JP2004524280A5 - - Google Patents
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- Publication number
- JP2004524280A5 JP2004524280A5 JP2002545685A JP2002545685A JP2004524280A5 JP 2004524280 A5 JP2004524280 A5 JP 2004524280A5 JP 2002545685 A JP2002545685 A JP 2002545685A JP 2002545685 A JP2002545685 A JP 2002545685A JP 2004524280 A5 JP2004524280 A5 JP 2004524280A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethylaminomethyl
- cyclohexane
- phenyl
- bladder
- diol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 6
- 230000036724 intravesical pressure Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- -1 6-dimethylaminomethyl-1-phenyl-cyclohexane compound Chemical class 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 230000008602 contraction Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 230000027939 micturition Effects 0.000 description 3
- BCTAUJYAQUAGMU-UHFFFAOYSA-N 6-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexane-1,3-diol;hydrochloride Chemical compound Cl.COC1=CC=CC(C2(O)C(CCC(O)C2)CN(C)C)=C1 BCTAUJYAQUAGMU-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- BCTAUJYAQUAGMU-ISNMTSCSSA-N (1r,3r,6r)-6-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexane-1,3-diol;hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CC[C@@H](O)C2)CN(C)C)=C1 BCTAUJYAQUAGMU-ISNMTSCSSA-N 0.000 description 1
- GVSLZYPVERZJGU-BJJXKVORSA-N 3-[(1r,2r,5s)-2-[(dimethylamino)methyl]-1-hydroxy-5-methylcyclohexyl]phenol Chemical compound C1[C@@H](C)CC[C@H](CN(C)C)[C@@]1(O)C1=CC=CC(O)=C1 GVSLZYPVERZJGU-BJJXKVORSA-N 0.000 description 1
- MZDLFGXIEFIURY-UHFFFAOYSA-N 3-[2-[(dimethylamino)methyl]-1-hydroxy-5-(trifluoromethyl)cyclohexyl]phenol Chemical compound CN(C)CC1CCC(C(F)(F)F)CC1(O)C1=CC=CC(O)=C1 MZDLFGXIEFIURY-UHFFFAOYSA-N 0.000 description 1
- XWVBSHNCJYDZLZ-UHFFFAOYSA-N 6-[(dimethylamino)methyl]-1-(3-hydroxyphenyl)cyclohexane-1,3-diol;hydrochloride Chemical compound Cl.CN(C)CC1CCC(O)CC1(O)C1=CC=CC(O)=C1 XWVBSHNCJYDZLZ-UHFFFAOYSA-N 0.000 description 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000000921 Urge Urinary Incontinence Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- LQJLLAOISDVBJM-FMKPAKJESA-N axomadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CC[C@@H](O)C2)CN(C)C)=C1 LQJLLAOISDVBJM-FMKPAKJESA-N 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000001020 rhythmical effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000008925 spontaneous activity Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000013223 sprague-dawley female rat Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 206010046494 urge incontinence Diseases 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10059413A DE10059413A1 (de) | 2000-11-30 | 2000-11-30 | Verwendung von substituierten 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz |
| PCT/EP2001/013917 WO2002043714A2 (de) | 2000-11-30 | 2001-11-28 | Verwendung von substituierten 6-dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur therapie der harninkontinenz |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004524280A JP2004524280A (ja) | 2004-08-12 |
| JP2004524280A5 true JP2004524280A5 (https=) | 2009-03-05 |
| JP4284065B2 JP4284065B2 (ja) | 2009-06-24 |
Family
ID=7665211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002545685A Expired - Fee Related JP4284065B2 (ja) | 2000-11-30 | 2001-11-28 | 置換された６−ジメチルアミノメチル−１−フェニル−シクロヘキサン化合物を尿失禁の治療に使用する方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20040029878A1 (https=) |
| EP (1) | EP1353660B1 (https=) |
| JP (1) | JP4284065B2 (https=) |
| KR (1) | KR100835874B1 (https=) |
| CN (1) | CN1518444B (https=) |
| AT (1) | ATE315387T1 (https=) |
| AU (2) | AU2002223688B2 (https=) |
| BR (1) | BR0115881A (https=) |
| CA (1) | CA2430282C (https=) |
| CY (1) | CY1105142T1 (https=) |
| CZ (1) | CZ299343B6 (https=) |
| DE (2) | DE10059413A1 (https=) |
| DK (1) | DK1353660T3 (https=) |
| EC (1) | ECSP034632A (https=) |
| ES (1) | ES2256338T3 (https=) |
| HU (1) | HU227927B1 (https=) |
| IL (2) | IL156140A0 (https=) |
| MX (1) | MXPA03004801A (https=) |
| NO (1) | NO333963B1 (https=) |
| NZ (1) | NZ538924A (https=) |
| PL (1) | PL203093B1 (https=) |
| RU (1) | RU2279875C2 (https=) |
| SK (1) | SK287536B6 (https=) |
| WO (1) | WO2002043714A2 (https=) |
