AU2002223688B2 - Use of substituted 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treating urinary incontinence - Google Patents
Use of substituted 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treating urinary incontinence Download PDFInfo
- Publication number
- AU2002223688B2 AU2002223688B2 AU2002223688A AU2002223688A AU2002223688B2 AU 2002223688 B2 AU2002223688 B2 AU 2002223688B2 AU 2002223688 A AU2002223688 A AU 2002223688A AU 2002223688 A AU2002223688 A AU 2002223688A AU 2002223688 B2 AU2002223688 B2 AU 2002223688B2
- Authority
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- Australia
- Prior art keywords
- alkyl
- och
- unsubstituted
- dimethylaminomethyl
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 206010046543 Urinary incontinence Diseases 0.000 title claims abstract description 20
- BDPAJJIAIBKWER-UHFFFAOYSA-N n,n-dimethyl-1-(2-phenylcyclohexyl)methanamine Chemical class CN(C)CC1CCCCC1C1=CC=CC=C1 BDPAJJIAIBKWER-UHFFFAOYSA-N 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 33
- 206010027566 Micturition urgency Diseases 0.000 claims abstract description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims description 30
- 239000003814 drug Substances 0.000 claims description 26
- 229920006395 saturated elastomer Polymers 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 10
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 8
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 7
- LQJLLAOISDVBJM-UHFFFAOYSA-N 6-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexane-1,3-diol Chemical compound COC1=CC=CC(C2(O)C(CCC(O)C2)CN(C)C)=C1 LQJLLAOISDVBJM-UHFFFAOYSA-N 0.000 claims description 5
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- 125000004076 pyridyl group Chemical group 0.000 claims description 3
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- 238000000034 method Methods 0.000 abstract description 8
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10059413A DE10059413A1 (de) | 2000-11-30 | 2000-11-30 | Verwendung von substituierten 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz |
| DE10059413.1 | 2000-11-30 | ||
| PCT/EP2001/013917 WO2002043714A2 (de) | 2000-11-30 | 2001-11-28 | Verwendung von substituierten 6-dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur therapie der harninkontinenz |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002223688A1 AU2002223688A1 (en) | 2002-08-15 |
| AU2002223688B2 true AU2002223688B2 (en) | 2006-06-01 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002223688A Ceased AU2002223688B2 (en) | 2000-11-30 | 2001-11-28 | Use of substituted 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treating urinary incontinence |
| AU2368802A Pending AU2368802A (en) | 2000-11-30 | 2001-11-28 | Use of substituted 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treating urinary incontinence |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2368802A Pending AU2368802A (en) | 2000-11-30 | 2001-11-28 | Use of substituted 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treating urinary incontinence |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20040029878A1 (https=) |
| EP (1) | EP1353660B1 (https=) |
| JP (1) | JP4284065B2 (https=) |
| KR (1) | KR100835874B1 (https=) |
| CN (1) | CN1518444B (https=) |
| AT (1) | ATE315387T1 (https=) |
| AU (2) | AU2002223688B2 (https=) |
| BR (1) | BR0115881A (https=) |
| CA (1) | CA2430282C (https=) |
| CY (1) | CY1105142T1 (https=) |
| CZ (1) | CZ299343B6 (https=) |
| DE (2) | DE10059413A1 (https=) |
| DK (1) | DK1353660T3 (https=) |
| EC (1) | ECSP034632A (https=) |
| ES (1) | ES2256338T3 (https=) |
| HU (1) | HU227927B1 (https=) |
| IL (2) | IL156140A0 (https=) |
| MX (1) | MXPA03004801A (https=) |
| NO (1) | NO333963B1 (https=) |
| NZ (1) | NZ538924A (https=) |
| PL (1) | PL203093B1 (https=) |
| RU (1) | RU2279875C2 (https=) |
| SK (1) | SK287536B6 (https=) |
| WO (1) | WO2002043714A2 (https=) |
| ZA (1) | ZA200304999B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005245403B2 (en) * | 2004-05-14 | 2012-04-19 | Janssen Pharmaceutica N.V. | Carboxamido opioid compounds |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050176790A1 (en) | 2001-02-28 | 2005-08-11 | Johannes Bartholomaus | Pharmaceutical salts |
| DE10333835A1 (de) * | 2003-07-24 | 2005-03-10 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol enthaltendes Arzneimittel mit verzögerter Wirkstofffreisetzung |
| US20060254029A1 (en) * | 2005-05-11 | 2006-11-16 | Conrad Swenson | Pocket loss prevention device |
| WO2008027220A2 (en) * | 2006-08-28 | 2008-03-06 | Schering Corporation | Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3, 3a-dihydropyrazol0 [1, 5-a] pyrimidin-7-yl) -amino derivatives |
| DE102007022790A1 (de) * | 2007-05-11 | 2008-11-20 | Grünenthal GmbH | Axomadol zur Schmerzbehandlung bei Arthrose |
| EP2477960A1 (en) * | 2009-09-14 | 2012-07-25 | Grünenthal GmbH | Crystalline modifications of 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol |
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| US4371720A (en) * | 1980-09-19 | 1983-02-01 | Pfizer Inc. | 2-Hydroxy-4-(substituted) phenyl cycloalkanes and derivatives |
| GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| PT711289E (pt) * | 1993-07-30 | 2001-02-28 | Delta Pharmaceuticals Inc | Compostos piperazina utilizados em terapia |
| DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
| DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| AU6747698A (en) * | 1997-04-11 | 1998-11-11 | Nippon Shinyaku Co. Ltd. | Remedies for frequent urination and urinary incontinence |
| PE20010623A1 (es) * | 1999-10-05 | 2001-07-07 | Gruenenthal Chemie | Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria |
| DE10004926A1 (de) * | 2000-02-04 | 2001-08-09 | Gruenenthal Gmbh | Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten |
| US6326404B1 (en) * | 2000-02-21 | 2001-12-04 | Gruenenthal Gmbh | Use of O-desmethyl-N-mono-desmethyl-tramadol |
| DE10059411A1 (de) * | 2000-11-30 | 2002-06-13 | Gruenenthal Gmbh | Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz |
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2000
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005245403B2 (en) * | 2004-05-14 | 2012-04-19 | Janssen Pharmaceutica N.V. | Carboxamido opioid compounds |
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