JP2004514680A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004514680A5 JP2004514680A5 JP2002545475A JP2002545475A JP2004514680A5 JP 2004514680 A5 JP2004514680 A5 JP 2004514680A5 JP 2002545475 A JP2002545475 A JP 2002545475A JP 2002545475 A JP2002545475 A JP 2002545475A JP 2004514680 A5 JP2004514680 A5 JP 2004514680A5
- Authority
- JP
- Japan
- Prior art keywords
- blood
- photosensitizer
- photosensitizers
- pat
- endogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003504 photosensitizing agent Substances 0.000 description 33
- 210000004369 blood Anatomy 0.000 description 14
- 239000008280 blood Substances 0.000 description 14
- 238000005202 decontamination Methods 0.000 description 13
- 230000003588 decontaminative effect Effects 0.000 description 13
- 239000012503 blood component Substances 0.000 description 11
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 11
- 239000012530 fluid Substances 0.000 description 10
- 239000010836 blood and blood product Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 7
- 229940125691 blood product Drugs 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 230000002779 inactivation Effects 0.000 description 6
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 5
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 5
- 241000700605 Viruses Species 0.000 description 5
- 239000003146 anticoagulant agent Substances 0.000 description 5
- 229940127219 anticoagulant drug Drugs 0.000 description 5
- 239000000306 component Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- HAUGRYOERYOXHX-UHFFFAOYSA-N Alloxazine Chemical compound C1=CC=C2N=C(C(=O)NC(=O)N3)C3=NC2=C1 HAUGRYOERYOXHX-UHFFFAOYSA-N 0.000 description 4
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 230000000975 bioactive effect Effects 0.000 description 4
- 210000001772 blood platelet Anatomy 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 235000019192 riboflavin Nutrition 0.000 description 4
- 239000002151 riboflavin Substances 0.000 description 4
- 230000000996 additive effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine group Chemical group [C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=NC=2C(N)=NC=NC12 OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
- 230000010100 anticoagulation Effects 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- KFKRXESVMDBTNQ-UHFFFAOYSA-N 3-[18-(2-carboxylatoethyl)-8,13-bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-21,24-diium-2-yl]propanoate Chemical class N1C2=C(C)C(C(C)O)=C1C=C(N1)C(C)=C(C(O)C)C1=CC(C(C)=C1CCC(O)=O)=NC1=CC(C(CCC(O)=O)=C1C)=NC1=C2 KFKRXESVMDBTNQ-UHFFFAOYSA-N 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical group C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 229940123973 Oxygen scavenger Drugs 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000002617 apheresis Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 150000004775 coumarins Chemical class 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- FVVLHONNBARESJ-NTOWJWGLSA-H magnesium;potassium;trisodium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;acetate;tetrachloride;nonahydrate Chemical compound O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[Mg+2].[Cl-].[Cl-].[Cl-].[Cl-].[K+].CC([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O FVVLHONNBARESJ-NTOWJWGLSA-H 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 230000001443 photoexcitation Effects 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 230000015843 photosynthesis, light reaction Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229940081858 plasmalyte a Drugs 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 150000004032 porphyrins Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003761 preservation solution Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/725,426 US6548241B1 (en) | 2000-11-28 | 2000-11-28 | Storage solution containing photosensitizer for inactivation of biological contaminants |
