JP2004522402A5 - - Google Patents
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- JP2004522402A5 JP2004522402A5 JP2001500766A JP2001500766A JP2004522402A5 JP 2004522402 A5 JP2004522402 A5 JP 2004522402A5 JP 2001500766 A JP2001500766 A JP 2001500766A JP 2001500766 A JP2001500766 A JP 2001500766A JP 2004522402 A5 JP2004522402 A5 JP 2004522402A5
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- 108020004414 DNA Proteins 0.000 description 9
- 239000000523 sample Substances 0.000 description 8
- 101100028536 Prochlorococcus marinus (strain SARG / CCMP1375 / SS120) panB gene Proteins 0.000 description 7
- 108091034117 Oligonucleotide Proteins 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- 239000002299 complementary DNA Substances 0.000 description 6
- 239000002773 nucleotide Substances 0.000 description 6
- 125000003729 nucleotide group Chemical group 0.000 description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 description 5
- 108091035707 Consensus sequence Proteins 0.000 description 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 4
- 238000009396 hybridization Methods 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 108091026890 Coding region Proteins 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 102000012286 Chitinases Human genes 0.000 description 2
- 108010022172 Chitinases Proteins 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 2
- 238000001712 DNA sequencing Methods 0.000 description 2
- 238000012408 PCR amplification Methods 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 230000014621 translational initiation Effects 0.000 description 2
- 102000004452 Arginase Human genes 0.000 description 1
- 108700024123 Arginases Proteins 0.000 description 1
- 230000004988 N-glycosylation Effects 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000005084 renal tissue Anatomy 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
Applications Claiming Priority (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1999/012252 WO1999063088A2 (en) | 1998-06-02 | 1999-06-02 | Membrane-bound proteins and nucleic acids encoding the same |
| US14103799P | 1999-06-23 | 1999-06-23 | |
| US14304899P | 1999-07-07 | 1999-07-07 | |
| US14475899P | 1999-07-20 | 1999-07-20 | |
| US14569899P | 1999-07-26 | 1999-07-26 | |
| US14622299P | 1999-07-28 | 1999-07-28 | |
| US14939699P | 1999-08-17 | 1999-08-17 | |
| PCT/US1999/021090 WO2000015796A2 (en) | 1998-09-16 | 1999-09-15 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| PCT/US1999/021547 WO2000015797A2 (en) | 1998-09-17 | 1999-09-15 | Compositions and methods for the treatment of immune related diseases |
| US15866399P | 1999-10-08 | 1999-10-08 | |
| PCT/US1999/028313 WO2000032221A2 (en) | 1998-12-01 | 1999-11-30 | Promotion or inhibition of angiogenesis and cardiovascularization |
| PCT/US1999/028301 WO2000032776A2 (en) | 1998-12-01 | 1999-12-01 | Secreted amd transmembrane polypeptides and nucleic acids encoding the same |
| PCT/US1999/030095 WO2000037640A2 (en) | 1998-12-22 | 1999-12-16 | Compositions and methods for the treatment of tumor |
| PCT/US1999/030911 WO2000075316A1 (en) | 1999-06-02 | 1999-12-20 | Methods and compositions for inhibiting neoplastic cell growth |
| PCT/US2000/000219 WO2000053753A2 (en) | 1999-03-08 | 2000-01-05 | Promotion or inhibition of angiogenesis and cardiovascularization |
| PCT/US2000/000376 WO2000053755A2 (en) | 1999-03-08 | 2000-01-06 | Compositions and methods for the treatment of tumor |
| PCT/US2000/003565 WO2001053486A1 (en) | 1999-03-08 | 2000-02-11 | Compositions and methods for the treatment of tumor |
| PCT/US2000/004341 WO2000053756A2 (en) | 1999-03-08 | 2000-02-18 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| PCT/US2000/004414 WO2001004311A1 (en) | 1999-07-07 | 2000-02-22 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| PCT/US2000/004914 WO2000075327A1 (en) | 1999-06-02 | 2000-02-24 | Methods and compositions for inhibiting neoplastic cell growth |
