JP2004525082A5 - - Google Patents
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- Publication number
- JP2004525082A5 JP2004525082A5 JP2002532445A JP2002532445A JP2004525082A5 JP 2004525082 A5 JP2004525082 A5 JP 2004525082A5 JP 2002532445 A JP2002532445 A JP 2002532445A JP 2002532445 A JP2002532445 A JP 2002532445A JP 2004525082 A5 JP2004525082 A5 JP 2004525082A5
- Authority
- JP
- Japan
- Prior art keywords
- fifteen
- amino acid
- natural
- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C(*)C1*)C(*)C(*)(*)C1=* Chemical compound *C(C(*)C1*)C(*)C(*)(*)C1=* 0.000 description 5
- ZSXSQSLDROQFDL-ZYHUDNBSSA-N CC(C)(C)C1=C[C@@]2(C)O[C@H]2C2(CC2)C1=O Chemical compound CC(C)(C)C1=C[C@@]2(C)O[C@H]2C2(CC2)C1=O ZSXSQSLDROQFDL-ZYHUDNBSSA-N 0.000 description 1
- LXFAZSQLGQUJCW-OWRUSBMPSA-N CC(C)[C@@](C1)([C@H]1[C@H]1O[C@@]1(C)[C@@]12OC1)C2=O Chemical compound CC(C)[C@@](C1)([C@H]1[C@H]1O[C@@]1(C)[C@@]12OC1)C2=O LXFAZSQLGQUJCW-OWRUSBMPSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23755700P | 2000-10-02 | 2000-10-02 | |
| PCT/US2001/030951 WO2002028862A2 (en) | 2000-10-02 | 2001-10-02 | Triptolide analogs for the treatment of autoimmune and inflammatory disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008331610A Division JP2009102371A (ja) | 2000-10-02 | 2008-12-25 | 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004525082A JP2004525082A (ja) | 2004-08-19 |
| JP2004525082A5 true JP2004525082A5 (enExample) | 2008-07-17 |
| JP4269144B2 JP4269144B2 (ja) | 2009-05-27 |
Family
ID=22894243
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002532445A Expired - Fee Related JP4269144B2 (ja) | 2000-10-02 | 2001-10-02 | 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ |
| JP2008331610A Pending JP2009102371A (ja) | 2000-10-02 | 2008-12-25 | 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008331610A Pending JP2009102371A (ja) | 2000-10-02 | 2008-12-25 | 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6777441B2 (enExample) |
| EP (2) | EP1659125B1 (enExample) |
| JP (2) | JP4269144B2 (enExample) |
| AT (2) | ATE469907T1 (enExample) |
| AU (2) | AU2001296542B2 (enExample) |
| CA (1) | CA2424555A1 (enExample) |
| DE (2) | DE60121986T2 (enExample) |
| WO (1) | WO2002028862A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60121986T2 (de) * | 2000-10-02 | 2007-07-26 | Emory University | Triptpolidanaloge zur verendung in der behandlung von autoimmunbedingten und entzündlichen erkrankungen |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| AU2003243351B2 (en) * | 2002-05-31 | 2009-04-30 | Pharmagenesis, Inc. | Triptolide derivatives for modulation of apoptosis and immunosuppression |
| AU2003272450A1 (en) * | 2002-09-13 | 2004-04-30 | C. Steven Smith | Novel composition and method for treatment of upper respiratory conditions |
| TW200902047A (en) * | 2003-02-14 | 2009-01-16 | Combinatorx Inc | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
| ES2421139T3 (es) * | 2003-07-30 | 2013-08-29 | Rigel Pharmaceuticals, Inc. | Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias |
| TW200522932A (en) * | 2003-09-15 | 2005-07-16 | Combinatorx Inc | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
| US7820834B2 (en) * | 2003-12-24 | 2010-10-26 | Pharmagenesis, Inc. | Triptolide 5,6-derivatives as immunomodulators and anticancer agents |
| WO2005077008A2 (en) * | 2004-02-09 | 2005-08-25 | Pharmagenesis, Inc. | Methods for isolation of triptolide compounds from tripterygium wilfordii |
