JP2004538246A5 - - Google Patents
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- Publication number
- JP2004538246A5 JP2004538246A5 JP2002545686A JP2002545686A JP2004538246A5 JP 2004538246 A5 JP2004538246 A5 JP 2004538246A5 JP 2002545686 A JP2002545686 A JP 2002545686A JP 2002545686 A JP2002545686 A JP 2002545686A JP 2004538246 A5 JP2004538246 A5 JP 2004538246A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethylamino
- methyl
- pentan
- phenyl
- hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 19
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- -1 1-phenyl-3-dimethylamino-propane compound Chemical class 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 230000036724 intravesical pressure Effects 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000008602 contraction Effects 0.000 description 4
- 230000027939 micturition Effects 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- SJIXTOBRQDKANK-UHFFFAOYSA-N 1-(3-methylsulfanylphenyl)pentan-3-ol hydrochloride Chemical compound CCC(CCC1=CC(=CC=C1)SC)O.Cl SJIXTOBRQDKANK-UHFFFAOYSA-N 0.000 description 2
- 0 C*C(*)(CN(C)*)C(*)(C*)c1c(*)c(*)c(*)c(C)c1* Chemical compound C*C(*)(CN(C)*)C(*)(C*)c1c(*)c(*)c(*)c(C)c1* 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- ZHQYXSQFTRKZTE-CZUORRHYSA-N (3R,4R)-6-(dimethylamino)-3-(3-methoxyphenyl)-4-methylhexan-3-ol Chemical compound CC[C@](C1=CC(=CC=C1)OC)([C@H](C)CCN(C)C)O ZHQYXSQFTRKZTE-CZUORRHYSA-N 0.000 description 1
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 description 1
- KWLQXJCKUWCDBH-UHFFFAOYSA-N 1-(3-methoxyphenyl)-3-methylbutan-2-ol Chemical compound COC1=CC=CC(CC(O)C(C)C)=C1 KWLQXJCKUWCDBH-UHFFFAOYSA-N 0.000 description 1
- QSHYRDQULOQBSQ-UHFFFAOYSA-N 1-(dimethylamino)-3-(3-methoxyphenyl)-4,4-dimethylpentan-3-ol Chemical compound COC1=CC=CC(C(O)(CCN(C)C)C(C)(C)C)=C1 QSHYRDQULOQBSQ-UHFFFAOYSA-N 0.000 description 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 description 1
- UMTBGMDYYBKESP-ZWNOBZJWSA-N 3-[(2r,3r)-4-(dimethylamino)-2-hydroxy-3-methylbutan-2-yl]phenol Chemical compound CN(C)C[C@@H](C)[C@@](C)(O)C1=CC=CC(O)=C1 UMTBGMDYYBKESP-ZWNOBZJWSA-N 0.000 description 1
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 description 1
- YBYOJLGHTBBSOM-UHFFFAOYSA-N 4-(dimethylamino)-2-(3-methoxyphenyl)-3-methylbutan-2-ol Chemical compound COC1=CC=CC(C(C)(O)C(C)CN(C)C)=C1 YBYOJLGHTBBSOM-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- CBFGWFWDTULPPI-CXAGYDPISA-N [(2r,3r)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-yl] acetate Chemical compound CN(C)C[C@@H](C)[C@](OC(C)=O)(CC)C1=CC=CC(OC)=C1 CBFGWFWDTULPPI-CXAGYDPISA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000001020 rhythmical effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000008925 spontaneous activity Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000013223 sprague-dawley female rat Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- KWTWDQCKEHXFFR-SMDDNHRTSA-N tapentadol Chemical compound CN(C)C[C@H](C)[C@@H](CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-SMDDNHRTSA-N 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10059412A DE10059412A1 (de) | 2000-11-30 | 2000-11-30 | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie der Harninkontinenz |