| PCT/US2000/005004 WO2000053757A2 (en) | 1999-03-08 | 2000-02-24 | Promotion or inhibition of angiogenesis and cardiovascularization |
| PCT/US2000/005841 WO2000053758A2 (en) | 1999-03-08 | 2000-03-02 | Compositions and methods for the treatment of immune related diseases |
| PCT/US2000/006884 WO2001005972A1 (en) | 1999-07-20 | 2000-03-15 | Compositions and methods for the treatment of immune related diseases |
| PCT/US2000/007377 WO2001019991A1 (en) | 1999-09-15 | 2000-03-20 | Compositions and methods for the treatment of immune related diseases |
| PCT/US2000/008439 WO2000073454A1 (en) | 1999-06-02 | 2000-03-30 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002341509A Division JP4017507B2 (ja) | 1999-06-02 | 2002-09-25 | ポリペプチドを含有する医薬 |
| JP2005117472A Division JP2005304500A (ja) | 1999-07-20 | 2005-03-14 | ポリペプチドを含有する医薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004522402A JP2004522402A (ja) | 2004-07-29 |
| JP2004522402A5 true JP2004522402A5 (enExample) | 2004-12-24 |
Family
ID=42676646
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001500766A Pending JP2004522402A (ja) | 1999-06-02 | 2000-03-30 | 同一のものをコードする分泌及び膜貫通ポリペプチドと核酸 |
| JP2002341509A Expired - Lifetime JP4017507B2 (ja) | 1999-06-02 | 2002-09-25 | ポリペプチドを含有する医薬 |
| JP2007172879A Expired - Lifetime JP5512073B2 (ja) | 1999-06-02 | 2007-06-29 | ポリペプチドを含有する医薬 |
| JP2011138276A Pending JP2011236224A (ja) | 1999-06-02 | 2011-06-22 | ポリペプチドを含有する医薬 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002341509A Expired - Lifetime JP4017507B2 (ja) | 1999-06-02 | 2002-09-25 | ポリペプチドを含有する医薬 |
| JP2007172879A Expired - Lifetime JP5512073B2 (ja) | 1999-06-02 | 2007-06-29 | ポリペプチドを含有する医薬 |
| JP2011138276A Pending JP2011236224A (ja) | 1999-06-02 | 2011-06-22 | ポリペプチドを含有する医薬 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1210418B1 (enExample) |
| JP (4) | JP2004522402A (enExample) |
| AT (1) | ATE478145T1 (enExample) |
| AU (1) | AU3774300A (enExample) |
| CA (1) | CA2383254A1 (enExample) |
| WO (1) | WO2000073454A1 (enExample) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5773252A (en) | 1995-06-05 | 1998-06-30 | Human Genome Sciences, Inc. | Fibroblast growth factor 15 |
| WO2001049715A2 (en) * | 2000-01-06 | 2001-07-12 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| WO1999009155A1 (en) | 1997-08-19 | 1999-02-25 | Human Genome Sciences, Inc. | 70 human secreted proteins |
| US20030130182A1 (en) * | 1997-11-05 | 2003-07-10 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU764441B2 (en) | 1998-02-09 | 2003-08-21 | Genset S.A. | cDNAs encoding secreted proteins |
| US7160679B1 (en) | 1998-05-21 | 2007-01-09 | Diadexus, Inc. | Method of diagnosing, monitoring, and staging lung cancer |
| US7291712B2 (en) | 1998-06-25 | 2007-11-06 | Genentech, Inc. | Interleukin-8 homologous polypeptides and therapeutic uses thereof |
| US7264801B2 (en) | 1998-08-11 | 2007-09-04 | Genentech, Inc. | EG-VEGF nucleic acids and polypeptides and method of use |
| US20020172678A1 (en) | 2000-06-23 | 2002-11-21 | Napoleone Ferrara | EG-VEGF nucleic acids and polypeptides and methods of use |
| US20030003507A1 (en) | 1999-06-02 | 2003-01-02 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| CA2341142A1 (en) | 1998-09-02 | 2000-03-09 | Diadexus Llc | A novel method of diagnosing, monitoring, staging, imaging and treating various cancers |
| CA2341326A1 (en) * | 1998-09-03 | 2000-03-16 | Takeda Chemical Industries, Ltd. | Novel protein and process for producing the same |
| US7014996B1 (en) | 1998-10-02 | 2006-03-21 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating gynecologic cancers |
| US6902892B1 (en) | 1998-10-19 | 2005-06-07 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating prostate cancer |
