CA2439579A1 - Tetradentate peptide-chelate conjugates for colorectal cancer diagnosis - Google Patents

Tetradentate peptide-chelate conjugates for colorectal cancer diagnosis Download PDF

Info

Publication number
CA2439579A1
CA2439579A1 CA002439579A CA2439579A CA2439579A1 CA 2439579 A1 CA2439579 A1 CA 2439579A1 CA 002439579 A CA002439579 A CA 002439579A CA 2439579 A CA2439579 A CA 2439579A CA 2439579 A1 CA2439579 A1 CA 2439579A1
Authority
CA
Canada
Prior art keywords
peptide
sts
chelate conjugate
chelate
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002439579A
Other languages
English (en)
French (fr)
Inventor
Alan Cuthbertson
Marivi Mendizabal
Mark Dixon
Anthony Eamon Storey
Edward Richard Bacon
Vinay Chandrakant Desai
Sudakhar Kasina
Henry Raphael Wolfe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2439579A1 publication Critical patent/CA2439579A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CA002439579A 2001-03-02 2002-03-01 Tetradentate peptide-chelate conjugates for colorectal cancer diagnosis Abandoned CA2439579A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0105224.0A GB0105224D0 (en) 2001-03-02 2001-03-02 Improved peptide-chelate conjugates
GB0105224.0 2001-03-02
PCT/GB2002/000857 WO2002070018A2 (en) 2001-03-02 2002-03-01 Tetradentate peptide-chelate conjugates for colorectal cancer diagnosis

Publications (1)

Publication Number Publication Date
CA2439579A1 true CA2439579A1 (en) 2002-09-12

Family

ID=9909880

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002439579A Abandoned CA2439579A1 (en) 2001-03-02 2002-03-01 Tetradentate peptide-chelate conjugates for colorectal cancer diagnosis

Country Status (8)

Country Link
US (1) US7608242B2 (https=)
EP (1) EP1368064B1 (https=)
JP (1) JP2004524323A (https=)
AT (1) ATE556722T1 (https=)
CA (1) CA2439579A1 (https=)
ES (1) ES2385028T3 (https=)
GB (1) GB0105224D0 (https=)
WO (1) WO2002070018A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0224799D0 (en) * 2002-10-25 2002-12-04 Amersham Plc Improved complex compositions
NO20030115D0 (no) 2003-01-09 2003-01-09 Amersham Health As Kontrastmiddel
US8206704B2 (en) 2003-02-10 2012-06-26 Thomas Jefferson University Use of GCC ligands
US7842280B2 (en) * 2006-09-06 2010-11-30 Case Western Reserve University Flexibly labeling peptides
US20100316566A1 (en) * 2008-02-27 2010-12-16 Radiomedix Inc. Radiolabeled hedgehog derivatives for imaging and therapy
EP2355846A4 (en) 2008-09-03 2013-06-19 Univ Michigan State IMMUNOGENIC HEAT STABILIZER ESCHERICHIA COLI-ENTEROTOXIN
JP5984675B2 (ja) 2009-12-07 2016-09-06 アイアンウッド ファーマシューティカルズ インコーポレイテッド 胃腸障害の療法
GB201016206D0 (en) * 2010-09-27 2010-11-10 Ge Healthcare Ltd Apoptosis imaging agents
GB201103696D0 (en) 2011-03-04 2011-04-20 Ge Healthcare Ltd Technetium labelled peptides
US9617305B2 (en) 2011-06-08 2017-04-11 Ironwood Pharmaceuticals, Inc. Treatments for gastrointestinal disorders
WO2012170766A1 (en) 2011-06-08 2012-12-13 Ironwood Pharmaceuticals, Inc. Treatments for gastrointestinal disorders
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
EP3077407A4 (en) * 2013-12-03 2017-07-19 Millennium Pharmaceuticals, Inc. Compounds and compositions for imaging gcc-expressing cells
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4545931A (en) 1983-01-03 1985-10-08 Scripps Clinic And Research Foundation Synthetic heat-stable enterotoxin polypeptide of Escherichia coli
US4886663A (en) 1983-01-03 1989-12-12 Scripps Clinic And Research Foundation Synthetic heat-stable enterotoxin polypeptide of Escherichia coli and multimers thereof
US5242679A (en) * 1985-01-14 1993-09-07 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
WO1994008949A2 (en) * 1992-10-08 1994-04-28 Amersham International Plc Metal-oxime chelates for use as radiopharmaceutical agents
ATE337338T1 (de) 1993-06-23 2006-09-15 Diatide Inc Radioaktiv-markierte peptidderivate des somatostatins zur bildformenden und therapeutischen verwendung
EP0710228B1 (en) * 1993-07-19 1998-01-21 Resolution Pharmaceuticals Inc. Hydrazino-type radionuclide chelators having an n 3?s configuration
US5518888A (en) 1993-10-26 1996-05-21 Thomas Jefferson University ST receptor binding compounds and methods of using the same
EP0734264B1 (en) * 1993-10-26 2004-02-18 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
DE19536781A1 (de) * 1995-09-21 1997-03-27 Diagnostikforschung Inst Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ XSNS für radioaktive Isotope
WO1999021587A1 (en) 1997-10-15 1999-05-06 Nycomed Imaging As Complexing agents and targeting immunoreagents
WO1999039748A1 (en) 1998-02-06 1999-08-12 Nycomed Imaging As Targeting immunoreagents useful in therapeutic and diagnostic compositions and methods