| PCT/US2001/043591 WO2002043485A1 (en) | 2000-11-28 | 2001-11-21 | Storage solution containing photosensitizer for inactivation of biological contaminants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004514680A JP2004514680A (ja) | 2004-05-20 |
| JP2004514680A5 true JP2004514680A5 (enExample) | 2006-01-05 |
| JP4473508B2 JP4473508B2 (ja) | 2010-06-02 |
Family
ID=24914504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002545475A Expired - Lifetime JP4473508B2 (ja) | 2000-11-28 | 2001-11-21 | 生物的汚染物質を不活性化するための光増感物質を含む保存溶液 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6548241B1 (enExample) |
| EP (1) | EP1345491B1 (enExample) |
| JP (1) | JP4473508B2 (enExample) |
| AT (1) | ATE322162T1 (enExample) |
| AU (1) | AU2002225687A1 (enExample) |
| CA (1) | CA2397862C (enExample) |
| DE (1) | DE60118604T2 (enExample) |
| WO (1) | WO2002043485A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070099170A1 (en) * | 1998-07-21 | 2007-05-03 | Navigant Biotechnologies, Inc. | Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate |
| US20030215784A1 (en) * | 1998-07-21 | 2003-11-20 | Dumont Larry Joe | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US7220747B2 (en) * | 1999-07-20 | 2007-05-22 | Gambro, Inc. | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer |
| US7094378B1 (en) * | 2000-06-15 | 2006-08-22 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US7470245B2 (en) * | 2000-02-02 | 2008-12-30 | Xepmed, Inc. | Extracorporeal pathogen reduction system |
| US6969367B2 (en) * | 2000-02-02 | 2005-11-29 | Xepmed, Inc. | Extracorporeal pathogen reduction system |
| US6936413B1 (en) * | 2001-12-05 | 2005-08-30 | Baxter International Inc. | Methods and systems for preparing blood products |
| JP2005523337A (ja) * | 2002-04-24 | 2005-08-04 | ガンブロ インコーポレーテッド | 病原体が減少する血液および血液構成成分のプロセスの間でのアデニンの除去 |
| US20070031812A1 (en) * | 2003-06-20 | 2007-02-08 | Pall Corporation | Processing of platelet-containing biological fluids |
| US20070102858A1 (en) * | 2005-11-07 | 2007-05-10 | Navigant Biotechnologies, Inc. | Clamps and methods for displacing fluid from portions of fluid containers |
| JP2009518403A (ja) * | 2005-12-06 | 2009-05-07 | カリディアンビーシーティ バイオテクノロジーズ，エルエルシー | 内因性アロキサジンおよびアセテートを使用する血液および血液製剤の処理および保存方法 |
| CA2849648A1 (en) * | 2006-01-27 | 2007-08-09 | Terumo Bct Biotechnologies, Llc | Method for inactivating pathogens in a biological fluid |
| AU2012233033B2 (en) * | 2006-01-27 | 2014-11-06 | Terumo Bct Biotechnologies, Llc | Methods and compositions for the production of high concentration alloxazine solutions |
| US20080234622A1 (en) * | 2007-03-20 | 2008-09-25 | Gambro Bct Inc. | Methods and Systems for Preparing Blood Products |
| US8835104B2 (en) * | 2007-12-20 | 2014-09-16 | Fenwal, Inc. | Medium and methods for the storage of platelets |
| US8871434B2 (en) * | 2008-03-21 | 2014-10-28 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| US8968992B2 (en) * | 2008-03-21 | 2015-03-03 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| US20100190676A1 (en) * | 2008-07-22 | 2010-07-29 | Ecolab Inc. | Composition for enhanced removal of blood soils |
| WO2010039994A2 (en) * | 2008-10-01 | 2010-04-08 | Caridianbct, Inc. | Platelet additive solution for leukoreducing white blood cells in apheresed platelets |
| US9732324B2 (en) | 2008-10-23 | 2017-08-15 | Cornell University | Anti-viral method |
