JP2004521867A5 - - Google Patents
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- JP2004521867A5 JP2004521867A5 JP2002537179A JP2002537179A JP2004521867A5 JP 2004521867 A5 JP2004521867 A5 JP 2004521867A5 JP 2002537179 A JP2002537179 A JP 2002537179A JP 2002537179 A JP2002537179 A JP 2002537179A JP 2004521867 A5 JP2004521867 A5 JP 2004521867A5
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- Prior art keywords
- antigen
- dendritic cells
- administering
- cell
- ncm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 53
- 239000000427 antigen Substances 0.000 claims 29
- 102000036639 antigens Human genes 0.000 claims 29
- 108091007433 antigens Proteins 0.000 claims 29
- 210000001744 T-lymphocyte Anatomy 0.000 claims 27
- 210000004443 dendritic cell Anatomy 0.000 claims 23
- 210000001165 lymph node Anatomy 0.000 claims 23
- 230000003902 lesion Effects 0.000 claims 16
- 230000001737 promoting effect Effects 0.000 claims 14
- 230000035800 maturation Effects 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 13
- 230000004069 differentiation Effects 0.000 claims 12
- 108010002350 Interleukin-2 Proteins 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 8
- 206010027476 Metastases Diseases 0.000 claims 7
- 206010063397 Rosai-Dorfman syndrome Diseases 0.000 claims 7
- 208000006489 Sinus Histiocytosis Diseases 0.000 claims 7
- 230000001939 inductive effect Effects 0.000 claims 7
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 7
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 7
- 108090000695 Cytokines Proteins 0.000 claims 6
- 102000004127 Cytokines Human genes 0.000 claims 6
- 230000036039 immunity Effects 0.000 claims 6
- 230000005296 lymph node development Effects 0.000 claims 6
- 108010002352 Interleukin-1 Proteins 0.000 claims 5
- 108090001005 Interleukin-6 Proteins 0.000 claims 5
- 108090001007 Interleukin-8 Proteins 0.000 claims 5
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 5
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 5
- 230000007969 cellular immunity Effects 0.000 claims 5
- 208000026278 immune system disease Diseases 0.000 claims 5
- 230000009401 metastasis Effects 0.000 claims 5
- 230000002085 persistent effect Effects 0.000 claims 5
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 4
- 239000007972 injectable composition Substances 0.000 claims 4
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 3
- 230000000903 blocking effect Effects 0.000 claims 3
- 229960004397 cyclophosphamide Drugs 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 238000009169 immunotherapy Methods 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 238000007918 intramuscular administration Methods 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 238000007920 subcutaneous administration Methods 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- -1 δIFN Proteins 0.000 claims 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 229960000905 indomethacin Drugs 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000002458 infectious effect Effects 0.000 claims 2
- 210000001365 lymphatic vessel Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 1
- 206010025327 Lymphopenia Diseases 0.000 claims 1
- 229940047495 celebrex Drugs 0.000 claims 1
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000012645 endogenous antigen Substances 0.000 claims 1