| US6468546B1 (en) | 1998-12-17 | 2002-10-22 | Corixa Corporation | Compositions and methods for therapy and diagnosis of ovarian cancer |
| US7888477B2 (en) | 1998-12-17 | 2011-02-15 | Corixa Corporation | Ovarian cancer-associated antibodies and kits |
| AU2007216683B2 (en) * | 1998-12-17 | 2011-07-14 | Corixa Corporation | Compositions and methods for therapy and diagnosis of ovarian cancer |
| US6962980B2 (en) | 1999-09-24 | 2005-11-08 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| JP2002533082A (ja) * | 1998-12-23 | 2002-10-08 | コリクサ コーポレイション | 結腸癌の免疫療法および診断のための化合物およびそれらの使用のための方法 |
| US6242419B1 (en) * | 1999-03-25 | 2001-06-05 | Genesis Research & Development Corporation Ltd. | Compositions isolated from stromal cells and methods for their use |
| US7083791B2 (en) | 1999-03-25 | 2006-08-01 | Genesis Research & Development Corporation Limited | Methods for enhancing immune responses by fibroblast growth factor receptor 5 polypeptides |
| US6943235B1 (en) | 1999-04-12 | 2005-09-13 | Agensys, Inc. | Transmembrane protein expressed in prostate cancer |
| US7034132B2 (en) | 2001-06-04 | 2006-04-25 | Anderson David W | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| EP1623992A3 (en) * | 1999-09-01 | 2006-05-10 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP1208202A2 (en) * | 1999-09-01 | 2002-05-29 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| WO2001023553A2 (en) * | 1999-09-29 | 2001-04-05 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Metastasis-associated antigen c4.4a |
| CA2395539C (en) * | 1999-12-23 | 2009-08-25 | Zymogenetics, Inc. | Soluble interleukin-20 receptor |
| US6610286B2 (en) | 1999-12-23 | 2003-08-26 | Zymogenetics, Inc. | Method for treating inflammation using soluble receptors to interleukin-20 |
| US7122632B2 (en) | 1999-12-23 | 2006-10-17 | Zymogenetics, Inc. | Soluble Interleukin-20 receptor |
| JP2005508131A (ja) * | 2000-02-15 | 2005-03-31 | アムジェン インコーポレイテッド | 線維芽細胞成長因子−23分子およびその使用 |
| EP1947182A1 (en) * | 2000-02-15 | 2008-07-23 | Amgen Inc. | Fibroblast growth factor-23 molecules and uses thereof |
| US7135303B2 (en) | 2000-02-28 | 2006-11-14 | The United States Of America As Represented By The Department Of Health And Human Services | Regulators of type-1 tumor necrosis factor receptor and other cytokine receptor shedding |
| AU6802801A (en) * | 2000-03-01 | 2001-09-24 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP1261638A2 (en) * | 2000-03-08 | 2002-12-04 | Chiron Corporation | Human fgf-23 gene and gene expression products |
| US20030105302A1 (en) * | 2000-03-08 | 2003-06-05 | Nobuyuki Itoh | Human FGF-23 gene and gene expression products |
| DK1283214T3 (da) * | 2000-04-21 | 2007-06-11 | Fuso Pharmaceutical Ind | Hidtil ukendte kollektiner |
| AU2001259565A1 (en) * | 2000-05-04 | 2001-11-12 | Incyte Genomics, Inc. | Proteases |
| ATE473280T1 (de) * | 2000-05-11 | 2010-07-15 | Zymogenetics Inc | Zsig33-ähnliche peptide |
| US6897286B2 (en) | 2000-05-11 | 2005-05-24 | Zymogenetics, Inc. | Zsig33-like peptides |
| EP1176200A3 (de) | 2000-06-20 | 2005-01-12 | Switch Biotech Aktiengesellschaft | Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankung oder Wundheilung sowie ihre Verwendung zur Indentifizierung von pharmakologisch aktiven Substanzen |
| AU2001273194A1 (en) * | 2000-06-30 | 2002-01-14 | Amgen Inc. | B7-Like Molecules and Uses Thereof |
| WO2002006483A1 (fr) * | 2000-07-18 | 2002-01-24 | Takeda Chemical Industries, Ltd. | Nouveau peptide actif sur le plan physiologique et utilisation associee |
| ES2340662T3 (es) | 2000-07-19 | 2010-06-08 | Advanced Research And Technology Institute | Factor de crecimiento de fibroblastos (fgf23) nuevo procedimiento para el uso. |
| ES2344679T3 (es) * | 2000-08-11 | 2010-09-03 | Kyowa Hakko Kirin Co., Ltd. | Polipeptidos que controlan el metabolismo del acido fosforico, el metabolismo del calcio, el metabolismo de la calcificacion y de la vitamina d y moleculas de adn que los codifican. |