| ZA (1) | ZA200304999B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050176790A1 (en) | 2001-02-28 | 2005-08-11 | Johannes Bartholomaus | Pharmaceutical salts |
| DE10333835A1 (de) * | 2003-07-24 | 2005-03-10 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol enthaltendes Arzneimittel mit verzögerter Wirkstofffreisetzung |
| US20060254029A1 (en) * | 2005-05-11 | 2006-11-16 | Conrad Swenson | Pocket loss prevention device |
| MXPA06013270A (es) * | 2004-05-14 | 2007-04-23 | Johnson & Johnson | Compuestos de opioide carboxamido. |
| WO2008027220A2 (en) * | 2006-08-28 | 2008-03-06 | Schering Corporation | Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3, 3a-dihydropyrazol0 [1, 5-a] pyrimidin-7-yl) -amino derivatives |
| DE102007022790A1 (de) * | 2007-05-11 | 2008-11-20 | Grünenthal GmbH | Axomadol zur Schmerzbehandlung bei Arthrose |
| EP2477960A1 (en) * | 2009-09-14 | 2012-07-25 | Grünenthal GmbH | Crystalline modifications of 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4371720A (en) * | 1980-09-19 | 1983-02-01 | Pfizer Inc. | 2-Hydroxy-4-(substituted) phenyl cycloalkanes and derivatives |
| GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| PT711289E (pt) * | 1993-07-30 | 2001-02-28 | Delta Pharmaceuticals Inc | Compostos piperazina utilizados em terapia |
| DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
| DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| AU6747698A (en) * | 1997-04-11 | 1998-11-11 | Nippon Shinyaku Co. Ltd. | Remedies for frequent urination and urinary incontinence |
| PE20010623A1 (es) * | 1999-10-05 | 2001-07-07 | Gruenenthal Chemie | Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria |
| DE10004926A1 (de) * | 2000-02-04 | 2001-08-09 | Gruenenthal Gmbh | Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten |
| US6326404B1 (en) * | 2000-02-21 | 2001-12-04 | Gruenenthal Gmbh | Use of O-desmethyl-N-mono-desmethyl-tramadol |
| DE10059411A1 (de) * | 2000-11-30 | 2002-06-13 | Gruenenthal Gmbh | Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz |
-
2000
- 2000-11-30 DE DE10059413A patent/DE10059413A1/de not_active Withdrawn
-
2001
- 2001-11-28 AU AU2002223688A patent/AU2002223688B2/en not_active Ceased
- 2001-11-28 IL IL15614001A patent/IL156140A0/xx active IP Right Grant
- 2001-11-28 BR BR0115881-3A patent/BR0115881A/pt not_active Application Discontinuation
- 2001-11-28 WO PCT/EP2001/013917 patent/WO2002043714A2/de not_active Ceased
- 2001-11-28 DE DE50108711T patent/DE50108711D1/de not_active Expired - Lifetime
- 2001-11-28 AU AU2368802A patent/AU2368802A/xx active Pending
- 2001-11-28 CA CA2430282A patent/CA2430282C/en not_active Expired - Fee Related
- 2001-11-28 CZ CZ20031390A patent/CZ299343B6/cs not_active IP Right Cessation
- 2001-11-28 AT AT01998336T patent/ATE315387T1/de active
- 2001-11-28 CN CN018197205A patent/CN1518444B/zh not_active Expired - Fee Related
- 2001-11-28 RU RU2003117705/15A patent/RU2279875C2/ru not_active IP Right Cessation
- 2001-11-28 HU HU0303268A patent/HU227927B1/hu not_active IP Right Cessation
- 2001-11-28 JP JP2002545685A patent/JP4284065B2/ja not_active Expired - Fee Related
- 2001-11-28 EP EP01998336A patent/EP1353660B1/de not_active Expired - Lifetime
- 2001-11-28 ES ES01998336T patent/ES2256338T3/es not_active Expired - Lifetime
- 2001-11-28 DK DK01998336T patent/DK1353660T3/da active
- 2001-11-28 PL PL365517A patent/PL203093B1/pl unknown
- 2001-11-28 NZ NZ538924A patent/NZ538924A/en not_active IP Right Cessation
- 2001-11-28 SK SK595-2003A patent/SK287536B6/sk not_active IP Right Cessation
- 2001-11-28 MX MXPA03004801A patent/MXPA03004801A/es active IP Right Grant
- 2001-11-28 KR KR1020037007316A patent/KR100835874B1/ko not_active Expired - Fee Related
-
2003
- 2003-05-27 IL IL156140A patent/IL156140A/en not_active IP Right Cessation
- 2003-05-27 NO NO20032411A patent/NO333963B1/no not_active IP Right Cessation
- 2003-05-29 EC EC2003004632A patent/ECSP034632A/es unknown
- 2003-05-30 US US10/448,443 patent/US20040029878A1/en not_active Abandoned
- 2003-06-26 ZA ZA200304999A patent/ZA200304999B/en unknown
-
2004
- 2004-11-02 US US10/978,565 patent/US7361690B2/en not_active Expired - Fee Related
-
2006
- 2006-03-10 CY CY20061100341T patent/CY1105142T1/el unknown
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