| PCT/EP2001/013918 WO2002043715A2 (de) | 2000-11-30 | 2001-11-28 | Verwendung von 1-phenyl-3-dimethylamino-propanverbindungen zur therapie der harninkontinenz |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004538246A JP2004538246A (ja) | 2004-12-24 |
| JP2004538246A5 true JP2004538246A5 (https=) | 2009-03-05 |
| JP4284066B2 JP4284066B2 (ja) | 2009-06-24 |
Family
ID=7665210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002545686A Expired - Fee Related JP4284066B2 (ja) | 2000-11-30 | 2001-11-28 | １−フェニル−３−ジメチルアミノ−プロパン化合物を尿失禁の治療に使用する方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6841575B2 (https=) |
| EP (1) | EP1438034B1 (https=) |
| JP (1) | JP4284066B2 (https=) |
| KR (1) | KR100853364B1 (https=) |
| CN (1) | CN100421654C (https=) |
| AT (1) | ATE402694T1 (https=) |
| AU (2) | AU2002233210B2 (https=) |
| BR (1) | BR0115882A (https=) |
| CA (1) | CA2430332C (https=) |
| CY (1) | CY1108377T1 (https=) |
| CZ (1) | CZ20031508A3 (https=) |
| DE (2) | DE10059412A1 (https=) |
| DK (1) | DK1438034T3 (https=) |
| EC (1) | ECSP034635A (https=) |
| ES (1) | ES2311030T3 (https=) |
| HU (1) | HU228827B1 (https=) |
| IL (2) | IL156170A0 (https=) |
| MX (1) | MXPA03004712A (https=) |
| NO (1) | NO334109B1 (https=) |
| NZ (1) | NZ526603A (https=) |
| PL (1) | PL205081B1 (https=) |
| PT (1) | PT1438034E (https=) |
| RU (1) | RU2286768C2 (https=) |
| SI (1) | SI1438034T1 (https=) |
| SK (1) | SK287420B6 (https=) |
| UA (1) | UA74608C2 (https=) |
| WO (1) | WO2002043715A2 (https=) |
| ZA (1) | ZA200305006B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10109763A1 (de) * | 2001-02-28 | 2002-09-05 | Gruenenthal Gmbh | Pharmazeutische Salze |
| US20050176790A1 (en) | 2001-02-28 | 2005-08-11 | Johannes Bartholomaus | Pharmaceutical salts |
| DE10146275A1 (de) * | 2001-09-18 | 2003-04-24 | Gruenenthal Gmbh | Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz |
| US7410965B2 (en) | 2002-05-29 | 2008-08-12 | Gruenenthal Gmbh | Delayed release pharmaceutical composition containing 1-dimethyl-amino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol |
| DE10224108A1 (de) * | 2002-05-29 | 2004-01-29 | Grünenthal GmbH | 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol enthaltendes Arzneimiitel mit verzögerter Wirkstofffreisetzung |
| DE10224624A1 (de) * | 2002-05-30 | 2003-12-11 | Gruenenthal Gmbh | Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol |
| DE10224556A1 (de) * | 2002-05-31 | 2004-01-08 | Grünenthal GmbH | 1-Dimethylamino- 3-(3-methoxy-phenyl)2-methyl-pentan-3-ol entaltendes Arzneimittel in verschiedenen Formulierungen |
| DE10225315A1 (de) * | 2002-06-06 | 2003-12-24 | Gruenenthal Gmbh | Wirkstoffsalze und Ester von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol und 3-(3-Dimethylamino-1-ethyl-1-hydroxy-2-methyl- propyl)-phenol |
| PT1562567T (pt) | 2002-11-22 | 2017-08-24 | Gruenenthal Gmbh | Combinação de analgésicos selecionados e inibidores da cox-ii |
| MX2011002448A (es) * | 2008-09-05 | 2011-05-25 | Acucela Inc | Compuestos enlazados con azufre para el tratamiento de enfermedades y trastornos oftalmicos. |
| US8853393B2 (en) | 2011-07-29 | 2014-10-07 | Anhui New Star Pharmaceutical Development Co., Ltd. | Intermediate for preparing tapentadol or analogues thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1213219B (it) * | 1984-09-28 | 1989-12-14 | Consiglio Nazionale Ricerche | Derivati amminoalchilnaftalenici ad attivita' farmacologica. |