| CA2421056A1 (en) * | 2000-09-01 | 2002-03-28 | Genentech, Inc. | A polypeptide for use as a diagnostic marker for the presence of colon tumours |
| JP2004532609A (ja) | 2000-11-03 | 2004-10-28 | ザ リージェント オブ ザ ユニバーシティ オブ カリフォルニア | プロキネチシンポリペプチド、関連組成物および方法 |
| RU2003123108A (ru) * | 2000-12-26 | 2005-02-27 | Чугаи Сейяку Кабусики Кайся (Jp) | Мутантные формы человеческого белка fgf23, снижающие содержание фосфора в крови |
| EP1873245A1 (en) * | 2001-02-28 | 2008-01-02 | Genentech, Inc. | Interleukin-8 homologous polypeptides and therapeutic uses thereof |
| EP1881007A1 (en) * | 2001-03-27 | 2008-01-23 | Novartis AG | LLR-J24 related proteins |
| US6734289B2 (en) * | 2001-03-29 | 2004-05-11 | The University Of Chicago | Gastrokines and derived peptides including inhibitors |
| US7033790B2 (en) | 2001-04-03 | 2006-04-25 | Curagen Corporation | Proteins and nucleic acids encoding same |
| US7736654B2 (en) | 2001-04-10 | 2010-06-15 | Agensys, Inc. | Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers |
| WO2003002737A1 (fr) * | 2001-06-27 | 2003-01-09 | Riken | Nouvelle proteine inhibitrice de la topoisomerase humaine 2$g(a) et utilisation associee |
| IL159872A0 (en) * | 2001-07-26 | 2004-06-20 | Genset Sa | Gmg-2 polypeptides and their use |
| ATE441666T1 (de) | 2001-12-28 | 2009-09-15 | Kyowa Hakko Kirin Co Ltd | Antikírper gegen den fibroblastenwachstumsfaktor 23 |
| AU2003215761A1 (en) * | 2002-03-22 | 2003-10-08 | Bioxell S.P.A. | A novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof |
| WO2003090600A2 (en) * | 2002-04-23 | 2003-11-06 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| DE60324797D1 (de) * | 2002-05-31 | 2009-01-02 | Seikagaku Kogyo Co Ltd | Chondroitinsynthetase und das enzym codierende dna |
| AU2003261911A1 (en) * | 2002-09-04 | 2004-03-29 | Takeda Pharmaceutical Company Limited | Use of disease-associated gene |
| CA2505707A1 (en) * | 2002-11-07 | 2004-05-21 | National Institute Of Advanced Industrial Science And Technology | Method of detecting bone paget's disease |
| US7411048B2 (en) | 2002-11-19 | 2008-08-12 | Drg International, Inc. | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids |
| EP1578254B1 (en) | 2002-11-19 | 2013-03-06 | DRG International, Inc. | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor |
| US8017737B2 (en) | 2002-11-19 | 2011-09-13 | Hasan Kulaksiz | Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| US7312197B2 (en) | 2003-02-24 | 2007-12-25 | University Of Maryland, Baltimore | Method of modifying glucose activity using polypeptides selectively expressed in fat tissue |
| JP4912144B2 (ja) | 2003-03-12 | 2012-04-11 | ジェネンテック, インコーポレイテッド | 造血促進のためのbv8及び/又はeg−vegfの使用 |
| US20050025763A1 (en) | 2003-05-08 | 2005-02-03 | Protein Design Laboratories, Inc. | Therapeutic use of anti-CS1 antibodies |
| US7709610B2 (en) | 2003-05-08 | 2010-05-04 | Facet Biotech Corporation | Therapeutic use of anti-CS1 antibodies |
| EP1633882B1 (en) * | 2003-05-28 | 2008-05-14 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with puromycin-insensitive leucyl-specific aminopeptidase (pils) |
| NZ596984A (en) * | 2003-11-17 | 2013-10-25 | Genentech Inc | Compositions and methods for the treatment of tumor of hematopoietic origin |
| JP4658967B2 (ja) * | 2003-12-24 | 2011-03-23 | ジェネンテック, インコーポレイテッド | 造血系起源の腫瘍の治療のための組成物と方法 |
| WO2005068497A1 (en) * | 2004-01-06 | 2005-07-28 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Iis: a novel ifn-gamma-inducible protein, member of the secretoglobin family, that modulates cellular invasion and migration |
| DE102004024617A1 (de) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| JP2006034189A (ja) * | 2004-07-28 | 2006-02-09 | National Institute Of Advanced Industrial & Technology | 組織の癌化の検出方法 |
