JP2004526402A5 - - Google Patents
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- JP2004526402A5 JP2004526402A5 JP2001577530A JP2001577530A JP2004526402A5 JP 2004526402 A5 JP2004526402 A5 JP 2004526402A5 JP 2001577530 A JP2001577530 A JP 2001577530A JP 2001577530 A JP2001577530 A JP 2001577530A JP 2004526402 A5 JP2004526402 A5 JP 2004526402A5
- Authority
- JP
- Japan
- Prior art keywords
- tetramers
- double
- oligonucleotides
- multimeric
- oligonucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091034117 Oligonucleotide Proteins 0.000 description 58
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 41
- 239000002773 nucleotide Substances 0.000 description 40
- 125000003729 nucleotide group Chemical group 0.000 description 40
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 28
- 239000002751 oligonucleotide probe Substances 0.000 description 28
- 230000000295 complement effect Effects 0.000 description 22
- 238000002844 melting Methods 0.000 description 18
- 230000008018 melting Effects 0.000 description 18
- 239000000523 sample Substances 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- 102000003960 Ligases Human genes 0.000 description 10
- 108090000364 Ligases Proteins 0.000 description 10
- 108091028043 Nucleic acid sequence Proteins 0.000 description 10
- 238000013467 fragmentation Methods 0.000 description 8
- 238000006062 fragmentation reaction Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000012217 deletion Methods 0.000 description 4
- 230000037430 deletion Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 230000005945 translocation Effects 0.000 description 4
- 235000010469 Glycine max Nutrition 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 238000002966 oligonucleotide array Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19727100P | 2000-04-14 | 2000-04-14 | |
| US60/197,271 | 2000-04-14 | ||
| PCT/US2001/010958 WO2001079548A2 (en) | 2000-04-14 | 2001-04-04 | Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013222860A Division JP5992895B2 (ja) | 2000-04-14 | 2013-10-28 | リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004526402A JP2004526402A (ja) | 2004-09-02 |
| JP2004526402A5 true JP2004526402A5 (https=) | 2012-12-06 |
| JP5508654B2 JP5508654B2 (ja) | 2014-06-04 |
Family
ID=22728709
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001577530A Expired - Lifetime JP5508654B2 (ja) | 2000-04-14 | 2001-04-04 | リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法 |
| JP2013222860A Expired - Fee Related JP5992895B2 (ja) | 2000-04-14 | 2013-10-28 | リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法 |
| JP2016097780A Pending JP2016174613A (ja) | 2000-04-14 | 2016-05-16 | リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013222860A Expired - Fee Related JP5992895B2 (ja) | 2000-04-14 | 2013-10-28 | リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法 |
| JP2016097780A Pending JP2016174613A (ja) | 2000-04-14 | 2016-05-16 | リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US7455965B2 (https=) |
| EP (1) | EP1303639A2 (https=) |
| JP (3) | JP5508654B2 (https=) |
| AU (1) | AU2001293366A1 (https=) |
| CA (1) | CA2405412A1 (https=) |
| WO (1) | WO2001079548A2 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6852487B1 (en) * | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| EP1303639A2 (en) | 2000-04-14 | 2003-04-23 | Cornell Research Foundation, Inc. | Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction |
| CN1304559C (zh) * | 2001-10-09 | 2007-03-14 | 杭州康科生物技术有限公司 | 表达热休克蛋白的溶瘤微生物及其应用 |
| EP1513958B1 (en) | 2002-06-14 | 2011-08-10 | Gen-Probe Incorporated | Compositions for detecting hepatitis b virus |
| KR100695123B1 (ko) * | 2003-12-03 | 2007-03-14 | 삼성전자주식회사 | Ｔｍ에 따라 기판상에 고정화된 프로브 폴리뉴클레오티드군을 2이상 포함하는 폴리뉴클레오티드 어레이 및 그를이용하는 표적 핵산 검출 방법 |
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| US10533223B2 (en) | 2010-08-06 | 2020-01-14 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
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| US11031095B2 (en) | 2010-08-06 | 2021-06-08 | Ariosa Diagnostics, Inc. | Assay systems for determination of fetal copy number variation |
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| CN104204228A (zh) | 2012-02-14 | 2014-12-10 | 康奈尔大学 | 使用组合的核酸酶、连接和聚合酶反应用于核酸序列的相对定量、表达或拷贝变化的方法 |
| US10289800B2 (en) | 2012-05-21 | 2019-05-14 | Ariosa Diagnostics, Inc. | Processes for calculating phased fetal genomic sequences |
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| ES2746237T3 (es) | 2013-03-14 | 2020-03-05 | Univ Cornell | Método para la cuantificación relativa de cambios en la metilación del ADN, usando reacciones combinadas de nucleasa, ligamiento, y polimerasa |
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-
2001
- 2001-04-04 EP EP01969050A patent/EP1303639A2/en not_active Withdrawn
- 2001-04-04 US US10/257,158 patent/US7455965B2/en not_active Expired - Fee Related
- 2001-04-04 JP JP2001577530A patent/JP5508654B2/ja not_active Expired - Lifetime
- 2001-04-04 AU AU2001293366A patent/AU2001293366A1/en not_active Abandoned
- 2001-04-04 WO PCT/US2001/010958 patent/WO2001079548A2/en not_active Ceased
- 2001-04-04 CA CA002405412A patent/CA2405412A1/en not_active Abandoned
-
2008
- 2008-10-15 US US12/252,169 patent/US8492085B2/en not_active Expired - Fee Related
-
2013
- 2013-07-22 US US13/947,777 patent/US9340834B2/en not_active Expired - Fee Related
- 2013-10-28 JP JP2013222860A patent/JP5992895B2/ja not_active Expired - Fee Related
-
2016
- 2016-04-12 US US15/096,446 patent/US9725759B2/en not_active Expired - Fee Related
- 2016-05-16 JP JP2016097780A patent/JP2016174613A/ja active Pending
-
2017
- 2017-07-07 US US15/644,273 patent/US10131938B2/en not_active Expired - Fee Related
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