- 206010016165 failure to thrive Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229960001680 ibuprofen Drugs 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 231100001023 lymphopenia Toxicity 0.000 claims 1
- 238000011275 oncology therapy Methods 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24391200P | 2000-10-27 | 2000-10-27 | |
| PCT/US2001/048039 WO2002034119A2 (en) | 2000-10-27 | 2001-10-26 | Vaccine immunotherapy for immune suppressed patients |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008331616A Division JP2009102372A (ja) | 2000-10-27 | 2008-12-25 | 免疫抑制された患者のためのワクチン免疫療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004521867A JP2004521867A (ja) | 2004-07-22 |
| JP2004521867A5 true JP2004521867A5 (enExample) | 2005-04-21 |
Family
ID=22920630
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002537179A Withdrawn JP2004521867A (ja) | 2000-10-27 | 2001-10-26 | 免疫抑制された患者のためのワクチン免疫療法 |
| JP2008331616A Withdrawn JP2009102372A (ja) | 2000-10-27 | 2008-12-25 | 免疫抑制された患者のためのワクチン免疫療法 |
| JP2012020558A Expired - Lifetime JP5930742B2 (ja) | 2000-10-27 | 2012-02-02 | 免疫抑制された患者のためのワクチン免疫療法 |
| JP2013014029A Expired - Lifetime JP5963688B2 (ja) | 2000-10-27 | 2013-01-29 | 免疫抑制された患者のためのワクチン免疫療法 |
| JP2015089246A Withdrawn JP2015155446A (ja) | 2000-10-27 | 2015-04-24 | 免疫抑制された患者のためのワクチン免疫療法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008331616A Withdrawn JP2009102372A (ja) | 2000-10-27 | 2008-12-25 | 免疫抑制された患者のためのワクチン免疫療法 |
| JP2012020558A Expired - Lifetime JP5930742B2 (ja) | 2000-10-27 | 2012-02-02 | 免疫抑制された患者のためのワクチン免疫療法 |
| JP2013014029A Expired - Lifetime JP5963688B2 (ja) | 2000-10-27 | 2013-01-29 | 免疫抑制された患者のためのワクチン免疫療法 |
| JP2015089246A Withdrawn JP2015155446A (ja) | 2000-10-27 | 2015-04-24 | 免疫抑制された患者のためのワクチン免疫療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (8) | US6977072B2 (enExample) |
| EP (1) | EP1337149A4 (enExample) |
| JP (5) | JP2004521867A (enExample) |
| AU (2) | AU2002232560A1 (enExample) |
| CA (2) | CA2950109C (enExample) |
| MX (1) | MXPA03003638A (enExample) |
| WO (1) | WO2002034119A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070154399A1 (en) * | 2000-10-27 | 2007-07-05 | Hadden John W | Immunotherapy for immune suppressed patients |
| US7182942B2 (en) * | 2000-10-27 | 2007-02-27 | Irx Therapeutics, Inc. | Vaccine immunotherapy for immune suppressed patients |
| US20070031372A1 (en) * | 2004-08-05 | 2007-02-08 | Hadden John W | Vaccine immunotherapy for immune suppressed patients |
| CA2950109C (en) | 2000-10-27 | 2019-02-19 | John W. Hadden | Vaccine immunotherapy for immune suppressed patients |
| US20070025958A1 (en) * | 2000-10-27 | 2007-02-01 | Hadden John W | Vaccine immunotherapy |
| US20060194242A1 (en) * | 2000-10-27 | 2006-08-31 | Hadden John W | Immunotherapy for immune suppressed patients |
| DE10139965B4 (de) * | 2001-08-14 | 2005-12-29 | Biotest Ag | Gammasterilisierbares Kulturmedium zum Nachweis von Hefen und Pilzen |
| JP2005510491A (ja) * | 2001-10-26 | 2005-04-21 | イミュノ−アールエックス, インコーポレイテッド | 免疫抑制を逆転させるための免疫治療 |
| US20050002899A1 (en) * | 2003-07-03 | 2005-01-06 | Eyal Talor | Method of pre-sensitizing cancer prior to treament with radiation and/or chemotherapy and a novel cytokine mixture |
| US6896879B2 (en) * | 2003-07-03 | 2005-05-24 | Cel-Sci Corporation | Method of pre-sensitizing cancer prior to treatment with radiation and/or chemotherapy and a novel cytokine mixture |
