JP2004521111A5 - - Google Patents
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- Publication number
- JP2004521111A5 JP2004521111A5 JP2002559004A JP2002559004A JP2004521111A5 JP 2004521111 A5 JP2004521111 A5 JP 2004521111A5 JP 2002559004 A JP2002559004 A JP 2002559004A JP 2002559004 A JP2002559004 A JP 2002559004A JP 2004521111 A5 JP2004521111 A5 JP 2004521111A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- bupivacaine
- administration
- site
- local
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 17
- 238000009472 formulation Methods 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 17
- 239000004005 microsphere Substances 0.000 claims 13
- 230000036592 analgesia Effects 0.000 claims 9
- 210000005036 nerve Anatomy 0.000 claims 9
- 238000002690 local anesthesia Methods 0.000 claims 7
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 6
- 229960003150 bupivacaine Drugs 0.000 claims 6
- 229920001577 copolymer Polymers 0.000 claims 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 6
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 5
- 229960003957 dexamethasone Drugs 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- 229920000249 biocompatible polymer Polymers 0.000 claims 3
- 229920002988 biodegradable polymer Polymers 0.000 claims 3
- 239000004621 biodegradable polymer Substances 0.000 claims 3
- 150000001735 carboxylic acids Chemical group 0.000 claims 3
- 238000013270 controlled release Methods 0.000 claims 3
- 235000014655 lactic acid Nutrition 0.000 claims 3
- 239000004310 lactic acid Substances 0.000 claims 3
- 239000003589 local anesthetic agent Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000007911 parenteral administration Methods 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 206010002091 Anaesthesia Diseases 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 230000037005 anaesthesia Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 230000002045 lasting effect Effects 0.000 claims 2
- 238000001690 micro-dialysis Methods 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 231100000816 toxic dose Toxicity 0.000 claims 2
- 239000003981 vehicle Substances 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26418601P | 2001-01-25 | 2001-01-25 | |
| PCT/US2002/002461 WO2002058670A1 (en) | 2001-01-25 | 2002-01-25 | Local anesthetic, and method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004521111A JP2004521111A (ja) | 2004-07-15 |
| JP2004521111A5 true JP2004521111A5 (enExample) | 2005-10-27 |
Family
ID=23004954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002559004A Pending JP2004521111A (ja) | 2001-01-25 | 2002-01-25 | 局所麻酔薬および使用法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20030152637A1 (enExample) |
| EP (1) | EP1363602A4 (enExample) |
| JP (1) | JP2004521111A (enExample) |
| WO (1) | WO2002058670A1 (enExample) |
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-
2002
- 2002-01-25 EP EP02714794A patent/EP1363602A4/en not_active Withdrawn
- 2002-01-25 JP JP2002559004A patent/JP2004521111A/ja active Pending
- 2002-01-25 US US10/057,301 patent/US20030152637A1/en not_active Abandoned
- 2002-01-25 WO PCT/US2002/002461 patent/WO2002058670A1/en not_active Ceased
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