JP2004524323A5 - - Google Patents
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- Publication number
- JP2004524323A5 JP2004524323A5 JP2002569189A JP2002569189A JP2004524323A5 JP 2004524323 A5 JP2004524323 A5 JP 2004524323A5 JP 2002569189 A JP2002569189 A JP 2002569189A JP 2002569189 A JP2002569189 A JP 2002569189A JP 2004524323 A5 JP2004524323 A5 JP 2004524323A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- chelating agent
- chelate conjugate
- lys
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013522 chelant Substances 0.000 claims 9
- 239000000562 conjugate Substances 0.000 claims 9
- 239000002738 chelating agent Substances 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 150000004696 coordination complex Chemical class 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 239000012217 radiopharmaceutical Substances 0.000 claims 2
- 229940121896 radiopharmaceutical Drugs 0.000 claims 2
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims 1
- 125000004077 D-glutamic acid group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C([H])([H])C(N([H])[H])=O 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229960002684 aminocaproic acid Drugs 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 150000004985 diamines Chemical class 0.000 claims 1
- XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Natural products NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 claims 1
- 239000000863 peptide conjugate Substances 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0105224.0A GB0105224D0 (en) | 2001-03-02 | 2001-03-02 | Improved peptide-chelate conjugates |
| PCT/GB2002/000857 WO2002070018A2 (en) | 2001-03-02 | 2002-03-01 | Tetradentate peptide-chelate conjugates for colorectal cancer diagnosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004524323A JP2004524323A (ja) | 2004-08-12 |
| JP2004524323A5 true JP2004524323A5 (https=) | 2005-12-22 |
Family
ID=9909880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569189A Pending JP2004524323A (ja) | 2001-03-02 | 2002-03-01 | 結腸直腸癌診断のためのテトラデンテートペプチド−キレートコンジュゲート |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7608242B2 (https=) |
| EP (1) | EP1368064B1 (https=) |
| JP (1) | JP2004524323A (https=) |
| AT (1) | ATE556722T1 (https=) |
| CA (1) | CA2439579A1 (https=) |
| ES (1) | ES2385028T3 (https=) |
| GB (1) | GB0105224D0 (https=) |
| WO (1) | WO2002070018A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0224799D0 (en) * | 2002-10-25 | 2002-12-04 | Amersham Plc | Improved complex compositions |
| NO20030115D0 (no) | 2003-01-09 | 2003-01-09 | Amersham Health As | Kontrastmiddel |
| US8206704B2 (en) | 2003-02-10 | 2012-06-26 | Thomas Jefferson University | Use of GCC ligands |
| US7842280B2 (en) * | 2006-09-06 | 2010-11-30 | Case Western Reserve University | Flexibly labeling peptides |
| US20100316566A1 (en) * | 2008-02-27 | 2010-12-16 | Radiomedix Inc. | Radiolabeled hedgehog derivatives for imaging and therapy |
| EP2355846A4 (en) | 2008-09-03 | 2013-06-19 | Univ Michigan State | IMMUNOGENIC HEAT STABILIZER ESCHERICHIA COLI-ENTEROTOXIN |
| JP5984675B2 (ja) | 2009-12-07 | 2016-09-06 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | 胃腸障害の療法 |
| GB201016206D0 (en) * | 2010-09-27 | 2010-11-10 | Ge Healthcare Ltd | Apoptosis imaging agents |
| GB201103696D0 (en) | 2011-03-04 | 2011-04-20 | Ge Healthcare Ltd | Technetium labelled peptides |
| US9617305B2 (en) | 2011-06-08 | 2017-04-11 | Ironwood Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
| WO2012170766A1 (en) | 2011-06-08 | 2012-12-13 | Ironwood Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
| GB201314936D0 (en) | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| EP3077407A4 (en) * | 2013-12-03 | 2017-07-19 | Millennium Pharmaceuticals, Inc. | Compounds and compositions for imaging gcc-expressing cells |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4545931A (en) | 1983-01-03 | 1985-10-08 | Scripps Clinic And Research Foundation | Synthetic heat-stable enterotoxin polypeptide of Escherichia coli |
| US4886663A (en) | 1983-01-03 | 1989-12-12 | Scripps Clinic And Research Foundation | Synthetic heat-stable enterotoxin polypeptide of Escherichia coli and multimers thereof |
| US5242679A (en) * | 1985-01-14 | 1993-09-07 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| WO1994008949A2 (en) * | 1992-10-08 | 1994-04-28 | Amersham International Plc | Metal-oxime chelates for use as radiopharmaceutical agents |
| ATE337338T1 (de) | 1993-06-23 | 2006-09-15 | Diatide Inc | Radioaktiv-markierte peptidderivate des somatostatins zur bildformenden und therapeutischen verwendung |
| EP0710228B1 (en) * | 1993-07-19 | 1998-01-21 | Resolution Pharmaceuticals Inc. | Hydrazino-type radionuclide chelators having an n 3?s configuration |
| US5518888A (en) | 1993-10-26 | 1996-05-21 | Thomas Jefferson University | ST receptor binding compounds and methods of using the same |
| EP0734264B1 (en) * | 1993-10-26 | 2004-02-18 | Thomas Jefferson University | Compositions that specifically bind to colorectal cancer cells and methods of using the same |
| DE19536781A1 (de) * | 1995-09-21 | 1997-03-27 | Diagnostikforschung Inst | Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ XSNS für radioaktive Isotope |
| WO1999021587A1 (en) | 1997-10-15 | 1999-05-06 | Nycomed Imaging As | Complexing agents and targeting immunoreagents |
| WO1999039748A1 (en) | 1998-02-06 | 1999-08-12 | Nycomed Imaging As | Targeting immunoreagents useful in therapeutic and diagnostic compositions and methods |
-
2001
- 2001-03-02 GB GBGB0105224.0A patent/GB0105224D0/en not_active Ceased
-
2002
- 2002-03-01 EP EP02701431A patent/EP1368064B1/en not_active Expired - Lifetime
- 2002-03-01 AT AT02701431T patent/ATE556722T1/de active
- 2002-03-01 US US10/469,801 patent/US7608242B2/en not_active Expired - Fee Related
- 2002-03-01 WO PCT/GB2002/000857 patent/WO2002070018A2/en not_active Ceased
- 2002-03-01 JP JP2002569189A patent/JP2004524323A/ja active Pending
- 2002-03-01 ES ES02701431T patent/ES2385028T3/es not_active Expired - Lifetime
- 2002-03-01 CA CA002439579A patent/CA2439579A1/en not_active Abandoned
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