JP2004516314A5 - - Google Patents

Download PDF

Info

Publication number
JP2004516314A5
JP2004516314A5 JP2002552906A JP2002552906A JP2004516314A5 JP 2004516314 A5 JP2004516314 A5 JP 2004516314A5 JP 2002552906 A JP2002552906 A JP 2002552906A JP 2002552906 A JP2002552906 A JP 2002552906A JP 2004516314 A5 JP2004516314 A5 JP 2004516314A5
Authority
JP
Japan
Prior art keywords
alkyl
group
compound
alkoxy
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002552906A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004516314A (ja
JP4025200B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2001/049301 external-priority patent/WO2002051809A1/en
Publication of JP2004516314A publication Critical patent/JP2004516314A/ja
Publication of JP2004516314A5 publication Critical patent/JP2004516314A5/ja
Application granted granted Critical
Publication of JP4025200B2 publication Critical patent/JP4025200B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2002552906A 2000-12-22 2001-12-17 ピペリジンmchアンタゴニストおよび肥満の処置におけるそれらの使用 Expired - Fee Related JP4025200B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25787300P 2000-12-22 2000-12-22
PCT/US2001/049301 WO2002051809A1 (en) 2000-12-22 2001-12-17 Piperidine mch antagonists and their use in the treatment of obesity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007195250A Division JP2007284451A (ja) 2000-12-22 2007-07-26 ピペリジンmchアンタゴニストおよび肥満の処置におけるそれらの使用

Publications (3)

Publication Number Publication Date
JP2004516314A JP2004516314A (ja) 2004-06-03
JP2004516314A5 true JP2004516314A5 (US20080131398A1-20080605-C00009.png) 2005-04-14
JP4025200B2 JP4025200B2 (ja) 2007-12-19

Family

ID=22978138

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002552906A Expired - Fee Related JP4025200B2 (ja) 2000-12-22 2001-12-17 ピペリジンmchアンタゴニストおよび肥満の処置におけるそれらの使用
JP2007195250A Pending JP2007284451A (ja) 2000-12-22 2007-07-26 ピペリジンmchアンタゴニストおよび肥満の処置におけるそれらの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007195250A Pending JP2007284451A (ja) 2000-12-22 2007-07-26 ピペリジンmchアンタゴニストおよび肥満の処置におけるそれらの使用

Country Status (20)

Country Link
US (1) US6472394B1 (US20080131398A1-20080605-C00009.png)
EP (1) EP1343761B1 (US20080131398A1-20080605-C00009.png)
JP (2) JP4025200B2 (US20080131398A1-20080605-C00009.png)
KR (1) KR20040011447A (US20080131398A1-20080605-C00009.png)
CN (1) CN1273451C (US20080131398A1-20080605-C00009.png)
AR (1) AR031930A1 (US20080131398A1-20080605-C00009.png)
AT (1) ATE302185T1 (US20080131398A1-20080605-C00009.png)
AU (1) AU2002231097B2 (US20080131398A1-20080605-C00009.png)
CA (1) CA2431953A1 (US20080131398A1-20080605-C00009.png)
DE (1) DE60112791T2 (US20080131398A1-20080605-C00009.png)
ES (1) ES2243588T3 (US20080131398A1-20080605-C00009.png)
HK (1) HK1054390B (US20080131398A1-20080605-C00009.png)
HU (1) HUP0302582A2 (US20080131398A1-20080605-C00009.png)
IL (1) IL155772A0 (US20080131398A1-20080605-C00009.png)
MX (1) MXPA03005744A (US20080131398A1-20080605-C00009.png)
MY (1) MY134017A (US20080131398A1-20080605-C00009.png)
NZ (1) NZ525723A (US20080131398A1-20080605-C00009.png)
PE (1) PE20020658A1 (US20080131398A1-20080605-C00009.png)
WO (1) WO2002051809A1 (US20080131398A1-20080605-C00009.png)
ZA (1) ZA200303638B (US20080131398A1-20080605-C00009.png)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2414198A1 (en) 2000-07-06 2002-01-17 Neurogen Corporation Melanin concentrating hormone receptor ligands
JP2004529161A (ja) 2001-05-04 2004-09-24 トゥラリック インコーポレイテッド 縮合複素環式化合物
US6809104B2 (en) 2001-05-04 2004-10-26 Tularik Inc. Fused heterocyclic compounds
KR20040012851A (ko) 2001-05-22 2004-02-11 뉴로젠 코포레이션 멜라닌 농축성 호르몬 수용체 리간드: 치환된1-벤질-4-아릴 피페라진 유사체
CA2468015A1 (en) 2001-11-27 2003-06-05 Merck & Co., Inc. 2-aminoquinoline compounds
US7160879B2 (en) 2002-01-10 2007-01-09 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues
WO2003059289A2 (en) 2002-01-10 2003-07-24 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted benzoimidazole analogues
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
DE10238865A1 (de) * 2002-08-24 2004-03-11 Boehringer Ingelheim International Gmbh Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US7351719B2 (en) 2002-10-31 2008-04-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
CA2505372A1 (en) 2002-11-06 2004-05-27 Tularik Inc. Fused heterocyclic compounds
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JPWO2004069798A1 (ja) * 2003-02-10 2006-05-25 萬有製薬株式会社 ピペリジン誘導体を有効成分とするメラニン凝集ホルモン受容体拮抗剤
WO2004072018A1 (ja) * 2003-02-12 2004-08-26 Takeda Pharmaceutical Company Limited アミン誘導体
JP2007502283A (ja) * 2003-08-13 2007-02-08 アムジェン インコーポレイテッド メラニン凝集ホルモン受容体アンタゴニスト
MXPA06001636A (es) * 2003-08-13 2006-04-28 Amgen Inc Antagonista del receptor de la hormona concentradora de melanina.
AU2004274309B2 (en) 2003-09-22 2010-04-08 Msd K.K. Novel piperidine derivative
JP2007508303A (ja) * 2003-10-01 2007-04-05 ザ プロクター アンド ギャンブル カンパニー メラニン凝集ホルモン拮抗物質
US20060247239A1 (en) * 2003-10-01 2006-11-02 Hu Xiufeng E Melanin concentrating hormone antagonists
US7592373B2 (en) 2003-12-23 2009-09-22 Boehringer Ingelheim International Gmbh Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
US20050239791A1 (en) * 2004-04-07 2005-10-27 Hutchison Alan J Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues
US7253168B2 (en) 2004-04-07 2007-08-07 Neurogen Corporation Substituted 1-benzyl-4-substituted piperazine analogues
DE102004017934A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
US7524862B2 (en) 2004-04-14 2009-04-28 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
TW200609219A (en) * 2004-06-17 2006-03-16 Neurogen Corp Aryl-substituted piperazine derivatives
US7063034B2 (en) * 2004-08-10 2006-06-20 Watermark Paddlesports, Inc. Spray skirt for watercraft
US7572783B2 (en) 2004-08-13 2009-08-11 Amgen Inc. Substituted benzofused heterocycles
EP1814590B2 (en) 2004-11-01 2013-12-11 Amylin Pharmaceuticals, Inc. Treatment of obesity and related disorders
US8394765B2 (en) 2004-11-01 2013-03-12 Amylin Pharmaceuticals Llc Methods of treating obesity with two different anti-obesity agents
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
US8138206B2 (en) 2005-05-30 2012-03-20 Msd. K.K. Piperidine derivative
EP1891065A4 (en) * 2005-05-31 2010-07-28 Astrazeneca Ab NEW MCHR1 ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF SUFFERING AND ILLEGAL DISORDERS PROVIDED BY MCHR1
JPWO2007018248A1 (ja) 2005-08-10 2009-02-19 萬有製薬株式会社 ピリドン化合物
EP1922336B1 (en) 2005-08-11 2012-11-21 Amylin Pharmaceuticals, LLC Hybrid polypeptides with selectable properties
BRPI0614649A2 (pt) 2005-08-11 2011-04-12 Amylin Pharmaceuticals Inc polipeptìdeos hìbridos com propriedades selecionáveis
JPWO2007024004A1 (ja) 2005-08-24 2009-03-05 萬有製薬株式会社 フェニルピリドン誘導体
CA2621470A1 (en) 2005-09-07 2007-03-15 Banyu Pharmaceutical Co., Ltd. Bicyclic aromatic substituted pyridone derivative
EP1940842B1 (en) 2005-09-29 2012-05-30 Merck Sharp & Dohme Corp. Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
DE602006006463D1 (de) 2005-09-30 2009-06-04 Hoffmann La Roche Indanderivate als antagonisten des mch-rezeptors
JP2009512715A (ja) 2005-10-21 2009-03-26 ノバルティス アクチエンゲゼルシャフト レニン阻害剤と抗異脂肪血症剤および/または抗肥満症剤の組み合わせ
JPWO2007049798A1 (ja) 2005-10-27 2009-04-30 萬有製薬株式会社 新規ベンゾオキサチイン誘導体
NZ568292A (en) 2005-11-10 2011-08-26 Msd Kk Spiro[cyclohexane-1,1'-(3'H)-4'-azaisobenzofuran]-4-carboxamide derivatives
US7671221B2 (en) * 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
CA2635760C (en) * 2005-12-28 2014-07-15 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
WO2007124045A2 (en) * 2006-04-20 2007-11-01 Ampla Pharmaceuticals, Inc. Piperidine and piperazine compounds for use in the treatment of obesity, eating disorders and sexual dysfunction by potentiation of mc4 receptor activity
JP5489333B2 (ja) 2006-09-22 2014-05-14 メルク・シャープ・アンド・ドーム・コーポレーション 脂肪酸合成阻害剤を用いた治療の方法
WO2008038692A1 (fr) 2006-09-28 2008-04-03 Banyu Pharmaceutical Co., Ltd. dÉrivÉ de diarylcÉtimine
CA2674237C (en) 2006-12-28 2015-11-24 Rigel Pharmaceuticals, Inc. N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
EP2145884B1 (en) 2007-04-02 2014-08-06 Msd K.K. Indoledione derivative
JP5514716B2 (ja) * 2007-05-11 2014-06-04 コリア・リサーチ・インスティテュート・オブ・ケミカル・テクノロジー アリールピペリジン置換基を有するイミダゾール誘導体、その製造方法及びこれを含む医薬組成物
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
AU2009220605A1 (en) 2008-03-06 2009-09-11 Msd K.K. Alkylaminopyridine derivative
JPWO2009119726A1 (ja) 2008-03-28 2011-07-28 Msd株式会社 メラニン凝集ホルモン受容体拮抗作用を有するジアリールメチルアミド誘導体
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
CA2727914A1 (en) 2008-06-19 2009-12-23 Banyu Pharmaceutical Co., Ltd. Spirodiamine-diaryl ketoxime derivative technical field
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010013595A1 (ja) 2008-07-30 2010-02-04 萬有製薬株式会社 5員-5員又は5員-6員縮環シクロアルキルアミン誘導体
AU2009307884B2 (en) 2008-10-22 2014-07-31 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010051236A1 (en) 2008-10-30 2010-05-06 Merck Sharp & Dohme Corp. Isonicotinamide orexin receptor antagonists
US8329914B2 (en) 2008-10-31 2012-12-11 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
US20110243940A1 (en) 2008-12-16 2011-10-06 Schering Corporation Bicyclic pyranone derivatives and methods of use thereof
US20110245209A1 (en) 2008-12-16 2011-10-06 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
US8895596B2 (en) 2010-02-25 2014-11-25 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN105001219A (zh) 2011-02-25 2015-10-28 默沙东公司 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
KR20150036245A (ko) 2012-08-02 2015-04-07 머크 샤프 앤드 돔 코포레이션 항당뇨병 트리시클릭 화합물
BR112015019836A2 (pt) 2013-02-22 2017-07-18 Merck Sharp & Dohme composto, composição farmacêutica, e, uso de um composto
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
MX2017002610A (es) 2014-08-29 2017-10-11 Tes Pharma S R L INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA.
WO2018069532A1 (en) 2016-10-14 2018-04-19 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
US10968232B2 (en) 2016-12-20 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
EP3883930A1 (en) 2018-11-20 2021-09-29 Tes Pharma S.r.l. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
TW202045476A (zh) 2019-02-13 2020-12-16 美商默沙東藥廠 5-烷基吡咯啶食慾素受體促效劑
US20230018413A1 (en) 2019-08-08 2023-01-19 Merck Sharp & Dohme Corp. Heteroaryl pyrrolidine and piperidine orexin receptor agonists
KR20230053639A (ko) 2020-08-18 2023-04-21 머크 샤프 앤드 돔 엘엘씨 비시클로헵탄 피롤리딘 오렉신 수용체 효능제

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
IL117149A0 (en) 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
US5908830A (en) 1996-10-31 1999-06-01 Merck & Co., Inc. Combination therapy for the treatment of diabetes and obesity
US6040318A (en) 1997-06-25 2000-03-21 Novo Nordisk A/S Tricycle substituted with azaheterocyclic carboxylic acids
ES2295017T3 (es) * 1999-02-10 2008-04-16 Eli Lilly And Company Agonistas 5-ht1f.
WO2001009137A1 (en) * 1999-07-28 2001-02-08 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor

Similar Documents

Publication Publication Date Title
JP2004516314A5 (US20080131398A1-20080605-C00009.png)
JP2008510691A5 (US20080131398A1-20080605-C00009.png)
JP2007515405A5 (US20080131398A1-20080605-C00009.png)
JP2010530881A5 (US20080131398A1-20080605-C00009.png)
JP2007516180A5 (US20080131398A1-20080605-C00009.png)
RU2005107314A (ru) Пиримидопроизводные, характеризующиеся антипролиферативной активностью
JP2005523922A5 (US20080131398A1-20080605-C00009.png)
JP2018135343A5 (US20080131398A1-20080605-C00009.png)
CA2545427A1 (en) Selective kinase inhibitors
JP2006526590A5 (US20080131398A1-20080605-C00009.png)
JP2009520695A5 (US20080131398A1-20080605-C00009.png)
JP2009507896A5 (US20080131398A1-20080605-C00009.png)
JP2006524660A5 (US20080131398A1-20080605-C00009.png)
JP2010511721A5 (US20080131398A1-20080605-C00009.png)
JP2006182786A5 (US20080131398A1-20080605-C00009.png)
JP2007534636A5 (US20080131398A1-20080605-C00009.png)
JP2005508905A5 (US20080131398A1-20080605-C00009.png)
RU2008109914A (ru) Применение производных тиенопиридона в качестве активаторов амфк и фармацевтические композиции, которые их содержат
JP2010514786A5 (US20080131398A1-20080605-C00009.png)
JP2009536660A5 (US20080131398A1-20080605-C00009.png)
JP2010501478A5 (US20080131398A1-20080605-C00009.png)
JP2010505865A5 (US20080131398A1-20080605-C00009.png)
JP2007519654A5 (US20080131398A1-20080605-C00009.png)
JP2003503449A5 (US20080131398A1-20080605-C00009.png)
JP2010535706A5 (US20080131398A1-20080605-C00009.png)