWKXYBVLFLX-UHFFFAOYSA-N 0.000 claims description 3
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- 101100134925 Gallus gallus COR6 gene Proteins 0.000 claims 2
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract description 2
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- 125000004784 trichloromethoxy group Chemical group ClC(O*)(Cl)Cl 0.000 description 1
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10118551A DE10118551A1 (de) | 2001-04-14 | 2001-04-14 | Nikotinische Acetylcholinrezeptor Liganden |
| DE10118551.0 | 2001-04-14 | ||
| PCT/EP2002/002729 WO2002083640A1 (de) | 2001-04-14 | 2002-03-13 | Nikotinische acetylcholinrezeptor liganden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2443577A1 true CA2443577A1 (en) | 2002-10-24 |
Family
ID=7681551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002443577A Abandoned CA2443577A1 (en) | 2001-04-14 | 2002-03-13 | Nicotinic acetylcholine receptor ligands |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20040110788A1 (enExample) |
| EP (1) | EP1379502A1 (enExample) |
| JP (1) | JP2004527534A (enExample) |
| AR (1) | AR033156A1 (enExample) |
| CA (1) | CA2443577A1 (enExample) |
| CZ (1) | CZ20032999A3 (enExample) |
| DE (1) | DE10118551A1 (enExample) |
| HU (1) | HUP0303980A3 (enExample) |
| SK (1) | SK13722003A3 (enExample) |
| WO (1) | WO2002083640A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0400970D0 (sv) * | 2004-04-14 | 2004-04-14 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| WO2007110782A1 (en) * | 2005-12-30 | 2007-10-04 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9020051D0 (en) * | 1990-09-13 | 1990-10-24 | Pfizer Ltd | Muscarinic receptor antagonists |
| WO1998048801A1 (en) * | 1997-04-26 | 1998-11-05 | Sumitomo Pharmaceuticals Co., Ltd. | 2-azabicyclo compounds |
| GB9822945D0 (en) * | 1998-10-20 | 1998-12-16 | Isis Innovations Ltd | Epibatidine analogues |
| DE10044905A1 (de) * | 2000-09-12 | 2002-03-21 | Merck Patent Gmbh | (2-Azabicyclo[2.2.1]hept-7-yl)methanol-Derivate als nikontinische Acetylcholinrezeptor Agonisten |
-
2001
- 2001-04-14 DE DE10118551A patent/DE10118551A1/de not_active Withdrawn
-
2002
- 2002-03-13 SK SK1372-2003A patent/SK13722003A3/sk unknown
- 2002-03-13 JP JP2002581397A patent/JP2004527534A/ja not_active Withdrawn
- 2002-03-13 US US10/474,801 patent/US20040110788A1/en not_active Abandoned
- 2002-03-13 EP EP02732477A patent/EP1379502A1/de not_active Withdrawn
- 2002-03-13 CA CA002443577A patent/CA2443577A1/en not_active Abandoned
- 2002-03-13 WO PCT/EP2002/002729 patent/WO2002083640A1/de not_active Ceased
- 2002-03-13 CZ CZ20032999A patent/CZ20032999A3/cs unknown
- 2002-03-13 HU HU0303980A patent/HUP0303980A3/hu unknown
- 2002-04-12 AR ARP020101346A patent/AR033156A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1379502A1 (de) | 2004-01-14 |
| HUP0303980A2 (hu) | 2004-04-28 |
| JP2004527534A (ja) | 2004-09-09 |
| CZ20032999A3 (cs) | 2004-02-18 |
| WO2002083640A1 (de) | 2002-10-24 |
| AR033156A1 (es) | 2003-12-03 |
| HUP0303980A3 (en) | 2005-09-28 |
| US20040110788A1 (en) | 2004-06-10 |
| DE10118551A1 (de) | 2002-10-17 |
| SK13722003A3 (sk) | 2004-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |