JP2004518674A5 - - Google Patents
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- Publication number
- JP2004518674A5 JP2004518674A5 JP2002557947A JP2002557947A JP2004518674A5 JP 2004518674 A5 JP2004518674 A5 JP 2004518674A5 JP 2002557947 A JP2002557947 A JP 2002557947A JP 2002557947 A JP2002557947 A JP 2002557947A JP 2004518674 A5 JP2004518674 A5 JP 2004518674A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- cycloalkyl
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 36
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 11
- 102000005927 Cysteine Proteases Human genes 0.000 claims 7
- 108010005843 Cysteine Proteases Proteins 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 206010001935 American trypanosomiasis Diseases 0.000 claims 4
- 208000024699 Chagas disease Diseases 0.000 claims 4
- 241000223109 Trypanosoma cruzi Species 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 229910005965 SO 2 Inorganic materials 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 238000010171 animal model Methods 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000012790 confirmation Methods 0.000 claims 1
- -1 cyclohexylmethyl compound Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0101179A GB0101179D0 (en) | 2001-01-17 | 2001-01-17 | Biologically active compounds |
| US27535901P | 2001-03-13 | 2001-03-13 | |
| PCT/GB2002/000184 WO2002057270A1 (en) | 2001-01-17 | 2002-01-17 | Inhibitors of cruzipain and other cysteine proteases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004518674A JP2004518674A (ja) | 2004-06-24 |
| JP2004518674A5 true JP2004518674A5 (https=) | 2005-12-22 |
| JP4608183B2 JP4608183B2 (ja) | 2011-01-05 |
Family
ID=26245571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002557947A Expired - Fee Related JP4608183B2 (ja) | 2001-01-17 | 2002-01-17 | クルジパインおよび他のシステインプロテアーゼの阻害剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7425562B2 (https=) |
| EP (1) | EP1362052B1 (https=) |
| JP (1) | JP4608183B2 (https=) |
| KR (1) | KR100860067B1 (https=) |
| CN (1) | CN1269822C (https=) |
| AT (1) | ATE356130T1 (https=) |
| AU (1) | AU2002219397B2 (https=) |
| BR (1) | BR0206501A (https=) |
| CA (1) | CA2436462C (https=) |
| CY (1) | CY1106640T1 (https=) |
| DE (1) | DE60218633T2 (https=) |
| DK (1) | DK1362052T3 (https=) |
| ES (1) | ES2281516T3 (https=) |
| IL (2) | IL156774A0 (https=) |
| MX (1) | MXPA03006224A (https=) |
| NO (1) | NO328208B1 (https=) |
| NZ (1) | NZ526913A (https=) |
| PT (1) | PT1362052E (https=) |
| RU (1) | RU2329266C2 (https=) |
| WO (1) | WO2002057270A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
| JP2004523506A (ja) | 2000-12-22 | 2004-08-05 | アクシス・ファーマシューティカルズ・インコーポレイテッド | カテプシン阻害剤としての新規な化合物と組成物 |
| EP1436255A1 (en) | 2001-09-14 | 2004-07-14 | Aventis Pharmaceuticals, Inc. | Novel compounds and compositions as cathepsin inhibitors |
| YU34604A (sh) | 2001-11-14 | 2006-08-17 | Aventis Pharmaceuticals Inc. | Oligopeptidi kao inhibitori katepsina s i kompozicije koje ih sadrže |
| DE60326473D1 (en) * | 2002-07-16 | 2009-04-16 | Amura Therapeutics Ltd | Pyrrolderivate als hemmstoffe von cystein proteasen |
| US7399765B2 (en) * | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
| SE0400022D0 (sv) * | 2004-01-08 | 2004-01-08 | Medivir Ab | New compounds |
| BRPI0506719A (pt) * | 2004-01-08 | 2007-05-02 | Medivir Ab | composto, composição farmacêutica, e, uso de um composto |
| JP2005350417A (ja) * | 2004-06-11 | 2005-12-22 | Dai Ichi Seiyaku Co Ltd | 還元的エーテル化法を用いたピロリジン誘導体の製造法 |
| US7488848B2 (en) * | 2005-03-21 | 2009-02-10 | Virobay, Inc. | Alpha ketoamide compounds as cysteine protease inhibitors |
| GB0513840D0 (en) * | 2005-07-07 | 2005-08-10 | Medivir Ab | Cysteine protease inhibitors |
| GB0513839D0 (en) * | 2005-07-07 | 2005-08-10 | Medivir Ab | Cysteine protease inhibitors |
| GB0614073D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614042D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614046D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614037D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614053D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614044D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614052D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| WO2008114054A1 (en) * | 2007-03-19 | 2008-09-25 | Medivir Ab | Protease inhibitors |