| US8715920B2 (en) * | 2010-07-27 | 2014-05-06 | Biovec Transfusion, Llc | Composition for preserving platelets during photosensitization |
| US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
| US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US12089589B2 (en) | 2009-10-12 | 2024-09-17 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US11864553B2 (en) | 2009-10-23 | 2024-01-09 | Fenwal, Inc. | Methods and systems for providing red blood cell products with reduced plasma |
| EP2694131B1 (en) | 2011-04-07 | 2019-08-28 | Fenwal, Inc. | Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates |
| ES2941907T3 (es) * | 2011-07-05 | 2023-05-26 | Hemanext Inc | Procedimiento para el almacenamiento prolongado de glóbulos rojos |
| US8940228B2 (en) | 2012-01-11 | 2015-01-27 | Terumo Bct, Inc. | Slidable clamp for port isolation |
| US9289546B2 (en) * | 2012-08-16 | 2016-03-22 | Dirk Jerome Erickson | Exsanguination preventing device |
| US9863699B2 (en) | 2014-06-09 | 2018-01-09 | Terumo Bct, Inc. | Lyophilization |
| CN107530377B (zh) | 2015-03-10 | 2021-09-03 | 新健康科学股份有限公司 | 氧减少一次性套件、装置及其使用方法 |
| CA2983295C (en) | 2015-04-23 | 2024-02-13 | New Health Sciences, Inc. | Anaerobic blood storage containers |
| EP3434295B1 (en) | 2016-03-23 | 2022-03-09 | Terumo Kabushiki Kaisha | Light irradiation device |
| SG11202002438TA (en) * | 2017-09-20 | 2020-04-29 | Cerus Corp | Compositions and methods for pathogen inactivation of platelets |
Family Cites Families (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2786014A (en) | 1952-09-10 | 1957-03-19 | James L Tullis | Platelet preservation |
| US3629071A (en) | 1970-02-10 | 1971-12-21 | Upjohn Co | Storage-stable hemostatic transfusion suspensions of blood platelets, glucose, magnesium chloride and certain prostaglandins |
| US3874384A (en) | 1971-11-01 | 1975-04-01 | American Hospital Supply Corp | Improved blood storage unit and method of storing blood |
| DE2532183C3 (de) | 1975-07-18 | 1982-03-04 | Behringwerke Ag, 3550 Marburg | Polyionische isotonische Salzlösung zur Konservierung von Erythrozyten oder zur Perfusion und zur Konservierung von zur Transplantion bestimmter Organen |
| US4112070A (en) | 1977-06-08 | 1978-09-05 | Research Corporation | Blood preservation system |
| GB2034463B (en) | 1978-11-11 | 1983-03-30 | Ryan W | Plaetelet reference control |
| US4267269A (en) | 1980-02-05 | 1981-05-12 | Baxter Travenol Laboratories, Inc. | Red cell storage solution |
| US4568542A (en) | 1981-06-09 | 1986-02-04 | Lee Biomolecular Research Laboratories, Inc. | Vaccine compositions |
| US4390619A (en) | 1981-09-28 | 1983-06-28 | James Clifford Haight | Leukocyte or platelet storage using ion-exchange resins |
| JPS5862333A (ja) * | 1981-10-09 | 1983-04-13 | Mazda Motor Corp | エンジンのアイドル回転制御装置 |
| US4432750A (en) | 1981-12-02 | 1984-02-21 | Baxter Travenol Laboratories, Inc. | Additive sterol solution and method for preserving normal red cell morphology in whole blood during storage |
| DE3225408A1 (de) | 1982-07-07 | 1984-01-12 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Waessrige loesung zum suspendieren und lagern von zellen, insbesondere erythrozyten |
| CA1216518A (en) | 1982-11-01 | 1987-01-13 | Gail A. Rock | Plasma-free medium for platelet storage |
| US4748120A (en) | 1983-05-02 | 1988-05-31 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
| US4609372A (en) | 1983-10-13 | 1986-09-02 | Miles Laboratories, Inc. | Heat sterilizable storage solution for red blood cells |
| GB8328495D0 (en) | 1983-10-25 | 1983-11-23 | Wellcome Found | Pharmacologically active ketones |
| US4992363A (en) | 1983-11-09 | 1991-02-12 | Thomas Jefferson University | Method for preparing glucose free media for storing blood platelets |
| US4828976A (en) | 1983-12-29 | 1989-05-09 | Thomas Jefferson University | Glucose free media for storing blood platelets |
| CA1244774A (en) * | 1983-11-09 | 1988-11-15 | Thomas Jefferson University | Medium for storing blood platelets |
| US4585735A (en) | 1984-07-19 | 1986-04-29 | American National Red Cross | Prolonged storage of red blood cells |
| JPS61275228A (ja) | 1985-03-14 | 1986-12-05 | バクスタ−、トラベノ−ル、ラボラトリ−ズ、インコ−ポレイテツド | 治療用タンパク組成物中のビ−ルスの光動的不活性化 |
| US4704352A (en) | 1985-06-25 | 1987-11-03 | Baxter Travenol Laboratories, Inc. | L-ascorbate-2-phosphate salts in blood cell storage |
| US4675185A (en) | 1985-12-06 | 1987-06-23 | Baxter Travenol Laboratories, Inc. | Solution for stabilizing red blood cells during storage |
| US5281392A (en) | 1986-03-10 | 1994-01-25 | Rubinstein Alan I | Method for disinfecting red blood cells, blood products, and corneas |
| US5248506A (en) | 1986-03-19 | 1993-09-28 | American National Red Cross | Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets |
| US4961928A (en) | 1986-03-19 | 1990-10-09 | American Red Cross | Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets |
| US4695460A (en) | 1986-03-19 | 1987-09-22 | American Red Cross | Synthetic, plasma-free, transfusible platelet storage medium |
| US4769318A (en) | 1986-06-03 | 1988-09-06 | Ube Industries, Ltd. | Additive solution for blood preservation and activation |
| US4726949A (en) | 1986-08-26 | 1988-02-23 | Baxter Travenol Laboratories, Inc. | Irradiation of blood products |
| DE3805459A1 (de) | 1988-02-22 | 1989-08-31 | Biotest Pharma Gmbh | Verfahren zur sterilisation von blut, plasma, blut- und plasmaderivaten, zellsuspensionen oder dgl. |
| US4994367A (en) | 1988-10-07 | 1991-02-19 | East Carolina University | Extended shelf life platelet preparations and process for preparing the same |
| US5211960A (en) | 1988-11-29 | 1993-05-18 | Scripps Clinic And Research Foundation | Stabilization of leukocytes |
| US5041078A (en) | 1989-03-06 | 1991-08-20 | Baylor Research Foundation, A Nonprofit Corporation Of The State Of Texas | Photodynamic viral deactivation with sapphyrins |
| US4999375A (en) | 1989-04-11 | 1991-03-12 | Hoffmann-La Roche Inc. | Psoralen reagent compositions for extracorporeal treatment of blood |
| US4925665A (en) | 1989-06-22 | 1990-05-15 | Thomas Jefferson University | Glucose free primary anticoagulant for blood containing citrate ions |
| US5250303A (en) | 1989-10-06 | 1993-10-05 | The American National Red Cross | Procedure for storing red cells with prolonged maintenance of cellular concentrations of ATP and 2,3 DPG |
| US5236716A (en) | 1990-02-12 | 1993-08-17 | Miles Inc. | Platelets concentrate with low white blood cells content |
| US5147776A (en) | 1990-02-26 | 1992-09-15 | University Of Iowa Research Foundation | Use of 2,5-anhydromannitol for control of pH during blood storage |
| US5418130A (en) | 1990-04-16 | 1995-05-23 | Cryopharm Corporation | Method of inactivation of viral and bacterial blood contaminants |
| US5587490A (en) | 1990-04-16 | 1996-12-24 | Credit Managers Association Of California | Method of inactivation of viral and bacterial blood contaminants |
| US5798238A (en) | 1990-04-16 | 1998-08-25 | Baxter International Inc. | Method of inactivation of viral and bacterial blood contaminants with quinolines as photosensitizer |
| US5955256A (en) | 1990-04-16 | 1999-09-21 | Baxter International Inc. | Method of inactivation of viral and bacterial blood contaminants |
| ZA912842B (en) | 1990-04-16 | 1992-03-25 | Cryopharm Corp | Method of inactivation of viral and bacterial blood contaminants |
| US5516629A (en) | 1990-04-16 | 1996-05-14 | Cryopharm Corporation | Photoinactivation of viral and bacterial blood contaminants using halogenated coumarins |
| US5545516A (en) * | 1990-05-01 | 1996-08-13 | The American National Red Cross | Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light |
| US6077659A (en) | 1990-05-15 | 2000-06-20 | New York Blood Center, Inc. | Vitamin E and derivatives thereof prevent potassium ion leakage and other types of damage in red cells that are virus sterilized by phthalocyanines and light |
| US5658722A (en) | 1990-05-15 | 1997-08-19 | New York Blood Center, Inc. | Process for the sterilization of biological compositions using UVA1 irradiation |
| US5120649A (en) | 1990-05-15 | 1992-06-09 | New York Blood Center, Inc. | Photodynamic inactivation of viruses in blood cell-containing compositions |
| US5232844A (en) | 1990-05-15 | 1993-08-03 | New York Blood Center | Photodynamic inactivation of viruses in cell-containing compositions |
| WO1992008349A1 (en) | 1990-11-07 | 1992-05-29 | Baxter International Inc. | Blood platelet storage medium |
| EP0509083B1 (en) | 1990-11-07 | 1997-07-16 | Baxter International Inc. | Red blood cell storage solution |
| AU646533B2 (en) | 1990-12-20 | 1994-02-24 | Baxter International Inc. | Systems for eradicating contaminants in fluids |
| US5569579A (en) | 1991-04-01 | 1996-10-29 | Thomas Jefferson University | Synthetic-based platelet storage media |
| US5376524A (en) | 1991-04-01 | 1994-12-27 | Thomas Jefferson University | Platelet storage medium containing acetate and phosphate |
| FR2674753B1 (fr) | 1991-04-02 | 1995-03-10 | Jean Berque | Nouvelles indications therapeutiques, en particulier pour le traitement du sida, d'un medicament deja existant et fabrique a partir d'une molecule denuee de contre-indications et d'effets indesirables. |
| FR2715303A1 (fr) | 1991-04-02 | 1995-07-28 | Berque Jean | Utilisation du FAD et/ou du NAD comme médicaments. |
| WO1992019355A1 (en) | 1991-05-08 | 1992-11-12 | Baxter International Inc. | Methods for processing red blood cell products for long term storage free of microorganisms |
| NZ244270A (en) | 1991-09-13 | 1995-07-26 | Eisai Co Ltd | Injectable composition comprising riboflavin |
| US5234808A (en) | 1991-10-30 | 1993-08-10 | Thomas Jefferson University | Acetate addition to platelets stored in plasma |
| US5474891A (en) | 1991-10-30 | 1995-12-12 | Thomas Jefferson University | Plasma-based platelet concentrate preparations with additive |
| US5344752A (en) | 1991-10-30 | 1994-09-06 | Thomas Jefferson University | Plasma-based platelet concentrate preparations |
| US5247178A (en) | 1991-12-12 | 1993-09-21 | Fusion Systems Corporation | Method and apparatus for treating fluids by focusing reflected light on a thin fluid layer |
| US5459030A (en) | 1992-03-02 | 1995-10-17 | Steritech, Inc. | Synthetic media compositions for inactivating bacteria and viruses in blood preparations with 8-methoxypsoralen |
| US5288605A (en) | 1992-03-02 | 1994-02-22 | Steritech, Inc. | Methods for inactivating bacteria in blood preparations with 8-methoxypsoralen |
| US5618662A (en) | 1992-03-02 | 1997-04-08 | Cerus Corporation | Intravenous administration of psoralen |
| AU4107396A (en) | 1992-03-02 | 1996-06-06 | Cerus Corporation | Synthetic media for blood components |
| SE9201413L (sv) | 1992-04-30 | 1993-10-31 | Stiftelsen Foer Medicinsk Tekn | Beredning och sätt för aferesframställning av trombocytkoncentrat med väsentligt förlängd hållbarhet |
| US5378601A (en) | 1992-07-24 | 1995-01-03 | Montefiore Medical Center | Method of preserving platelets with apyrase and an antioxidant |
| ES2147203T3 (es) | 1992-08-07 | 2000-09-01 | Cerus Corp | Procedimientos de inactivacion de bacterias en las preparaciones a base de sangre con la ayuda de 8-metoxipsoraleno. |
| TW262386B (enExample) | 1992-09-30 | 1995-11-11 | Senju Pharma Co | |
| US5358844A (en) | 1993-02-18 | 1994-10-25 | Brigham And Women's Hospital, Inc. | Preservation of blood platelets |
| US6004741A (en) | 1993-06-28 | 1999-12-21 | Cerus Corporation | Method for the photoactivation of 4' and 5' primary aminoalkyl psoralens in platelet preparations |
| US5871900A (en) | 1993-06-28 | 1999-02-16 | Cerus Corporation | Method of inactivating pathogens in biological fluids using photoactivated 5-primaryamino psoralens |
| US5712085A (en) | 1993-06-28 | 1998-01-27 | Cerus Corporation | 5'-(4-amino-2-oxa)butye-4,4', 8-trinethylpsoralen in synthetic medium |
| US5593823A (en) | 1993-06-28 | 1997-01-14 | Cerus Corporation | Method for inactivating pathogens in blood using photoactivation of 4'-primary amino-substituted psoralens |
| DE69534151T2 (de) | 1994-02-22 | 2006-01-12 | Nippon Telegraph And Telephone Corp. | Gefriergetrocknete Blutzellen, Stammzellen und Plättchen und Verfahren zu deren Herstellung |
| FR2718353B3 (fr) | 1994-04-11 | 1996-06-28 | Jean Berque | Compositions pharmaceutiques à base de produits biologiques atoxiques destinées à la protection locale des muqueuses génitales et rectales. |
| US5709992A (en) | 1994-08-17 | 1998-01-20 | Rubinstein; Alan I. | Method for disinfecting red blood cells |
| US5622867A (en) | 1994-10-19 | 1997-04-22 | Lifecell Corporation | Prolonged preservation of blood platelets |
| US5919614A (en) | 1994-10-19 | 1999-07-06 | Lifecell Corporation | Composition comprising three platelet lesion inhibitors for platelet storage |
| US5691132A (en) | 1994-11-14 | 1997-11-25 | Cerus Corporation | Method for inactivating pathogens in red cell compositions using quinacrine mustard |
| WO1996014741A2 (en) | 1994-11-14 | 1996-05-23 | Pall Corporation | Long-term blood component storage system and method |
| JP4041171B2 (ja) * | 1994-12-14 | 2008-01-30 | 日本赤十字社 | 血小板保存液 |
| US5605934A (en) | 1995-03-23 | 1997-02-25 | Baxter International Inc. | Method of manufacturing and storing solutions |
| US5624794A (en) | 1995-06-05 | 1997-04-29 | The Regents Of The University Of California | Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas |
| US5656154A (en) | 1995-06-07 | 1997-08-12 | Organ, Inc. | Method and apparatus for separating a fluid into components and for washing a material |
| JPH11508264A (ja) | 1995-06-23 | 1999-07-21 | メディケム リサーチ インコーポレイテッド | 抗ウィルス剤としてのビフラバノイドおよびその誘導体 |
| JP2930908B2 (ja) | 1995-07-19 | 1999-08-09 | 川澄化学工業株式会社 | 血小板保存液 |
| US5736313A (en) | 1995-10-20 | 1998-04-07 | The United States Of America As Represented By The Secretary Of The Navy | Method of lyophilizing platelets by incubation with high carbohydrate concentrations and supercooling prior to freezing |
| US5834198A (en) | 1996-03-21 | 1998-11-10 | Boehringer Mamnnheim Gmbh | Selective photoinducted flavin-dependent cleavage of RNA at G-U base pairs and kits therefor |
| US6060233A (en) | 1996-06-14 | 2000-05-09 | Biostore New Zealand, Ltd | Methods for the lyophilization of platelets, platelet membranes or erythrocytes |
| US5783093A (en) | 1997-01-02 | 1998-07-21 | Haemonetics Corporation | Blood cell concentrates using a single solution for anticoagulation and preservation |
| AU740547B2 (en) * | 1997-01-21 | 2001-11-08 | American National Red Cross, The | Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light |
| US6605699B1 (en) * | 1997-01-21 | 2003-08-12 | Human Genome Sciences, Inc. | Galectin-11 polypeptides |