Also Published As

Publication number Publication date
JP2004524323A (ja) 2004-08-12
WO2002070018A2 (en) 2002-09-12
WO2002070018A3 (en) 2002-12-05
ES2385028T3 (es) 2012-07-17
US20060222593A1 (en) 2006-10-05
US7608242B2 (en) 2009-10-27
EP1368064B1 (en) 2012-05-09
EP1368064A2 (en) 2003-12-10
GB0105224D0 (en) 2001-04-18
ATE556722T1 (de) 2012-05-15

Similar Documents

Publication Publication Date Title
JP7534498B2 (ja) Ｇｒｐｒ陽性ガンの検出、診断及び治療のためのｇｒｐｒアンタゴニスト
US12409240B2 (en) Positron emitting radionuclide labeled peptides for human uPAR PET imaging
JP5784911B2 (ja) ボンベシンアナログペプチドアンタゴニスト複合体
CN103533963B (zh) 用通过nota络合的[18]氟化铝标记的her2结合肽
Failla et al. Peptide-based positron emission tomography probes: current strategies for synthesis and radiolabelling
Hausner et al. In vitro and in vivo evaluation of the effects of aluminum [18F] fluoride radiolabeling on an integrin αvβ6-specific peptide
EP1368064B1 (en) Synthesis of tetradentate peptide-chelate conjugates for colorectal cancer diagnosis
CN103402550B (zh) 用含有18f的有机硅化合物标记的her2结合肽
Ma et al. Gallium-68 complex of a macrobicyclic cage amine chelator tethered to two integrin-targeting peptides for diagnostic tumor imaging
Abiraj et al. Tetraamine‐derived bifunctional chelators for technetium‐99m labelling: synthesis, bioconjugation and evaluation as targeted SPECT imaging probes for GRP‐receptor‐positive tumours
JP2005503350A (ja) コレシストキニンアゴニストおよびアンタゴニストの調製ならびにそれらの治療および診断の使用
RU2394837C2 (ru) Контрастный агент, нацеленный на рецептор урокиназного активатора плазминогена
CA2485339C (en) Radiopharmaceutical formulations
Maecke Radiolabeled peptides in nuclear oncology: influence of peptide structure and labeling strategy on pharmacology
JP2001523257A (ja) カルシトニン受容体結合ペプチド
KR20220152322A (ko) 생체내 알파-v-베타-6-인테그린 접근을 위한 환형 펩타이드 및 그의 컨쥬게이트
Ishizaki et al. Fundamental study of radiogallium-labeled aspartic acid peptides introducing octreotate derivatives
AU2002234761A1 (en) Tetradentate peptide-chelate conjugates for colorectal cancer diagnosis
Floresta et al. RSC Medicinal Chemistry
AU2024344671A1 (en) Functionalized peptides for in-vivo addressing of pd-l1 expression
WO2026027771A1 (en) Alpha v beta 6-integrin binding cyclopeptides with non-natural amino acids, and conjugates thereof
Eiblmaier Copper-64 radiopharmaceuticals for receptor-mediated tumor imaging and radiotherapy
Jackson et al. Molecular Imaging of Breast Cancer Tissue via Site-Directed Radiopharmaceuticals
Shirmardi et al. Preparation and evaluation of 67Ga-DOTA-Bombesin (7-14) as a tumor scintigraphic agent
HK1193987A (en) Her2 binding peptides labeled with aluminium-[18] fluoride complexed by nota

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued