JP2004516928A5 - - Google Patents
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- JP2004516928A5 JP2004516928A5 JP2002554197A JP2002554197A JP2004516928A5 JP 2004516928 A5 JP2004516928 A5 JP 2004516928A5 JP 2002554197 A JP2002554197 A JP 2002554197A JP 2002554197 A JP2002554197 A JP 2002554197A JP 2004516928 A5 JP2004516928 A5 JP 2004516928A5
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- 239000003446 ligand Substances 0.000 description 288
- 239000000126 substance Substances 0.000 description 117
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- 150000002500 ions Chemical class 0.000 description 52
- 230000003993 interaction Effects 0.000 description 49
- 238000001179 sorption measurement Methods 0.000 description 48
- 229920002684 Sepharose Polymers 0.000 description 43
- 238000005342 ion exchange Methods 0.000 description 41
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- 150000003839 salts Chemical class 0.000 description 36
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 35
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- 239000000872 buffer Substances 0.000 description 33
- 238000006467 substitution reaction Methods 0.000 description 33
- -1 sulfopropyl groups Chemical group 0.000 description 31
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 30
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- 239000002585 base Substances 0.000 description 26
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| PCT/EP2001/014895 WO2002053252A2 (en) | 2000-12-31 | 2001-12-17 | A method for mixed mode adsorption and mixed mode adsorbents |
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| SE (1) | SE0004932D0 (https=) |
| WO (1) | WO2002053252A2 (https=) |
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| US6908770B1 (en) * | 1998-07-16 | 2005-06-21 | Board Of Regents, The University Of Texas System | Fluid based analysis of multiple analytes by a sensor array |
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| WO2004072613A2 (en) * | 2003-02-07 | 2004-08-26 | Board Of Regents, The University Of Texas System | Multi-shell microspheres with integrated chomatographic and detection layers for use in array sensors |
| PL1615945T3 (pl) | 2003-04-09 | 2012-03-30 | Ratiopharm Gmbh | Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami |
| US7943393B2 (en) * | 2003-07-14 | 2011-05-17 | Phynexus, Inc. | Method and device for extracting an analyte |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| GB2407783A (en) * | 2003-11-07 | 2005-05-11 | Novexin Ltd | Chromatographic separation |
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| US8105849B2 (en) * | 2004-02-27 | 2012-01-31 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements |
| US8101431B2 (en) * | 2004-02-27 | 2012-01-24 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems |
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| EP1693108A1 (en) * | 2004-12-04 | 2006-08-23 | MERCK PATENT GmbH | Mixed-modal anion-exchange type separation material |
| US9029331B2 (en) * | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| WO2006121569A2 (en) * | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
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| CA2711503A1 (en) * | 2008-01-08 | 2009-07-16 | Biogenerix Ag | Glycoconjugation of polypeptides using oligosaccharyltransferases |
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| CA2782518A1 (en) * | 2009-12-17 | 2011-06-23 | Klaus Gottschall | Specific sorbent for binding proteins and peptides, and separation method using the same |
| CN105911183B (zh) * | 2011-02-10 | 2019-03-22 | 积水医疗株式会社 | 离子交换色谱法用填充剂以及核酸链的分离检测方法 |
| JP2012211110A (ja) * | 2011-03-31 | 2012-11-01 | Asahi Kasei Medical Co Ltd | 多孔質吸着膜 |
| EP2570181A1 (en) * | 2011-09-15 | 2013-03-20 | InstrAction GmbH | Sorbent comprising its surface an aliphatic unit having an anionic or deprotonizable group for the purfication of organic molecules |
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| KR20150052808A (ko) * | 2012-05-31 | 2015-05-14 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | 단백질 제제 내에서 응집체 함량을 감소시키는 혼합된 다기능성 금속 친화성 표면들 |
| EP2812091B1 (en) | 2012-09-17 | 2021-03-10 | W.R. Grace & CO. - CONN. | Chromatography media and devices |
| EP2811983B1 (en) * | 2012-09-17 | 2019-05-01 | W.R. Grace & CO. - CONN. | Functionalized particulate support material and methods of making and using the same |
| KR20150112978A (ko) * | 2013-02-06 | 2015-10-07 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | 단백질 제제 내의 응집체 함량을 감소시키기 위한 혼합 다관능 금속 친화성 표면들 |
| US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
| ES2887110T3 (es) | 2014-01-16 | 2021-12-21 | Grace W R & Co | Medios para cromatografía de afinidad y dispositivos para cromatografía |
| PL3137209T3 (pl) | 2014-05-02 | 2023-01-02 | W.R. Grace & Co. - Conn. | Funkcjonalizowany materiał nośnikowy i sposoby wytwarzania oraz stosowania funkcjonalizowanego materiału nośnikowego |
| KR102566292B1 (ko) | 2015-06-05 | 2023-08-10 | 더블유.알. 그레이스 앤드 캄파니-콘. | 흡착성 바이오프로세싱 정화제와 이의 제조 및 사용 방법 |
| CN110844886A (zh) * | 2019-12-02 | 2020-02-28 | 锦西化工研究院有限公司 | 一种二硫化钠水溶液的合成方法 |
| CN111617747B (zh) * | 2020-05-11 | 2022-05-31 | 贵州大学 | 一种壳聚糖/纳米金属复合水凝胶及其制备方法和应用 |
| US11731108B2 (en) * | 2021-03-17 | 2023-08-22 | Bio-Rad Laboratories, Inc. | Mixed mode cation exchange chromatography ligands based on 1,3-dioxoisoindolin-2-yl structures |
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| US4767670A (en) * | 1987-01-21 | 1988-08-30 | E. I. Du Pont De Nemours And Company | Chromatographic supports for separation of oligonucleotides |
| JPH0564748A (ja) * | 1991-09-06 | 1993-03-19 | Tosoh Corp | イオン交換体 |
| US5652348A (en) * | 1994-09-23 | 1997-07-29 | Massey University | Chromatographic resins and methods for using same |
| SE9600590D0 (sv) * | 1996-02-19 | 1996-02-19 | Pharmacia Biotech Ab | Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris |
| SE9802214D0 (sv) * | 1998-06-18 | 1998-06-18 | Amersham Pharm Biotech Ab | Jonbytare och användning därav |
| US6310199B1 (en) | 1999-05-14 | 2001-10-30 | Promega Corporation | pH dependent ion exchange matrix and method of use in the isolation of nucleic acids |
| SE9904197D0 (sv) | 1999-11-22 | 1999-11-22 | Amersham Pharm Biotech Ab | A method for anion exchange adsorption on matrices carrying mixed mode ligands |
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2000
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2001
- 2001-12-17 CA CA2431012A patent/CA2431012C/en not_active Expired - Lifetime
- 2001-12-17 EP EP01985893A patent/EP1345695A2/en not_active Withdrawn
- 2001-12-17 US US10/451,192 patent/US7008542B2/en not_active Expired - Lifetime
- 2001-12-17 AU AU2002235786A patent/AU2002235786B2/en not_active Expired
- 2001-12-17 WO PCT/EP2001/014895 patent/WO2002053252A2/en not_active Ceased
- 2001-12-17 JP JP2002554197A patent/JP2004516928A/ja active Pending
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