| US5789151A (en) | 1997-05-15 | 1998-08-04 | The Regents Of The University Of California | Prolonged cold storage of red blood cells by oxygen removal and additive usage |
| US6063624A (en) | 1997-06-09 | 2000-05-16 | Baxter International Inc. | Platelet suspensions and methods for resuspending platelets |
| US5922256A (en) * | 1997-06-26 | 1999-07-13 | Textron Automotive Company, Inc. | Molding method for making plastic foam-backed shells |
| US5955257A (en) | 1997-10-21 | 1999-09-21 | Regents Of The University Of Minnesota | Infusible grade short-term cell storage medium for mononuclear cells |
| US7094378B1 (en) * | 2000-06-15 | 2006-08-22 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US6268120B1 (en) * | 1999-10-19 | 2001-07-31 | Gambro, Inc. | Isoalloxazine derivatives to neutralize biological contaminants |
-
2000
- 2000-11-28 US US09/725,426 patent/US6548241B1/en not_active Expired - Lifetime
-
2001
- 2001-11-21 AT AT01995177T patent/ATE322162T1/de not_active IP Right Cessation
- 2001-11-21 AU AU2002225687A patent/AU2002225687A1/en not_active Abandoned
- 2001-11-21 CA CA2397862A patent/CA2397862C/en not_active Expired - Lifetime
- 2001-11-21 DE DE60118604T patent/DE60118604T2/de not_active Expired - Lifetime
- 2001-11-21 EP EP01995177A patent/EP1345491B1/en not_active Expired - Lifetime
- 2001-11-21 JP JP2002545475A patent/JP4473508B2/ja not_active Expired - Lifetime
- 2001-11-21 WO PCT/US2001/043591 patent/WO2002043485A1/en not_active Ceased
-
2003
- 2003-02-25 US US10/374,907 patent/US20040023201A9/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004514680A5 (enExample) | ||
| CA2397862C (en) | Storage solution containing photosensitizer for inactivation of biological contaminants | |
| EP2174669B1 (en) | System for treating a fluid for inactivation of biological contaminats using photosensitizers | |
| US6258577B1 (en) | Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers | |
| EP1289991B1 (en) | Method for inactivation of microorganisms using photosensitizers | |
| US20110014239A1 (en) | Preparation of Vaccines Using Photosensitizer and Light | |
| WO2001094349A1 (en) | Method and apparatus for inactivation of biological contaminants using photosensitizers | |
| US20030215784A1 (en) | Method and apparatus for inactivation of biological contaminants using photosensitizers | |
| EP1404379A2 (en) | Viral inactivation process using antioxidant | |
| US20030073650A1 (en) | Method and apparatus for inactivation of biological contaminants using photosensitizers | |
| EP1456359B1 (en) | Preparation of vaccines using photosensitizer and light | |
| AU770614B2 (en) | Method and apparatus for inactivation of biological contaminants using photosensitizers | |
| AuBuchon et al. | Inactivation of microbial contaminants of blood components | |
| Ben-Hura et al. | Pathogen Reduction in Blood for Transfusion Using Photodynamic | |
| CA2585179C (en) | Method and apparatus for inactivation of biological contaminants using photosensitizers | |
| CZ20001406A3 (cs) | Řešení se týká léčiva k léčení získaného hyperkoagulovatelného stavu nebo získané nedostatečnosti proteinu C. Týká se lidských pacientů se získaným hyperkoagulovatelným stavem nebo získanou nedostatečností proteinu C souvisejícím se sepsí, purpura fulminans, meningokokální sepsí, transplantací kostní dřeně nebo dalšími transplantacemi, těžkými popáleninami, těhotenstvím, těžkými chirurgickými zákroky, těžkým traumatem nebo ARDS, které zahrnuje podávání aktivovaného proteinu C, který představuje vysoce selektivní terapeutické činidlo s nízkým potenciálem způsobení komplikací představujících krvácením. | |
| HK1033775A (en) | Method and apparatus for inactivation of biological contaminats using photosensitizers |