JP2004526427A5 - - Google Patents

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Publication number
JP2004526427A5
JP2004526427A5 JP2002551170A JP2002551170A JP2004526427A5 JP 2004526427 A5 JP2004526427 A5 JP 2004526427A5 JP 2002551170 A JP2002551170 A JP 2002551170A JP 2002551170 A JP2002551170 A JP 2002551170A JP 2004526427 A5 JP2004526427 A5 JP 2004526427A5
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JP
Japan
Prior art keywords
yeast cell
cell according
plasminogen
seq
nucleotide sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002551170A
Other languages
English (en)
Japanese (ja)
Other versions
JP4047170B2 (ja
JP2004526427A (ja
Filing date
Publication date
Priority claimed from GB0031196A external-priority patent/GB0031196D0/en
Priority claimed from GB0116690A external-priority patent/GB0116690D0/en
Priority claimed from GB0116702A external-priority patent/GB0116702D0/en
Application filed filed Critical
Priority claimed from PCT/BE2001/000217 external-priority patent/WO2002050290A1/en
Publication of JP2004526427A publication Critical patent/JP2004526427A/ja
Publication of JP2004526427A5 publication Critical patent/JP2004526427A5/ja
Application granted granted Critical
Publication of JP4047170B2 publication Critical patent/JP4047170B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2002551170A 2000-12-21 2001-12-20 酵母発現ベクターおよび酵母細胞における発現による組換えタンパク質の製造方法 Expired - Lifetime JP4047170B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0031196A GB0031196D0 (en) 2000-12-21 2000-12-21 Recombinant human plasminogen and plasmin: methods for high yield production stabilization and use for treatment
GB0116690A GB0116690D0 (en) 2001-07-09 2001-07-09 Human plasminogen and plasmin
GB0116702A GB0116702D0 (en) 2001-07-09 2001-07-09 Human plasminogen and plasmin
PCT/BE2001/000217 WO2002050290A1 (en) 2000-12-21 2001-12-20 A yeast expression vector and a method of making a recombinant protein by expression in a yeast cell

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007067213A Division JP4250660B2 (ja) 2000-12-21 2007-03-15 活性化されたミクロプラスミンの産生方法

Publications (3)

Publication Number Publication Date
JP2004526427A JP2004526427A (ja) 2004-09-02
JP2004526427A5 true JP2004526427A5 (https=) 2005-05-19
JP4047170B2 JP4047170B2 (ja) 2008-02-13

Family

ID=27256020

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002551170A Expired - Lifetime JP4047170B2 (ja) 2000-12-21 2001-12-20 酵母発現ベクターおよび酵母細胞における発現による組換えタンパク質の製造方法
JP2007067213A Expired - Lifetime JP4250660B2 (ja) 2000-12-21 2007-03-15 活性化されたミクロプラスミンの産生方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007067213A Expired - Lifetime JP4250660B2 (ja) 2000-12-21 2007-03-15 活性化されたミクロプラスミンの産生方法

Country Status (11)

Country Link
US (1) US7445775B2 (https=)
EP (1) EP1343903B1 (https=)
JP (2) JP4047170B2 (https=)
AT (1) ATE378413T1 (https=)
AU (1) AU2002218890A1 (https=)
CY (1) CY1107866T1 (https=)
DE (1) DE60131450T2 (https=)
DK (1) DK1343903T3 (https=)
ES (1) ES2296705T3 (https=)
PT (1) PT1343903E (https=)
WO (1) WO2002050290A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998121B2 (en) * 2003-01-23 2006-02-14 Milkhaus Laboratory, Inc. Method of treatment of connective tissue disorders by administration of streptolysin O
DE10390418D2 (de) * 2002-02-06 2005-01-13 N Zyme Biotec Gmbh Verfahren zur Herstellung von rekombinanten Proteinen in Mikroorganismen
AU2003210137A1 (en) * 2002-02-06 2003-09-02 N-Zyme Biotec Gmbh Method for producing recombinant proteins in micro-organisms
GB0228409D0 (en) 2002-12-06 2003-01-08 Thromb X Nv Pharmacological vitreolysis
KR100595864B1 (ko) * 2004-01-27 2006-06-30 재단법인 목암생명공학연구소 형질전환 사카로마이세스 세레비지애 균주 및 이를 이용한ｌｋ8 단백질의 생산방법
CN1938427A (zh) 2004-02-11 2007-03-28 比奥莱克斯公司 纤溶酶原和微纤溶酶原在浮萍中的表达
CN102660564B (zh) * 2004-04-22 2013-05-08 泰勒克里斯生物治疗学公司 重组修饰的纤溶酶
CN100368524C (zh) * 2005-05-17 2008-02-13 上海大学 巴士德毕赤酵母gs115/pfk-k5的高密度发酵方法
US20070134231A1 (en) * 2005-12-13 2007-06-14 Jani Dharmendra M Method for prolonging activity of autodegradable enzymes and compositions thereof
US20070134230A1 (en) * 2005-12-13 2007-06-14 Jani Dharmendra M Method for prolonging activity of autodegradable enzymes
US20070196350A1 (en) * 2006-02-22 2007-08-23 Bartels Stephen P Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment
US20070212358A1 (en) * 2006-03-10 2007-09-13 Bartels Stephen P Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment
PL2220221T3 (pl) * 2007-11-29 2015-07-31 Grifols Therapeutics Inc Rekombinacyjnie zmodyfikowana plazmina
WO2009104199A1 (en) * 2008-02-19 2009-08-27 Biocon Limited A method of obtaining purified heterologous insulins expressed in yeast
MX2010013282A (es) 2008-06-04 2010-12-21 Talecris Biotherapeutics Inc Composicion, metodo y kit para la preparacion de plasmina.
HUE025670T2 (en) 2009-03-03 2016-04-28 Grifols Therapeutics Inc A method for producing plasminogen
WO2011004011A1 (en) 2009-07-10 2011-01-13 Thrombogenics Nv Variants of plasminogen and plasmin
ES2534911T3 (es) 2009-08-28 2015-04-30 Thrombogenics N.V. Uso de plasmina para el tratamiento de fallo de filtración después de trabeculectomía
JP6085568B2 (ja) 2011-01-05 2017-02-22 スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ プラスミノーゲンおよびプラスミンの変異体
US9644196B2 (en) 2011-08-12 2017-05-09 Thrombogenics Nv Plasminogen and plasmin variants
CN110066783B (zh) * 2019-05-16 2021-07-13 重庆派金生物科技有限公司 一种无自切形式的微纤溶酶制备方法
CN113355309B (zh) * 2021-08-10 2021-11-05 迈威(上海)生物科技股份有限公司 重组截短型人纤维蛋白溶酶制备工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4774087A (en) * 1987-08-14 1988-09-27 Northwestern University Micro-size fibrinolytic plasmin
WO1990013640A1 (en) 1989-05-01 1990-11-15 The University Of Notre Dame Du Lac Methods and materials for expression of human plasminogen in a eukaryotic cell system
GB9222758D0 (en) * 1992-10-29 1992-12-09 British Bio Technology Proteins and nucleic acids
US5288489A (en) 1991-08-28 1994-02-22 Orion Therapeutic Systems, Inc. Fibrinolysis and fibrinogenolysis treatment
ATE349226T1 (de) * 1998-09-29 2007-01-15 Leuven Res & Dev Vzw Verwendung von verbindungen die alpha2- antiplasmin in vivo reduzieren zur herstellung einer zusammensetzung zur behandlung ischämischer schlaganfälle

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