JP2004515575A5 - - Google Patents
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- Publication number
- JP2004515575A5 JP2004515575A5 JP2002545053A JP2002545053A JP2004515575A5 JP 2004515575 A5 JP2004515575 A5 JP 2004515575A5 JP 2002545053 A JP2002545053 A JP 2002545053A JP 2002545053 A JP2002545053 A JP 2002545053A JP 2004515575 A5 JP2004515575 A5 JP 2004515575A5
- Authority
- JP
- Japan
- Prior art keywords
- fgf7
- heparin
- anticoagulant
- fusion protein
- support
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 17
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 15
- 229960002897 heparin Drugs 0.000 description 15
- 229920000669 heparin Polymers 0.000 description 15
- 239000003146 anticoagulant agent Substances 0.000 description 14
- 229940127219 anticoagulant drug Drugs 0.000 description 13
- 102100028071 Fibroblast growth factor 7 Human genes 0.000 description 12
- 101001060261 Homo sapiens Fibroblast growth factor 7 Proteins 0.000 description 12
- 239000000463 material Substances 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 9
- 230000004927 fusion Effects 0.000 description 8
- 229920002971 Heparan sulfate Polymers 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 108010023321 Factor VII Proteins 0.000 description 4
- 102000037865 fusion proteins Human genes 0.000 description 4
- 108020001507 fusion proteins Proteins 0.000 description 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 4
- 239000003102 growth factor Substances 0.000 description 4
- 229920000936 Agarose Polymers 0.000 description 3
- 102000005720 Glutathione transferase Human genes 0.000 description 3
- 108010070675 Glutathione transferase Proteins 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000000701 coagulant Substances 0.000 description 2
- 229960003180 glutathione Drugs 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 102000003972 Fibroblast growth factor 7 Human genes 0.000 description 1
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 229940098448 fibroblast growth factor 7 Drugs 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003055 low molecular weight heparin Substances 0.000 description 1
- 229940127215 low-molecular weight heparin Drugs 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25222500P | 2000-11-21 | 2000-11-21 | |
| US27773501P | 2001-03-21 | 2001-03-21 | |
| US32550201P | 2001-09-28 | 2001-09-28 | |
| US32561301P | 2001-09-28 | 2001-09-28 | |
| PCT/US2001/043817 WO2002042336A2 (en) | 2000-11-21 | 2001-11-21 | Fgf-affinity chromatography |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004515575A JP2004515575A (ja) | 2004-05-27 |
| JP2004515575A5 true JP2004515575A5 (https=) | 2009-02-19 |
| JP4262979B2 JP4262979B2 (ja) | 2009-05-13 |
Family
ID=27500424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002545053A Expired - Fee Related JP4262979B2 (ja) | 2000-11-21 | 2001-11-21 | Ｆｇｆアフィニティークロマトグラフィー |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6812221B2 (https=) |
| EP (1) | EP1414866A2 (https=) |
| JP (1) | JP4262979B2 (https=) |
| AU (1) | AU2002236477A1 (https=) |
| WO (1) | WO2002042336A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8366787B2 (en) * | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
| US6638312B2 (en) | 2000-08-04 | 2003-10-28 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa (SIS) |
| US8025896B2 (en) | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
| WO2003007839A2 (en) | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Devices form naturally occurring biologically derived |
| JP2005515802A (ja) | 2001-07-16 | 2005-06-02 | デピュイ・プロダクツ・インコーポレイテッド | 混成生物／合成品型多孔質細胞外基質支持骨格 |
| US7819918B2 (en) * | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
| EP1416886A4 (en) * | 2001-07-16 | 2007-04-18 | Depuy Products Inc | SCAFFOLD AND METHOD FOR CARTILAGE REPAIR AND REGENERATION |
| WO2003007786A2 (en) | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Porous delivery scaffold and method |
| AU2002354911B2 (en) | 2001-07-16 | 2007-08-30 | Depuy Products, Inc. | Meniscus regeneration device and method |
| US7163563B2 (en) | 2001-07-16 | 2007-01-16 | Depuy Products, Inc. | Unitary surgical device and method |
| WO2003033512A2 (en) * | 2001-10-16 | 2003-04-24 | Procognia, Ltd. | Method of preparing purified biologically active oligosaccharide libraries |
| JP4828795B2 (ja) | 2002-03-11 | 2011-11-30 | モメンタ ファーマシューティカルズ インコーポレイテッド | 硫酸化多糖類の分析 |
| WO2005079817A1 (en) * | 2004-02-18 | 2005-09-01 | The Texas A & M University System | Affinity purified heparin/heparan sulfate for controlling the biological activity of the fgf receptor |
| US7569233B2 (en) | 2004-05-04 | 2009-08-04 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
| US7513866B2 (en) | 2004-10-29 | 2009-04-07 | Depuy Products, Inc. | Intestine processing device and associated method |
| US7354627B2 (en) | 2004-12-22 | 2008-04-08 | Depuy Products, Inc. | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
| US20060183712A1 (en) * | 2005-02-17 | 2006-08-17 | The Texas A&M University System | Affinity purified heparin/heparan sulfate for controlling the biological activity of the FGF receptor |
| US7595062B2 (en) | 2005-07-28 | 2009-09-29 | Depuy Products, Inc. | Joint resurfacing orthopaedic implant and associated method |
| US7871440B2 (en) | 2006-12-11 | 2011-01-18 | Depuy Products, Inc. | Unitary surgical device and method |
| US9139876B1 (en) * | 2007-05-03 | 2015-09-22 | Momenta Pharmacueticals, Inc. | Method of analyzing a preparation of a low molecular weight heparin |
| GB0812919D0 (en) * | 2008-07-15 | 2008-08-20 | Norwegian University Of Life Sciences | Process |
| GB0818255D0 (en) * | 2008-10-06 | 2008-11-12 | Agency Science Tech & Res | Isolation and identification of glycosaminoglycans |
| US9498494B2 (en) | 2008-09-11 | 2016-11-22 | Agency For Science, Technology And Research | Glycosaminoglycans |
| WO2011090948A1 (en) * | 2010-01-19 | 2011-07-28 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
| WO2012115952A1 (en) | 2011-02-21 | 2012-08-30 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
| CN103570847B (zh) * | 2013-11-15 | 2015-11-18 | 重庆三腾食品有限公司 | 一种肝素钠加工方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2597484B1 (fr) * | 1986-04-17 | 1988-12-23 | Sanofi Sa | Glycosaminoglycanes de type heparine ou heparane-sulfate dotes d'une activite sur la division et la differentiation cellulaires, leur preparation et leurs applications therapeutiques. |
| HU215581B (hu) | 1989-07-06 | 1999-01-28 | Regents Of The University Of California | Eljárás fibroblaszt növekedési faktor receptorok előállítására és terápiás alkalmazására |
| JP3130313B2 (ja) * | 1989-12-19 | 2001-01-31 | 武田薬品工業株式会社 | ヒトｂＦＧＦムテインの製造法 |
| AUPN271295A0 (en) | 1995-05-02 | 1995-05-25 | Gropep Pty Ltd | Method of treatment |
| FI921689L (fi) * | 1991-04-16 | 1992-10-17 | Seikagagu Kogyo Kabushiki Kais | Oligosackarid med affinitet foer fibroblasttillvaextfaktor och foerfarande foer framstaellning av denna |
| US5807982A (en) | 1991-04-29 | 1998-09-15 | Cornell Research Foundation, Inc. | Affinity purified heparin |
| US5655870A (en) | 1993-03-01 | 1997-08-12 | Kawasaki Steel Corporation | Stacker crane in a warehouse |
| US5814605A (en) | 1993-03-26 | 1998-09-29 | Amgen Inc. | Therapeutic uses of keratinocyte growth factor |
| CA2166278A1 (en) | 1993-06-29 | 1995-01-12 | Denis J. Gospodarowicz | A truncated keratinocyte growth factor (kgf) having increased biological activity |
| US6127347A (en) | 1994-01-12 | 2000-10-03 | Univ Michigan | Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes |
| AU2435795A (en) * | 1994-05-06 | 1995-11-29 | Glycomed Incorporated | O-desulfated heparin derivatives, methods of making and uses thereof |
| US5733893A (en) | 1995-03-15 | 1998-03-31 | Washington University | Method of identifying molecules that regulate FGF activity |
| US5801063A (en) * | 1995-05-09 | 1998-09-01 | Grandics; Peter | Device and process for the biospecific removal of heparin |
| US5814485A (en) * | 1995-06-06 | 1998-09-29 | Chiron Corporation | Production of interferon-β (IFN-β) in E. coli |
| JP2003521483A (ja) * | 1999-11-11 | 2003-07-15 | エイエム ファーマ ビーブイ | ヒトラクトフェリンの第１カチオンクラスターの抗菌活性 |
-
2001
- 2001-11-21 US US09/990,578 patent/US6812221B2/en not_active Expired - Fee Related
- 2001-11-21 AU AU2002236477A patent/AU2002236477A1/en not_active Abandoned
- 2001-11-21 EP EP01986008A patent/EP1414866A2/en not_active Withdrawn
- 2001-11-21 JP JP2002545053A patent/JP4262979B2/ja not_active Expired - Fee Related
- 2001-11-21 WO PCT/US2001/043817 patent/WO2002042336A2/en not_active Ceased
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