JP2004523559A5 - - Google Patents
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- Publication number
- JP2004523559A5 JP2004523559A5 JP2002567309A JP2002567309A JP2004523559A5 JP 2004523559 A5 JP2004523559 A5 JP 2004523559A5 JP 2002567309 A JP2002567309 A JP 2002567309A JP 2002567309 A JP2002567309 A JP 2002567309A JP 2004523559 A5 JP2004523559 A5 JP 2004523559A5
- Authority
- JP
- Japan
- Prior art keywords
- tetrahydro
- dioxo
- purin
- bis
- methyl ether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 substituted C 6 aryl Chemical group 0.000 claims 172
- 125000000217 alkyl group Chemical group 0.000 claims 40
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 26
- 229940114081 cinnamate Drugs 0.000 claims 22
- 229920000847 nonoxynol Polymers 0.000 claims 18
- LERWZBXJAOSNBN-DTQAZKPQSA-N (e)-3-[4-[1,3-bis(cyclohexylmethyl)-2,6-dioxo-7h-purin-8-yl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C1=NC(C(N(CC2CCCCC2)C(=O)N2CC3CCCCC3)=O)=C2N1 LERWZBXJAOSNBN-DTQAZKPQSA-N 0.000 claims 14
- 150000002148 esters Chemical class 0.000 claims 14
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 12
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 12
- 150000001408 amides Chemical class 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 239000012453 solvate Substances 0.000 claims 10
- 229910052717 sulfur Inorganic materials 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 8
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 8
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims 8
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 8
- 241001465754 Metazoa Species 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 6
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 6
- PHPTYNIVTRERGL-CCEZHUSRSA-N (e)-3-[3-[1,3-bis(cyclohexylmethyl)-2,6-dioxo-7h-purin-8-yl]phenyl]prop-2-enoic acid Chemical compound OC(=O)\C=C\C1=CC=CC(C=2NC3=C(C(N(CC4CCCCC4)C(=O)N3CC3CCCCC3)=O)N=2)=C1 PHPTYNIVTRERGL-CCEZHUSRSA-N 0.000 claims 4
- CNGGDAGBSQGQJU-UHFFFAOYSA-N 8-[4-(aminomethyl)phenyl]-1,3-bis(cyclohexylmethyl)-7h-purine-2,6-dione Chemical compound C1=CC(CN)=CC=C1C1=NC(C(N(CC2CCCCC2)C(=O)N2CC3CCCCC3)=O)=C2N1 CNGGDAGBSQGQJU-UHFFFAOYSA-N 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 102100038591 Endothelial cell-selective adhesion molecule Human genes 0.000 claims 4
- 101000882622 Homo sapiens Endothelial cell-selective adhesion molecule Proteins 0.000 claims 4
- CCRCUPLGCSFEDV-UHFFFAOYSA-N cinnamic acid methyl ester Natural products COC(=O)C=CC1=CC=CC=C1 CCRCUPLGCSFEDV-UHFFFAOYSA-N 0.000 claims 4
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 4
- 208000010643 digestive system disease Diseases 0.000 claims 4
- 125000000524 functional group Chemical group 0.000 claims 4
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- IJVFPDHKTFXORE-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol propanoic acid Chemical class COCCOCCOCCOCCOCCOCCOCCOCCOCCO.C(CC)(=O)O IJVFPDHKTFXORE-UHFFFAOYSA-N 0.000 claims 2
- WGKYSFRFMQHMOF-UHFFFAOYSA-N 3-bromo-5-methylpyridine-2-carbonitrile Chemical compound CC1=CN=C(C#N)C(Br)=C1 WGKYSFRFMQHMOF-UHFFFAOYSA-N 0.000 claims 2
- BUUVGKATBLTPSK-UHFFFAOYSA-N 8-[4-(aminomethyl)phenyl]-1,3-bis(cyclohexylmethyl)-7h-purine-2,6-dione;2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound COCCOCCOCCOCCOCCOCCOCCO.C1=CC(CN)=CC=C1C(N1)=NC2=C1C(=O)N(CC1CCCCC1)C(=O)N2CC1CCCCC1 BUUVGKATBLTPSK-UHFFFAOYSA-N 0.000 claims 2
- XWSKURWERJWSKI-UHFFFAOYSA-N COCCOCCOCCOCCOCCOCCOCCOCCOCCO.C(C=CC1=CC=CC=C1)(=O)O Chemical compound COCCOCCOCCOCCOCCOCCOCCOCCOCCO.C(C=CC1=CC=CC=C1)(=O)O XWSKURWERJWSKI-UHFFFAOYSA-N 0.000 claims 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- DNMZJIGSDQVGSA-UHFFFAOYSA-N methoxymethane;hydrochloride Chemical compound Cl.COC DNMZJIGSDQVGSA-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27211501P | 2001-02-28 | 2001-02-28 | |
| PCT/US2002/005973 WO2002067942A2 (en) | 2001-02-28 | 2002-02-26 | Methods of treating irritable bowel syndrome and functional dyspepsia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004523559A JP2004523559A (ja) | 2004-08-05 |
| JP2004523559A5 true JP2004523559A5 (https=) | 2005-12-22 |
Family
ID=23038466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002567309A Pending JP2004523559A (ja) | 2001-02-28 | 2002-02-26 | 過敏性腸症候群および機能性胃腸症の治療方法 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1372661B1 (https=) |
| JP (1) | JP2004523559A (https=) |
| AT (1) | ATE326225T1 (https=) |
| AU (1) | AU2002252134A1 (https=) |
| DE (1) | DE60211495T2 (https=) |
| ES (1) | ES2262798T3 (https=) |
| WO (1) | WO2002067942A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004009091A1 (en) | 2002-06-17 | 2004-01-29 | Glaxo Group Limited | Purine derivatives as liver x receptor agonists |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| BRPI0513811A (pt) | 2004-07-27 | 2008-07-15 | Gilead Sciences Inc | imidazo [4,5-d] pirimidinas, seus usos e processos de preparação |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2527360B1 (en) | 2007-06-04 | 2015-10-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5017577A (en) * | 1986-04-25 | 1991-05-21 | Burroughs Wellcome Co. | Methods for treating viral infection |
| GB9703044D0 (en) * | 1997-02-14 | 1997-04-02 | Glaxo Group Ltd | Phenyl xanthine esters and amides |
| WO1999043673A1 (en) * | 1998-02-26 | 1999-09-02 | Zenyaku Kogyo Kabushiki Kaisha | 1-azaindolizine derivatives |
| GB9817623D0 (en) * | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
-
2002
- 2002-02-26 DE DE60211495T patent/DE60211495T2/de not_active Expired - Fee Related
- 2002-02-26 EP EP02721191A patent/EP1372661B1/en not_active Expired - Lifetime
- 2002-02-26 AU AU2002252134A patent/AU2002252134A1/en not_active Abandoned
- 2002-02-26 WO PCT/US2002/005973 patent/WO2002067942A2/en not_active Ceased
- 2002-02-26 AT AT02721191T patent/ATE326225T1/de not_active IP Right Cessation
- 2002-02-26 ES ES02721191T patent/ES2262798T3/es not_active Expired - Lifetime
- 2002-02-26 JP JP2002567309A patent/JP2004523559A/ja active Pending
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