| ES2385716T3 (es) * | 2004-03-02 | 2012-07-30 | Pharmagenesis, Inc. | Derivados en el anillo de lactona de triptolida como inmunomoduladores y agentes anticáncer |
| EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| US20070244080A1 (en) * | 2004-06-25 | 2007-10-18 | Pharmagenesis, Inc. | Method for Treatment of Inflammatory Disorders Using Triptolide Compounds |
| US8617906B2 (en) * | 2004-10-13 | 2013-12-31 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
| WO2007053844A2 (en) * | 2005-10-31 | 2007-05-10 | Rigel Pharmaceuticals, Inc. | Compositions and methods for treating inflammatory disorders |
| EP2240460A4 (en) * | 2008-01-07 | 2012-02-22 | Univ Emory | BRANCHED DIEPXYDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS |
| WO2011041542A2 (en) | 2009-09-30 | 2011-04-07 | Ultimaxx, Inc. | Herbal pain killer compositions |
| CN104478832B (zh) * | 2015-01-05 | 2016-04-20 | 项敬来 | 二萜化合物，含其的药物组合物及其制备方法和应用 |
| JP6743135B2 (ja) * | 2015-09-02 | 2020-08-19 | アッヴィ・インコーポレイテッド | 抗ウィルス性テトラヒドロフラン誘導体 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1179866A (en) | 1967-09-08 | 1970-02-04 | Agfa Gevaert Nv | Photopolymerisation of Ethylenically Unsaturated Organic Compounds |
| US3917652A (en) | 1968-04-29 | 1975-11-04 | Hoffmann La Roche | Juvabione and derivatives thereof |
| BE789948A (fr) | 1971-10-13 | 1973-04-11 | Sandoz Sa | Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments |
| US3816437A (en) | 1972-12-22 | 1974-06-11 | Sandoz Ag | Thieno(2,3-g)indazoles |
| US3957816A (en) | 1973-01-31 | 1976-05-18 | Sandoz, Inc. | Substituted naphtho pyrazoles |
| JPS5473766A (en) | 1977-11-21 | 1979-06-13 | Nippon Terpen Kagaku Kk | Manufacture of menthofuran |
| GB2104516B (en) | 1981-07-13 | 1985-12-04 | Univ Brunel | M-alkylphenol derivatives and their use in copper extraction |
| DE3219048A1 (de) | 1982-05-21 | 1983-11-24 | Basf Ag, 6700 Ludwigshafen | Thermoplastische formmassen |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| DE3440826A1 (de) | 1983-11-10 | 1985-05-23 | Basf Ag, 6700 Ludwigshafen | 1,1-ethanoretinsaeuren und ihre c(pfeil abwaerts)1(pfeil abwaerts)-c(pfeil abwaerts)4(pfeil abwaerts)-alkylester |
| JPS61197573A (ja) | 1985-02-26 | 1986-09-01 | Chugai Pharmaceut Co Ltd | ５，６−エポキシ化トランスビタミンｄ３ |
| ES2157934T3 (es) | 1988-09-15 | 2001-09-01 | Upjohn Co | Fenil-5-beta-amidometiloxazolidin-2-onas sustituidas con nitrogeno en la posicion 3. |
| DE3913310A1 (de) | 1989-04-20 | 1990-10-25 | Schering Ag | Spirocyclopropane in der vitamin d-reihe |
| JPH03197464A (ja) | 1989-12-16 | 1991-08-28 | Basf Ag | 置換アゾリルメチルシクロアルカノール及びこれを含有する殺菌剤 |
| US5430054A (en) * | 1989-12-22 | 1995-07-04 | Jiangsu Family Planning Institute | Preparation methods of diterpene lactone compounds and application of the same to antifertility |
| AU7570191A (en) * | 1990-03-14 | 1991-10-10 | Board Of Regents, The University Of Texas System | Tripterygium wilfordii hook f extracts and components thereof for immunosuppression |
| US5216175A (en) | 1990-03-23 | 1993-06-01 | Sri International | Antimalarial analogs of artemisinin |
| US5581004A (en) | 1991-09-23 | 1996-12-03 | Board Of Regents Of The University Of Nebraska | Preparation and use of (2-butene-1,4-diyl) magnesium complexes in organic synthesis |
| AU2466092A (en) | 1992-07-22 | 1994-02-14 | Michael F. Lucey | Highly filled polymeric compositions |
| AU6826194A (en) * | 1993-05-06 | 1994-12-12 | Pharmagenesis, Inc. | 16-hydroxytriptolide composition and method for immunotherapy |