| SE9202218D0 (sv) * | 1992-07-22 | 1992-07-22 | Kabi Pharmacia Ab | Pharmacologically active alfa-(tertiary-aminomethyl)-benzenemethanol derivatives, pharmaceutical composition containing them, therapeutical use thereof and processes for their preparation |
| TW344661B (en) * | 1993-11-24 | 1998-11-11 | Lilly Co Eli | Pharmaceutical composition for treatment of incontinence |
| DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| US5561154A (en) * | 1994-07-27 | 1996-10-01 | Institut De Recherches Chimiques Et Bioloques Appliquees Irceba | Treatment of acute urinary retention |
| EP1005861B1 (en) | 1997-04-11 | 2005-06-29 | Nippon Shinyaku Co., Ltd. | Remedies for frequent urination and urinary incontinence |
| DE19933421A1 (de) * | 1999-07-16 | 2001-01-25 | Gruenenthal Gmbh | 2-Benzyl-3-dimethylamino-1-phenyl-propanderi- vate |
-
2000
- 2000-11-30 DE DE10059412A patent/DE10059412A1/de not_active Withdrawn
-
2001
- 2001-11-28 WO PCT/EP2001/013918 patent/WO2002043715A2/de not_active Ceased
- 2001-11-28 AU AU2002233210A patent/AU2002233210B2/en not_active Ceased
- 2001-11-28 CZ CZ20031508A patent/CZ20031508A3/cs unknown
- 2001-11-28 HU HU0302430A patent/HU228827B1/hu not_active IP Right Cessation
- 2001-11-28 MX MXPA03004712A patent/MXPA03004712A/es active IP Right Grant
- 2001-11-28 JP JP2002545686A patent/JP4284066B2/ja not_active Expired - Fee Related
- 2001-11-28 EP EP01984781A patent/EP1438034B1/de not_active Expired - Lifetime
- 2001-11-28 SI SI200130874T patent/SI1438034T1/sl unknown
- 2001-11-28 CN CNB018223478A patent/CN100421654C/zh not_active Expired - Fee Related
- 2001-11-28 ES ES01984781T patent/ES2311030T3/es not_active Expired - Lifetime
- 2001-11-28 DK DK01984781T patent/DK1438034T3/da active
- 2001-11-28 SK SK663-2003A patent/SK287420B6/sk not_active IP Right Cessation
- 2001-11-28 CA CA2430332A patent/CA2430332C/en not_active Expired - Fee Related
- 2001-11-28 UA UA2003066043A patent/UA74608C2/uk unknown
- 2001-11-28 KR KR1020037007270A patent/KR100853364B1/ko not_active Expired - Fee Related
- 2001-11-28 NZ NZ526603A patent/NZ526603A/en not_active IP Right Cessation
- 2001-11-28 IL IL15617001A patent/IL156170A0/xx active IP Right Grant
- 2001-11-28 DE DE50114181T patent/DE50114181D1/de not_active Expired - Lifetime
- 2001-11-28 PT PT01984781T patent/PT1438034E/pt unknown
- 2001-11-28 PL PL366051A patent/PL205081B1/pl unknown
- 2001-11-28 RU RU2003117707/15A patent/RU2286768C2/ru not_active IP Right Cessation
- 2001-11-28 BR BR0115882-1A patent/BR0115882A/pt not_active Application Discontinuation
- 2001-11-28 AT AT01984781T patent/ATE402694T1/de active
- 2001-11-28 AU AU3321002A patent/AU3321002A/xx active Pending
-
2003
- 2003-05-27 NO NO20032406A patent/NO334109B1/no not_active IP Right Cessation
- 2003-05-28 IL IL156170A patent/IL156170A/en not_active IP Right Cessation
- 2003-05-30 EC EC2003004635A patent/ECSP034635A/es unknown
- 2003-05-30 US US10/448,454 patent/US6841575B2/en not_active Expired - Fee Related
- 2003-06-26 ZA ZA200305006A patent/ZA200305006B/en unknown
-
2008
- 2008-09-25 CY CY20081101059T patent/CY1108377T1/el unknown
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