| US7893067B2 (en) * | 2007-06-27 | 2011-02-22 | Medivir Ab | Cysteine protease inhibitors |
| EP2719700A1 (en) | 2008-01-09 | 2014-04-16 | Amura Therapeutics Limited | Tetrahydrofuro(3,2-b)pyrrol-3-one derivatives as inhibitors of cysteine proteinases |
| GB0804701D0 (en) | 2008-03-13 | 2008-04-16 | Amura Therapeutics Ltd | Compounds |
| GB0804702D0 (en) * | 2008-03-13 | 2008-04-16 | Amura Therapeutics Ltd | Compounds |
| US9409880B2 (en) | 2011-01-20 | 2016-08-09 | The Regents Of The University Of Colorado, A Body Corporate | Modulators of TLR3/dsRNA complex and uses thereof |
| PT2891492T (pt) * | 2012-08-30 | 2022-12-13 | Univ Tokyo | Agente de controlo de endoparasitas |
| CN106279188A (zh) * | 2016-07-21 | 2017-01-04 | 青岛科技大学 | 一种多取代呋喃并[2,3‑b]吡咯衍生物的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652574A (en) * | 1970-04-01 | 1972-03-28 | Abbott Lab | Certain 1 2 3 4 - tetrahydro-5h-pyrido (4 3-b)indoles and the corresponding 1 2 3 4-tetrahydro-9h-pyrido(3 4-b)indoles and derivatives thereof |
| DE3601226A1 (de) * | 1986-01-17 | 1987-07-23 | Bayer Ag | Dihydropyridinlactole, verfahren zur herstellung und ihre verwendung in arzneimitteln |
| RU2137768C1 (ru) * | 1993-12-15 | 1999-09-20 | Мерк энд Ко, Инк. | Ингибиторы hiv протеазы |
| DZ2285A1 (fr) | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
| EP0923535A4 (en) | 1996-08-28 | 2001-01-10 | Smithkline Beecham Corp | CYSTEINE PROTEASE INHIBITORS |
| EA002100B1 (ru) | 1996-12-23 | 2001-12-24 | Элан Фармасьютикалз, Инк. | ЦИКЛОАЛКИЛЬНЫЕ СОЕДИНЕНИЯ, ЛАКТАМЫ, ЛАКТОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ, СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ВЫСВОБОЖДЕНИЯ И/ИЛИ СИНТЕЗА β-АМИЛОИДНОГО ПЕПТИДА С ПОМОЩЬЮ УКАЗАННЫХ СОЕДИНЕНИЙ |
| AR013079A1 (es) * | 1997-05-06 | 2000-12-13 | Smithkline Beecham Corp | Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios |
| MA26618A1 (fr) | 1998-04-09 | 2004-12-20 | Smithkline Beecham Corp | Composes et compositions pharmaceutiques pour le traitement du paludisme |
| CO5150165A1 (es) | 1998-11-13 | 2002-04-29 | Smithkline Beecham Plc | Inhibidores de proteasa: tipo catepsina k |
| GB9911417D0 (en) * | 1999-05-18 | 1999-07-14 | Peptide Therapeutics Ltd | Furanone derivatives as inhibitors of cathepsin s |
| JP2004513942A (ja) | 2000-11-17 | 2004-05-13 | メディヴァー ユーケイ リミテッド | システインプロテアーゼインヒビター |
| JP2004523506A (ja) | 2000-12-22 | 2004-08-05 | アクシス・ファーマシューティカルズ・インコーポレイテッド | カテプシン阻害剤としての新規な化合物と組成物 |
-
2002
- 2002-01-17 US US10/466,384 patent/US7425562B2/en not_active Expired - Fee Related
- 2002-01-17 ES ES02732145T patent/ES2281516T3/es not_active Expired - Lifetime
- 2002-01-17 JP JP2002557947A patent/JP4608183B2/ja not_active Expired - Fee Related
- 2002-01-17 EP EP02732145A patent/EP1362052B1/en not_active Expired - Lifetime
- 2002-01-17 BR BR0206501-0A patent/BR0206501A/pt not_active IP Right Cessation
- 2002-01-17 MX MXPA03006224A patent/MXPA03006224A/es active IP Right Grant
- 2002-01-17 AT AT02732145T patent/ATE356130T1/de active
- 2002-01-17 AU AU2002219397A patent/AU2002219397B2/en not_active Ceased
- 2002-01-17 IL IL15677402A patent/IL156774A0/xx active IP Right Grant
- 2002-01-17 DE DE60218633T patent/DE60218633T2/de not_active Expired - Lifetime
- 2002-01-17 NZ NZ526913A patent/NZ526913A/xx not_active IP Right Cessation
- 2002-01-17 KR KR1020037009524A patent/KR100860067B1/ko not_active Expired - Fee Related
- 2002-01-17 CA CA2436462A patent/CA2436462C/en not_active Expired - Fee Related
- 2002-01-17 WO PCT/GB2002/000184 patent/WO2002057270A1/en not_active Ceased
- 2002-01-17 DK DK02732145T patent/DK1362052T3/da active
- 2002-01-17 RU RU2003125270/04A patent/RU2329266C2/ru not_active IP Right Cessation
- 2002-01-17 CN CNB028038142A patent/CN1269822C/zh not_active Expired - Fee Related
- 2002-01-17 PT PT02732145T patent/PT1362052E/pt unknown
-
2003
- 2003-07-03 IL IL156774A patent/IL156774A/en not_active IP Right Cessation
- 2003-07-16 NO NO20033220A patent/NO328208B1/no not_active IP Right Cessation
-
2007
- 2007-06-04 CY CY20071100742T patent/CY1106640T1/el unknown
-
2008
- 2008-09-15 US US12/211,069 patent/US20090247471A1/en not_active Abandoned
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