| FR2707992B1 (fr) | 1993-07-21 | 1995-10-13 | Flamel Tech Sa | Nouveaux produits organiques contenant des fonctions thiols réactives, l'un de leurs procédés de préparation et les biomatériaux les contenant. |
| GB9325415D0 (en) | 1993-12-13 | 1994-02-16 | Res Inst Medicine Chem | Chemical compounds |
| GB9405715D0 (en) | 1994-03-23 | 1994-05-11 | Res Inst Medicine Chem | Chemical compounds |
| FR2733498B1 (fr) | 1995-04-27 | 1997-05-30 | Adir | Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5723632A (en) | 1996-08-08 | 1998-03-03 | Mgi Pharma, Inc. | Total synthesis of antitumor acylfulvenes |
| IT1287174B1 (it) | 1996-11-15 | 1998-08-04 | Angelini Ricerche Spa | Diaril-ciclometilenpirazoli farmacologicamente attivi,procedimento per prepararli e composizioni farmaceutiche che li contengono |
| US5972998A (en) * | 1997-05-23 | 1999-10-26 | Hoechst Marion Roussel, Inc. | Triptolide derivatives useful in the treatment of autoimmune diseases |
| JP2001519412A (ja) | 1997-10-14 | 2001-10-23 | ザ スクリップス リサーチ インスティテュート | Ｃｃ−１０６５およびデュオカルマイシンのイソ−ｃｂｉおよびイソ−ｃｉ類似体 |
| IL136489A0 (en) | 1997-12-08 | 2001-06-14 | Scripps Research Inst | Synthesis of cc-1065/duocarmycin analogs |
| DE19855859A1 (de) | 1998-12-03 | 2000-06-08 | Degussa | Katalysatoren für die enantioselektive Epoxidierung von C=C-Doppelbindungen |
| FR2787451B1 (fr) | 1998-12-18 | 2001-01-26 | Adir | Nouveaux composes imidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AR023071A1 (es) | 1998-12-23 | 2002-09-04 | Syngenta Participations Ag | Compuestos de piridincetona, compuestos intermediarios, composicion herbicida e inhibidora del crecimiento de plantas, metodo para controlar la vegetacion indeseada, metodo para inhibir el crecimiento de las plantas, y uso de la composicion para controlar el crecimiento indeseado de plantas. |
| US6331642B1 (en) | 1999-07-12 | 2001-12-18 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
| DE60121986T2 (de) | 2000-10-02 | 2007-07-26 | Emory University | Triptpolidanaloge zur verendung in der behandlung von autoimmunbedingten und entzündlichen erkrankungen |
| US20040204394A1 (en) | 2003-04-11 | 2004-10-14 | Aderis Pharmaceuticals, Inc. | Triptolide analogues |
-
2001
- 2001-10-02 DE DE60121986T patent/DE60121986T2/de not_active Expired - Lifetime
- 2001-10-02 AT AT05077239T patent/ATE469907T1/de not_active IP Right Cessation
- 2001-10-02 AU AU2001296542A patent/AU2001296542B2/en not_active Ceased
- 2001-10-02 AT AT01977423T patent/ATE334986T1/de not_active IP Right Cessation
- 2001-10-02 AU AU9654201A patent/AU9654201A/xx active Pending
- 2001-10-02 CA CA002424555A patent/CA2424555A1/en not_active Abandoned
- 2001-10-02 DE DE60142313T patent/DE60142313D1/de not_active Expired - Lifetime
- 2001-10-02 US US09/970,089 patent/US6777441B2/en not_active Expired - Lifetime
- 2001-10-02 JP JP2002532445A patent/JP4269144B2/ja not_active Expired - Fee Related
- 2001-10-02 WO PCT/US2001/030951 patent/WO2002028862A2/en not_active Ceased
- 2001-10-02 EP EP05077239A patent/EP1659125B1/en not_active Expired - Lifetime
- 2001-10-02 EP EP01977423A patent/EP1330459B1/en not_active Expired - Lifetime
-
2004
- 2004-08-17 US US10/919,824 patent/US7557139B2/en not_active Expired - Fee Related
-
2008
- 2008-12-25 JP JP2008331610A patent/JP2009102371A/ja active Pending
-
2009
- 2009-05-29 US US12/474,305 patent/US8193249B2/en not_active Expired - Fee Related
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