| US7544659B2 (en) | 2004-08-13 | 2009-06-09 | Genentech, Inc. | Promotion of axonal regeneration |
| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| CA2630483C (en) | 2005-12-08 | 2015-05-19 | Medarex, Inc. | Human monoclonal antibodies to o8e |
| CN100460013C (zh) * | 2006-09-05 | 2009-02-11 | 重庆康卫生物科技有限公司 | 口服重组幽门螺杆菌疫苗及其制备方法 |
| US8058014B2 (en) | 2006-09-29 | 2011-11-15 | University Of Maryland, Baltimore | Method of diagnosing or predicting disease states in a subject using omentin 1 and omentin 2 |
| US7883705B2 (en) | 2007-02-14 | 2011-02-08 | Kyowa Hakko Kirin Co., Ltd. | Anti FGF23 antibody and a pharmaceutical composition comprising the same |
| AR069062A1 (es) | 2007-11-02 | 2009-12-23 | Lilly Co Eli | Anticuerpo anti-hepcidina |
| ES2432018T3 (es) | 2008-08-06 | 2013-11-29 | Eli Lilly And Company | Anticuerpos selectivos anti-hepcidina-25 y usos de los mismos |
| WO2011104381A2 (en) | 2010-02-26 | 2011-09-01 | Novo Nordisk A/S | Stable antibody containing compositions |
| CA2800188A1 (en) | 2010-05-28 | 2011-12-01 | Novo Nordisk A/S | Stable multi-dose compositions comprising an antibody and a preservative |
| WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
| EA035645B1 (ru) | 2013-03-15 | 2020-07-21 | Дженентек, Инк. | ПОЛИПЕПТИДЫ IL-22, ХИМЕРНЫЕ БЕЛКИ IL-22 Fc И ИХ ПРИМЕНЕНИЕ |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5707829A (en) * | 1995-08-11 | 1998-01-13 | Genetics Institute, Inc. | DNA sequences and secreted proteins encoded thereby |
| US5824504A (en) * | 1996-09-26 | 1998-10-20 | Elshourbagy; Nabil A. | Human 7-transmembrane receptor and DNA |
| CA2283299A1 (en) * | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 186 human secreted proteins |
| EP0998490A2 (en) * | 1997-03-25 | 2000-05-10 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| JP2001512013A (ja) * | 1997-08-01 | 2001-08-21 | ジェンセット | 前立腺に発現される分泌タンパク質の5’est |
| DE19811194A1 (de) * | 1998-03-10 | 1999-09-16 | Metagen Gesellschaft Fuer Genomforschung Mbh | Menschliche Nukleinsäuresequenzen aus Prostatagewebe |
| DE19817557A1 (de) * | 1998-04-09 | 1999-10-21 | Metagen Gesellschaft Fuer Genomforschung Mbh | Menschliche Nukleinsäuresequenzen aus Ovartumorgewebe |
| JPH11332571A (ja) * | 1998-05-29 | 1999-12-07 | Taisho Pharmaceut Co Ltd | 新規遺伝子とそれにコードされる蛋白質 |
| IL139686A0 (en) * | 1998-06-02 | 2002-02-10 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| WO2000008145A2 (en) * | 1998-08-03 | 2000-02-17 | Novartis Ag | Novel genes in control of hematopoiesis |
| CA2296792A1 (en) * | 1999-02-26 | 2000-08-26 | Genset S.A. | Expressed sequence tags and encoded human proteins |
| AU3386800A (en) * | 1999-03-01 | 2000-09-21 | Millennium Pharmaceuticals, Inc. | Secreted proteins and nucleic acids encoding them |
| CA2373231A1 (en) * | 1999-05-19 | 2000-11-23 | Incyte Genomics, Inc. | Extracellular signaling molecules |
| WO2001036465A2 (en) * | 1999-11-16 | 2001-05-25 | Zymogenetics, Inc. | Human zven proteins |
| CA2399776A1 (en) * | 2000-02-03 | 2001-08-09 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
-
2000
- 2000-03-30 JP JP2001500766A patent/JP2004522402A/ja active Pending
- 2000-03-30 CA CA002383254A patent/CA2383254A1/en not_active Abandoned
- 2000-03-30 AU AU37743/00A patent/AU3774300A/en not_active Abandoned
- 2000-03-30 AT AT00916675T patent/ATE478145T1/de not_active IP Right Cessation
- 2000-03-30 WO PCT/US2000/008439 patent/WO2000073454A1/en not_active Ceased
- 2000-03-30 EP EP00916675A patent/EP1210418B1/en not_active Expired - Lifetime
-
2002
- 2002-09-25 JP JP2002341509A patent/JP4017507B2/ja not_active Expired - Lifetime
-
2007
- 2007-06-29 JP JP2007172879A patent/JP5512073B2/ja not_active Expired - Lifetime
-
2011
- 2011-06-22 JP JP2011138276A patent/JP2011236224A/ja active Pending
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