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| US20060257357A1 (en) * | 2005-05-10 | 2006-11-16 | Cel-Sci Corporation | Method for modulating HLA class II tumor cell surface expression with a cytokine mixture |
| WO2007149381A2 (en) * | 2006-06-19 | 2007-12-27 | The Cleveland Clinic Foundation | Compositions comprising a ptp-ase inhibitor and use thereof in treating cancer |
| US20080131396A1 (en) * | 2006-12-04 | 2008-06-05 | Cel-Sci Corp. | Method for altering the CD4/CD8 ratio and the mononuclear cellular infiltrate into a tumor |
| AU2008329741B2 (en) * | 2007-11-28 | 2013-09-12 | Irx Therapeutics, Inc. | Method of increasing immunological effect |
| WO2009137238A2 (en) * | 2008-04-14 | 2009-11-12 | Irx Therapeutics, Inc. | Irx-2 modified manufacturing process |
| AU2009251277A1 (en) * | 2008-05-29 | 2009-12-03 | Irx Therapeutics, Inc. | Mechanism of action of primary cell derived biologic |
| CA3017298C (en) | 2009-05-15 | 2021-09-28 | Irx Therapeutics, Inc. | Compositions comprising primary cell-derived biologics for enhancing immune responses in patients |
| CN103097543A (zh) | 2009-12-08 | 2013-05-08 | 伊尔克斯治疗有限公司 | 逆转朗格汉斯细胞免疫抑制的方法 |
| WO2012037551A2 (en) * | 2010-09-17 | 2012-03-22 | Irx Therapeutics, Inc. | Primary cell-derived biologic and wt1 synthetic long peptide vaccine |
| US11712474B2 (en) * | 2019-07-29 | 2023-08-01 | Regen BioPharma, Inc. | Reduction of post-surgery cancer metastasis by combination of cannabidiol and NR2F6 inhibition |
| AU2022208435A1 (en) | 2021-01-18 | 2023-08-10 | Conserv Bioscience Limited | Coronavirus immunogenic compositions, methods and uses thereof |
| CN112972669A (zh) * | 2021-03-08 | 2021-06-18 | 河南道特尔医药科技股份有限公司 | 一种提高新冠疫苗对特殊人群抗体分泌的动物实验操作方法 |
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-
2001
- 2001-10-26 CA CA2950109A patent/CA2950109C/en not_active Expired - Lifetime
- 2001-10-26 AU AU2002232560A patent/AU2002232560A1/en not_active Abandoned
- 2001-10-26 CA CA2464228A patent/CA2464228C/en not_active Expired - Lifetime
- 2001-10-26 JP JP2002537179A patent/JP2004521867A/ja not_active Withdrawn
- 2001-10-26 EP EP01988547A patent/EP1337149A4/en not_active Ceased
- 2001-10-26 US US10/015,123 patent/US6977072B2/en not_active Expired - Lifetime
- 2001-10-26 WO PCT/US2001/048039 patent/WO2002034119A2/en not_active Ceased
- 2001-10-26 MX MXPA03003638A patent/MXPA03003638A/es unknown
-
2003
- 2003-05-05 US US10/430,506 patent/US7153499B2/en not_active Expired - Lifetime
-
2004
- 2004-12-07 US US11/006,451 patent/US20050152874A1/en not_active Abandoned
-
2006
- 2006-10-16 US US11/582,063 patent/US20070041956A1/en not_active Abandoned
-
2007
- 2007-07-27 AU AU2007203505A patent/AU2007203505B2/en not_active Expired
-
2008
- 2008-12-25 JP JP2008331616A patent/JP2009102372A/ja not_active Withdrawn
-
2012
- 2012-02-02 JP JP2012020558A patent/JP5930742B2/ja not_active Expired - Lifetime
-
2013
- 2013-01-29 JP JP2013014029A patent/JP5963688B2/ja not_active Expired - Lifetime
- 2013-07-12 US US13/940,558 patent/US20140010779A1/en not_active Abandoned
- 2013-07-12 US US13/940,579 patent/US8784796B2/en not_active Expired - Fee Related
-
2014
- 2014-06-04 US US14/295,598 patent/US9789172B2/en not_active Expired - Fee Related
- 2014-06-04 US US14/295,660 patent/US9789173B2/en not_active Expired - Fee Related
-
2015
- 2015-04-24 JP JP2015089246A patent/JP2015155446A/ja not_active Withdrawn
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